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Lumír Krejčí

Masaryk University
H指数:43
被引数:7,308

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Discovery of Two Structurally Distinct Classes of Inhibitors Targeting the Nuclease MUS81 and Enhancing Efficacy of Chemotherapy in Cancer Cells

针对核酸酶MUS81的两类结构不同的抑制剂的发现及其在增强癌细胞化疗疗效中的作用

Journal of Medicinal Chemistry
IF6.8
2026-02-010
OA
Prochazkova, Jana; Carbain, Benoit; Marini, Victoria; Nikulenkov, Fedor; Havel, Stepan; Akavaram, Naresh; Khirsariya, Prashant; Sisakova, Alexandra; Cibulka, Jakub; Boudova, Michala; Zacpalova, Magdalena; Kalovska, Magdalena; Rodrigues, Joana; Daniel, Lukas; Brezovsky, Jan; Bartunek, Petr; Azzalin, Claus; Paruch, Kamil; Krejci, Lumir
Discovery of new inhibitors of nuclease MRE11
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
IF5.9
2025-03-010
PRE
Nikulenkov, Fedor; Carbain, Benoit; Biswas, Raktim; Havel, Stepan; Prochazkova, Jana; Sisakova, Alexandra; Zacpalova, Magdalena; Chavdarova, Melita; Marini, Victoria; Vsiansky, Vit; Weisova, Veronika; Slavikova, Kristina; Biradar, Dhanraj; Khirsariya, Prashant; Vitek, Marco; Sedlak, David; Bartunek, Petr; Daniel, Lukas; Brezovsky, Jan; Damborsky, Jiri; Paruch, Kamil; Krejci, Lumir
The CHK1 inhibitor MU380 significantly increases the sensitivity of human docetaxel-resistant prostate cancer cells to gemcitabine through the induction of mitotic catastrophe

CHK1抑制剂MU380通过诱导有丝分裂灾难显着增加人类多西他赛耐药前列腺癌细胞对吉西他滨的敏感性

MOLECULAR ONCOLOGY
IF4.5
2020-07-1614
OAAI
Drapela, Stanislav; Khirsariya, Prashant; van Weerden, Wytske M.; Fedr, Radek; Suchankova, Tereza; Buzova, Diana; Cerveny, Jan; Hampl, Ales; Puhr, Martin; Watson, William R.; Culig, Zoran; Krejci, Lumir; Paruch, Kamil; Soucek, Karel
Deficiency and haploinsufficiency of histone macroH2A1.1 in mice recapitulate hematopoietic defects of human myelodysplastic syndrome

组蛋白macroH2A1.1在小鼠中的缺乏和单倍体不足概括了人类骨髓增生异常综合征的造血缺陷

CLINICAL EPIGENETICS
IF4.4
2019-08-2222
OAAI
Bereshchenko, Oxana; Lo Re, Oriana; Nikulenkov, Fedor; Flamini, Sara; Kotaskova, Jana; Mazza, Tommaso; Le Pannerer, Marguerite-Marie; Buschbeck, Marcus; Giallongo, Cesarina; Palumbo, Giuseppe; Li Volti, Giovanni; Pazienza, Valerio; Cervinek, Libor; Riccardi, Carlo; Krejci, Lumir; Pospisilova, Sarka; Stewart, A. Francis; Vinciguerra, Manlio

研究方向

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P
Patrick Sung
H 指数:88论文数:394被引数:2.8万
V
Veronika Altmannová
H 指数:16论文数:84被引数:1,510
V
Victoria Marini
H 指数:15论文数:31被引数:916
M
Mário Špı́rek
H 指数:18论文数:29被引数:986
M
Marek Šebesta
H 指数:15论文数:53被引数:833
X
Xiaolan Zhao
H 指数:49论文数:234被引数:1.1万
P
Peter Kolesár
H 指数:13论文数:34被引数:648
M
Michael Lisby
H 指数:0论文数:2被引数:37
A
Alexandra Sisáková
H 指数:6论文数:36被引数:265
P
Prashant Khirsariya
H 指数:11论文数:41被引数:477