Jamie J. Arnold - Publications, H-index & Citations

Jamie J. Arnold

University of North Carolina School of Medicine

46H指数

158论文数

9.8K被引数

收录论文 71

发表时间

Copy-back RNA synthesis by coronavirus polymerase requires helicase activity and is stimulated by remdesivir and molnupiravir 冠状病毒聚合酶介导的复制回环RNA合成需要解旋酶活性，并受到瑞德西韦和莫诺拉韦的刺激

Science Advances

IF12.5

2026-06-19

OAAI

Asif Rakib; Arnab Das; Subhas C. Bera; Jelmer Cnossen; Refugio Robles-Sikisaka; Meghan V. Diefenbacher; Pim P. B. America; Misha Klein; Thomas K. Anderson; John C. Marecki; Bing Wang; Eline Bogers; Joy Y. Feng; John P. Bilello; Flávia S. Papini; Quinte Smitskamp; Timothy P. Sheahan; Jamie J. Arnold; Andrew Routh; Irina Artsimovitch; Robert N. Kirchdoerfer; Craig E. Cameron; Kevin D. Raney; David Dulin

NS5 polymerase stimulates RNA duplex unwinding by the Orthoflavivirus NS3 helicase NS5聚合酶通过正黄病毒属NS3解旋酶刺激RNA双链解旋

Journal of Biological Chemistry

IF3.9

2026-05-06

OAAI

Jamie J. Arnold; Shubeena Chib; Craig E. Cameron

RNA virus polymerase-helicase coupling enables rapid elongation through duplex RNA RNA病毒聚合酶-解旋酶偶联通过双链RNA实现快速延伸

Cell Reports

IF6.9

2026-04-16

OAAI

Pim P.B. America; Subhas C. Bera; Arnab Das; Thomas K. Anderson; John C. Marecki; Flávia S. Papini; Jamie J. Arnold; Robert N. Kirchdoerfer; Craig E. Cameron; Kevin D. Raney; Martin Depken; David Dulin

Incorporation of arabinose-CTP and arabinose-UTP inhibit viral polymerases by inducing long pauses 阿拉伯糖-CTP和阿拉伯糖-UTP的掺入通过诱导长暂停来抑制病毒聚合酶

Journal of Biological Chemistry

IF3.9

2025-12-09

OAAI

Ziyang Xiao; Arnab Das; Abha Jain; Thomas K. Anderson; Craig E. Cameron; Jamie J. Arnold; David Dulin; Robert N. Kirchdoerfer

Minimal Polymerase-Containing Precursor Required for Chikungunya Virus RNA Synthesis 合成基孔肯雅病毒RNA所需的最小含聚合酶前体

Viruses 2025, Vol. 17, Page 1556

IF3.5

2025-11-29

OAAI

David Aponte-Diaz; Abha Jain; Jayden M. Harris; Jamie J. Arnold; Craig E. Cameron

Enantioselective Chemical Probe for Chikungunya nsP2 Helicase with Antialphaviral Activity 手性选择性化学探针用于查加斯病毒nsP2解旋酶，并具有抗阿尔法病毒活性

ACS Infectious Diseases

IF3.8

2025-07-18

OAAI

Bose Muthu Ramalingam; Hans J. Oh; John D. Sears; Chun-Hsing Chen; Anand Vala; Shubin Liu; Kacey M. Talbot; Mohammed Anwar Hossain; Peter J. Brown; Scott Houliston; Julia Garcia Perez; Fengling Li; Meareg G. Amare; Peter Halfmann; Jessica L. Smith; Alec J. Hirsch; Cheryl H. Arrowsmith; Levon Halabelian; Ava Vargason; Rafael M. Couñago; Jamie J. Arnold; Craig E. Cameron; Nathaniel J. Moorman; Mark T. Heise; Timothy M. Willson

Identification of Direct-Acting nsP2 Helicase Inhibitors with Antialphaviral Activity 直接作用型nsP2解旋酶抑制剂的抗甲病毒活性鉴定

Journal of Medicinal Chemistry

IF6.8

2025-07-09

OAAI

Bose Muthu Ramalingam; John D. Sears; Kacey M. Talbot; Yuan-Wei Norman Su; Scott Houliston; Mohammed Anwar Hossain; Zachary W. Davis-Gilbert; Chunqing Zhao; Hans J. Oh; Peter J. Brown; Marcia K. Sanders; Stella R. Moorman; Durbadal Ojha; Jane E. Burdick; Isabella Law; Noah L. Morales; Sabian A. Martinez; Peter Loppnau; Julia Garcia Perez; Adam M. Drobish; Thomas E. Morrison; Zachary J. Streblow; Daniel N. Streblow; Cheryl H. Arrowsmith; Ava Vargason; Rafael M. Couñago; Levon Halabelian; Jamie J. Arnold; Craig E. Cameron; Nathaniel J. Moorman; Mark T. Heise; Timothy M. Willson

A post-assembly conformational change makes the SARS-CoV-2 polymerase elongation-competent 组装后的构象变化使SARS-CoV-2聚合酶获得延伸活性。

NUCLEIC ACIDS RESEARCH

IF13.1

2025-06-10

PREAI

Klein, Misha; Das, Arnab; Bera, Subhas C.; Anderson, Thomas K.; Kocincova, Dana; Lee, Hery W.; Wang, Bing; Papini, Flavia S.; Marecki, John C.; Arnold, Jamie J.; Cameron, Craig E.; Raney, Kevin D.; Artsimovitch, Irina; Gotte, Mathias; Kirchdoerfer, Robert N.; Depken, Martin; Dulin, David

Mechanism of Forced-Copy-Choice RNA Recombination by Enteroviral RNA-Dependent RNA Polymerases 肠道病毒RNA依赖性RNA聚合酶介导的强制复制选择RNA重组机制

ACS BIO & MED CHEM AU

IF4.3

2025-05-06

OAAI

Arnold, JJ; Martinez, A; Jain, A; Liu, XR; Moustafa, IM; Cameron, CE

Single-Cell Virology: On-Chip, Quantitative Characterization of the Dynamics of Virus Spread from One Single Cell to Another

VIRUSES-BASEL

IF3.5

2024-10-24

OAAI

Liu, Wu; Wilke, Claus O.; Arnold, Jamie J.; Sotoudegan, Mohamad S.; Cameron, Craig E.

Identification of a cell- active chikungunya virus nsP2 protease inhibitor using a covalent fragment- based screening approach

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

IF9.1

2024-10-10

PREAI

Merten, Eric M.; Sears, John D.; Leisner, Tina M.; Hardy, P. Brian; Ghoshal, Anirban; Hossain, Mohammad Anwar; Asressu, Kesatebrhan Haile; Brown, Peter J.; Tse, Edwin G.; Stashko, Michael A.; Li, Kelin; Drouin, Jacqueline L. Norris -; Herring, Laura E.; Mordant, Angie L.; Webb, Thomas S.; Mills, Christine A.; Barker, Natalie K.; Streblow, Zachary J.; Perveen, Sumera; Arrowsmith, Cheryl H.; Counago, Rafael Miguez; Arnold, Jamie J.; Cameron, Craig E.; Streblow, Daniel N.; Moorman, Nathaniel J.; Heise, Mark T.; Willson, Timothy M.; Popov, Konstantin I.; Pearce, Kenneth H.

Interfering with nucleotide excision by the coronavirus 3′-to-5′ exoribonuclease

NUCLEIC ACIDS RESEARCH

IF13.1

2022-12-22

OAAI

Chinthapatla, Rukesh; Sotoudegan, Mohamad; Srivastava, Pankaj; Anderson, Thomas K.; Moustafa, Ibrahim M.; Passow, Kellan T.; Kennelly, Samantha A.; Moorthy, Ramkumar; Dulin, David; Feng, Joy Y.; Harki, Daniel A.; Kirchdoerfer, Robert N.; Cameron, Craig E.; Arnold, Jamie J.

Enteroviral 2C protein is an RNA-stimulated ATPase and uses a two-step mechanism for binding to RNA and ATP

NUCLEIC ACIDS RESEARCH

IF13.1

2022-11-18

OAAI

Yeager, Calvin; Carter, Griffin; Gohara, David W.; Yennawar, Neela H.; Enemark, Eric J.; Arnold, Jamie J.; Cameron, Craig E.

Induced intra- and intermolecular template switching as a therapeutic mechanism against RNA viruses

MOLECULAR CELL

IF16.6

2021-11-01

OAAI

Janissen, Richard; Woodman, Andrew; Shengjuler, Djoshkun; Vallet, Thomas; Lee, Kuo-Ming; Kuijpers, Louis; Moustafa, Ibrahim M.; Fitzgerald, Fiona; Huang, Peng-Nien; Perkins, Angela L.; Harki, Daniel A.; Arnold, Jamie J.; Solano, Belen; Shih, Shin-Ru; Vignuzzi, Marco; Cameron, Craig E.; Dekker, Nynke H.

A Chemical Strategy for Intracellular Arming of an Endogenous Broad-Spectrum Antiviral Nucleotide

JOURNAL OF MEDICINAL CHEMISTRY

IF6.8

2021-10-18

OAAI

Passow, Kellan T.; Caldwell, Haley S.; Ngo, Kiet A.; Arnold, Jamie J.; Antczak, Nicole M.; Narayanan, Anoop; Jose, Joyce; Sturla, Shana J.; Cameron, Craig E.; Ciota, Alexander T.; Harki, Daniel A.

The nucleotide addition cycle of the SARS-CoV-2 polymerase

CELL REPORTS

IF6.9

2021-08-01

OAAI

Bera, Subhas Chandra; Seifert, Mona; Kirchdoerfer, Robert N.; van Nies, Pauline; Wubulikasimu, Yibulayin; Quack, Salina; Papini, Flavia S.; Arnold, Jamie J.; Canard, Bruno; Cameron, Craig E.; Depken, Martin; Dulin, David

Temperature controlled high-throughput magnetic tweezers show striking difference in activation energies of replicating viral RNA-dependent RNA polymerases

NUCLEIC ACIDS RESEARCH

IF13.1

2020-04-14

OAAI

Seifert, Mona; van Nies, Pauline; Papini, Flavia S.; Arnold, Jamie J.; Poranen, Minna M.; Cameron, Craig E.; Depken, Martin; Dulin, David

2?-C-methylated nucleotides terminate virus RNA synthesis by preventing active site closure of the viral RNA-dependent RNA polymerase

JOURNAL OF BIOLOGICAL CHEMISTRY

IF3.9

2019-11-01

OAAI

Boehr, Alyson K.; Arnold, Jamie J.; Oh, Hyung S.; Cameron, Craig E.; Boehr, David D.

More than efficacy revealed by single-cell analysis of antiviral therapeutics

SCIENCE ADVANCES

IF12.5

2019-10-11

OAAI

Liu, Wu; Caglar, Mehmet; Mao, Zhangming; Woodman, Andrew; Arnold, Jamie J.; Wilke, Claus O.; Cameron, Craig E.

Multiple poliovirus-induced organelles suggested by comparison of spatiotemporal dynamics of membranous structures and phosphoinositides

PLOS PATHOGENS

IF4.9

2018-04-27

OAAI

Oh, Hyung S.; Banerjee, Sravani; Aponte-Diaz, David; Sharma, Suresh D.; Aligo, Jason; Lodeiro, Maria F.; Ning, Gang; Sharma, Rajni; Arnold, Jamie J.; Cameron, Craig E.

研究方向