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H

Hidetaka Akita

tohoku university

58H指数
362论文数
1.4W被引数
收录论文 142
发表时间
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Combining Anti-Inflammatory Drugs and Cell-Specific Expression-Suppression Reduces the Adjuvant Activity of mRNA-LNPs
errMOLECULAR PHARMACEUTICS
IF4.5
err2026-01-01
err0
PREAI
errTanaka, Hiroki; Nishiumi, Naomasa; Shirane, Daiki; Kosegawa, Yuto; Siril, Yves Junior; Akita, Hidetaka
err分享
err收藏
Lipid nanoparticle-encapsulated microRNA-192: an anti-inflammatory adjuvant that enhances vaccine efficacy in aged mice脂质纳米颗粒包封的microRNA-192：一种增强老年小鼠疫苗效力的抗炎佐剂
errMolecular Therapy Nucleic Acids
IF6.1
err2025-11-26
err0
errOAAI
errYuriko Takagi; Tasuku Nishimura; Suraiya Aktar; Daisuke Katayama; Ken Takashima; Tomomi Kawakita; Toshiki Sekiya; Masashi Shingai; Hiroki Tanaka; Hidetaka Akita; Yusuke Miyashita; Kimitoshi Nakamura; Takahisa Kouwaki; Hiroyuki Oshiumi
err分享
err收藏
Combination of ionizable lipids with oleic acid and vitamin E scaffolds for RNA cancer vaccine delivery可电离脂质与油酸和维生素E骨架的组合用于RNA癌症疫苗递送
errJournal of Controlled Release
IF11.5
err2025-11-17
err0
PREAI
errJessica Anindita; Hiroki Tanaka; Ryotaro Oyama; Atsuya Matsumaru; Yuta Nakai; Kota Tange; Koji Nagaoka; Hideyuki Nakanishi; Takeshi Kawamura; Toshiya Tanaka; Takefumi Yamashita; Akihiro Kuroda; Sachiyo Nomura; Hiroto Hatakeyama; Keiji Itaka; Tatsuhiko Kodama; Kazuhiro Kakimi; Hidetaka Akita
err分享
err收藏
Neoantigen mRNA vaccines induce progenitor-exhausted T cells that support anti-PD-1 therapy in gastric cancer with peritoneal metastasis新抗原mRNA疫苗诱导祖细胞耗竭型T细胞，支持在伴有腹膜转移的胃癌中抗PD-1疗法
errGastric Cancer
IF5.1
err2025-07-31
err0
errOAAI
errKoji Nagaoka; Hideyuki Nakanishi; Hiroki Tanaka; Jessica Anindita; Takeshi Kawamura; Toshiya Tanaka; Takefumi Yamashita; Akihiro Kuroda; Sachiyo Nomura; Hidetaka Akita; Keiji Itaka; Tatsuhiko Kodama; Kazuhiro Kakimi
err分享
err收藏
Modulating Immunogenicity and Reactogenicity in mRNA-Lipid Nanoparticle Vaccines through Lipid Component Optimization通过脂质组分优化调节mRNA-脂质纳米粒疫苗的免疫原性和反应原性
errACS Nano
IF16
err2025-07-23
err0
errOAAI
errYoshino Kawaguchi; Mari Kimura; Tatsuya Karaki; Hiroki Tanaka; Chikako Ono; Tatsuhiro Ishida; Yoshiharu Matsuura; Toshiro Hirai; Hidetaka Akita; Taro Shimizu; Yasuo Yoshioka
err分享
err收藏
Investigation of a novel method of gene transduction in early embryo早期胚胎中一种新型基因转导方法的研究
errJournal of Reproductive Immunology
IF2.9
err2025-05-29
err0
PREAI
errChihiro Emori; Hiroki Tanaka; Hidetaka Akita; Masahito Ikawa
err分享
err收藏
A Post-Encapsulation Method for the Preparation of mRNA-LNPs via the Nucleic Acid-Bridged Fusion of mRNA-Free LNPs通过无mRNA的lnp的核酸桥接融合制备mrna-lnp的后封装方法
errNANO LETTERS
IF9.1
err2025-04-12
err0
PREAI
errTanaka, Hiroki; Sato, Yuka; Nakabayashi, Tomoya; Tanaka, Akari; Nishio, Kazuma; Matsumoto, Chika; Matsumaru, Atsuya; Yamakawa, Takuma; Ishizaki, Kota; Ueda, Keisuke; Higashi, Kenjirou; Moribe, Kunikazu; Nakai, Yuta; Tange, Kota; Akita, Hidetaka
err分享
err收藏
Low-inflammatory lipid nanoparticle-based mRNA vaccine elicits protective immunity against H5N1 influenza virus with reduced adverse reactions低炎症脂质纳米颗粒载体mRNA疫苗可引发针对H5N1流感病毒的具有保护性免疫，同时不良反应减少。
errMOLECULAR THERAPY
IF12
err2025-02-01
err2
errOAAI
errKawai, Atsushi; Shimizu, Taro; Tanaka, Hiroki; Shichinohe, Shintaro; Anindita, Jessica; Hirose, Mika; Kawahara, Eigo; Senpuku, Kota; Shimooka, Makoto; Mai, Le Thi Quynh; Suzuki, Ryo; Nogimori, Takuto; Yamamoto, Takuya; Hirai, Toshiro; Kato, Takayuki; Watanabe, Tokiko; Akita, Hidetaka; Yoshioka, Yasuo
err分享
err收藏
EVs-miR-17-5p attenuates the osteogenic differentiation of vascular smooth muscle cells potentially via inhibition of TGF-β signaling under high glucose conditions (vol 14, 16323, 2024)
errSCIENTIFIC REPORTS
IF3.9
err2024-08-23
err0
errOAAI
errBaba, Isashi; Matoba, Tetsuya; Katsuki, Shunsuke; Koga, Jun-ichiro; Kawahara, Takuro; Kimura, Mitsukuni; Akita, Hidetaka; Tsutsui, Hiroyuki
err分享
err收藏
EVs-miR-17-5p attenuates the osteogenic differentiation of vascular smooth muscle cells potentially via inhibition of TGF-β signaling under high glucose conditions
errSCIENTIFIC REPORTS
IF3.9
err2024-07-15
err2
errOAAI
errBaba, Isashi; Matoba, Tetsuya; Katsuki, Shunsuke; Koga, Jun-ichiro; Kawahara, Takuro; Kimura, Mitsukuni; Akita, Hidetaka; Tsutsui, Hiroyuki
err分享
err收藏
The stress-responsive cytotoxic effect of diesel exhaust particles on lymphatic endothelial cells
errSCIENTIFIC REPORTS
IF3.9
err2024-05-07
err1
errOAAI
errSakurai, Yu; Oba, Eiki; Honda, Akiko; Tanaka, Hiroki; Takano, Hirohisa; Akita, Hidetaka
err分享
err收藏
Intranasal immunization with an RBD-hemagglutinin fusion protein harnesses preexisting immunity to enhance antigen-specific responses
errJOURNAL OF CLINICAL INVESTIGATION
IF13.6
err2023-12-01
err3
errOAAI
errKawai, Atsushi; Tokunoh, Nagisa; Kawahara, Eigo; Tamiya, Shigeyuki; Okamura, Shinya; Ono, Chikako; Anindita, Jessica; Tanaka, Hiroki; Akita, Hidetaka; Yamasaki, Sho; Kunisawa, Jun; Okamoto, Toru; Matsuura, Yoshiharu; Hirai, Toshiro; Yoshika, Yasuo
err分享
err收藏
Development of a Ready-to-Use-Type RNA Vaccine Carrier Based on an Intracellular Environment-Responsive Lipid-like Material with Immune-Activating Vitamin E Scaffolds基于具有免疫激活维生素e支架的细胞内环境响应性脂质样材料的即用型RNA疫苗载体的开发
errPHARMACEUTICS
IF5.5
err2023-11-29
err3
errOAAI
errAnindita, Jessica; Tanaka, Hiroki; Oyama, Ryotaro; Hagiwara, Shinya; Shirane, Daiki; Taneichi, Sakura; Nakai, Yuta; Tange, Kota; Hatakeyama, Hiroto; Sakurai, Yu; Akita, Hidetaka
err分享
err收藏
An Ionizable Lipid Material with a Vitamin E Scaffold as an mRNA Vaccine Platform for Efficient Cytotoxic T Cell Responses具有维生素e支架的可电离脂质材料作为有效的细胞毒性T细胞反应的mRNA疫苗平台
errACS NANO
IF16
err2023-09-26
err10
errOAAI
errOyama, Ryotaro; Ishigame, Harumichi; Tanaka, Hiroki; Tateshita, Naho; Itazawa, Moeko; Imai, Ryosuke; Nishiumi, Naomasa; Kishikawa, Jun-ichi; Kato, Takayuki; Anindita, Jessica; Nishikawa, Yoshifumi; Maeki, Masatoshi; Tokeshi, Manabu; Tange, Kota; Nakai, Yuta; Sakurai, Yu; Okada, Takaharu; Akita, Hidetaka
err分享
err收藏
Tolerogenic Lipid Nanoparticles for Delivering Self-Antigen mRNA for the Treatment of Experimental Autoimmune Encephalomyelitis耐受性脂质纳米粒递送自身抗原mRNA治疗实验性自身免疫性脑脊髓炎
errPHARMACEUTICALS
IF4.8
err2023-09-07
err5
errOAAI
errGomi, Masaki; Nakayama, Yuka; Sakurai, Yu; Oyama, Ryotaro; Iwasaki, Koki; Doi, Mizuki; Liu, Yi; Hori, Mizuho; Watanabe, Himeka; Hashimoto, Kohei; Tanaka, Hiroki; Tange, Kota; Nakai, Yuta; Akita, Hidetaka
err分享
err收藏
Comprehensive Evaluation of Lipid Nanoparticles and Polyplex Nanomicelles for Muscle-Targeted mRNA Delivery用于肌肉靶向mRNA递送的脂质纳米粒和复合物纳米胶束的综合评价
errPHARMACEUTICS
IF5.5
err2023-09-07
err8
errOAAI
errDu, Xuan; Yada, Erica; Terai, Yuki; Takahashi, Takuya; Nakanishi, Hideyuki; Tanaka, Hiroki; Akita, Hidetaka; Itaka, Keiji
err分享
err收藏
A nasal vaccine with inactivated whole-virion elicits protective mucosal immunity against SARS-CoV-2 in mice
errFRONTIERS IN IMMUNOLOGY
IF5.9
err2023-08-31
err11
errOAAI
errTokunoh, Nagisa; Tamiya, Shigeyuki; Watanabe, Masato; Okamoto, Toru; Anindita, Jessica; Tanaka, Hiroki; Ono, Chikako; Hirai, Toshiro; Akita, Hidetaka; Matsuura, Yoshiharu; Yoshioka, Yasuo
err分享
err收藏
Development of an Alcohol Dilution-Lyophilization Method for the Preparation of mRNA-LNPs with Improved Storage Stability酒精稀释-冻干法制备储存稳定性提高的mrna-lnps的研究
errPHARMACEUTICS
IF5.5
err2023-06-26
err11
errOAAI
errShirane, Daiki; Tanaka, Hiroki; Sakurai, Yu; Taneichi, Sakura; Nakai, Yuta; Tange, Kota; Ishii, Itsuko; Akita, Hidetaka
err分享
err收藏
Ready-to-Use-Type Lyophilized Lipid Nanoparticle Formulation for the Postencapsulation of Messenger RNA用于信使RNA后包封的即用型冻干脂质纳米粒制剂
errACS NANO
IF16
err2023-01-31
err15
PREAI
errTanaka, Hiroki; Hagiwara, Shinya; Shirane, Daiki; Yamakawa, Takuma; Sato, Yuka; Matsumoto, Chika; Ishizaki, Kota; Hishinuma, Miho; Chida, Katsuyuki; Sasaki, Kasumi; Yonemochi, Etsuo; Ueda, Keisuke; Higashi, Kenjirou; Moribe, Kunikazu; Tadokoro, Takashi; Maenaka, Katsumi; Taneichi, Sakura; Nakai, Yuta; Tange, Kota; Sakurai, Yu; Akita, Hidetaka
err分享
err收藏
Reactivation of Anticancer Immunity by Resetting Interorgan Crosstalk in Immune-Suppressive Cells with a Nanoparticulated Anti-Inflammatory Drug通过用纳米颗粒抗炎药重置免疫抑制细胞中的器官间串扰来重新激活抗癌免疫
errSMALL
IF12.1
err2023-01-26
err2
errOAAI
errDoi, Mizuki; Tanaka, Hiroki; Ohoto, Takara; Miura, Naoya; Sakurai, Yu; Hatakeyama, Hiroto; Akita, Hidetaka
err分享
err收藏

研究方向

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合作学者
合作期刊
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Charles M. Rice
H 指数: 166 · 论文数: 718
K
Kazunori Kataoka
H 指数: 153 · 论文数: 1.1K
Y
Yuichi Sugiyama
H 指数: 112 · 论文数: 1.1K
Y
Yasuhiko Tabata
H 指数: 105 · 论文数: 1.2K
T
Tatsuhiko Kodama
H 指数: 104 · 论文数: 594
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