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C

Christian D. Klein

heidelberg university

38H指数
144论文数
5.5K被引数
收录论文 66
发表时间
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Peptide Thioester and Triazole Derivatives Through On-Resin Dual-Modification of Peptide Thiosulfonates通过在树脂上对肽硫代磺酸酯进行双修饰制备肽硫酯和三唑衍生物
errAngewandte Chemie-International Edition
IF16.9
err2026-07-27
err0
errOAAI
errMarius Werner; Agnes Bergmann; Chenxi Liu; Mira Behnam; Christian Klein; Franziska Thomas
err分享
err收藏
Development of Novel Proline- and Pipecolic Acid-Based Allosteric Inhibitors of Dengue and Zika Virus NS2B/NS3 Protease新型脯氨酸和哌啶酸基构象变构抑制剂的研发：针对登革热病毒和寨卡病毒NS2B/NS3蛋白酶
errPharmaceuticals
IF4.8
err2026-03-04
err0
errOAAI
errJosè Starvaggi; Carla Di Chio; Johannes Lang; Valentina Belgiovine; Daniela Trisciuzzi; Santo Previti; Christian Klein; Orazio Nicolotti; Salvatore Di Maro; Maria Zappalà; Roberta Ettari
err分享
err收藏
Decoding of Inconsistent Biological Data: A Critical Step toward Enhanced AI Predictivity in Drug Discovery
errACS PHARMACOLOGY & TRANSLATIONAL SCIENCE
IF3.7
err2025-12-01
err0
PREAI
errBehnam, Mira A. M.; Cavalli, Andrea; Lousa, Diana; Soares, Claudio M.; Klein, Christian D.
err分享
err收藏
Enhancing T cell responses to glioma-specific vaccines through optimized altered peptide ligands通过优化的改造肽配体增强T细胞对胶质瘤特异性疫苗的应答
errNEURO-ONCOLOGY
IF13.4
err2025-11-01
err0
errOAAI
errPaul, Alina; Werner, Marius; Sanghvi, Khwab; Klein, Christian; Thomas, Franziska; Bunse, Lukas; Platten, Michael
err分享
err收藏
Exploring Nirmatrelvir Derivatives Through P2 Substituent Modifications and Warhead Innovations Targeting the Main Protease of SARS-CoV-2通过P2取代基修饰和靶向SARS-CoV-2主蛋白酶的药效团创新探索Nirmatrelvir衍生物
errARCHIV DER PHARMAZIE
IF3.6
err2025-11-01
err0
errOAAI
errMartins, Felipe Cardoso Prado; Lang, Johannes; Rocho, Fernanda Dos Reis; Wang, Xianxian; Bonatto, Vinicius; Lameira, Jeronimo; Klein, Christian; Montanari, Carlos Alberto
err分享
err收藏
Efficient Acyloxymethylation of Psilocin and Other Tryptamines Yielding ACOM Prodrugs for Psychedelic-Assisted Therapy高效乙酰氧甲酰化反应修饰裸盖菇素及其他色胺类物质，制备用于致幻剂辅助治疗的ACOM前药
errArchiv der Pharmazie
IF3.6
err2025-07-23
err0
errOAAI
errJudith Stirn; Christian D. Klein
err分享
err收藏
Discovery of Pyrazole-3-Carboxylic Acid Derivatives as Dengue Virus Protease Inhibitors with Antiviral Activity吡唑-3-羧酸衍生物作为具有抗病毒活性的登革病毒蛋白酶抑制剂的发现
errACS Medicinal Chemistry Letters
IF4
err2025-07-15
err0
PREAI
errJohannes Lang; Jeannette Koch; Sudip K. Dutta; Mila M. Leuthold; Byron Martina; Christian D. Klein
err分享
err收藏
Towards "unmakable" psychedelics: SAR exploration of psilocin analogs obtained by a HATU-mediated amide coupling strategy朝向“不可合成”的致幻剂：基于HATU介导的酰胺偶联策略获得的裸盖菇素类似物的SAR探索
errEuropean Journal of Medicinal Chemistry Reports
IF4.1
err2025-06-03
err0
errOAAI
errJudith Stirn; Raphael Berger; Harald Hübner; Peter Gmeiner; Christian D. Klein
err分享
err收藏
Alternate recognition by dengue protease: Proteolytic and binding assays provide functional evidence beyond an induced-fit登革热蛋白酶的替代识别: 蛋白水解和结合测定提供了超出诱导拟合的功能证据
errBIOCHIMIE
IF3
err2024-12-01
err2
errOAAI
errBehnam, Mira A. M.; Klein, Christian D.
err分享
err收藏
Peptide Boronic Acids by Late-Stage Hydroboration on the Solid Phase
errADVANCED SCIENCE
IF14.1
err2024-05-29
err0
errOAAI
errWerner, Marius; Brinkhofer, Julian; Hammermueller, Leon; Heim, Thomas; Pham, Truc Lam; Huber, Jonas; Klein, Christian; Thomas, Franziska
err分享
err收藏
Expanding Per- and Polyfluoroalkyl Substances Coverage in Nontargeted Analysis Using Data-Independent Analysis and IonDecon
errJOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY
IF2.7
err2023-09-26
err6
PREAI
errKoelmel, Jeremy P.; Kummer, Michael; Chevallier, Olivier; Hindle, Ralph; Hunt, Kathy; Camacho, Camden G.; Abril, Nandarani; Gill, Emily L.; Beecher, Christopher W. W.; Garrett, Timothy J.; Yost, Richard A.; Townsend, Timothy G.; Klein, Christian; Rennie, Emma E.; Bowden, John A.; Pollitt, Krystal J. Godri
err分享
err收藏
N -sulfonyl peptide-hybrids as a new class of dengue virus protease inhibitors
errEUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
IF5.9
err2023-05-01
err11
PREAI
errBehrouz, Somayeh; Kuehl, Nikos; Klein, Christian D.
err分享
err收藏
Discovery of potent benzoxaborole inhibitors against SARS-CoV-2 main and dengue virus proteases
errEUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
IF5.9
err2022-10-01
err13
errOAAI
errKuehl, Nikos; Lang, Johannes; Leuthold, Mila M.; Klein, Christian D.
err分享
err收藏
Insights into the design of inhibitors of the EGFR family with anticancer activity overcoming resistance: A case of optimizing thieno[2,3-d]pyrimidine-based EGFR inhibitors
errJOURNAL OF MOLECULAR STRUCTURE
IF4.7
err2022-07-01
err8
PREAI
errMilik, Sandra N.; Abdel-Aziz, Amal Kamal; El-Hendawy, Morad M.; El-Gogary, Riham, I; Saadeldin, Mona Kamal; Minucci, Saverio; Klein, Christian D.; Abouzid, Khaled A. M.
err分享
err收藏
New Drug Development for Known and Emerging Viruses
errCHEMMEDCHEM
IF3.4
err2022-05-19
err0
PREAI
errKlein, Christian
err分享
err收藏
The spectrum between substrates and inhibitors: Pinpointing the binding mode of dengue protease ligands with modulated basicity and hydrophobicity底物和抑制剂之间的光谱: 确定具有调节的碱性和疏水性的登革热蛋白酶配体的结合模式
errBIOORGANIC & MEDICINAL CHEMISTRY
IF3
err2021-10-01
err3
PREAI
errDrazc, Tonko; Kuhl, Nikos; Gottscheber, Nicole; Hacker, Christina N.; Klein, Christian D.
err分享
err收藏
Inhibitor potency and assay conditions: A case study on SARS-CoV-2 main protease
errPROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
IF9.1
err2021-09-02
err10
errOAAI
errBehnam, Mira A. M.; Klein, Christian D.
err分享
err收藏
Improved Protein and PTM Characterization with a Practical Electron-Based Fragmentation on Q-TOF Instruments
errJOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY
IF2.7
err2021-04-29
err30
errOAAI
errBeckman, Joseph S.; Voinov, Valery G.; Hare, Michael; Sturgeon, Derrill; Vasil'ev, Yury; Oppenheimer, Diana; Shaw, Jared B.; Wu, Shuai; Glaskin, Rebecca; Klein, Christian; Schwarzer, Cody; Stafford, George
err分享
err收藏
Beyond Basicity: Discovery of Nonbasic DENV-2 Protease Inhibitors with Potent Activity in Cell Culture
errJOURNAL OF MEDICINAL CHEMISTRY
IF6.8
err2021-04-14
err18
PREAI
errKuehl, Nikos; Leuthold, Mila M.; Behnam, Mira A. M.; Klein, Christian D.
err分享
err收藏
Peptide-β-lactam Inhibitors of Dengue and West Nile Virus NS2B-NS3 Protease Display Two Distinct Binding Modes (vol 63, pg 140, 2020)
errJOURNAL OF MEDICINAL CHEMISTRY
IF6.8
err2020-09-01
err0
errOAAI
errDrazic, Tonko; Kopf, Sara; Corridan, James; Leuthold, Mila M.; Bertosa, Branimir; Klein, Christian D.
err分享
err收藏

研究方向

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