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K

Kelly Chibale

university of cape town

42H指数
281论文数
6.3K被引数
收录论文 162
发表时间
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The Human Chk1 Inhibitor CHIR-124 Shows Multistage Activity against the Human Malaria Parasite Plasmodium falciparum via Polypharmacological Inhibition of PfArk1 and Hemozoin Formation人源Chk1抑制剂CHIR-124通过多药理抑制作用抑制PfArk1和血红素结晶形成，对人疟原虫恶性疟原虫表现出多阶段活性
errACS Chemical Biology
IF3.8
err2026-06-13
err0
errOAAI
errKathryn J. Wicht; John G. Woodland; Larnelle F. Garnie; Henrico Langeveld; Dale Taylor; Luiz C. Godoy; Charisse Flerida A. Pasaje; Mariana Laureano de Souza; Jair L. Siqueira-Neto; Sonja Ghidelli-Disse; Maria Jose Lafuente-Monasterio; Francisco-Javier Gamo; Dina Coertzen; Janette Reader; Mariëtte van der Watt; Jessica L. Bridgford; Gareth Girling; Rachael Coyle; Christian Scheurer; Sergio Wittlin; Arne Alder; Tim-Wolf Gilberger; Marcus C. S. Lee; Till S. Voss; Elizabeth A. Winzeler; David A. Fidock; Jacquin C. Niles; Lyn-Marié Birkholtz; Lauren B. Coulson; Kelly Chibale
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Front Cover: Structure- and Ligand-Based Discovery of Novel 3-Chymotrypsin-Like Protease Nonpeptidomimetic Hits (ChemMedChem 7/2026)封面：基于结构与配体的新型类糜蛋白酶非肽类拟物先导物的发现 (ChemMedChem 7/2026)
errChemMedChem
IF3.4
err2026-04-18
err0
errOAAI
errSabrina Silva-Mendonça; Donald Seanego; Christopher Jurisch; Melina Mottin; Flávia Nader Motta; Beatriz S. A. Rodrigues; Gilberto S. M. Junior; Alexandra Maria dos Santos Carvalho; Fábio Muniz de Oliveira; Sunniva Sigurdardóttir; Per Sunnerhagen; Izabela Marques Dourado Bastos; Richard Gessner; Kelly Chibale; Carolina Horta Andrade
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Effect of Stereochemistry on the Antiplasmodial Activity and Metabolomic Profile of Novel Tadalafil Analogues立体化学对新型他达拉非类似物的抗疟疾活性和代谢组学特征的影响
errACS Medicinal Chemistry Letters
IF4
err2026-04-14
err0
PREAI
errEsraa A. Elhalawaty; Howida A. Alseedy; John G. Woodland; Kathryn J. Wicht; Tarryn Swart; Gabriel W. Rangel; Heinrich C Hoppe; Kelly Chibale; Manuel Llinás; Ashraf H. Abadi; Nermin S. Ahmed
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Structure- and Ligand-Based Discovery of Novel 3-Chymotrypsin-Like Protease Nonpeptidomimetic Hits基于结构和配体的新型类胰凝乳蛋白酶样蛋白酶非肽类拟物活性分子发现
errChemMedChem
IF3.4
err2026-04-09
err0
errOAAI
errSabrina Silva-Mendonça; Donald Seanego; Christopher Jurisch; Melina Mottin; Flávia Nader Motta; Beatriz S. A. Rodrigues; Gilberto S. M. Junior; Alexandra Maria dos Santos Carvalho; Fábio Muniz de Oliveira; Sunniva Sigurdardóttir; Per Sunnerhagen; Izabela Marques Dourado Bastos; Richard Gessner; Kelly Chibale; Carolina Horta Andrade
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Structure−Activity Relationship and Optimization of Drug-like Properties of Antituberculosis 3-(4,4-dimethyl-1,4-azasilinane)methylpyrazole MmpL3 Inhibitors构效关系及抗结核3-(4,4-二甲基-1,4-氮杂硅环戊烷)甲基吡唑MmpL3抑制剂的成药性优化
errEuropean Journal of Medicinal Chemistry
IF5.9
err2026-04-08
err0
errOAAI
errLutete Peguy Khonde; Nashied Peton; Keabetswe Masike; Tania Valentine; Frank Zindo; Stephen Fienberg; Charles Omollo; Mathew Njoroge; Francesco Vallini; Chiara Tammaro; Michela Guida; Dirk Schnappinger; Lauren Ames; Mariangela Biava; Vinayak Singh; Tanya Parish; Giovanna Poce; Sandeep R. Ghorpade; Kelly Chibale
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Enhanced Antiviral Activity of Novel Umifenovir Derivatives against SARS-CoV-2: Insights from an International Collaborative Study新型乌米芬韦衍生物对SARS-CoV-2的增强抗病毒活性：国际协作研究启示
errACS Omega
IF4.3
err2026-04-06
err0
errOAAI
errMelina Mottin; Christopher D. Jurisch; Sabrina Silva-Mendonça; Donald Seanego; Paulo R. P. da Silva Ramos; Caroline S. Freitas; Mayara Mattos; Natalia Fintelman-Rodrigues; Carolina Q. Sacramento; Florence Guivel-Benhassine; Timothée Bruel; Liezl Krugmann; Ana C. Puhl; Fabio Urbina; Thomas R. Lane; Eric M. Merten; Kenneth H. Pearce; Alexander Lepioshkin; Artem Poromov; Natalia Monakhova; Olivier Schwartz; Kelly Chibale; Thiago M. L. Souza; Sean Ekins; Vadim Makarov; Richard K. Gessner; Carolina H. Andrade
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Call for Papers: Advances in Pharmaceutical Sciences in Africa征集论文：非洲药学科学进展
errMolecular Pharmaceutics
IF4.5
err2026-03-01
err0
PREAI
errChoonara, Yahya E.; Chibale, Kelly; Thuo, Martin; Bhaw-Luximon, Archana; Elmeshad, Aliaa
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Bheka Thina (“Look At Us”): The Emergence of an Integrated Drug Discovery Ecosystem in South Africa比卡·瑟纳（“看看我们”）：南非整合药物发现生态系统的兴起
errACS Medicinal Chemistry Letters
IF4
err2026-02-22
err0
errOAAI
errJohn G. Woodland; Clinton G. L. Veale; Kelly Chibale
err分享
err收藏
Call for Papers: Medicinal Chemistry and Pharmacology of Antiviral Drugs
errJournal of Medicinal Chemistry
IF6.8
err2026-01-22
err0
errOAAI
errPeng Zhan; Stefano Alcaro; Scott Pegan; Craig W. Lindsley; Jayanta Haldar; Kelly Chibale; Christa E. Müller
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A Novel Class of Orally Bioavailable Phenylglycine-Benzoxaborole Conjugates with Antimalarial Activity and Potentially Novel Mechanism of Action一类具有抗疟活性和潜在新型作用机制的新型口服生物利用型苯甘氨酸-苯并硼杂唑偶联物
errACS MEDICINAL CHEMISTRY LETTERS
IF4
err2025-12-01
err0
PREAI
errMorake, Mokhitli; Taylor, Dale; Coertzen, Dina; Njoroge, Mathew; Krugmann, Liezl; Leshabane, Meta; Da Rocha, Shante; Qahash, Tarrick; Girling, Gareth; Coyle, Rachael; Lee, Marcus C. S.; Wittlin, Sergio; Llinas, Manuel; Birkholtz, Lyn-Marie; Basarab, Gregory S.; Chibale, Kelly
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Addressing infectious diseases in Africa by accelerating drug discovery through data science通过数据科学加速药物发现，应对非洲的传染病
errCommunications Medicine
IF6.3
err2025-11-25
err0
errOAAI
errGemma Turon; Jason Hlozek; Miquel Duran-Frigola; Kelly Chibale; John G. Woodland
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Structural Biology Enabling Drug Discovery结构生物学赋能药物发现
errJournal of Medicinal Chemistry
IF6.8
err2025-11-19
err0
errOAAI
errDavid E. Heppner; Simone V. Bigi-Botterill; Andrew P. Riley; Kelly Chibale; Craig W. Lindsley
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Targeting Aurora Kinases as Essential Cell-Cycle Regulators to Deliver Multi-Stage Antimalarials Against Plasmodium Falciparum靶向Aurora Kinases这一关键细胞周期调控因子，以递送针对Plasmodium Falciparum的多阶段抗疟药。
errAngewandte Chemie International Edition
IF16.9
err2025-10-23
err0
errOAAI
errHenrico Langeveld; Keletso Maepa; Marché Maree; Jessica L. Thibaud; Nicolaas Salomane; Rosie Bridgwater; Mufuliat T. Famodimu; Luiz C. Godoy; Charisse Flerida A. Pasaje; Nonlawat Boonyalai; Mariana Laureano de Souza; Justin Fong; Tayla Rabie; Mariëtte van der Watt; Rensu P. Theart; Sonja Ghidelli-Disse; Jacquin C. Niles; Marcus C. S. Lee; Elizabeth A. Winzeler; Michael J. Delves; Kelly Chibale; Kathryn J. Wicht; Lauren B. Coulson; Lyn-Marié Birkholtz
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Optimization of 2; 8-Diaryl-1; 5-naphthyridines as Plasmodium falciparum Phosphatidylinositol 4-Kinase Inhibitors with Improved ADME Profiles and In Vivo Efficacy2;8-二芳基-1;5-萘啶的优化：作为恶性疟原虫磷脂酰肌醇4-激酶抑制剂的改进ADME性质和体内疗效
errJournal of Medicinal Chemistry
IF6.8
err2025-10-07
err0
errOAAI
errGodwin A. Dziwornu; Donald Seanego; Stephen Fienberg; Venkata S. Sypu; Nicolaas Salomane; Liezl Krugmann; Dale Taylor; Keabetswe Masike; Mathew Njoroge; Nonlawat Boonyalai; Marcus C. S. Lee; Luiz C. Godoy; Charisse Flerida Pasaje; Jacquin C. Niles; Gregory S. Basarab; Lauren B. Coulson; Sandeep R. Ghorpade; Kelly Chibale
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Maximizing Potential: Academic–Industry Collaborations in Drug Discovery最大化潜力：药物发现中的学术-产业合作
errACS Medicinal Chemistry Letters
IF4
err2025-07-03
err0
errOAAI
errSusan Winks; Jutta Reinhard-Rupp; Kelly Chibale
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Medicinal Chemistry Progression of Sapanisertib, the Anticancer and Dual Plasmodium Phosphatidylinositol 4-Kinase Beta and cGMP-Dependent Protein Kinase Inhibitor, for MalariaSapanisertib的药物化学进展，该化合物为一种抗癌药物，同时是疟原虫磷脂酰肌醇4-激酶β和cGMP依赖性蛋白激酶的双重抑制剂，用于疟疾治疗。
errJOURNAL OF MEDICINAL CHEMISTRY
IF6.8
err2025-05-16
err0
errOAAI
errGachuhi, Samuel; Kamunya, Stephanie; Fienberg, Stephen; Wambua, Lynn; Salomane, Nicolaas; Mayoka, Godfrey; Taylor, Dale; Coertzen, Dina; van der Watt, Mariette; Reader, Janette; Birkholtz, Lyn-Marie; Wittlin, Sergio; Krugmann, Liezl; Coulson, Lauren B.; Chibale, Kelly
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Design of Novel Mercapto-3-phenylpropanoyl Dipeptides as Dual Angiotensin-Converting Enzyme C-Domain-Selective/Neprilysin Inhibitors新型巯基-3-苯基丙酰基二肽作为双重血管紧张素转化酶C-域选择性/中性内肽酶抑制剂的研制
errJOURNAL OF MEDICINAL CHEMISTRY
IF6.8
err2025-04-01
err0
errOAAI
errCozier, Gyles E.; Coulson, Lauren B.; Eyermann, Charles J.; Basarab, Gregory S.; Schwager, Sylva L.; Chibale, Kelly; Sturrock, Edward D.
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Synthesis and SAR Studies of Acyl-Thiourea Platinum(II) Complexes Yield Analogs with Dual-Stage Antiplasmodium Activity
errACS MEDICINAL CHEMISTRY LETTERS
IF4
err2025-02-17
err0
errOAAI
errIshmail, Fatima-Zahra; Coertzen, Dina; Tshabalala, Sizwe; Leshabane, Meta; da Rocha, Shante; Njoroge, Mathew; Gibhard, Liezl; Birkholtz, Lyn-Marie; Woodland, John G.; Egan, Timothy J.; Wicht, Kathryn J.; Chibale, Kelly
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Special Issue: Exploring the Use of AI/ML Technologies in Medicinal Chemistry and Drug Discovery特刊: 探索AI/ML技术在药物化学和药物发现中的应用
errACS MEDICINAL CHEMISTRY LETTERS
IF4
err2025-02-04
err1
PREAI
errChoi, Sun; Adams, Ashley M.; Chibale, Kelly
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Molecular basis of human angiotensin-1 converting enzyme inhibition by a series of diprolyl-derived compounds
errFEBS JOURNAL
IF4.2
err2025-01-06
err0
errOAAI
errGregory, Kyle S.; Cozier, Gyles E.; Fienberg, Stephen; Chibale, Kelly; Sturrock, Edward D.; Acharya, K. Ravi
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研究方向

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