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D

Daniel Merk

university of munich

39H指数
235论文数
5.5K被引数
收录论文 145
发表时间
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Dosing PPARγ Activation With Light Using Fast Relaxing Photoswitches利用快速弛豫光开关进行光控PPARγ激活给药
errAngewandte Chemie-International Edition
IF16.9
err2026-08-28
err0
errOAAI
errLoris Knümann; Alba Rodriguez-Paniagua; Martin Reynders; Silke Duensing-Kropp; Oliver Thorn-Seshold; Vasily Morozov; Julian A. Marschner; Daniel Merk
err分享
err收藏
Development of a Brain-Penetrant Nurr1 Agonist Tool开发一种能穿透血脑屏障的Nurr1激动剂工具
errChemMedChem
IF3.4
err2026-06-14
err0
errOAAI
errJan Vietor; Tanja Stiller; Christian Gege; Wael Saeb; Úrsula López-García; Hella Kohlhof; Daniel Vitt; Daniel Merk
err分享
err收藏
An Activator of Tailless’ Repressor Function Stimulates Anti-Neurodegenerative Gene Expression尾less转录抑制因子功能的激活剂可刺激抗神经退行性基因的表达
errJournal of Medicinal Chemistry
IF6.8
err2026-06-03
err0
PREAI
errEmily C. Hank; Romy Busch; Úrsula López-García; Till Kasch; Loris Knümann; Vasily Morozov; Georg Höfner; Julian A. Marschner; Daniel Merk
err分享
err收藏
C-H functionalization reactions of heterocycles with alkyl halides via halogen atom transfer通过卤原子转移实现杂环与卤代烷的C-H官能团化反应
errOrganic Chemistry Frontiers
IF4.7
err2026-06-01
err0
PREAI
errSenapati, Sudip; Das, Anindya; Weizel, Lilia; Merk, Daniel; Proschak, Ewgenij; Murarka, Sandip; Koenigs, Rene M.
err分享
err收藏
Enhanced Intramuscular mRNA Activity of Peptide–Lipid Nanoparticles with Hydrophobized Head Groups具有疏水化头基的肽-脂质纳米颗粒增强肌肉内mRNA活性
errBioconjugate Chemistry
IF3.9
err2026-05-25
err0
PREAI
errEric Weidinger; Tobias Burghardt; Lennart Obeser; Janin Germer; Jana Pöhmerer; Mina Yazdi; Miriam Höhn; Daniel Merk; Ernst Wagner
err分享
err收藏
An Agonist/Antagonist Photo-Switchable Vitamin D Mimetic Enables Bidirectional Optical Control of VDR阿片激动剂/拮抗剂光开关维生素D模拟物实现维生素D受体（VDR）的双向光学控制
errAngewandte Chemie International Edition
IF16.9
err2026-05-11
err0
errOAAI
errXiu Ge; Sabine Willems; Francesco Melfi; Tufan Mukhopadhyay; Johannes Morstein; Jordan Artzy; Loris Knümann; Giorgia Sbriccoli; Jörg Pabel; Julian A. Marschner; Dirk Trauner; Daniel Merk
err分享
err收藏
An aerosolized dual-action autotaxin inhibitor-PPARγ agonist for the treatment of pulmonary fibrosis气雾化双效自泌运动因子抑制剂-过氧化物酶体增殖物激活受体γ激动剂用于治疗肺纤维化
errCell Reports Medicine
IF10.6
err2026-04-30
err0
errOAAI
errAlexios N. Matralis; Elli-Anna Stylianaki; Eleni M. Ladopoulou; Paraskevi Kanellopoulou; Stefanos Smyrniotis; Christiana Magkrioti; Konstantinos D. Papavasileiou; Sabine Willems; Juan Pablo Rincon Pabon; Dimitris Nastos; Alexandros Galaras; Céline Moro; Skarlatos G. Dedos; Eleanna Kaffe; Pantelis Hatzis; Hanan Osman-Ponchet; Daniel Merk; Argyris Politis; Antreas Afantitis; Ioulia Tseti
err分享
err收藏
Structural optimization of drug molecules with incrementally trained language models增量训练语言模型的药物分子结构优化
errNature Communications
IF15.7
err2026-04-11
err0
errOAAI
errTim Hörmann; Domenic Mayer; Max Lewandowski; Andrea Hunklinger; Thomas Wein; Daniel Merk
err分享
err收藏
Dual Nurr1/RXR Agonism of Valerenic Acid and Synthetic Mimetics Enables Dimer-Selective Nurr1 Modulation缬草酸及其合成模拟物的双重Nurr1/RXR激动作用实现了二聚体选择性Nurr1调控
errACS Medicinal Chemistry Letters
IF4
err2025-12-09
err0
PREAI
errKatharina Scholz; Úrsula López-García; Romy Busch; Julian A. Marschner; Daniel Merk
err分享
err收藏
De Novo Discovery of α; α-Disubstituted α-amino Acid-Containing α-helical Peptides as Competitive PPARγ PPI Inhibitors从头发现含α; α-二取代α-氨基酸的α-螺旋肽作为竞争性PPARγ PPI抑制剂
errJournal of the American Chemical Society
IF15.6
err2025-11-04
err0
PREAI
errMaxwell Sigal; Markus Egner; Chikako Okada; Daniel Merk; Toru Sengoku; Takayuki Katoh; Hiroaki Suga
err分享
err收藏
Structural Tuning of Partial RXR Agonism and Antagonism部分RXR激动剂和拮抗剂的结构调谐
errJOURNAL OF MEDICINAL CHEMISTRY
IF6.8
err2025-11-01
err0
PREAI
errLewandowski, Max; Granger--Riviere, Marie; Mayer, Domenic; Kasch, Till; Nawa, Felix; Egner, Markus; Marschner, Julian A.; Morozov, Vasily; Merk, Daniel
err分享
err收藏
Scaffold Fusion and SAR Transfer with a Chemical Language Model Generates Novel Liver X Receptor Modulators化学语言模型的支架融合和SAR转移产生新型肝X受体调节剂
errJOURNAL OF MEDICINAL CHEMISTRY
IF6.8
err2025-10-01
err0
PREAI
errBandomir, Nils Christiaan; Hormann, Tim; Karcher, Annette; Kaiser, Astrid; Merk, Daniel; Heitel, Pascal
err分享
err收藏
Fragment-based discovery of dual ligand pharmacophores for lipid-sensing transcription factors for designed polypharmacology基于片段的双配体药效团的发现，用于脂质传感转录因子的设计性多靶点药物开发
errRSC Med. Chem.
IF3.6
err2025-08-22
err0
PREAI
errTanja Stiller; Silke Duensing-Kropp; Julian A. Marschner; Daniel Merk
err分享
err收藏
Targeting the SARS-CoV-2 RNA Translation Initiation Element SL1 by Molecules of Low Molecular Weight靶向SARS-CoV-2 RNA翻译起始元件SL1的低分子量分子
errJournal of the American Chemical Society
IF15.6
err2025-08-04
err0
errOAAI
errSabrina Toews; Francesca Donà; Marco Keller; Jürgen Krauß; Franz Bracher; Úrsula López-García; Jörg Pabel; Daniel Merk; Marcel J. J. Blommers; Jan Ferner; Anna Wacker; Christian Richter; Harald Schwalbe
err分享
err收藏
Development of an RXR Agonist Scaffold with Pronounced Homodimer Preference具有显著同源二聚体偏好性的RXR激动剂骨架的开发
errJournal of Medicinal Chemistry
IF6.8
err2025-07-24
err0
PREAI
errFelix Nawa; Arthur Kardanov; Till Kasch; Max Lewandowski; Thomas Wein; Georg Höfner; Julian A. Marschner; Vasily Morozov; Daniel Merk
err分享
err收藏
Carboxylic Acid Bioisosteres Boost Nurr1 Agonist Selectivity羧酸生物电子等排体增强Nurr1激动剂的选择性
errJournal of Medicinal Chemistry
IF6.8
err2025-07-17
err0
errOAAI
errTanja Stiller; Christian Gege; Wael Saeb; Jan Vietor; Úrsula López-García; Romy Busch; Hella Kohlhof; Daniel Vitt; Daniel Merk
err分享
err收藏
RXR agonist S169 inhibits HBV/HDV entry in vitro by disrupting KIF4-dependent NTCP traffickingRXR激动剂S169通过破坏KIF4依赖的NTCP转运，在体外抑制HBV/HDV的进入。
errAntiviral Research
IF4
err2025-06-14
err0
errOAAI
errSameh A. Gad; Doaa A. Abo Elwafa; Saied A. Hussein; Kento Fukano; Takanobu Kato; Ikuo Shoji; Kazuaki Chayama; Masamichi Muramatsu; Masanori Isogawa; Takaji Wakita; Daniel Merk; Hussein H. Aly
err分享
err收藏
Novel thiazolones for the simultaneous modulation of PPARγ, COX-2 and 15-LOX to address metabolic disease-associated portal inflammation
errEUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
IF5.9
err2025-05-01
err0
errOAAI
errEl-Shoukrofy, Mai S.; Ismail, Azza; Elhamammy, Reem H.; Abdelhady, Sherien A.; Nassra, Rasha; Makkar, Monica S.; Agami, Mahmoud A.; Wahid, Ahmed; Nematalla, Hisham A.; Sai, Minh; Merk, Daniel; El-Yazbi, Ahmed F.; Belal, Ahmed S. F.; Eid, Ali H.; Elzahhar, Perihan A.
err分享
err收藏
Fragment-Based Discovery of Drug-like LRH-1 Agonists
errACS MEDICINAL CHEMISTRY LETTERS
IF4
err2025-03-01
err0
PREAI
errLang, Alisa; Ildefeld, Niklas; Lillich, Felix F.; Kaiser, Astrid; Busch, Romy; Marschner, Julian A.; Proschak, Ewgenij; Heering, Jan; Schubert-Zsilavecz, Manfred; Merk, Daniel
err分享
err收藏
Comparative Evaluation and Profiling of Chemical Tools for the Nuclear Hormone Receptor Family 2核激素受体家族2的化学工具比较评估与特征分析
errACS PHARMACOLOGY & TRANSLATIONAL SCIENCE
IF3.7
err2025-02-20
err0
PREAI
errLewandowski, M; Busch, R; Marschner, JA; Merk, D
err分享
err收藏

研究方向

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合作学者
合作期刊
C
Charles N. Serhan
H 指数: 175 · 论文数: 839
K
Kazuaki Chayama
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M
Michael Trauner
H 指数: 128 · 论文数: 3.4K
B
Bruce D. Hammock
H 指数: 124 · 论文数: 1.9K
I
Ivan Đikić
H 指数: 119 · 论文数: 509
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