Christian Melander - Publications, H-index & Citations

Christian Melander

University of Notre Dame

51H指数

218论文数

8.3K被引数

收录论文 106

发表时间

IMD-0354 optimization generates potent colistin adjuvants with in vivo activity and reduced eukaryotic toxicity IMD-0354优化产生具有体内活性和降低真核细胞毒性的粘菌素佐剂

European Journal of Medicinal Chemistry

IF5.9

2026-09-29

OAAI

Cowart, Luke J.; Nemeth, Ansley M.; Jania, Leigh A.; Overly, Moira; Ellis, Courtney F.; Koller, Beverly H.; Melander, Roberta J.; Doi, Yohei; Ernst, Robert K.; Melander, Christian

Discovery of a Novel Benzothiophene Inhibitor of Penicillin-Binding Protein 2 with Potent Gram-Positive Activity 发现一种新型苯并噻吩类青霉素结合蛋白2抑制剂，具有强效革兰氏阳性菌活性

Antibiotics-Basel

IF4.6

2026-08-27

OAAI

Monica A. Stefaniak; Vijay Singh Gondil; Jingdong Yang; Adil Omar; Allen G. Oliver; Ansley M. Nemeth; Roberta J. Melander; Mayland Chang; Paul M. Dunman; Christian Melander

Growth-Inhibitory Activity of a Clerodane Diterpene from Callicarpa americana Leaf Extracts and Its Derivatives against Cutibacterium acnes 美洲紫珠叶提取物中 clerodane 二萜及其衍生物对痤疮丙酸杆菌的生长抑制活性

ACS Infectious Diseases

IF3.8

2026-04-01

PREAI

Kittleson, Ben; Woo, Sunmin; Marquez, Lewis; Zeiler, Michael J.; Daher, Isabel; Melander, Christian; Quave, Cassandra L.

A mouse model for studying chronic Salmonella Typhi infection and anti-biofilm interventions 研究慢性伤寒沙门氏菌感染及抗生物膜干预的鼠模型

mBio

IF4.7

2025-12-01

PREAI

Cole, Allysa L.; Woolard, Katherine J.; Sorge, Amy; Melander, Christian; Gunn, John S.

PmrA Mutations in Drug-Resistant Acinetobacter baumannii Affect Sensor Kinase-Response Regulator Interaction and Phosphotransfer 鲍曼不动杆菌耐药菌株中PmrA基因突变影响传感器激酶-应答调节蛋白相互作用及磷酸转移

Microorganisms 2025, Vol. 13, Page 2600

IF4.2

2025-11-18

OAAI

Felicia E. Jaimes; Alexander D. Hondros; Jude Kinkead; Morgan E. Milton; Richele J. Thompson; Aimee M. Figg; Christian Melander; John Cavanagh

Genome sequences of two highly colistin-resistant Pseudomonas aeruginosa clinical isolates from the cystic fibrosis lung 来自囊性纤维化肺的两个高度耐粘菌素的铜绿假单胞菌临床分离株的基因组序列

MICROBIOLOGY RESOURCE ANNOUNCEMENTS

IF0.6

2025-11-01

PREAI

Mattingly, Anne E.; Doi, Yohei; Melander, Christian

Mechanisms of antibiofilm compounds JG-1 and M4 across multiple species: alterations of protein interactions essential to biofilm formation 多物种中抗菌膜化合物JG-1和M4的作用机制：对生物膜形成所必需的蛋白质相互作用的影响

Frontiers in Cellular and Infection Microbiology

IF4.8

2025-09-21

OAAI

Aliyah N. Bennett†; Jacob F. Maziarz; Baileigh Laipply; Allysa L. Cole†; Katherine J. Woolard†; Amy Sorge; Michael J. Zeiler; Roberta J. Melander†; Christian Melander†; John S. Gunn†

Testing the Luedemann hypothesis: the discovery of novel antimicrobials from slow-growing microbes from nutrient-limited environments 检验Luedemann假说：从养分限制环境中生长缓慢的微生物中发现新型抗菌剂

MSPHERE

IF3.1

2025-09-01

PREAI

Lin, Brendan; Woo, Sunmin; Philbrick, Alesa; Bacsa, John; Laskey, Emily; Mehra, Nancy; Gondil, Vijay S.; Mei, Jia A.; Jones, George; Pavelka, Martin S.; Dziejman, Michelle; Shutter, Daniel A.; Melander, Christian; Perritt, Alexander M.; Jakober, Rick; Shen, Yaoyao; Chang, Wei-Chen; Quave, Cassandra L.; Dunman, Paul M.; Luedemann, George

2-Aminoimidazole-benzimidazole Conjugates Potentiate the Gram-Positive Selective Antibiotic Clarithromycin against Acinetobacter baumannii 2-氨基咪唑-苯并咪唑偶联物增强了革兰氏阳性选择性抗生素克拉霉素对鲍曼不动杆菌的活性

ACS Medicinal Chemistry Letters

IF4

2025-07-01

PREAI

Ashley N. Crotteau; Ansley M. Nemeth; Roberta J. Melander; Christian Melander

Validation of a Cystic Fibrosis Co-Culture Model for the Identification of Dual Acting Compounds with Antibiotic and Antibiotic Adjuvant Properties 验证一种囊性纤维化共培养模型，用于识别具有抗生素和抗生素增效剂特性的双效化合物

ACS INFECTIOUS DISEASES

IF3.8

2025-05-11

PREAI

Mattingly, AE; Li, HT; Melander, RJ; Melander, C

Two-Component System Sensor Kinase Inhibitors Target the ATP-Lid of PmrB to Disrupt Colistin Resistance in Acinetobacter baumannii 双组分系统感应激酶抑制剂靶向PmrB的ATP盖子以破坏鲍曼不动杆菌的黏菌素耐药性

BIOCHEMISTRY

IF3

2025-03-08

PREAI

Hondros, Alexander D.; Young, Milah M.; Jaimes, Felicia E.; Kinkead, Jude; Thompson, Richele J.; Melander, Christian; Cavanagh, John

Adjuvants restore colistin sensitivity in mouse models of highly colistin-resistant isolates, limiting bacterial proliferation and dissemination

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

IF4.5

2024-10-08

PREAI

Koller, Beverly H.; Jania, Leigh A.; Li, Haoting; Barker, William T.; Melander, Roberta J.; Melander, Christian

Development of phenyl-urea-based small molecules that target penicillin-binding protein 4 苯脲类小分子靶向青霉素结合蛋白4的研究进展

CHEMICAL BIOLOGY & DRUG DESIGN

IF3.3

2024-06-14

PREAI

Gondil, Vijay S.; Butman, Hailey S.; Young, Mikaeel; Walsh, Danica J.; Narkhede, Yogesh; Zeiler, Michael J.; Crow, Andrew H.; Carpenter, Morgan E.; Mardikar, Aashay; Melander, Roberta J.; Wiest, Olaf; Dunman, Paul M.; Melander, Christian

Synthesis, Stereochemical Resolution, and Analogue Synthesis of Variabiline, an Aporphine Alkaloid That Sensitizes Acinetobacter baumannii and Klebsiella pneumoniae to Colistin

ACS INFECTIOUS DISEASES

IF3.8

2024-03-16

PREAI

Li, Haoting; Nemeth, Ansley M.; Melander, Roberta J.; Melander, Christian

Spectrum of activity of Salmonella anti-biofilm compounds: Evaluation of activity against biofilm-forming ESKAPE pathogens

BIOFILM

IF4.9

2023-12-01

OAAI

Bennett, Aliyah N.; Woolard, Katherine J.; Sorge, Amy; Melander, Christian; Gunn, John S.

Sensitization of Gram-Negative Bacteria to Aminoglycosides with 2-Aminoimidazole Adjuvants 2-氨基咪唑佐剂对革兰阴性菌对氨基糖苷类药物的增敏作用

ANTIBIOTICS-BASEL

IF4.6

2023-10-25

OAAI

Crotteau, Ashley N.; Hubble, Veronica B.; Marrujo, Santiana A.; Mattingly, Anne E.; Melander, Roberta J.; Melander, Christian

Small Molecule Attenuates Bacterial Virulence by Targeting Conserved Response Regulator

MBIO

IF4.7

2023-06-27

OAAI

Liu, Chang; Zhang, Hua; Peng, Xian; Blackledge, Meghan S.; Furlani, Robert E.; Li, Haoting; Su, Zhaoming; Melander, Roberta J.; Melander, Christian; Michalek, Suzanne; Wu, Hui

Pyochelin biotransformation by Staphylococcus aureus shapes bacterial competition with Pseudomonas aeruginosa in polymicrobial infections

CELL REPORTS

IF6.9

2023-06-01

OAAI

Jenul, Christian; Keim, Klara C.; Jens, Justin N.; Zeiler, Michael J.; Schilcher, Katrin; Schurr, Michael J.; Melander, Christian; Phelan, Vanessa V.; Horswill, Alexander R.

Dimeric 2-aminoimidazoles are highly active adjuvants for gram-positive selective antibiotics against Acinetobacter baumannii

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

IF5.9

2023-05-01

OAAI

Marrujo, Santiana A.; Hubble, Veronica B.; Yang, Jingdong; Wang, Man; Nemeth, Ansley M.; Barlock, Samantha L.; Juarez, Dane; Smith, Richard D.; Melander, Roberta J.; Ernst, Robert K.; Chang, Mayland; Melander, Christian

Promoter scanning for transcription inhibition with DNA-binding polyamides

MOLECULAR AND CELLULAR BIOLOGY

IF2.7

2023-03-28

OAAI

Ehley, JA; Melander, C; Herman, D; Baird, EE; Ferguson, HA; Goodrich, JA; Dervan, PB; Gottesfeld, JM

研究方向