Sarel J. Fleishman - Publications, H-index & Citations

Sarel J. Fleishman

Weizmann Institute of Science

51H指数

195论文数

1.1W被引数

收录论文 77

发表时间

Computational design of optimized and preferentially paired human TCR constant regions for improved T cell function 优化和优先配对的人TCR恒定区域的计算设计以提高T细胞功能

Science Advances

IF12.5

2026-09-23

OAAI

Maria Radman; Astar Shamul-Raybi; Jake Parker; Sarel J. Fleishman; Cyrille J. Cohen

De novo enzyme design: Controlling structure to design function 从头酶设计：通过调控结构来设计功能

Current Opinion in Structural Biology

IF7

2026-05-23

OAAI

Listov, Dina; Fleishman, Sarel J.

The transmembrane domain structure of TNFR1 suppresses ligand-independent autoactivation but is not required for TNF-induced signaling TNFR1跨膜域结构抑制配体非依赖性自激活，但并非TNF诱导信号传导所必需

Science Signaling

IF6.6

2026-05-12

PREAI

Panxue Wang; Assaf Elazar; Jonathan Y. Weinstein; Nicholas J. Chandler; Sarel J. Fleishman; Melissa J. Call; Matthew E. Call; John Silke

Complete biosynthesis of psychedelic tryptamines from three kingdoms in plants 从三个植物界中完成致幻色胺的全生物合成

Science Advances

IF12.5

2026-04-01

OAAI

Paula Berman; Janka Höfer; Herschel Mehlman; Efrat Almekias-Siegl; Olga Khersonsky; Younghui Dong; Uwe Heinig; Liron Sulimani; Let Kho Hao; Shahar Cohen; Yoav Peleg; Sagit Meir; Ilana Rogachev; David Meiri; Sarel J. Fleishman; Asaph Aharoni

Optimizing Stability in Dynamic Small-Molecule Binding Proteins 优化动态小分子结合蛋白的稳定性

Journal of the American Chemical Society

IF15.6

2025-12-29

OAAI

Marc Scherer; Mark Kriegel; Birte Höcker; Sarel J. Fleishman

Computationally Designed Peroxygenases That Exhibit Diverse and Selective Terpene Oxyfunctionalization 计算设计具有多样性和选择性的萜烯氧官能化过氧化物酶

ACS Catalysis

IF13.1

2025-07-14

OAAI

Judith Münch; Jordi Soler; Ofir Gildor-Cristal; Sarel J. Fleishman; Marc Garcia-Borràs; Martin J. Weissenborn

Stabilized designs of the malaria adhesin protein PvRB use as a potential diagnostic for Plasmodium vivax

JOURNAL OF BIOLOGICAL CHEMISTRY

IF3.9

2025-02-01

OAAI

Sa, Jaison; Krauss, Lucas; Smith, Lauren; Andrea, Laura D. '; Chan, Li-Jin; Abraham, Anju; Kiernan-Walker, Nicholas; Mazhari, Ramin; Lamont, Macie; Lim, Pailene S.; Sattabongkot, Jetsumon; Lacerda, Marcus VG.; Wini, Lyndes; Mueller, Ivo; Longley, Rhea J.; Pymm, Phillip; Fleishman, Sarel J.; Tham, Wai-Hong

Preclinical development of a stabilized RH5 virus-like particle vaccine that induces improved antimalarial antibodies

CELL REPORTS MEDICINE

IF10.6

2024-07-01

OAAI

King, Lloyd D. W.; Pulido, David; Barrett, Jordan R.; Davies, Hannah; Quinkert, Doris; Lias, Amelia M.; Silk, Sarah E.; Pattinson, David J.; Diouf, Ababacar; Williams, Barnabas G.; Mchugh, Kirsty; Rodrigues, Ana; Rigby, Cassandra A.; Strazza, Veronica; Suurbaar, Jonathan; Rees-Spear, Chloe; Dabbs, Rebecca A.; Ishizuka, Andrew S.; Zhou, Yu; Gupta, Gaurav; Jin, Jing; Li, Yuanyuan; Carnrot, Cecilia; Minassian, Angela M.; Campeotto, Ivan; Fleishman, Sarel J.; Noe, Amy R.; Macgill, Randall S.; King, C. Richter; Birkett, Ashley J.; Soisson, Lorraine A.; Long, Carole A.; Miura, Kazutoyo; Ashfield, Rebecca; Skinner, Katherine; Howarth, Mark R.; Biswas, Sumi; Draper, Simon J.

Opportunities and challenges in design and optimization of protein function 蛋白质功能设计与优化的机遇与挑战

NATURE REVIEWS MOLECULAR CELL BIOLOGY

IF90.2

2024-04-02

PREAI

Listov, Dina; Goverde, Casper A.; Correia, Bruno E.; Fleishman, Sarel Jacob

Functionally Diverse Peroxygenases by AlphaFold2, Design, and Signal Peptide Shuffling 通过AlphaFold2，设计和信号肽改组实现功能多样化的过氧化物酶

ACS CATALYSIS

IF13.1

2024-03-13

OAAI

Muench, Judith; Dietz, Niklas; Barber-Zucker, Shiran; Seifert, Franziska; Matschi, Susanne; Puellmann, Pascal; Fleishman, Sarel J.; Weissenborn, Martin J.

Computational optimization of antibody humanness and stability by systematic energy-based ranking

NATURE BIOMEDICAL ENGINEERING

IF26.6

2023-08-07

PREAI

Tennenhouse, Ariel; Khmelnitsky, Lev; Khalaila, Razi; Yeshaya, Noa; Noronha, Ashish; Lindzen, Moshit; Makowski, Emily K. K.; Zaretsky, Ira; Sirkis, Yael Fridmann; Galon-Wolfenson, Yael; Tessier, Peter M. M.; Abramson, Jakub; Yarden, Yosef; Fass, Deborah; Fleishman, Sarel J. J.

The C-terminal tail of CSNAP attenuates the CSN complex

LIFE SCIENCE ALLIANCE

IF2.9

2023-07-17

OAAI

Fuzesi-Levi, Maria G.; Ben-Nissan, Gili; Listov, Dina; Sirkis, Yael Fridmann; Hayouka, Zvi; Fleishman, Sarel; Sharon, Michal

Allosteric regulation of the 20S proteasome by the Catalytic Core Regulators (CCRs) family

NATURE COMMUNICATIONS

IF15.7

2023-05-30

OAAI

Deshmukh, Fanindra Kumar; Ben-Nissan, Gili; Olshina, Maya A.; Fuzesi-Levi, Maria G.; Polkinghorn, Caley; Arkind, Galina; Leushkin, Yegor; Fainer, Irit; Fleishman, Sarel J.; Tawfik, Dan; Sharon, Michal

Designed active-site library reveals thousands of functional GFP variants

NATURE COMMUNICATIONS

IF15.7

2023-05-20

OAAI

Weinstein, Jonathan Yaacov; Marti-Gomez, Carlos; Lipsh-Sokolik, Rosalie; Hoch, Shlomo Yakir; Liebermann, Demian; Nevo, Reinat; Weissman, Haim; Petrovich-Kopitman, Ekaterina; Margulies, David; Ivankov, Dmitry; McCandlish, David M.; Fleishman, Sarel J.

Computational design and molecular dynamics simulations suggest the mode of substrate binding in ceramide synthases

NATURE COMMUNICATIONS

IF15.7

2023-04-22

OAAI

Zelnik, Iris D. D.; Mestre, Beatriz; Weinstein, Jonathan J. J.; Dingjan, Tamir; Izrailov, Stav; Ben-Dor, Shifra; Fleishman, Sarel J. J.; Futerman, Anthony H. H.

Design of a stable human acid-β-glucosidase: towards improved Gaucher disease therapy and mutation classification 稳定的人酸性-β-葡萄糖苷酶的设计: 改善戈谢病的治疗和突变分类

FEBS JOURNAL

IF4.2

2023-03-23

OAAI

Pokorna, Sarka; Khersonsky, Olga; Lipsh-Sokolik, Rosalie; Goldenzweig, Adi; Nielsen, Rebekka; Ashani, Yacov; Peleg, Yoav; Unger, Tamar; Albeck, Shira; Dym, Orly; Tirosh, Asa; Tarayra, Rana; Hocquemiller, Michael; Laufer, Ralph; Ben-Dor, Shifra; Silman, Israel; Sussman, Joel L. L.; Fleishman, Sarel J. J.; Futerman, Anthony H. H.

Computational design of BclxL inhibitors that target transmembrane domain interactions 靶向跨膜结构域相互作用的BclxL抑制剂的计算设计

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

IF9.1

2023-03-07

OAAI

Duart, Gerard; Elazar, Assaf; Weinstein, Jonathan Y.; Gadea-Salom, Laura; Ortiz-Mateu, Juan; Fleishman, Sarel J.; Mingarro, Ismael; Martinez-Gil, Luis

Repertoire of Computationally Designed Peroxygenases for Enantiodivergent C-H Oxyfunctionalization Reactions

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

IF15.6

2023-01-23

OAAI

de Santos, Patricia Gomez; Mateljak, Ivan; Hoang, Manh Dat; Fleishman, Sarel J.; Hollmann, Frank; Alcalde, Miguel

Designed High-Redox Potential Laccases Exhibit High Functional Diversity

ACS CATALYSIS

IF13.1

2022-10-13

OAAI

Barber-Zucker, Shiran; Mateljak, Ivan; Goldsmith, Moshe; Kupervaser, Meital; Alcalde, Miguel; Fleishman, Sarel J.