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S

Stefano Sainas

University of Turin
H指数:17
被引数:920

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Targeting Dihydroorotate Dehydrogenase (hDHODH) beyond the barrier: discovery of MEDS700 as blood-brain barrier permeable hDHODH inhibitor

靶向二氢乳清酸脱氢酶（hDHODH）突破屏障：发现MEDS700作为可透过血脑屏障的hDHODH抑制剂

European Journal of Medicinal Chemistry
IF5.9
2026-04-270
PRE
Stefano Sainas; Chiara Vigato; Paola Circosta; Manuela Zonfrillo; Tiziana Servidei; Marta Alberti; Martina Rescigno; Riccardo Miggiano; Valentina Gaidano; Nicoletta Vitale; Alice Passoni; Alessia Lanno; Barbara Buccinnà; Marco Piccinini; Martina Lorenzati; Serena Gentile; Gianluca Sferrazza; Alessandro Sgambato; Giuseppe Saglio; Marta Giorgis
Fluorescent Isostere (Fluostere) of the Carboxylate: Design of hDHODH Fluorescent Inhibitors as Proof of Concept

羧酸根的荧光同系物(荧光同位体)：作为概念验证的人DHODH荧光抑制剂的研制

Journal of Medicinal Chemistry
IF6.8
2025-06-180
OA
Stefano Sainas; Elena Martino; Claudio Garino; Paola Circosta; Anna Luganini; Marta Giorgis; Francesco Bavo; Marco Piccinini; Cristina Ramondetti; Marta Alberti; Riccardo Miggiano; Giorgio Gribaudo; Donatella Boschi; Bente Frølund; Marco Lucio Lolli
Structure-guided optimization of 3-hydroxybenzoisoxazole derivatives as inhibitors of Aldo-keto reductase 1C3 (AKR1C3) to target prostate cancer

3-羟基苯并异恶唑衍生物作为醛酮还原酶1C3 (AKR1C3) 抑制剂靶向前列腺癌的结构指导优化

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
IF5.9
2024-03-014
OAAI
Pippione, Agnese Chiara; Kovachka, Sandra; Vigato, Chiara; Bertarini, Laura; Mannella, Iole; Sainas, Stefano; Rolando, Barbara; Denasio, Enrica; Piercy-Mycock, Helen; Romalho, Linda; Salladini, Edoardo; Adinolfi, Salvatore; Zonari, Daniele; Peraldo-Neia, Caterina; Chiorino, Giovanna; Passoni, Alice; Mirza, Osman Asghar; Frydenvang, Karla; Pors, Klaus; Lolli, Marco Lucio; Spyrakis, Francesca; Oliaro-Bosso, Simonetta; Boschi, Donatella
Targeting Acute Myelogenous Leukemia Using Potent Human Dihydroorotate Dehydrogenase Inhibitors Based on the 2-Hydroxypyrazolo[1,5-a]pyridine Scaffold: SAR of the Aryloxyaryl Moiety br
JOURNAL OF MEDICINAL CHEMISTRY
IF6.8
2022-09-2614
OAAI
Sainas, Stefano; Giorgis, Marta; Circosta, Paola; Poli, Giulio; Alberti, Marta; Passoni, Alice; Gaidano, Valentina; Pippione, Agnese C.; Vitale, Nicoletta; Bonanni, Davide; Rolando, Barbara; Cignetti, Alessandro; Ramondetti, Cristina; Lanno, Alessia; Ferraris, Davide M.; Canepa, Barbara; Buccinna, Barbara; Piccinini, Marco; Rizzi, Menico; Saglio, Giuseppe; Al-Karadaghi, Salam; Boschi, Donatella; Miggiano, Riccardo; Tuccinardi, Tiziano; Lolli, Marco L.
Dihydroorotate dehydrogenase inhibition reveals metabolic vulnerability in chronic myeloid leukemia
CELL DEATH & DISEASE
IF9.6
2022-06-305
OAAI
Houshmand, Mohammad; Vitale, Nicoletta; Orso, Francesca; Cignetti, Alessandro; Molineris, Ivan; Gaidano, Valentina; Sainas, Stefano; Giorgis, Marta; Boschi, Donatella; Fava, Carmen; Passoni, Alice; Gai, Marta; Geuna, Massimo; Sora, Federica; Iurlo, Alessandra; Abruzzese, Elisabetta; Breccia, Massimo; Mulas, Olga; Caocci, Giovanni; Castagnetti, Fausto; Taverna, Daniela; Oliviero, Salvatore; Pane, Fabrizio; Lolli, Marco Lucio; Circosta, Paola; Saglio, Giuseppe
Targeting Acute Myelogenous Leukemia Using Potent Human Dihydroorotate Dehydrogenase Inhibitors Based on the 2-Hydroxypyrazolo[1,5-a]pyridine Scaffold: SAR of the Biphenyl Moiety
JOURNAL OF MEDICINAL CHEMISTRY
IF6.8
2021-04-1222
OAAI
Sainas, Stefano; Giorgis, Marta; Circosta, Paola; Gaidano, Valentina; Bonanni, Davide; Pippione, Agnese C.; Bagnati, Renzo; Passoni, Alice; Qiu, Yaqi; Cojocaru, Carina Florina; Canepa, Barbara; Bona, Alessandro; Rolando, Barbara; Mishina, Mariia; Ramondetti, Cristina; Buccinna, Barbara; Piccinini, Marco; Houshmand, Mohammad; Cignetti, Alessandro; Giraudo, Enrico; Al-Karadaghi, Salam; Boschi, Donatella; Saglio, Giuseppe; Lolli, Marco L.
Hydroxyazole scaffold-based Plasmodium falciparum dihydroorotate dehydrogenase inhibitors: Synthesis, biological evaluation and X-ray structural studies
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
IF5.9
2019-02-0129
OAAI
Pippione, Agnese C.; Sainas, Stefano; Goyal, Parveen; Fritzson, Ingela; Cassiano, Gustavo C.; Giraudo, Alessandro; Giorgis, Marta; Tavella, Tatyana A.; Bagnati, Renzo; Rolando, Barbara; Caing-Carlsson, Rhawnie; Costa, Fabio T. M.; Andrade, Carolina Horta; Al-Karadaghi, Salam; Boschi, Donatella; Friemann, Rosmarie; Lolli, Marco L.
Targeting Myeloid Differentiation Using Potent 2-Hydroxypyrazolo[1,5-a]pyridine Scaffold-Based Human Dihydroorotate Dehydrogenase Inhibitors (vol 61, pg 6034, 2018)
JOURNAL OF MEDICINAL CHEMISTRY
IF6.8
2019-01-290
OAAI
Sainas, Stefano; Pippione, Agnese C.; Lupino, Elisa; Giorgis, Marta; Circosta, Paola; Gaidano, Valentina; Goyal, Parveen; Bonanni, Davide; Rolando, Barbara; Cignetti, Alessandro; Ducime, Alex; Andersson, Mikael; Jarva, Michael; Friemann, Rosmarie; Piccinini, Marco; Ramondetti, Cristina; Buccinna, Barbara; Al-Karadaghi, Salam; Boschi, Donatella; Saglio, Giuseppe; Lolli, Marco L.
Targeting Myeloid Differentiation Using Potent 2-Hydroxypyrazolo[1,5-a]pyridine Scaffold-Based Human Dihydroorotate Dehydrogenase Inhibitors
JOURNAL OF MEDICINAL CHEMISTRY
IF6.8
2018-06-2571
OAAI
Sainas, Stefano; Pippione, Agnese C.; Lupino, Elisa; Giorgis, Marta; Circosta, Paola; Gaidano, Valentina; Goyal, Parveen; Bonanni, Davide; Rolando, Barbara; Cignetti, Alessandro; Ducime, Alex; Andersson, Mikael; Jarva, Michael; Friemann, Rosmarie; Piccinini, Marco; Ramondetti, Cristina; Buccinna, Barbara; Al-Karadaghi, Salam; Boschi, Donatella; Saglio, Giuseppe; Lolli, Marco L.
Design, synthesis, biological evaluation and X-ray structural studies of potent human dihydroorotate dehydrogenase inhibitors based on hydroxylated azole scaffolds

基于羟化唑支架的强效人二氢乳清酸脱氢酶抑制剂的设计、合成、生物学评价及X-射线结构研究

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
IF5.9
2017-03-0153
PREAI
Sainas, Stefano; Pippione, Agnese C.; Giorgis, Marta; Lupino, Elisa; Goyal, Parveen; Ramondetti, Cristina; Buccinna, Barbara; Piccinini, Marco; Braga, Rodolpho C.; Andrade, Carolina H.; Andersson, Mikael; Moritzer, Ann-Christin; Friemann, Rosmarie; Mensa, Stefano; Al-Kadaraghi, Salam; Boschi, Donatella; Lolli, Marco L.

研究方向

暂未获取到该数据
M
Marco L. Lolli
H 指数:27论文数:132被引数:2,070
D
Donatella Boschi
H 指数:26论文数:137被引数:1,738
M
Marta Giorgis
H 指数:24论文数:80被引数:1,621
A
Agnese Chiara Pippione
H 指数:19论文数:57被引数:1,103
B
Barbara Rolando
H 指数:31论文数:163被引数:2,822
P
Paola Circosta
H 指数:21论文数:65被引数:2,170
M
Marco Piccinini
H 指数:21论文数:91被引数:1,438
G
Giuseppe Saglio
H 指数:101论文数:1,568被引数:5.4万
S
Salam Al‐Karadaghi
H 指数:37论文数:135被引数:4,253
V
Valentina Gaidano
H 指数:15论文数:53被引数:769