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刘

刘新泳 (Xinyong Liu)

Ningbo University

54H指数
426论文数
1.2W被引数
收录论文 292
发表时间
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Special Issue “Antiviral Drugs Discovery”专刊“抗病毒药物发现”
errInternational Journal of Molecular Sciences
IF4.9
err2026-09-11
err0
errOAAI
errSining Tao; Zhenzhen Zhou; Xinyong Liu; Dongwei Kang
err分享
err收藏
Natural variation in SL6 determines fatty acid components and seed longevity in riceSL6中的自然变异决定了水稻的脂肪酸组成和种子寿命
errScience Advances
IF12.5
err2026-09-04
err0
errOAAI
errYifeng Wang; Jiezheng Ying; Jia Li; Xinyong Liu; Qianya Zhou; Shuang Jia; Guanghao Li; Wanning Liu; Zhenghao Tao; Hongzhou Li; Zhiyong Li; Jie Huang; Xiaohong Tong; Xixi Liu; Yu Cheng; Yuxuan Hou; Guangheng Zhang; Yangjun Zhang; Kun Zhou; Xiaoshan Zeng; Jian Zhang
err分享
err收藏
Discovery of piperazine-based multi-site occupying coronavirus Mpro inhibitors with potent and broad-spectrum antiviral activity基于哌嗪的多位点结合的冠状病毒Mpro抑制剂的发现：具有强效和广谱抗病毒活性
errEuropean Journal of Medicinal Chemistry
IF5.9
err2026-08-22
err0
PREAI
errBing Ye; Myoungkyu Lee; Letian Song; Yeon Seo Jeon; Mei Wang; Xianghan Bai; Shenghua Gao; Meehyein Kim; Peng Zhan; Xinyong Liu
err分享
err收藏
Novel Mechanisms of SARS-CoV-2 Drug Resistance and Rational Design of Anti-Resistant Antivirals新型冠状病毒SARS-CoV-2耐药性的新型机制及抗耐药抗病毒药物的合理设计
errMolecules
IF4.6
err2026-08-01
err0
errOAAI
errXianghan Bai; Bing Ye; Shenghua Gao; Peng Zhan; Xinyong Liu
err分享
err收藏
Dual prodrugs of N4-hydroxycytidine with ProTide and ester modifications as anti-SARS-CoV-2 agentsN4-羟基胞苷的双前药，含ProTide和酯基修饰，作为抗SARS-CoV-2的药物
errEuropean Journal of Medicinal Chemistry
IF5.9
err2026-07-01
err0
PREAI
errLi, Ye; Zhang, Wenbo; Gao, Ni; Zhang, Chaoran; De Jonghe, Steven; Jochmans, Dirk; Neyts, Johan; Kang, Dongwei; Liu, Xinyong
err分享
err收藏
Pyridoimidazolyl Sulfonamide Compound 2: A Superior Dual-Acting Drug Candidate with Potent URAT1 Inhibition and Anti-Inflammatory Activity for Gout Management吡啶咪唑基磺酰胺化合物2：一种具有强效URAT1抑制和抗炎活性的优效双作用痛风管理候选药物
errJournal of Medicinal Chemistry
IF6.8
err2026-05-26
err0
PREAI
errXiaoyu Shi; Cheng Shi; Mingyu Yang; Zeqi Yu; Qian Yang; Zhenming Liu; Jianxin Pang; Peng Zhan; Xinyong Liu; Tong Zhao
err分享
err收藏
Discovery of a Novel Thienopyrimidine Derivative as a Potent Dual URAT1/GLUT9 Inhibitor with Enhanced Urate-Lowering Efficacy; Superior Pharmacokinetics; and Favorable Safety Profile for Gout and Hyperuricemia发现一种新型噻吩嘧啶衍生物作为高效URAT1/GLUT9双重抑制剂，具有增强的降尿酸功效、优越的药代动力学和良好的安全性，适用于痛风和高尿酸血症
errJournal of Medicinal Chemistry
IF6.8
err2026-05-06
err0
PREAI
errQian Yang; Danhui Qi; Wenjie Ye; Xiaoyu Shi; Mingyu Yang; Ting Wu; Zhenkun Wu; Yuexin Xu; Youzhao Wang; Shujing Xu; Zhenqian Wang; Shenghua Gao; Fan Yi; Jianxin Pang; Xinyong Liu; Peng Zhan
err分享
err收藏
Enhancement of thermal stability and electrochemical performance of polypropylene separator by boehmite coating modification通过勃姆石涂层改性提升聚丙烯隔膜的热稳定性和电化学性能
errIonics
IF2.6
err2026-05-01
err0
PREAI
errLiu, Xinyong; Lu, Yong; Yu, Junhe; Wang, Chen; Lu, Jiacun
err分享
err收藏
A Novel Pyrrole Acylsulfonamide; Compound 42; as a Dual URAT1/GLUT9 Inhibitor: Potent Urate-Lowering Efficacy; Reduced Off-Target Effects; and Promising Druggability for Hyperuricemia新型吡咯基酰基磺酰胺；化合物42；作为URAT1/GLUT9双重抑制剂：显著的降尿酸效力；降低脱靶效应；以及治疗高尿酸血症的潜在成药性
errJournal of Medicinal Chemistry
IF6.8
err2026-04-17
err0
PREAI
errZhenqian Wang; Xiaoyu Shi; Zitao Guo; Zhenkun Wu; Yuexin Xu; Mingyu Yang; Mei Wang; Qian Yang; Ting Wu; Jianxin Pang; Fan Yi; Peng Zhan; Xinyong Liu
err分享
err收藏
Recent Advances of Non-Nucleoside Polymerase Inhibitors With Broad-Spectrum Antiviral Activities非核苷类聚合酶抑制剂广谱抗病毒活性的最新进展
errMedicinal Research Reviews
IF11.6
err2026-03-22
err0
PREAI
errSining Tao; Zhenzhen Zhou; Xin Li; Xian-Wei Wang; Xinyong Liu; Dongwei Kang
err分享
err收藏
Antiviral drug discovery and development: challenges and future directions抗病毒药物发现与开发：挑战与未来方向
errSignal Transduction and Targeted Therapy
IF52.7
err2026-02-25
err0
errOAAI
errShaoqing Du; Xueping Hu; Ping Li; Shujing Xu; Meehyein Kim; Xinyong Liu; Peng Zhan
err分享
err收藏
Research Progress on the Structural Biology of Paramyxovirus Polymerase and Its Inhibitors副黏病毒聚合酶及其抑制剂的分子结构生物学研究进展
errJournal of Medicinal Chemistry
IF6.8
err2026-02-09
err0
PREAI
errJinyuan Wu; Sining Tao; An-chao Ge; Zhongxia Zhou; Dongwei Kang; Xinyong Liu
err分享
err收藏
Discovery and optimization of 2,3-Dihydroindole derivatives as STING receptor allosteric agonists2,3-二氢吲哚衍生物作为STING受体别构激动剂的发现与优化
errBioorganic & Medicinal Chemistry Letters
IF2.2
err2025-12-16
err0
PREAI
errYing Liu; Jing Wu; Ni Gao; Lin Zheng; Wenbo Zhang; Fabao Zhao; Bairu Meng; Xinyong Liu; Lanyu Liu; Huajun Zhao; Dongwei Kang
err分享
err收藏
Recent Advances in Long-Acting Antiviral Agents: Innovations in Design and Strategies for Extended Duration
errJOURNAL OF MEDICINAL CHEMISTRY
IF6.8
err2025-12-01
err0
PREAI
errWang, Shuo; Ma, Feiyue; Lindsley, Craig W.; Xu, Shujing; Liu, Xinyong; Zhan, Peng
err分享
err收藏
Design, Synthesis, and Biological Evaluation of Highly Potent Boronic Acid (Boronate Ester)-Bearing Heteroaryldihydropyrimidine Derivatives as HBV Capsid Assembly Modulators
errJOURNAL OF MEDICINAL CHEMISTRY
IF6.8
err2025-12-01
err1
PREAI
errJin, Yu; Sun, Yang; Zhao, Shujie; Wang, Shuo; Dou, Yutong; Wang, Kai; Li, Qilan; Tavis, John E.; Wu, Zhuanchang; Zhan, Peng; Liu, Xinyong
err分享
err收藏
Multisite Occupancy and Multidimensional Optimization: Design and Evaluation of Piperazine-Thioureidobenzamide Derivatives as Potent HBV Capsid Assembly Modulators多位点占据与多维优化：哌嗪-硫脲基苯甲酰胺衍生物的设计与评价作为强效HBV衣壳组装调节剂
errJournal of Medicinal Chemistry
IF6.8
err2025-11-10
err0
PREAI
errMinghui Liang; Yutong Dou; Jian Zhang; Zechun Yang; Yuanyuan Liu; Mei Wang; Yiyan Mao; Lindan Guan; Aixin Li; Yuqing Cai; Yan Wang; Peng Xue; Lei Zhang; Zhuanchang Wu; Xinyong Liu; Peng Zhan; Haiyong Jia
err分享
err收藏
Deciphering the HIV reservoir: From epigenetic regulators to RNA-mediated regulation解析HIV储库：从表观遗传调控因子到RNA介导的调控
errChinese Chemical Letters
IF8.9
err2025-10-24
err0
PREAI
errXiaojia Xue; Xiangyi Jiang; Jiaojiao Dai; Xinyong Liu; Eline Pellaers; Debyser Zeger; Peng Zhan
err分享
err收藏
Correction to “Exploring the HIV-1 Reverse Transcriptase p51/p66 Interface: Structure-Based Design and Optimization of Novel 2; 4; 6-Trisubstituted Pyrimidines as Potent NNRTIs with Improved Resistance Profiles”“对《探索HIV-1逆转录酶p51/p66界面：基于结构的2; 4; 6-三取代嘧啶类新型非核苷逆转录酶抑制剂的设计与优化及其改进的抗药性谱》的更正”
errJournal of Medicinal Chemistry
IF6.8
err2025-10-23
err0
errOAAI
errXiangkai Ji; Xiangyi Jiang; Zhen Gao; Heng Gao; Xing Huang; Fabao Zhao; Erik De Clercq; Zhao Wang; Christophe Pannecouque; Dongwei Kang; Peng Zhan; Xinyong Liu
err分享
err收藏
Construction of a comprehensive water quality assessment framework integrating abiotic indicators, multi-taxonomic biological communities, and machine learning构建一个综合水质评估框架，整合非生物指标、多分类群生物群落和机器学习
errJournal of Hydrology
IF6.3
err2025-10-10
err0
PREAI
errTianyi Chen; Qian Chen; Xinzong Xiao; Xuefeng Guo; Fang Guo; Xinyong Liu; Yitao Lv; Nan Xu; Weiling Sun
err分享
err收藏
Spatiotemporal evolution characteristics, driving factors, and risk assessment of water quality in long-distance inter-basin water transfer projects during 2015–20232015—2023年跨流域长距离调水工程中水质时空演变特征、驱动因素及风险评估
errJournal of Environmental Management
IF8.4
err2025-10-03
err0
PREAI
errQifan Zhang; Pengfei Wang; Weijun Sun; Zhibing Chang; Jiankui Liang; Xinyong Liu; Guodong Ji
err分享
err收藏

研究方向

抗病毒药物研究HBVHCV计算机辅助合理药物设计抗病毒活性研究HIV-1逆转录酶核苷类药物非核苷类抑制剂研究HIV-1侵入过程病毒gp120吸附抑制剂辅助受体CCR5拮抗剂研究开展基于HIV-1转录过程Tat-TAR相互作用抑制剂的研究整合酶抑制剂研究和多靶点药物研究。同时，开展基于HBV侵入转录和包装过程的非核苷类抗乙肝病毒抑制剂研究开展基于流感病毒神经氨酸酶RNA聚合酶为靶点的抑制剂研究基于SARS-CoV-2复制过程中的RNA聚合酶和主蛋白酶为靶标的核苷类共价以及非共价抑制剂的研究。 2. 基于靶标结构活性片段与药效团模型的抗心脑血管药物抗痛风药物抗老年痴呆药物研究。开展基于片段药效团模型的抗凝血抗血小板凝聚药物的研究开展中药川芎活性成分川芎嗪川芎咔啉碱衍生物的结构修饰及其抗氧化损伤抗凝血抗血栓抗血脂抗缺血等心脑血管活性研究开展基于片段药效团模型的抗痛风药物的研究开展基于靶标结构的抗老年痴呆药物及抗肿瘤药物研究药物活性先导物发现的方法学研究。开展基于优势结构组合化学新技术新颖模块化反应药物先导发现新方法研究创新药物的开发与产业化重点开展具有自主产权的创新药物成药性和产业化研究
合作学者
合作期刊
E
Erik De Clercq
H 指数: 162 · 论文数: 4.0K
张莉娜 封面图
张莉娜 (Lina Zhang)
H 指数: 126 · 论文数: 1.7K
T
Thomas A. Steitz
H 指数: 120 · 论文数: 515
张建 封面图
张建 (Jian Zhang)
H 指数: 99 · 论文数: 1.6K
C
Christa E. Müller
H 指数: 94 · 论文数: 1.0K
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