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A First-in-Class Hepatocyte Nuclear Factor 4 Agonist 一类首创的肝细胞核因子4激动剂 Schallmayer, Espen; Morozov, Vasily; Duensing-Kropp, Silke; Schallmayer, Lasse; Schueffner, Leann; Schubert-Zsilavecz, Manfred; Pabel, Joerg; Hoefner, Georg; Heering, Jan; Marschner, Julian A. 分享 收藏
S1PR4-dependent effects of Etrasimod on primary human myeloid immune cell activation Etrasimod对人源髓系免疫细胞活化的S1PR4依赖性效应 Sailer, Fiona K.; Palmer, Megan A.; Aliraj, Blerina; Heering, Jan; Brockmann, Andreas; Elewa, Mohammed A. F.; Roehrig, Aissa; Proschak, Ewgenij; Stepniak, Dariusz T.; Ramsey, Simeon; Bruene, Bernhard; Weigert, Andreas 分享 收藏
Fragment-Based Discovery of Drug-like LRH-1 Agonists Lang, Alisa; Ildefeld, Niklas; Lillich, Felix F.; Kaiser, Astrid; Busch, Romy; Marschner, Julian A.; Proschak, Ewgenij; Heering, Jan; Schubert-Zsilavecz, Manfred; Merk, Daniel 分享 收藏
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Orphan G protein-coupled receptor GPRC5B controls macrophage function by facilitating prostaglandin E receptor 2 signaling 孤儿G蛋白偶联受体GPRC5B通过促进前列腺素E受体2信号传导来调控巨噬细胞功能。 Kwon, Jeonghyeon; Kawase, Haruya; Mattonet, Kenny; Guenther, Stefan; Hahnefeld, Lisa; Shamsara, Jamal; Heering, Jan; Kirchhofer, Sina; Murthy, Sripriya; Orlandi, Cesare; Sadik, Christian D.; Geisslinger, Gerd; Buenemann, Moritz; Kolb, Peter; Offermanns, Stefan; Wettschureck, Nina 分享 收藏
Critical assessment of LC3/GABARAP ligands used for degrader development and ligandability of LC3/GABARAP binding pockets Schwalm, Martin P.; Dopfer, Johannes; Kumar, Adarsh; Greco, Francesco A.; Bauer, Nicolas; Loehr, Frank; Heering, Jan; Cano-Franco, Sara; Lechner, Severin; Hanke, Thomas; Jaser, Ivana; Morasch, Viktoria; Lenz, Christopher; Fearon, Daren; Marples, Peter G.; Tomlinson, Charles W. E.; Brunello, Lorene; Saxena, Krishna; Adams, Nathan B. P.; von Delft, Frank; Mueller, Susanne; Stolz, Alexandra; Proschak, Ewgenij; Kuster, Bernhard; Knapp, Stefan; Rogov, Vladimir V. 分享 收藏
The endocannabinoid anandamide mediates anti-inflammatory effects through activation of NR4A nuclear receptors Teichmann, Tom; Pflueger-Mueller, Beatrice; Gimenez, Virna Margarita Martin; Sailer, Fiona; Dirks, Henrik; Zehr, Simonida; Warwick, Timothy; Brettner, Felix; Munoz-Tello, Paola; Zimmer, Andreas; Tegeder, Irmgard; Thomas, Dominique; Gurke, Robert; Guenther, Stefan; Heering, Jan; Proschak, Ewgenij; Geisslinger, Gerd; Bibli, Iris-S.; zu Heringdorf, Dagmar Meyer; Manucha, Walter; Windbergs, Maike; Knapp, Stefan; Weigert, Andreas; Leisegang, Matthias S.; Kojetin, Douglas; Brandes, Ralf P. 分享 收藏
SPMs exert anti- inflammatory and pro- resolving effects through positive allosteric modulation of the prostaglandin EP4 receptor Alnouri, Mohamad Wessam; Roquid, Kenneth Anthony; Bonnavion, Remy; Cho, Haaglim; Heering, Jan; Kwon, Jeonghyeon; Jaeger, Yannick; Wang, ShengPeng; Guenther, Stefan; Wettschureck, Nina; Geisslingerb, Gerd; Gurke, Robert; Mueller, Christa E.; Proschak, Ewgenij; Offermanns, Stefan 分享 收藏
Tuning RXR Modulators for PGC1α Recruitment Nawa, Felix; Sai, Minh; Vietor, Jan; Schwarzenbach, Roman; Biticc, Anesa; Wolff, Sina; Ildefeld, Niklas; Pabel, Joerg; Wein, Thomas; Marschner, Julian A.; Heering, Jan; Merk, Daniel 分享 收藏
Development of a Potent and Selective G2A (GPR132) Agonist Hernandez-Olmos, Victor; Heering, Jan; Marinescu, Beatrice; Schermeng, Tina; Ivanov, Vladimir V.; Moroz, Yurii S.; Nevermann, Sheila; Mathes, Marius; Ehrler, Johanna H. M.; Alnouri, Mohamad Wessam; Wolf, Markus; Haydo, Alicia S.; Schmachtel, Tessa; Zaliani, Andrea; Ho''fner, Georg; Kaiser, Astrid; Schubert-Zsilavecz, Manfred; Beck-Sickinger, Annette G.; Offermanns, Stefan; Gribbon, Philipp; Rieger, Michael A.; Merk, Daniel; Sisignano, Marco; Steinhilber, Dieter; Proschak, Ewgenij 分享 收藏
Discovery of a Small Molecule Activator of Slack (Kcnt1) Potassium Channels That Significantly Reduces Scratching in Mouse Models of Histamine-Independent and Chronic Itch Balzulat, Annika; Zhu, W. Felix; Flauaus, Cathrin; Hernandez-Olmos, Victor; Heering, Jan; Sethumadhavan, Sunesh; Dubiel, Mariam; Frank, Annika; Menge, Amelie; Hebchen, Maureen; Metzner, Katharina; Lu, Ruirui; Lukowski, Robert; Ruth, Peter; Knapp, Stefan; Mueller, Susanne; Steinhilber, Dieter; Haenelt, Inga; Stark, Holger; Proschak, Ewgenij; Schmidtko, Achim 分享 收藏
Targeting the Alternative Vitamin E Metabolite Binding Site Enables Noncanonical PPARγ Modulation Arifi, Silvia; Marschner, Julian A.; Pollinger, Julius; Isigkeit, Laura; Heitel, Pascal; Kaiser, Astrid; Obeser, Lennart; Hoefner, Georg; Proschak, Ewgenij; Knapp, Stefan; Chaikuad, Apirat; Heering, Jan; Merk, Daniel 分享 收藏
Mechanistic Impact of Different Ligand Scaffolds on FXR Modulation Suggests Avenues to Selective Modulators Heering, Jan; Jores, Nathalie; Kilu, Whitney; Schallmayer, Espen; Peelen, Evelyn; Muehler, Andreas; Kohlhof, Hella; Vitt, Daniel; Linhard, Verena; Gande, Santosh L.; Chaikuad, Apirat; Sreeramulu, Sridhar; Schwalbe, Harald; Merk, Daniel 分享 收藏
Compilation and evaluation of a fatty acid mimetics screening library Ehrler, Johanna H. M.; Brunst, Steffen; Tjaden, Amelie; Kilu, Whitney; Heering, Jan; Hernandez-Olmos, Victor; Krommes, Andre; Kramer, Jan S.; Steinhilber, Dieter; Schubert-Zsilavecz, Manfred; Muller, Susanne; Merk, Daniel; Proschak, Ewgenij 分享 收藏
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