John G. Lock - Publications, H-index & Citations

John G. Lock

university of new south wales sydney

24H指数

69论文数

2.7K被引数

收录论文 36

发表时间

Epithelial-mesenchymal cell state heterogeneity predetermines differential phospho-signaling responses to EGF stimulation 上皮-间充质细胞状态异质性预决定了EGF刺激下不同的磷酸化信号反应

Molecular Biology of the Cell

IF2.7

2026-01-01

PREAI

Kohane, Felix, V; Johnstone, Chantelle; Neumann, Daniel P.; Gunawan, Ihuan; Huang, Tim; Vafaee, Fatemeh; Chaffer, Christine L.; Lock, John G.

Large-scale drug screening in iPSC-derived motor neurons from sporadic ALS patients identifies a potential combinatorial therapy 对散发型ALS患者来源的iPSC诱导运动神经元进行大规模药物筛选，识别出一种潜在的联合治疗方案

Nature Neuroscience

IF20

2025-11-24

OAAI

Christopher R. Bye; Elizabeth Qian; Katherine Lim; Maciej Daniszewski; Fleur C. Garton; Bảo C. Trần-Lê; Helena H. Liang; Tian Lin; John G. Lock; Duncan E. Crombie; Steven Morgan; Yi Hu; Samantha K. Barton; Lucy M. Palmer; Elvan Djouma; Saritha Kodikara; Kim-Anh Lê Cao; Thanuja Dharmadasa; Anjali K. Henders; Laura A. Ziser; Matthew C. Kiernan; Kevin Talbot; Merrilee Needham; Susan Fletcher; Paul Talman; Susan Mathers; Naomi R. Wray; Alex W. Hewitt; Alice Pebay; Bradley J. Turner

Capillary constrictions prime cancer cell tumorigenicity through PIEZO1 毛细血管收缩通过PIEZO1促进癌细胞成瘤性

Nature Communications

IF15.7

2025-09-01

OAAI

Giulia Silvani; Chantal Kopecky; Sara Romanazzo; Vanina Rodríguez; Ayan Das; Elvis Pandzic; John G. Lock; Christine L. Chaffer; Kate Poole; Kristopher A. Kilian

Extensible Immunofluorescence (ExIF) accessibly generates high-plexity datasets by integrating standard 4-plex imaging data 可扩展免疫荧光（ExIF）通过整合标准的4-plex成像数据，便捷地生成高复杂性数据集。

NATURE COMMUNICATIONS

IF15.7

2025-05-17

OAAI

Gunawan, Ihuan; Kohane, Felix V.; Dey, Moumitha; Nguyen, Kathy; Zheng, Ye; Neumann, Daniel P.; Vafaee, Fatemeh; Meijering, Erik; Lock, John G.

Genomic and Phenotypic Biomarkers for Precision Medicine Guidance in Advanced Prostate Cancer 晚期前列腺癌精准医学指导的基因组和表型生物标志物

CURRENT TREATMENT OPTIONS IN ONCOLOGY

IF4.7

2023-08-10

OAAI

Davoudi, Fatemeh; Moradi, Afshin; Becker, Therese M. M.; Lock, John G. G.; Abbey, Brian; Fontanarosa, Davide; Haworth, Annette; Clements, Judith; Ecker, Rupert C. C.; Batra, Jyotsna

An introduction to representation learning for single-cell data analysis

CELL REPORTS METHODS

IF4.5

2023-08-01

OAAI

Gunawan, Ihuan; Vafaee, Fatemeh; Meijering, Erik; Lock, John George

Copper chelation suppresses epithelial-mesenchymal transition by inhibition of canonical and non-canonical TGF-β signaling pathways in cancer

CELL AND BIOSCIENCE

IF6.2

2023-07-21

OAAI

Poursani, Ensieh M.; Mercatelli, Daniele; Raninga, Prahlad; Bell, Jessica L.; Saletta, Federica; Kohane, Felix V.; Neumann, Daniel P.; Zheng, Ye; Rouaen, Jourdin R. C.; Jue, Toni Rose; Michniewicz, Filip T.; Schadel, Piper; Kasiou, Erin; Tsoli, Maria; Cirillo, Giuseppe; Waters, Shafagh; Shai-Hee, Tyler; Cazzoli, Riccardo; Brettle, Merryn; Slapetova, Iveta; Kasherman, Maria; Whan, Renee; Souza-Fonseca-Guimaraes, Fernando; Vahdat, Linda; Ziegler, David; Lock, John G.; Giorgi, Federico M.; Khanna, KumKum; Vittorio, Orazio

Choice of antibody is critical for specific and sensitive detection of androgen receptor splice variant-7 in circulating tumor cells

SCIENTIFIC REPORTS

IF3.9

2022-09-28

OAAI

Khan, Tanzila; Lock, John G.; Ma, Yafeng; Harman, David G.; de Souza, Paul; Chua, Wei; Balakrishnar, Bavanthi; Scott, Kieran F.; Becker, Therese M.

Mapping Phenotypic Plasticity upon the Cancer Cell State Landscape Using Manifold Learning 使用流形学习在癌细胞状态景观上映射表型可塑性

CANCER DISCOVERY

IF33.3

2022-06-23

OAAI

Burkhardt, Daniel B.; San Juan, Beatriz P.; Lock, John G.; Krishnaswamy, Smita; Chaffer, Christine L.

Population subgroup differences in the use of a COVID-19 chatbot

NPJ DIGITAL MEDICINE

IF15.1

2021-02-19

OAAI

Schubel, Laura C.; Wesley, Deliya B.; Booker, Ethan; Lock, John; Ratwani, Raj M.

High-Content Imaging of Unbiased Chemical Perturbations Reveals that the Phenotypic Plasticity of the Actin Cytoskeleton Is Constrained

CELL SYSTEMS

IF7.7

2019-11-01

OAAI

Bryce, Nicole S.; Failes, Tim W.; Stehn, Justine R.; Baker, Karen; Zahler, Stefan; Arzhaeva, Yulia; Bischof, Leanne; Lyons, Ciaran; Dedova, Irina; Arndt, Greg M.; Gaus, Katharina; Goult, Benjamin T.; Hardeman, Edna C.; Gunning, Peter W.; Lock, John G.

Chemical biology approaches targeting the actin cytoskeleton through phenotypic screening 通过表型筛选靶向肌动蛋白细胞骨架的化学生物学方法

CURRENT OPINION IN CHEMICAL BIOLOGY

IF6.1

2019-08-01

OAAI

Bryce, Nicole S.; Hardeman, Edna C.; Gunning, Peter W.; Lock, John G.

Clathrin-containing adhesion complexes 含网格蛋白的粘附复合物

JOURNAL OF CELL BIOLOGY

IF6.4

2019-06-17

OAAI

Lock, John G.; Baschieri, Francesco; Jones, Matthew C.; Humphries, Jonathan D.; Montagnac, Guillaume; Stromblad, Staffan; Humphries, Martin J.

Reticular adhesions are a distinct class of cell-matrix adhesions that mediate attachment during mitosis 网状粘连是一类独特的细胞-基质粘连，在有丝分裂过程中介导附着

NATURE CELL BIOLOGY

IF19.1

2018-10-22

104

PREAI

Lock, John G.; Jones, Matthew C.; Askari, Janet A.; Gong, Xiaowei; Oddone, Anna; Olofsson, Helene; Goransson, Sara; Lakadamyali, Melike; Humphries, Martin J.; Stromblad, Staffan

KIF13A-regulated RhoB plasma membrane localization governs membrane blebbing and blebby amoeboid cell migration KIF13A-regulated RhoB质膜定位控制膜泡化和泡状变形虫细胞迁移

EMBO JOURNAL

IF8.3

2018-08-01

OAAI

Gong, Xiaowei; Didan, Yuliia; Lock, John G.; Stromblad, Staffan

Spheroids-on-a-chip: Recent advances and design considerations in microfluidic platforms for spheroid formation and culture

SENSORS AND ACTUATORS B-CHEMICAL

IF7.7

2018-06-01

216

OAAI

Moshksayan, Khashayar; Kashaninejad, Navid; Warkiani, Majid Ebrahimi; Lock, John G.; Moghadas, Hajar; Firoozabadi, Bahar; Saidi, Mohammad Said; Nam-Trung Nguyen

Active and inactive β1 integrins segregate into distinct nanoclusters in focal adhesions

JOURNAL OF CELL BIOLOGY

IF6.4

2018-04-09

OAAI

Spiess, Matthias; Hernandez-Varas, Pablo; Oddone, Anna; Olofsson, Helene; Blom, Hans; Waithe, Dominic; Lock, John G.; Lakadamyali, Melike; Stromblad, Staffan

An analysis toolbox to explore mesenchymal migration heterogeneity reveals adaptive switching between distinct modes

ELIFE

IF0

2016-01-29

OAAI

Shafqat-Abbasi, Hamdah; Kowalewski, Jacob M.; Kiss, Alexa; Gong, Xiaowei; Hernandez-Varas, Pablo; Berge, Ulrich; Jafari-Mamaghani, Mehrdad; Lock, John G.; Stromblad, Staffan

Repression of Lateral Organ Boundary Genes by PENNYWISE and POUND-FOOLISH Is Essential for Meristem Maintenance and Flowering in Arabidopsis

PLANT PHYSIOLOGY

IF6.9

2015-09-28

OAAI

Khan, Madiha; Ragni, Laura; Tabb, Paul; Salasini, Brenda C.; Chatfield, Steven; Datla, Raju; Lock, John; Kuai, Xiahezi; Despres, Charles; Proveniers, Marcel; Cao Yongguo; Xiang, Daoquan; Morin, Halima; Rulliere, Jean-Pierre; Citerne, Sylvie; Hepworth, Shelley R.; Pautot, Veronique

A plastic relationship between vinculin-mediated tension and adhesion complex area defines adhesion size and lifetime

NATURE COMMUNICATIONS

IF15.7

2015-06-25

OAAI

Hernandez-Varas, Pablo; Berge, Ulrich; Lock, John G.; Stromblad, Staffan

研究方向