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P

Patrick E. MacDonald

university of alberta

61H指数
269论文数
1.5W被引数
收录论文 117
发表时间
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The comparative cell physiology of stem cell-derived and primary human β cells干细胞来源和原代人类β细胞的比较细胞生理学
errNature Reviews Endocrinology
IF40
err2026-09-04
err0
PREAI
errJasmine Maghera; Chieh Min Jamie Chu; Christopher Schaaf; Jennifer E. Bruin; James D. Johnson; Francis C. Lynn; Patrick E. MacDonald
err分享
err收藏
TBL1X/TBL1XR1 govern β-cell identity through a PAX6-containing gene regulatory networkTBL1X/TBL1XR1通过PAX6-containing基因调控网络控制 β 细胞身份
errNature Communications
IF15.7
err2026-04-23
err0
errOAAI
errAlina A. Walth-Hummel; Celine Jouffe; Peter Weber; Karsten Motzler; Julia Geppert; Michael Sterr; Wei Gan; Iwona Szczerbinska; Ann-Christine König; Stefanie M. Hauck; Raul Terron-Exposito; Daniela Hass; Congcong Wang; Kenneth A. Dyar; James G. Lyon; Heiko Lickert; Carina Ämmälä; Stephan Herzig; Frances M. Ashcroft; Mostafa Bakhti; Patrick E. MacDonald; Maria Rohm
err分享
err收藏
Persistent organic pollutant concentrations in human pancreas correlate with markers of beta cell dysfunction持久性有机污染物浓度在人体胰腺中与β细胞功能障碍标志物相关
errNature Communications
IF15.7
err2026-04-15
err0
errOAAI
errMyriam P. Hoyeck; Ma. Enrica Angela Ching; Jana Palaniyandi; Evgenia Fadzeyeva; Jelena Kolic; Jillian Ashley-Martin; James Lyon; Nancy Smith; Erin E. Mulvihill; James D. Johnson; Jocelyn E. Manning Fox; Patrick E. MacDonald; Jennifer E. Bruin
err分享
err收藏
CK2 regulates somatostatin expression in pancreatic delta cellsCK2调节胰腺δ细胞中生长抑素的表达
errIslets
IF1.7
err2025-12-31
err0
PREAI
errWrublewsky, Selina; Clemenz, Annika; Boewe, Anne S.; Wilden, Cedric; Bickelmann, Caroline; Goetz, Claudia; MacDonald, Patrick E.; Laschke, Matthias W.; Ampofo, Emmanuel
err分享
err收藏
Altered immune and metabolic molecular pathways drive islet cell dysfunction in human type 1 diabetes
errJOURNAL OF CLINICAL INVESTIGATION
IF13.6
err2025-12-01
err1
errOAAI
errDos Santos, Theodore; Dai, Xiao-Qing; Jones, Robert C.; Spigelman, Aliya F.; Mummey, Hannah M.; Ewald, Jessica D.; Ellis, Cara E.; Lyon, James G.; Smith, Nancy; Bautista, Austin; Fox, Jocelyn E. Manning; Neff, Norma F.; Detweiler, Angela M.; Tan, Michelle; Arrojo e Drigo, Rafael; Xia, Jianguo; Camunas-Soler, Joan; Gaulton, Kyle J.; Quake, Stephen R.; Macdonald, Patrick E.
err分享
err收藏
Heparan sulfate fine-tuned interleukin-1 (IL-1) signaling inhibits insulin secretion of grafted pancreatic islets硫酸乙酰肝素精细调控的白细胞介素-1（IL-1）信号通路抑制了移植胰腺岛的胰岛素分泌。
errScience Advances
IF12.5
err2025-08-08
err0
errOAAI
errSelina Wrublewsky; Sandra Rother; Franziska Pohlemann; Toni Radanovic; Fabian Junker; Anne S. Boewe; Stefan Schunk; Leticia P. Roma; Gloria Ruiz-Gómez; M. Teresa Pisabarro; Patrick E. MacDonald; Michael D. Menger; Matthias W. Laschke; Emmanuel Ampofo
err分享
err收藏
Spatially Bound Functional Heterogeneity Drives Modular Organization in Beta Cell Networks空间受限的功能异质性驱动β细胞网络中的模块化组织
errBiophysical Journal
IF3.1
err2025-08-05
err0
errOAAI
errMaja Duh; Marko Šterk; Lidija Križančić Bombek; Patrick E. MacDonald; Andraž Stožer; Marko Gosak
err分享
err收藏
Scale up manufacturing approach for production of human induced pluripotent stem cell-derived islets using Vertical Wheel® bioreactors使用Vertical Wheel®生物反应器扩大人类诱导多能干细胞来源的胰岛的生产制造方法
errnpj Regenerative Medicine
IF6.5
err2025-05-29
err0
errOAAI
errNidheesh Dadheech; Mario Bermúdez de León; Zofia Czarnecka; Nerea Cuesta-Gomez; Ila Tewari Jasra; Rena Pawlick; Braulio Marfil-Garza; Sandhya Sapkota; Kevin Verhoeff; Haide Razavy; Perveen Anwar; Abhineet Singh; Nilanjan Ray; Doug O’ Gorman; Glen Jickling; James Lyon; Patrick MacDonald; A. M. James Shapiro
err分享
err收藏
Cisplatin Exposure Dysregulates Insulin Secretion in Male and Female Mice顺铂暴露导致雌雄小鼠胰岛素分泌失调
errDIABETES
IF7.5
err2025-01-14
err1
PREAI
errBasu, Lahari; Grieco-St-Pierre, Lili; Ching, Ma. Enrica Angela; Stead, John D. H.; Hanson, Antonio A.; Palaniyandi, Jana; van Zyl, Erin; Hoyeck, Myriam P.; Mckay, Kelsea S.; van Allen, Kyle A.; Lee, Hyojin; Dai, Xiao-Qing; Bautista, Austin; Fadzeyeva, Evgenia; Mulvihill, Erin E.; Yauk, Carole L.; Mennigen, Jan A.; Macdonald, Patrick E.; Bruin, Jennifer E.
err分享
err收藏
An INSULIN and IAPP dual reporter enables tracking of functional maturation of stem cell- derived insulin producing cells
errMOLECULAR METABOLISM
IF6.6
err2024-11-01
err0
errOAAI
errBayly, Carmen L.; Dai, Xiao-Qing; Nian, Cuilan; Orban, Paul C.; Verchere, C. Bruce; MacDonald, Patrick E.; Lynn, Francis C.
err分享
err收藏
Scalable Bioreactor-based Suspension Approach to Generate Stem Cell-derived Islets From Healthy Donor-derived iPSCs
errTRANSPLANTATION
IF5
err2024-07-18
err2
PREAI
errVerhoeff, Kevin; Cuesta-Gomez, Nerea; Maghera, Jasmine; Dadheech, Nidheesh; Pawlick, Rena; Smith, Nancy; O'Gorman, Doug; Razavy, Haide; Marfil-Garza, Braulio; Young, Lachlan G.; Thiesen, Aducio; Macdonald, Patrick E.; Shapiro, A. M. James
err分享
err收藏
Proteomic predictors of individualized nutrient-specific insulin secretion in health and disease
errCELL METABOLISM
IF30.9
err2024-07-01
err5
errOAAI
errKolic, Jelena; Sun, WenQing Grace; Cen, Haoning Howard; Ewald, Jessica D.; Rogalski, Jason C.; Sasaki, Shugo; Sun, Han; Rajesh, Varsha; Xia, Yi Han; Moravcova, Renata; Skovso, Sos; Spigelman, Aliya F.; Fox, Jocelyn E. Manning; Lyon, James; Beet, Leanne; Xia, Jianguo; Lynn, Francis C.; Gloyn, Anna L.; Foster, Leonard J.; Macdonald, Patrick E.; Johnson, James D.
err分享
err收藏
MetaboAnalyst 6.0: towards a unified platform for metabolomics data processing, analysis and interpretationMetaboAnalyst 6.0: 迈向代谢组学数据处理，分析和解释的统一平台
errNUCLEIC ACIDS RESEARCH
IF13.1
err2024-04-08
err135
errOAAI
errPang, Zhiqiang; Lu, Yao; Zhou, Guangyan; Hui, Fiona; Xu, Lei; Viau, Charles; Spigelman, Aliya F.; Macdonald, Patrick E.; Wishart, David S.; Li, Shuzhao; Xia, Jianguo
err分享
err收藏
CK2 activity is crucial for proper glucagon expression
errDIABETOLOGIA
IF10.2
err2024-03-20
err0
errOAAI
errAmpofo, Emmanuel; Pack, Mandy; Wrublewsky, Selina; Boewe, Anne S.; Spigelman, Aliya F.; Koch, Hanna; Macdonald, Patrick E.; Laschke, Matthias W.; Montenarh, Mathias; Goetz, Claudia
err分享
err收藏
Web-based multi-omics integration using the Analyst software suite
errNATURE PROTOCOLS
IF16
err2024-02-14
err28
PREAI
errEwald, Jessica D.; Zhou, Guangyan; Lu, Yao; Kolic, Jelena; Ellis, Cara; Johnson, James D.; Macdonald, Patrick E.; Xia, Jianguo
err分享
err收藏
A role and mechanism for redox sensing by SENP1 in β-cell responses to high fat feeding
errNATURE COMMUNICATIONS
IF15.7
err2024-01-06
err3
errOAAI
errLin, Haopeng; Suzuki, Kunimasa; Smith, Nancy; Li, Xi; Nalbach, Lisa; Fuentes, Sonia; Spigelman, Aliya F.; Dai, Xiao-Qing; Bautista, Austin; Ferdaoussi, Mourad; Aggarwal, Saloni; Pepper, Andrew R.; Roma, Leticia P.; Ampofo, Emmanuel; Li, Wen-hong; MacDonald, Patrick E.
err分享
err收藏
HNF1α maintains pancreatic α and β cell functions in primary human islets
errJCI INSIGHT
IF6.1
err2023-12-22
err2
errOAAI
errQian, Mollie F.; Bevacqua, Romina J.; Coykendall, Vy M. N.; Liu, Xiong; Zhao, Weichen; Chang, Charles A.; Gu, Xueying; Dai, Xiao-Qing; MacDonald, Patrick E.; Kim, Seung K.
err分享
err收藏
RFX6 Maintains Gene Expression and Function of Adult Human Islet α-Cells
errDIABETES
IF7.5
err2023-12-08
err3
errOAAI
errCoykendall, Vy M. N.; Qian, Mollie F.; Tellez, Krissie; Bautista, Austin; Bevacqua, Romina J.; Gu, Xueying; Hang, Yan; Neukam, Martin; Zhao, Weichen; Chang, Charles; MacDonald, Patrick E.; Kim, Seung K.
err分享
err收藏
Modulation of insulin secretion by RBFOX2-mediated alternative splicing
errNATURE COMMUNICATIONS
IF15.7
err2023-11-25
err2
errOAAI
errMoss, Nicole D.; Wells, Kristen L.; Theis, Alexandra; Kim, Yong-Kyung; Spigelman, Aliya F.; Liu, Xiong; Macdonald, Patrick E.; Sussel, Lori
err分享
err收藏
Deletion of Carboxypeptidase E in β-Cells Disrupts Proinsulin Processing but Does Not Lead to Spontaneous Development of Diabetes in MiceΒ 细胞中羧肽酶E的缺失会破坏胰岛素原的加工，但不会导致小鼠糖尿病的自发发展。
errDIABETES
IF7.5
err2023-06-26
err5
errOAAI
errChen, Yi-Chun; Taylor, Austin J.; Fulcher, James M.; Swensen, Adam C.; Dai, Xiao-Qing; Komba, Mitsuhiro; Wrightson, Kenzie L. C.; Fok, Kenny; Patterson, Annette E.; Klein Geltink, Ramon I.; MacDonald, Patrick E.; Qian, Wei-Jun; Verchere, C. Bruce
err分享
err收藏

研究方向

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合作学者
合作期刊
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Mark I. McCarthy
H 指数: 222 · 论文数: 1.5K
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H 指数: 181 · 论文数: 1.6K
M
Michael Boehnke
H 指数: 168 · 论文数: 770
P
Philippe Froguel
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