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收藏分享 收藏 分享 收藏 分享 收藏 分享 收藏 分享 收藏 分享 收藏 分享 收藏 分享 收藏 分享 收藏 分享 收藏 Targeted disruption of PRC1.1 complex enhances bone remodeling靶向破坏PRC1.1复合物可增强骨重塑
Xing, Liangyu; Xu, Jinxin; Gong, Meihan; Liu, Yunzhi; Li, Xuanyuan; Meng, Lingyu; Du, Ruyue; Zhou, Ying; Ouyang, Zhaoguang; Liu, Xu; Tao, Shaofei; Cao, Yuxin; Liu, Chunyi; Gao, Feng; Han, Ruohui; Shen, Hui; Dong, Yan; Xu, Yong; Li, Tao; Chen, He; Zhao, Yingying; Fan, Baoyou; Sui, Lei 分享 收藏 Identification of indoles as potential endogenous ligands of ERRγ and their modulation on drug binding吲哚作为ERRγ潜在内源性配体的鉴定及其对药物结合的调节Shuai, YY; Zhang, HY; Chen, R; Wang, BL; Ding, P; Dong, Y; Sun, MZ; Wu, XS; Xu, Y; Zhang, Y; Liu, JS; Wang, N; Xu, TT 分享 收藏 Structural basis for the asymmetric binding of coactivator SRC1 to FXR-RXRα and allosteric communication within the complexSheng, Yanan; Guo, Yaoting; Zhao, Beibei; Sun, Mingze; Dong, Yan; Yin, Yue; Wang, Yanwu; Peng, Chao; Xu, Yong; Wang, Na; Liu, Jinsong 分享 收藏 Discovery of 5-imidazole-3-methylbenz[d]isoxazole derivatives as potent and selective CBP/p300 bromodomain inhibitors for the treatment of acute myeloid leukemia作为强效且选择性的CBP/p300溴域抑制剂，5-咪唑-3-甲基苯[d]异恶唑衍生物的发现，可用于急性髓系白血病的治疗。Hu, JK; Tang, X; Luo, GL; Zhang, C; Wu, TB; Wang, C; Shen, H; Zhao, XF; Wu, XS; Smaill, JB; Xu, Y; Zhang, Y; Xiang, QP 分享 收藏 Discovery of the First BRD4 Second Bromodomain (BD2)-Selective InhibitorsLi, Junhua; Hu, Qingqing; Zhu, Run; Dong, Ruibo; Shen, Hui; Hu, Jiankang; Zhang, Cheng; Zhang, Xiaohan; Xu, Tingting; Xiang, Qiuping; Zhang, Yan; Lin, Bin; Zhao, Linxiang; Wu, Xishan; Xu, Yong 分享 收藏 Discovery of CZL-046 with an (S)-3-Fluoropyrrolidin-2-one Scaffold as a p300 Bromodomain Inhibitor for the Treatment of Multiple MyelomaChen, Zonglong; Yang, Hong; Zhang, Yan; Lyu, Xiaodong; Shi, Qiongyu; Zhang, Cheng; Wang, Xingcan; Wang, Zekun; Zhang, Ying; Deng, Yue; Wang, Yujie; Huang, Yuting; Xu, Yong; Huang, Xun; Li, Yingxia 分享 收藏 分享 收藏 Discovery of a Promising CBP/p300 Degrader XYD129 for the Treatment of Acute Myeloid LeukemiaWu, Tianbang; Hu, Jiankang; Zhao, Xiaofan; Zhang, Cheng; Dong, Ruibo; Hu, Qingqing; Xu, Hongrui; Shen, Hui; Zhang, Xiaohan; Zhang, Yan; Lin, Bin; Wu, Xishan; Xiang, Qiuping; Xu, Yong 分享 收藏 Discovery of Highly Potent and Efficient CBP/p300 Degraders with Strong In Vivo Antitumor ActivityHu, Jiankang; Xu, Hongrui; Wu, Tianbang; Zhang, Cheng; Shen, Hui; Dong, Ruibo; Hu, Qingqing; Xiang, Qiuping; Chai, Shuang; Luo, Guolong; Chen, Xiaoshan; Huang, Yumin; Zhao, Xiaofan; Peng, Chao; Wu, Xishan; Lin, Bin; Zhang, Yan; Xu, Yong 分享 收藏 
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