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T

Timothy M. Willson

university of north carolina

110H指数
418论文数
6.9W被引数
收录论文 159
发表时间
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N -Alkyl Sulfamates as a New Class of nsP2 Cysteine Protease Inhibitors with Broad-Spectrum Antialphaviral Activity
errJOURNAL OF MEDICINAL CHEMISTRY
IF6.8
err2025-10-01
err0
PREAI
errGhoshal, Anirban; Sears, John D.; Hossain, Mohammad Anwar; Tse, Edwin G.; Howell, Stefanie; Burdick, Jane E.; Morales, Noah L.; Martinez, Sabian A.; Law, Isabella; Streblow, Zachary J.; Streblow, Daniel N.; Counago, Rafael M.; Moorman, Nathaniel J.; Heise, Mark T.; Willson, Timothy M.
err分享
err收藏
Targeting STK17B kinase activates ferroptosis and suppresses drug resistance in multiple myeloma靶向STK17B激酶能激活铁死亡并抑制多发性骨髓瘤中的药物抵抗
errBlood
IF23.1
err2025-09-15
err0
PREAI
errZhibo Yan; Zhannan Han; Yihui Wang; Maja Beus; Yu Zhang; Alfredo Picado; Carrow I. Wells; Jian Wu; Loren B. Weidenhammer; Karla M. Pires; Elizabeth A. Leibold; Liang Liu; David M. Gooden; Ivan Spasojevic; Erik J. Soderblom; Yubin Kang; Lawrence H. Boise; Timothy M. Willson; Mikhail A. Nikiforov
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Enantioselective Chemical Probe for Chikungunya nsP2 Helicase with Antialphaviral Activity手性选择性化学探针用于查加斯病毒nsP2解旋酶，并具有抗阿尔法病毒活性
errACS Infectious Diseases
IF3.8
err2025-07-18
err0
errOAAI
errBose Muthu Ramalingam; Hans J. Oh; John D. Sears; Chun-Hsing Chen; Anand Vala; Shubin Liu; Kacey M. Talbot; Mohammed Anwar Hossain; Peter J. Brown; Scott Houliston; Julia Garcia Perez; Fengling Li; Meareg G. Amare; Peter Halfmann; Jessica L. Smith; Alec J. Hirsch; Cheryl H. Arrowsmith; Levon Halabelian; Ava Vargason; Rafael M. Couñago; Jamie J. Arnold; Craig E. Cameron; Nathaniel J. Moorman; Mark T. Heise; Timothy M. Willson
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err收藏
Identification of Direct-Acting nsP2 Helicase Inhibitors with Antialphaviral Activity直接作用型nsP2解旋酶抑制剂的抗甲病毒活性鉴定
errJournal of Medicinal Chemistry
IF6.8
err2025-07-09
err0
errOAAI
errBose Muthu Ramalingam; John D. Sears; Kacey M. Talbot; Yuan-Wei Norman Su; Scott Houliston; Mohammed Anwar Hossain; Zachary W. Davis-Gilbert; Chunqing Zhao; Hans J. Oh; Peter J. Brown; Marcia K. Sanders; Stella R. Moorman; Durbadal Ojha; Jane E. Burdick; Isabella Law; Noah L. Morales; Sabian A. Martinez; Peter Loppnau; Julia Garcia Perez; Adam M. Drobish; Thomas E. Morrison; Zachary J. Streblow; Daniel N. Streblow; Cheryl H. Arrowsmith; Ava Vargason; Rafael M. Couñago; Levon Halabelian; Jamie J. Arnold; Craig E. Cameron; Nathaniel J. Moorman; Mark T. Heise; Timothy M. Willson
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Thienopyridine Based Estrogen Receptor Modulators Adopt Unique Ligand Binding Poses to Elicit Anti Proliferative Activities in ER plus Breast Cancer Cells噻吩并吡啶类雌激素受体调节剂通过独特的配体结合构象在ER阳性乳腺癌细胞中诱导抗增殖活性
errENDOCRINOLOGY
IF3.3
err2025-04-21
err0
PREAI
errMateus, Sofia Lucia; Fink, Emma C.; Meganathan, Nandakumar; Sammeta, Vamshi K. R.; Norris, John D.; McDonnell, Donald Patrick; Willson, Timothy; Fanning, Sean William
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A covalent chemical probe for Chikungunya nsP2 cysteine protease with antialphaviral activity and proteome-wide selectivity具有抗甲病毒活性和全蛋白质组选择性的基孔肯雅nsP2半胱氨酸蛋白酶的共价化学探针
errSCIENTIFIC REPORTS
IF3.9
err2025-03-01
err0
errOAAI
errGhoshal, Anirban; Tse, Edwin G.; Hossain, Mohammad Anwar; Asressu, Kesatebrhan Haile; Merten, Eric M.; Sears, John D.; Howell, Stefanie; Perveen, Sumera; Burdick, Jane; Morales, Noah L.; Martinez, Sabian A.; Law, Isabella; Davenport, Bennett J.; Morrison, Thomas E.; Streblow, Zachary J.; Streblow, Daniel N.; Mordant, Angie L.; Webb, Thomas S.; Cabrera, Aurora; Herring, Laura E.; Arrowsmith, Cheryl H.; Pearce, Kenneth H.; Moorman, Nathaniel J.; Heise, Mark T.; Counago, Rafael M.; Brown, Peter J.; Willson, Timothy M.
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Toward target 2035: EUbOPEN - a public-private partnership to enable & unlock biology in the open迈向目标2035: EUbOPEN-一个公私合作伙伴关系，以开放和解锁生物学
errRSC MEDICINAL CHEMISTRY
IF3.6
err2025-01-01
err1
errOAAI
errTredup, Claudia; Ackloo, Suzanne; Beck, Hartmut; Brown, Peter J.; Bullock, Alex N.; Ciulli, Alessio; Dikic, Ivan; Edfeldt, Kristina; Edwards, Aled M.; Elkins, Jonathan M.; Farin, Henner F.; Fon, Edward A.; Gstaiger, Matthias; Guenther, Judith; Gustavsson, Anna-Lena; Haeberle, Sandra; Isigkeit, Laura; Huber, Kilian V. M.; Kotschy, Andras; Kraemer, Oliver; Leach, Andrew R.; Marsden, Brian D.; Matsui, Hisanori; Merk, Daniel; Montel, Florian; Mulder, Monique P. C.; Mueller, Susanne; Owen, Dafydd R.; Proschak, Ewgenij; Roehm, Sandra; Stolz, Alexandra; Sundstroem, Michael; von Delft, Frank; Willson, Timothy M.; Arrowsmith, Cheryl H.; Knapp, Stefan
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Identification of a cell- active chikungunya virus nsP2 protease inhibitor using a covalent fragment- based screening approach
errPROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
IF9.1
err2024-10-10
err0
PREAI
errMerten, Eric M.; Sears, John D.; Leisner, Tina M.; Hardy, P. Brian; Ghoshal, Anirban; Hossain, Mohammad Anwar; Asressu, Kesatebrhan Haile; Brown, Peter J.; Tse, Edwin G.; Stashko, Michael A.; Li, Kelin; Drouin, Jacqueline L. Norris -; Herring, Laura E.; Mordant, Angie L.; Webb, Thomas S.; Mills, Christine A.; Barker, Natalie K.; Streblow, Zachary J.; Perveen, Sumera; Arrowsmith, Cheryl H.; Counago, Rafael Miguez; Arnold, Jamie J.; Cameron, Craig E.; Streblow, Daniel N.; Moorman, Nathaniel J.; Heise, Mark T.; Willson, Timothy M.; Popov, Konstantin I.; Pearce, Kenneth H.
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Thienopyrimidine-Based Estrogen Receptor Modulators Adopt Unique Ligand Binding Poses to Elicit Anti-Proliferative Activities in ER+ Breast Cancer Cells
errJOURNAL OF THE ENDOCRINE SOCIETY
IF3.1
err2024-10-05
err0
errOAAI
errFink, Emma C.; Mateus, Sofia Lucia; Meganathan, Nandakumar; Sammeta, Vamshi K. R.; Norris, John D.; Mcdonnell, Donald Patrick; Willson, Timothy; Fanning, Sean William
err分享
err收藏
Structure Activity of β-Amidomethyl Vinyl Sulfones as Covalent Inhibitors of Chikungunya nsP2 Cysteine Protease with Antialphavirus Activity
errJOURNAL OF MEDICINAL CHEMISTRY
IF6.8
err2024-09-05
err1
errOAAI
errGhoshal, Anirban; Asressu, Kesatebrhan Haile; Hossain, Mohammad Anwar; Brown, Peter J.; Nandakumar, Meganathan; Vala, Anand; Merten, Eric M.; Sears, John D.; Law, Isabella; Burdick, Jane E.; Morales, Noah L.; Perveen, Sumera; Pearce, Kenneth H.; Popov, Konstantin I.; Moorman, Nathaniel J.; Heise, Mark T.; Willson, Timothy M.
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err收藏
Strategic Fluorination to Achieve a Potent, Selective, Metabolically Stable, and Orally Bioavailable Inhibitor of CSNK2
errMOLECULES
IF4.6
err2024-09-02
err0
errOAAI
errOng, Han Wee; Yang, Xuan; Smith, Jeffery L.; Taft-Benz, Sharon; Howell, Stefanie; Dickmander, Rebekah J.; Havener, Tammy M.; Sanders, Marcia K.; Brown, Jason W.; Counago, Rafael M.; Chang, Edcon; Kraemer, Andreas; Moorman, Nathaniel J.; Heise, Mark; Axtman, Alison D.; Drewry, David H.; Willson, Timothy M.
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A data science roadmap for open science organizations engaged in early-stage drug discovery面向从事早期药物发现的开放科学组织的数据科学路线图
errNATURE COMMUNICATIONS
IF15.7
err2024-07-05
err4
errOAAI
errEdfeldt, Kristina; Edwards, Aled M.; Engkvist, Ola; Guenther, Judith; Hartley, Matthew; Hulcoop, David G.; Leach, Andrew R.; Marsden, Brian D.; Menge, Amelie; Misquitta, Leonie; Mueller, Susanne; Owen, Dafydd R.; Schuett, Kristof T.; Skelton, Nicholas; Steffen, Andreas; Tropsha, Alexander; Vernet, Erik; Wang, Yanli; Wellnitz, James; Willson, Timothy M.; Clevert, Djork-Arne; Haibe-Kains, Benjamin; Schiavone, Lovisa Holmberg; Schapira, Matthieu
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More than an Amide Bioisostere: Discovery of 1,2,4-Triazole-containing Pyrazolo[1,5-a]pyrimidine Host CSNK2 Inhibitors for Combatting β-Coronavirus Replication
errJOURNAL OF MEDICINAL CHEMISTRY
IF6.8
err2024-07-03
err2
errOAAI
errOng, Han Wee; Yang, Xuan; Smith, Jeffery L.; Dickmander, Rebekah J.; Brown, Jason W.; Havener, Tammy M.; Taft-Benz, Sharon; Howell, Stefanie; Sanders, Marcia K.; Capener, Jacob L.; Counago, Rafael M.; Chang, Edcon; Kraemer, Andreas; Moorman, Nathaniel J.; Heise, Mark; Axtman, Alison D.; Drewry, David H.; Willson, Timothy M.
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Identification of Dihydropyrazolo[1,5-a]pyrazin-4(5H)-ones as Cyclic Products of β-Amidomethyl Vinyl Sulfone Alphavirus Cysteine Protease Inhibitors鉴定二氢吡唑并 [1，5-a]pyrazin-4 (5h)-酮作为 β-酰胺甲基乙烯基砜甲病毒半胱氨酸蛋白酶抑制剂的环状产物
errPHARMACEUTICALS
IF4.8
err2024-06-26
err3
errOAAI
errGhoshal, Anirban; Magalhaes, alvaro F.; Asressu, Kesatebrhan Haile; Hossain, Mohammad Anwar; Todd, Matthew H.; Willson, Timothy M.
err分享
err收藏
STOPLIGHT: A Hit Scoring Calculator
errJOURNAL OF CHEMICAL INFORMATION AND MODELING
IF5.3
err2024-05-20
err3
PREAI
errWellnitz, James; Martin, Holli-Joi; Hossain, Mohammad Anwar; Rath, Marielle; Fox, Colton; Popov, Konstantin I.; Willson, Timothy M.; Muratov, Eugene N.; Tropsha, Alexander
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Discovery and optimization of narrow spectrum inhibitors of Tousled like kinase 2 (TLK2) using quantitative structure activity relationships
errEUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
IF5.9
err2024-05-01
err0
errOAAI
errAsquith, Christopher R. M.; East, Michael P.; Laitinen, Tuomo; Alamillo-Ferrer, Carla; Hartikainen, Erkka; Wells, Carrow I.; Axtman, Alison D.; Drewry, David H.; Tizzard, Graham J.; Poso, Antti; Willson, Timothy M.; Johnson, Gary L.
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Illuminating function of the understudied kinome
errDRUG DISCOVERY TODAY
IF7.5
err2024-03-01
err3
PREAI
errGomez, Shawn M.; Axtman, Alison D.; Willson, Timothy M.; Major, Michael B.; Townsend, Reid R.; Sorger, Peter K.; Johnson, Gary L.
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err收藏
Synthesis of 5-Benzylamino and 5-Alkylamino-Substituted Pyrimido[4,5-c]quinoline Derivatives as CSNK2A Inhibitors with Antiviral Activity
errPHARMACEUTICALS
IF4.8
err2024-02-27
err2
errOAAI
errAsressu, Kesatebrhan Haile; Smith, Jeffery L.; Dickmander, Rebekah J.; Moorman, Nathaniel J.; Wellnitz, James; Popov, Konstantin I.; Axtman, Alison D.; Willson, Timothy M.
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Fused Tetrahydroquinolines Are Interfering with Your Assay
errJOURNAL OF MEDICINAL CHEMISTRY
IF6.8
err2023-10-24
err2
errOAAI
errBashore, Frances M.; Annor-Gyamfi, Joel; Du, Yuhong; Katis, Vittorio; Nwogbo, Felix; Flax, Raymond G.; Frye, Stephen V.; Pearce, Kenneth H.; Fu, Haian; Willson, Timothy M.; Drewry, David H.; Axtman, Alison D.
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Dual Inhibition of Mycobacterium tuberculosis and the Host TGFBR1 by an Anilinoquinazoline
errJOURNAL OF MEDICINAL CHEMISTRY
IF6.8
err2023-10-23
err1
PREAI
errNandakumar, Meganathan; Ollodart, Anja; Fleck, Neil; Kapadia, Nirav R.; Frando, Andrew; Boradia, Vishant; Smith, Jeffery L.; Chen, Junxi; Zuercher, William J.; Willson, Timothy M.; Grundner, Christoph
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