logo
科言猫学术研究的AI总结
language
手机端手机端
  • Phone Feature微信小程序
简体中文简体中文
notice消息通知
博客博客
delete
arrow
返回
S

Stefan Laufer

eberhard karls university tbingen

70H指数
821论文数
2.0W被引数
收录论文 247
发表时间
logo
Thinking Outside the Binding Site: A Self-Encapsulating Kinase Inhibitor Remodels Its Pocket to Achieve Selectivity跳出结合位点：一种自包封激酶抑制剂通过重塑其口袋实现选择性
errAngewandte Chemie-International Edition
IF16.9
err2026-09-16
err0
errOAAI
errNico J. Seidler; Monica R. MacDonald; Athina A. Moschopoulou; Sahba Cunningham; Tess M. Weber; Nader N. Nasief; Lorenz Mayer; Frederik W. Hacker; Ekaterina Hermann; Mareike B. Möllers; Yuliia Skliarenko; Tahereh Damghani; Abid N. Manzar; Kaly S. Lin; Ramona Rudalska; Marcia I. Goettert; Lars Zender; Daniel Dauch; Michael Forster; Stefan A. Laufer; David E. Heppner
err分享
err收藏
Inhibitors Targeting SARS-CoV-2 Papain-Like Protease: Screening, Design, Synthesis, and Biological Evaluation靶向SARS-CoV-2半胱氨酸蛋白酶的抑制剂：筛选、设计、合成与生物评价
errChemMedChem
IF3.4
err2026-05-08
err0
errOAAI
errElena-Oriana Iuga; Nilu Gone; Mariana Ortiz de Godoy; Gabriel Correa Verissimo; Giovanna de Jesus Agostinetto; Liam Urich; Nadine Krüger; Thales Kronenberger; Rafael Victorio Carvalho Guido; Anthony J. O’Donoghue; Stefan A. Laufer; Thanigaimalai Pillaiyar
err分享
err收藏
Darizmetinib (HRX215): A Promising 1st-in-Class Liver Regenerating Drug in Phase 1b/2a Clinical Development; Targeting the Stress Signaling Protein Kinase MKK4达里泽替尼 (HRX215)：一种有前景的1类肝脏再生药物，处于1b/2a期临床开发阶段；靶向应激信号蛋白激酶MKK4
errJournal of Medicinal Chemistry
IF6.8
err2026-05-06
err0
errOAAI
errWolfgang Albrecht; Roland Selig; Bent Pfaffenrot; Philip Kloevekorn; Michael Juchum; Stefan Zwirner; Sabrina Klotz; Lars Zender; Stefan Laufer
err分享
err收藏
New Quinoline Kinase Inhibitors With Good Selectivity for NAK Kinases and Anti-Tumor Activity Against Ewing Sarcoma新型喹啉激酶抑制剂，对NAK激酶具有良好的选择性，并具有抗尤因肉瘤的肿瘤活性
errArchiv der Pharmazie
IF3.6
err2026-01-01
err0
errOAAI
errGentz, Caroline de Bem; Fernandes, Thais Helena Maciel; Lopes, Marcela Silva; Elson, Lewis; Kramer, Andreas; de Souza, Lucas Rodrigo; Fortes, Isadora Serraglio; Pinto, Georgia Silva; Martins, Martha Cestari Silva; de Lima, Henrique Barros; Santiago, Andre da Silva; Gregianin, Lauro Jose; Massirer, Katlin Brauer; Bengtson, Mario Henrique; Roesler, Rafael; Knapp, Stefan; Laufer, Stefan A.; de Andrade, Saulo Fernandes
err分享
err收藏
Investigation on LASSBio-1971 and LASSBio-1974 Cellular Cytotoxic Mechanism and Their Comparative DMPK ProfileLASSBio-1971和LASSBio-1974的细胞毒性机制研究及其DMPK比较分析
errARCHIV DER PHARMAZIE
IF3.6
err2025-11-01
err0
errOAAI
errde Moraes Junior, Manoel Oliveira; Barbosa, Gisele; da Costa, Caroline Marques Xavier; Pillpe-Meza, Raysa Magali; de Gouveia, Wesley Leandro; do Amaral, Daniel Nascimento; Gelves, Luis Gabriel Valdivieso; Laufer, Stefan; Lima, Lidia Moreira
err分享
err收藏
A twist in the tale: shifting from covalent targeting of a tyrosine in JAK3 to a lysine in MK2故事的转折：从靶向JAK3中酪氨酸的共价键转移到靶向MK2中的赖氨酸
errRSC Med. Chem.
IF3.6
err2025-08-22
err0
errOAAI
errLaura Hillebrand ‡; Guiqun Wang ‡; Alexander Rasch; Benedikt Masberg; Apirat Chaikuad; Thales Kronenberger; Ellen Günther; Michael Forster; Antti Poso; Michael Lämmerhofer; Stefan A. Laufer; Stefan Knapp; Matthias Gehringer
err分享
err收藏
Structure–Activity Relationships of Inactive-Conformation Binding EGFR Inhibitors: Linking the ATP and Allosteric Pockets非活性构象结合EGFR抑制剂的构效关系：连接ATP和别构口袋
errArchiv der Pharmazie
IF3.6
err2025-07-16
err0
errOAAI
errSurbhi P. Chitnis; Florian Wittlinger; Mareike Möllers; Tyler J. Hartman; Marcel Günther; Michael J. Eck; Stefan A. Laufer; David E. Heppner
err分享
err收藏
Discovery of the First Highly Selective 1; 4-dihydropyrido[3; 4-b]pyrazin-3(2H)-one MKK4 Inhibitor首次发现的高选择性1;4-二氢吡啶并[3;4-b]哒嗪-3(2H)-酮MKK4抑制剂
errJournal of Medicinal Chemistry
IF6.8
err2025-07-11
err0
errOAAI
errLeon Katzengruber; Pascal Sander; Stefan Zwirner; Alexander Rasch; Eric Eberlein; Roland Selig; Wolfgang Albrecht; Lars Zender; Stefan A. Laufer
err分享
err收藏
Caffeinated and Decaffeinated Yerba Mate (Ilex paraguariensis) Infusion Extracts Alter CD73 and Reduce the Migration and Adhesion of Glioblastoma Cells咖啡因和脱咖啡因巴拉圭茶（Ilex paraguariensis）浸提物可改变CD73并降低胶质母细胞瘤细胞的迁移和粘附。
errPlant Foods for Human Nutrition
IF3.6
err2025-06-13
err0
PREAI
errDimitryus Rodrigues Birkhan; Rafael Diogo Weimer; Fernando Mendonça Diz; Leticia de Leon Aguiar; Vinicius Padilha Pedroso; Vitor Justo Pereira; Gabriela Santos Rocha; Eduardo Luiz Pedrazza; Stefan Laufer; Bruna Sgarioni; Victor Hugo Silva Rodrigues; Eduardo Cassel; Fernanda Bueno Morrone
err分享
err收藏
A Ligand First Approach toward Selective, Covalent JNK2/3 Inhibitors一种配体优先策略，用于选择性共价JNK2/3抑制剂的研发
errJOURNAL OF MEDICINAL CHEMISTRY
IF6.8
err2025-05-22
err0
errOAAI
errWydra, Valentin R.; Plank, Nicole; Zwirner, Stefan; Selig, Roland; Rasch, Alexander; Masberg, Benedikt; Laemmerhofer, Michael; Zender, Lars; Koch, Pierre; Albrecht, Wolfgang; Laufer, Stefan
err分享
err收藏
An overview of progress in human metapneumovirus (hMPV) research: Structure, function, and therapeutic opportunities人类鼻病毒（hMPV）研究进展概述：结构、功能及治疗机遇
errDRUG DISCOVERY TODAY
IF7.5
err2025-05-01
err0
errOAAI
errKrueger, Nadine; Laufer, Stefan A.; Pillaiyar, Thanigaimalai
err分享
err收藏
The European Federation for Medicinal Chemistry and Chemical Biology (EFMC) Best Practice Initiative: Hit to Lead欧洲药物化学和化学生物学联合会 (EFMC) 最佳实践倡议: 领先
errCHEMMEDCHEM
IF3.4
err2025-02-16
err0
PREAI
errQuancard, Jean; Bach, Anders; Borsari, Chiara; Craft, Russell; Gnamm, Christian; Gueret, Stephanie M.; Hartung, Ingo V.; Koolman, Hannes F.; Laufer, Stefan; Lepri, Susan; Messinger, Josef; Ritter, Kurt; Sbardella, Gianluca; Lopez, Andrea Unzue; Willwacher, Marina K.; Cox, Brian; Young, Robert J.
err分享
err收藏
An investigation of the drug release kinetics of 3D-Printed two compartment Theophylline and Prednisolone tablets
errINTERNATIONAL JOURNAL OF PHARMACEUTICS
IF5.2
err2025-02-01
err0
errOAAI
errPflieger, Thomas; Venkatesh, Rakesh; Dachtler, Markus; Laufer, Stefan; Lunter, Dominique
err分享
err收藏
Design, Synthesis, and Biochemical Evaluation of Novel MLK3 Inhibitors: A Target Hopping Example
errJOURNAL OF MEDICINAL CHEMISTRY
IF6.8
err2024-12-16
err0
PREAI
errSander, Pascal; Schwalm, Martin P.; Kraemer, Andreas; Elson, Lewis; Rasch, Alexander; Masberg, Benedikt; Selig, Roland; Sievers-Engler, Adrian; Laemmerhofer, Michael; Mueller, Susanne; Knapp, Stefan; Albrecht, Wolfgang; Laufer, Stefan A.
err分享
err收藏
Tilting the Scales toward EGFR Mutant Selectivity: Expanding the Scope of Bivalent Type V Kinase Inhibitors
errJOURNAL OF MEDICINAL CHEMISTRY
IF6.8
err2024-12-03
err0
PREAI
errWittlinger, Florian; Chitnis, Surbhi P.; Pham, Calvin D.; Damghani, Tahereh; Patel, Kishan B.; Moellers, Mareike; Schaeffner, Ilse K.; Abidakun, Omobolanle A.; Deng, Matthew Q.; Ogboo, Blessing C.; Rasch, Alexander; Beyett, Tyler S.; Buckley, Brian; Feru, Frederic; Shaurova, Tatiana; Knappe, Cornelius; Eck, Michael J.; Hershberger, Pamela A.; Scott, David A.; Brandt, Asher L.; Laufer, Stefan A.; Heppner, David E.
err分享
err收藏
Hemin promotes platelet activation and plasma membrane disintegration regulated by the subtilisin-like proprotein convertase furin氯化血红素促进枯草杆菌蛋白酶样前蛋白转化酶弗林蛋白酶调节的血小板活化和质膜崩解
errFASEB JOURNAL
IF4.2
err2024-11-12
err1
errOAAI
errSchaale, David; Laspa, Zoi; Balmes, Aylin; Sigle, Manuel; Dicenta-Baunach, Valerie; Hochuli, Ravi; Fu, Xiaoqing; Serafimov, Kristian; Castor, Tatsiana; Harm, Tobias; Mueller, Karin Anne Lydia; Rohlfing, Anne-Katrin; Laufer, Stefan; Schaeffer, Tilman E.; Laemmerhofer, Michael; Gawaz, Meinrad
err分享
err收藏
Hemin-induced platelet activation is regulated by the ACKR3 chemokine surface receptor and has implications for passivation of vulnerable atherosclerotic plaques
errFEBS JOURNAL
IF4.2
err2024-10-10
err1
errOAAI
errLaspa, Zoi; Dicenta-Baunach, Valerie; Schaale, David; Sigle, Manuel; Hochuli, Ravi; Castor, Tatsiana; Bayrak, Alp; Harm, Tobias; Mueller, Karin Anne Lydia; Pillaiyar, Thanigaimalai; Laufer, Stefan; Rohlfing, Anne-Katrin; Gawaz, Meinrad Paul
err分享
err收藏
ACKR3 agonism induces heterodimerization with chemokine receptor CXCR4 and attenuates platelet function
errEUROPEAN JOURNAL OF CLINICAL INVESTIGATION
IF3.6
err2024-10-07
err1
errOAAI
errDicenta-Baunach, Valerie; Laspa, Zoi; Schaale, David; Sigle, Manuel; Bayrak, Alp; Castor, Tatsiana; Pillaiyar, Thanigaimalai; Laufer, Stefan; Gawaz, Meinrad Paul; Rohlfing, Anne-Katrin
err分享
err收藏
The potential role of purinergic signaling in cancer therapy: perspectives on anti-CD73 strategies for prostate cancer
errFRONTIERS IN IMMUNOLOGY
IF5.9
err2024-09-17
err3
errOAAI
errGardani, Carla Fernanda Furtado; Diz, Fernando Mendonca; Donde, Luisa Brandalise; Rockenbach, Liliana; Laufer, Stefan; Morrone, Fernanda Bueno
err分享
err收藏
Novel Small-Molecule Atypical Chemokine Receptor 3 Agonists: Design, Synthesis, and Pharmacological Evaluation for Antiplatelet Therapy
errJOURNAL OF MEDICINAL CHEMISTRY
IF6.8
err2024-08-08
err2
PREAI
errBayrak, Alp; Szpakowska, Martyna; Dicenta-Baunach, Valerie; Counson, Manuel; Rasch, Alexander; Rohlfing, Anne-Katrin; Chevigne, Andy; Gawaz, Meinrad; Laufer, Stefan A.; Pillaiyar, Thanigaimalai
err分享
err收藏

研究方向

暂无研究方向
合作学者
合作期刊
P
Pasi A. Jänne
H 指数: 163 · 论文数: 2.3K
S
Scott W. Lowe
H 指数: 156 · 论文数: 977
G
Georg Schett
H 指数: 154 · 论文数: 1.7K
K
K. A. Jellinger
H 指数: 136 · 论文数: 1.6K
A
Albert J. R. Heck
H 指数: 132 · 论文数: 1.2K
查看更多