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李志裕 封面图

李志裕 (Zhiyu Li)

china pharmaceutical university

49H指数
417论文数
8.0K被引数
收录论文 205
发表时间
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Tumor-Oriented Delivery of a Dimeric STING Agonist Using an H-Ferritin Nanocage Widens the Therapeutic Window for Cancer Immunotherapy肿瘤靶向递送二聚体STING激动剂利用H-铁蛋白纳米笼扩大癌症免疫治疗的疗效窗口
errACS Applied Materials & Interfaces
IF0
err2026-06-05
err0
PREAI
errBin Yu; Xingda Wu; Chang Xu; Xiankang Zhang; Ziruo Zhao; Zhiyu Li; Neil R. Thomas; Jinlei Bian; Yi Ma
err分享
err收藏
Evolving Strategies for Previously Drugged Therapeutic Targets: Medicinal Chemistry Insights from Paradigmatic Cases针对先前已药物治疗的靶点的演变策略：来自典范案例的药物化学见解
errJournal of Medicinal Chemistry
IF6.8
err2026-06-02
err0
PREAI
errYujun Deng; Shouwei Wang; Lei Geng; Zhiwei Meng; Fangrong Chen; Xiaoxiao Yang; Feng Wang; Yuanli Chen; Zhiyu Li; Zhouling Xie
err分享
err收藏
Discovery of YYSW001: A Highly Selective; Orally Bioavailable JAK1 Inhibitor Achieving Efficacy under a Moderate-Inhibition Strategy with Improved Preclinical TolerabilityYYSW001的发现：一种选择性高、口服生物利用度好的JAK1抑制剂，通过适度抑制策略实现疗效，并具有改善的药理学前临床耐受性
errJournal of Medicinal Chemistry
IF6.8
err2026-03-20
err0
PREAI
errKaiyong Hu; Yezhi Wang; Pengfei Xu; Tian Jing; Xinying Cheng; Pei Shen; Baoxin Wang; Kang Fu; Min Zhang; Mingjing Gao; Zhiyu Li; Jubo Wang; Zhixia Qiu; Jinlei Bian
err分享
err收藏
Correction: The role of TMEM163 protein in thyroid microcarcinoma: expression pattern and clinical implicationsCorrection: TMEM163蛋白在甲状腺微小癌中的作用：表达模式与临床意义
errJournal of Endocrinological Investigation
IF3.5
err2025-12-09
err0
errOAAI
errYe Wang; Jiafu Li; Shichun Gao; Dejing Dang; Yanlin Chen; Zhiyu Li; Hong Yang
err分享
err收藏
Molecular mechanism of resistance to lonafarnib conferred by mutations in the cysteine-rich region of respiratory syncytial virus fusion glycoprotein and discovery of a lonafarnib-derived antiviral PROTAC洛那法尼耐药性的分子机制：由呼吸道合胞病毒融合糖蛋白富半胱氨酸区域的突变赋予，以及洛那法尼衍生的抗病毒PROTAC的发现
errJOURNAL OF VIROLOGY
IF3.8
err2025-12-01
err0
PREAI
errYang, Qi; Xue, Bao; Qiu, Xianjie; Yang, Kaixin; Tang, Jielin; Zhou, Anqi; Zou, Jingjing; Mao, Yuhan; Zhong, Jiayi; Zhou, Yuan; Zhang, Wei; Zhang, Qiong; Xiao, Qingyu; Tang, Wei; Li, Zhiyu; Ye, Wencai; Zou, Gang; Peng, Wei; Shang, Jinsai; Xu, Xi; Li, Yixue; Chen, Xinwen
err分享
err收藏
The binding mechanism of a novel ferrous ion chelating peptide from chicken blood hemoglobin and the bioavailability of the chelate一种来自鸡血血红蛋白的新型亚铁离子螯合肽的结合机制及其螯合物的生物利用度
errFood Chemistry: X
IF8.2
err2025-11-29
err0
errOAAI
errHanyu Guo; Ying Zhou; Cancan Luo; Zhiyu Li; Jiulan Peng; Weimin Xu; Daoying Wang; Jing Yang
err分享
err收藏
Design, synthesis, and pharmacological evaluation of novel isoindoline-based HPK1 degraders基于异吲哚啉的HPK1降解剂的构建、合成及药理学评价
errEuropean Journal of Medicinal Chemistry
IF5.9
err2025-11-20
err0
PREAI
errZhisheng Zhang; Xuan Zhang; Tizhi Wu; Shengnan Shi; Jiahui Tu; Manqi Zhang; Yan Liang; Mengyang Ma; Sai Zhang; Guangyue Gong; Bing Huang; Ahmed R. Ali; Zhixia Qiu; Jinlei Bian; Hongxi Wu; Zhiyu Li; Xi Xu; Jubo Wang
err分享
err收藏
Enhanced defluoridation using covalently bonded organosilicon-bimetallic composite coagulants: Al-Mg and Al-Fe driven divergence in hydrolysis speciation and active site substitution pathways通过共价键合的有机硅双金属复合混凝剂增强除氟：Al-Mg和Al-Fe驱动的水解物种分布及活性位点替代途径的分歧
errWater Research
IF12.4
err2025-11-08
err0
PREAI
errYahua Zhou; Zhiyu Li; Pengjun Zhang; Yanli Kong; Jiangya Ma
err分享
err收藏
Cancer Biology of GSPT1: Mechanisms and Targeted Therapy Opportunities of Molecular Glue DegradersGSPT1的癌症生物学：分子胶降解剂的机制和靶向治疗机会
errAdvanced Science
IF14.1
err2025-11-05
err0
errOAAI
errQiqi Lin; Wenjing Liu; Wenjia Lu; Monong Zhao; Lin Cao; Zhiyu Li; Jubo Wang; Xi Xu; Hongxi Wu
err分享
err收藏
Systemic immune-inflammation index: a key biomarker guiding personalized adjuvant chemotherapy in intrahepatic cholangiocarcinoma系统性免疫炎症指数：指导肝内胆管癌个性化辅助化疗的关键生物标志物
errFrontiers in Oncology
IF3.3
err2025-10-31
err0
errOAAI
errXin Yin†; Yanjiang Yin†; Wenzhuo Li†; Jinliang Tong†; Yi Liu; Jianping Chang; Jindong Ma; Yaoyu Xie; Xin Li; Hossein Mehrabanidil; Xiao Chen; Yefan Zhang; Jianqiang Cai; Caiyun Li; Bowen Xu; Zhiyu Li; Xinyu Bi
err分享
err收藏
Combination strategies with STING agonists: Current advances and future directionsSTING激动剂的联合策略：当前进展与未来方向
errEuropean Journal of Pharmacology
IF4.7
err2025-10-24
err0
PREAI
errKun Sun; Xuanyu Fu; Yuying Man; Fangzhou Liu; Zhipeng Qu; Yuanying Ou; Wenqi Cheng; Jinlei Bian; Zhiyu Li; Jubo Wang; Hongxi Wu
err分享
err收藏
Association of atherogenic index of plasma with cardiovascular disease mortality in patients with type 2 diabetes mellitus and diabetic kidney disease: a cross-sectional study2型糖尿病合并糖尿病肾病患者血浆致动脉粥样硬化指数与心血管疾病死亡率关系的横断面研究
errBMC CARDIOVASCULAR DISORDERS
IF2.3
err2025-10-21
err0
errOAAI
errLi, Zhiyu; Xu, Hongyang
err分享
err收藏
Corrigendum to “Huangqi Guizhi Wuwu decoction alleviate Oxaliplatin-Induced Peripheral Neuropathy by adjusting the myelin regeneration” [Phytomedicine 145 (2025) 157039]勘误：“Huangqi Guizhi Wuwu decoction alleviate Oxaliplatin-Induced Peripheral Neuropathy by adjusting the myelin regeneration” [Phytomedicine 145 (2025) 157039]
errPhytomedicine
IF8.3
err2025-09-06
err0
PREAI
errXueying Yang; Huaying Zhu; Zhiyu Li; Qianyu Wang; Yingjie Gao; Ziwen Li; Lihuiping Tao; Liu Li; Dongdong Sun; Lin Zhang; Weixing Shen; Haibo Cheng
err分享
err收藏
Exploring the protective mechanisms of the yunpi jiedu tongluo qushi decoction on methotrexate-induced reproductive damage in male rats based on Nrf2/HO-1 signaling pathway基于Nrf2/HO-1信号通路探讨云皮解毒通络祛湿汤对甲氨蝶呤诱导的雄性大鼠生殖损伤的保护机制
errFrontiers in Cell and Developmental Biology
IF4.3
err2025-08-22
err0
errOAAI
errWu Chen†; Min Chen†; Dian-Ming Li; Wei-Man Shi; Min Zhang; Zhi-Yu Li; Lin Huang; Cheng-Ping Wen; Qiao Wang
err分享
err收藏
Huangqi Guizhi Wuwu decoction alleviate Oxaliplatin-Induced Peripheral Neuropathy by adjusting the myelin regeneration黄芪桂枝五物汤通过调节髓鞘再生来缓解奥沙利铂诱导的周围神经病变
errPhytomedicine
IF8.3
err2025-07-01
err0
errOAAI
errXueying Yang; Huaying Zhu; Zhiyu Li; Qianyu Wang; Yingjie Gao; Ziwen Li; Lihuiping Tao; Liu Li; Dongdong Sun; Lin Zhang; Weixing Shen; Haibo Cheng
err分享
err收藏
WRN as a Novel Target of Synthetic Lethality: Current Advances and Future Perspectives作为合成致死的新型靶点：最新进展与未来展望
errJournal of Medicinal Chemistry
IF6.8
err2025-06-17
err0
PREAI
errYinghao Zhang; Jiamin Zhang; Cheng Tang; Gang Zhao; Huawei Pan; Tiejun Bing; Zhiyu Li; Xi Xu; Jinlei Bian
err分享
err收藏
Association between non-high-density lipoprotein cholesterol to high-density lipoprotein cholesterol ratio and cardiovascular disease mortality in patients with type 2 diabetes mellitus and diabetic kidney disease
errFRONTIERS IN ENDOCRINOLOGY
IF4.6
err2025-02-28
err0
errOAAI
errLi, Zhiyu; Xu, Hongyang
err分享
err收藏
Safety and immunogenicity of hepatitis E vaccine in compensated liver cirrhosis with chronic hepatitis B乙型肝炎慢性肝炎合并代偿性肝硬化的戊型肝炎疫苗的安全性和免疫原性
errClinical Microbiology and Infection
IF8.5
err2025-02-28
err0
errOAAI
errXuejiao Liao; Dapeng Li; Yingying Su; Xinwu Wang; Shuting Wu; Yanling Chen; Zhiyu Li; Qiyuan Tang; Zhenghua Ma; Xiaobin Wan; Jingke Dong; Liping Zhang; Changxiang Lai; Haiyan Wang; Qing He; Jun Zhang; Fang Wang; Zheng Zhang
err分享
err收藏
Mitochondrial Regulation of Ferroptosis in Cancer Cells癌症细胞中细胞器的铁死亡调控
errINTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
IF10
err2025-02-24
err0
errOAAI
errDing, Zilin; Li, Zhiyu; Sun, Kai; Liu, Yi; Fang, Zhou; Sun, Shengrong; Li, Chenyuan; Wang, Zhong
err分享
err收藏
Knowledge structures and research hotspots of immunotherapy for brain metastasis, glioma, meningioma, and pituitary adenoma: A bibliometric and visualization reviewYu, D.; Wang, J.; Hu, L.; Wu, Y.; Wang, T.; Li, Z.; Wang, Z.; Ding, Q.; Sun, Y.; Li, Z. 脑转移瘤、胶质瘤、脑膜瘤和垂体腺瘤免疫治疗的认知结构与研究热点：一项文献计量与可视化综述。Chin. Chem. Lett. 2025, 110995. [Google Scholar] [CrossRef]
errChinese Chemical Letters
IF8.9
err2025-02-21
err0
PREAI
errDonghu Yu; Junneng Wang; Lei Hu; Youxian Wu; Tianqing Wang; Zhiyu Li; Zefen Wang; Qihang Ding; Yao Sun; Zhiqiang Li
err分享
err收藏

研究方向

学术兼职 国家级实验教学示范中心联席会药学学科组副组长基于天然产物的创新药物研究药物化学小分子抗肿瘤免疫药物的开发药物绿色合成工艺和晶型研究小分子抑制剂急性髓细胞白血病色氨酸-犬尿氨酸通路双加氧酶抑制剂抗肝癌原创新药JAK抑制剂药物分子设计及合成DKLS原料及其滴眼剂研制开发Jubo Wang#Min WangXinyu YuanLei LiChao ZhangHuidan Huang*Tian JingChenchen WangChao TongLiwen ZhouYing MengPengfei XuJunping KouZhixia QiuZhiyu Li*靶向谷氨酰胺酶1变构结合位点的新型大环抑制剂的结构导向发现Bin Dong#Renbing WangDechun HuangJubo Wang*Xi FengJinlei Bian*Zhen Qin抗SARS-CoV-2药物EIDD-2801的制备基于机器学习的快速评估Lian QinCdc2-like Kinase 2抑制剂Xinying ChengKang LiuTizhi WuXiaqiu QiuZijian Kuang芳香乙炔化合物合成Dongdong LiaoDongyu LiuAn PingIDO1抑制剂开发癌症治疗Jie HanHongyu LuanJubo WangCheng LuoHong DingQianming Du#GLS1荧光探针开发与变构抑制剂高通量筛选Glutaminase InhibitorsXi Feng#Yinuo WangXi XuYan ZhangXinliang Qu
合作学者
合作期刊
陈晓栋 封面图
陈晓栋 (Xiaohong Chen)
H 指数: 258 · 论文数: 1.9W
B
Ben Zhong Tang
H 指数: 212 · 论文数: 4.2K
K
Kwok‐Yung Yuen
H 指数: 161 · 论文数: 1.7K
K
Klaus Rajewsky
H 指数: 156 · 论文数: 671
S
Siamon Gordon
H 指数: 149 · 论文数: 681
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