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A

Anna D. Staniszewska

AstraZeneca
H指数:20
被引数:1,829

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Homologous recombination deficiency and hemizygosity drive resistance in breast cancer

乳腺癌的同源重组缺陷和半合子驱动抵抗

Nature
IF48.5
2026-03-040
OAAI
Anton Safonov; Minna Lee; David N. Brown; Luca Boscolo Bielo; Miika Mehine; Chaitanya Bandlamudi; Ben O’Leary; Hong Shao; Laia Vicente; Daniel Muldoon; Allen Zhu; Susana Ros; Antonio Marra; Pier Selenica; Ivan Bieche; Bradley Wubbenhorst; Emanuela Ferraro; Laura Courtois; Rania El Botty; Mehnaj Ahmed; Enrico Moiso; Julia Ah-Reum An; Mark T. A. Donoghue; Marie Will; Fresia Pareja; Emily Nizialek; Natalia Lukashchuk; Eleni Sofianopoulou; Yuan Liu; Xin Huang; Colombe Chappey; Anna D. Staniszewska; Dara Ross; Diana Mandelker; Marc Ladanyi; Nikolaus Schultz; Michael F. Berger; Maurizio Scaltriti; Jorge S. Reis-Filho; Bob T. Li; Kenneth Offit; Larry Norton; Ronglai Shen; Kara N. Maxwell; Fergus Couch; Susan M. Domchek; Elisabetta Marangoni; Sohrab Shah; Mark R. Albertella; Violeta Serra; Britta Weigelt; David B. Solit; Katherine L. Nathanson; Mark E. Robson; Nicholas C. Turner; Sarat Chandarlapaty; Pedram Razavi
Subtype selective PET imaging of PARP1 binding in non-human primates, healthy volunteers and patients with glioblastoma using [11C]AZ14193391
Neuro-Oncology
IF13.4
2025-12-230
PRE
Zsolt Cselényi; Aurelija Jucaite; Giuseppe Stragliotto; Jiri Bartek; Peter Johnström; Andy Pike; Miguel A Cortés González; Antonia Högnäsbacka; Kenneth Dahl; Avipsa Ghosh; Jeffrey W Johannes; Anna D Staniszewska; Elisabetta Leo; Petra Hamerlik; Barry Davies; Sabina Cosulich; John Swales; Rachel Lawrence; Massimo Squatrito; Nancy Kathryn Mueller; Yasir Khani; Vasco C Sousa; Per Stenkrona; Christer Halldin; Lars Farde; Magnus Schou
Androgen receptor inhibition extends PARP inhibitor activity in prostate cancer models beyond BRCA mutations and defects in homologous recombination repair

雄激素受体抑制在前列腺癌模型中扩展了PARP抑制剂的活性，超越了BRCA突变和同源重组修复缺陷。

NAR CANCER
IF3.2
2025-12-010
OAAI
Illuzzi, Giuditta; Galbiati, Alessandro; Staniszewska, Anna D.; Hanson, Robert; Michaloglou, Chrysiis; Cooke, Sophie L.; Uznanska, Karolina; Bialecka, Maja; Solarczyk, Kamil; Dev, Harveer S.; Massie, Charlie E.; Albertella, Mark R.; Leo, Elisabetta; Forment, Josep, V; O'Connor, Mark J.
Discovery of 6-Fluoro-5-{4-[(5-fluoro-2-methyl-3-oxo-3,4-dihydroquinoxalin-6-yl)methyl]piperazin-1-yl}-N-methylpyridine-2-carboxamide (AZD9574): A CNS-Penetrant, PARP1-Selective Inhibitor
JOURNAL OF MEDICINAL CHEMISTRY
IF6.8
2024-12-100
PRE
Johannes, Jeffrey W.; Balazs, Amber Y. S.; Barratt, Derek; Bista, Michal; Chuba, Matthew D.; Cosulich, Sabina; Critchlow, Susan E.; Degorce, SebastienL.; Di Fruscia, Paolo; Edmondson, Scott D.; Embrey, Kevin J.; Fawell, Stephen; Ghosh, Avipsa; Gill, Sonja J.; Gunnarsson, Anders; Hande, Sudhir M.; Heightman, Tom D.; Hemsley, Paul; Illuzzi, Giuditta; Lane, Jordan; Larner, Carrie J. B.; Leo, Elisabetta; Liu, Lina; Madin, Andrew; Mcwilliams, Lisa; O'Connor, Mark J.; Orme, Jonathan P.; Pachl, Fiona; Packer, Martin J.; Pei, Xiaohui; Pike, Andy; Schimpl, Marianne; She, Hongyao; Staniszewska, Anna D.; Talbot, Verity; Underwood, Elizabeth; Varnes, Jeffrey G.; Xue, Lin; Yao, Tieguang; Zhang, Ke; Zhang, Andrew X.; Zheng, Xiaolan
Preclinical Characterization of AZD9574, a Blood-Brain Barrier Penetrant Inhibitor of PARP1
CLINICAL CANCER RESEARCH
IF10.2
2023-11-158
PRE
Staniszewska, Anna D.; Pilger, Domenic; Gill, Sonja J.; Jamal, Kunzah; Bohin, Natacha; Guzzetti, Sofia; Gordon, Jacob; Hamm, Gregory; Mundin, Gill; Illuzzi, Giuditta; Pike, Andy; McWilliams, Lisa; Maglennon, Gareth; Rose, Jonathan; Hawthorne, Glen; Gonzalez, Miguel Cortes; Halldin, Christer; Johnstroem, Peter; Schou, Magnus; Critchlow, Susan E.; Fawell, Stephen; Johannes, Jeffrey W.; Leo, Elisabetta; Davies, Barry R.; Cosulich, Sabina; Sarkaria, Jann N.; O'Connor, Mark J.; Hamerlik, Petra
Preclinical evaluation of a novel B7-H4 targeted antibody-drug conjugate AZD8205 as a single agent and in combination with novel PARP inhibitor and checkpoint blockade
CANCER RESEARCH
IF16.6
2023-04-040
PRE
Cazes, Alex; Kinneer, Krista; Omar, Bilal; Chesebrough, Jon; Anderton, Judith; Wang, Jixin; Staniszewska, Anna D.; Arbitman, Steven; Daita, Kalyani; Desai, Himanshi; Johnson, Yoshimi; Rothstein, Raymond; Gymnopoulos, Marco; Fabbri, Giulia; Cooper, Zachary A.; Albertella, Mark; Hammond, Scott A.; Cosulich, Sabina; Luheshi, Nadia; Sapra, Puja
Design and Preclinical Evaluation of a Novel B7-H4-Directed Antibody-Drug Conjugate, AZD8205, Alone and in Combination with the PARP1-Selective Inhibitor AZD5305
CLINICAL CANCER RESEARCH
IF10.2
2022-11-1030
OA
Kinneer, Krista; Wortmann, Philipp; Cooper, Zachary A.; Dickinson, Niall J.; Masterson, Luke; Cailleau, Thais; Hutchinson, Ian; Vijayakrishnan, Balakumar; McFarlane, Mary; Ball, Kathryn; Davies, Michael; Lewis, Arthur; Huang, Yue; Rosenbaum, Anton I.; Yuan, Jiaqi; Chesebrough, Jon; Anderton, Judith; Monks, Noel; Novick, Steven; Wang, Jixin; Dimasi, Nazzareno; Christie, R. James; Sabol, Darrin; Tosto, Frances Anne; Wallez, Yann; Leo, Elisabetta; Albertella, Mark R.; Staniszewska, Anna D.; Tice, David A.; Howard, Philip W.; Luheshi, Nadia; Sapra, Puja
AKT-mTORC1 reactivation is the dominant resistance driver for PI3Kβ/AKT inhibitors in PTEN-null breast cancer and can be overcome by combining with Mcl-1 inhibitors
ONCOGENE
IF7.3
2022-10-148
OAAI
Dunn, Shanade; Eberlein, Cath; Yu, Jason; Gris-Oliver, Albert; Ong, Swee Hoe; Yelland, Urs; Cureton, Natalie; Staniszewska, Anna; McEwen, Robert; Fox, Millie; Pilling, James; Hopcroft, Philip; Coker, Elizabeth A.; Jaaks, Patricia; Garnett, Mathew J.; Isherwood, Beverley; Serra, Violeta; Davies, Barry R.; Barry, Simon T.; Lynch, James T.; Yusa, Kosuke
Preclinical Characterization of AZD5305, A Next-Generation, Highly Selective PARP1 Inhibitor and Trapper br
CLINICAL CANCER RESEARCH
IF10.2
2022-08-0574
OAAI
Illuzzi, Giuditta; Staniszewska, Anna D.; Gill, Sonja J.; Pike, Andy; McWilliams, Lisa; Critchlow, Susan E.; Cronin, Anna; Fawell, Stephen; Hawthorne, Glen; Jamal, Kunzah; Johannes, Jeffrey; Leonard, Emilyanne; Macdonald, Ruth; Maglennon, Gareth; Nikkila, Jenni; O'Connor, Mark J.; Smith, Aaron; Southgate, Harriet; Wilson, Joanne; Yates, James; Cosulich, Sabina; Leo, Elisabetta
Discovery of 5-{4-[(7-Ethyl-6-oxo-5,6-dihydro-1,5-naphthyridin-3-yl)methyl]piperazin-1-yl}-N-methylpyridine-2-carboxamide (AZD5305): A PARP1-DNA Trapper with High Selectivity for PARP1 over PARP2 and Other PARPs
JOURNAL OF MEDICINAL CHEMISTRY
IF6.8
2021-09-2781
PREAI
Johannes, Jeffrey W.; Balazs, Amber; Barratt, Derek; Bista, Michal; Chuba, Matthew D.; Cosulich, Sabina; Critchlow, Susan E.; Degorce, Sebastien L.; Di Fruscia, Paolo; Edmondson, Scott D.; Embrey, Kevin; Fawell, Stephen; Ghosh, Avipsa; Gill, Sonja J.; Gunnarsson, Anders; Hande, Sudhir M.; Heightman, Tom D.; Hemsley, Paul; Illuzzi, Giuditta; Lane, Jordan; Larner, Carrie; Leo, Elisabetta; Liu, Lina; Madin, Andrew; Martin, Scott; McWilliams, Lisa; O'Connor, Mark J.; Orme, Jonathan P.; Pachl, Fiona; Packer, Martin J.; Pei, Xiaohui; Pike, Andrew; Schimpl, Marianne; She, Hongyao; Staniszewska, Anna D.; Talbot, Verity; Underwood, Elizabeth; Varnes, Jeffrey G.; Xue, Lin; Yao, Tieguang; Zhang, Ke; Zhang, Andrew X.; Zheng, Xiaolan

研究方向

暂未获取到该数据
G
Giuditta Illuzzi
H 指数:18论文数:82被引数:1,204
S
Sabina Cosulich
H 指数:36论文数:293被引数:5,851
E
Elisabetta Leo
H 指数:31论文数:160被引数:4,944
M
Mark R. Albertella
H 指数:18论文数:193被引数:2,834
J
Jonathan P. Orme
H 指数:10论文数:59被引数:785
E
Elaine Cadogan
H 指数:26论文数:128被引数:2,864
M
Molly A. Taylor
H 指数:20论文数:57被引数:2,165
L
Larissa S. Carnevalli
H 指数:22论文数:115被引数:1,777
M
Mark J. O’Connor
H 指数:69论文数:435被引数:2.1万
J
James Yates
H 指数:38论文数:323被引数:5,868