未登录 Discovery of Two Structurally Distinct Classes of Inhibitors Targeting the Nuclease MUS81 and Enhancing Efficacy of Chemotherapy in Cancer Cells 针对核酸酶MUS81的两类结构不同的抑制剂的发现及其在增强癌细胞化疗疗效中的作用 Prochazkova, Jana; Carbain, Benoit; Marini, Victoria; Nikulenkov, Fedor; Havel, Stepan; Akavaram, Naresh; Khirsariya, Prashant; Sisakova, Alexandra; Cibulka, Jakub; Boudova, Michala; Zacpalova, Magdalena; Kalovska, Magdalena; Rodrigues, Joana; Daniel, Lukas; Brezovsky, Jan; Bartunek, Petr; Azzalin, Claus; Paruch, Kamil; Krejci, Lumir 分享 收藏
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Discovery of new inhibitors of nuclease MRE11 Nikulenkov, Fedor; Carbain, Benoit; Biswas, Raktim; Havel, Stepan; Prochazkova, Jana; Sisakova, Alexandra; Zacpalova, Magdalena; Chavdarova, Melita; Marini, Victoria; Vsiansky, Vit; Weisova, Veronika; Slavikova, Kristina; Biradar, Dhanraj; Khirsariya, Prashant; Vitek, Marco; Sedlak, David; Bartunek, Petr; Daniel, Lukas; Brezovsky, Jan; Damborsky, Jiri; Paruch, Kamil; Krejci, Lumir 分享 收藏
Cooperativity of Mus81•Mms4 with Rad54 in the resolution of recombination and replication intermediates (Withdrawal of Vol 300, art no 107747, 2024) (Withdrawn Publication. See vol. 300, 2024) Matulova, Petra; Marini, Victoria; Burgess, Rebecca C.; Sisakova, Alexandra; Kwon, Youngho; Rothstein, Rodney; Sung, Patrick; Krejci, Lumir 分享 收藏
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MutSβ-MutLβ-FANCJ axis mediates the restart of DNA replication after fork stalling at cotranscriptional G4/R-loops Isik, Esin; Shukla, Kaustubh; Pospisilova, Michaela; Koenig, Christiane; Andrs, Martin; Rao, Satyajeet; Rosano, Vinicio; Dobrovolna, Jana; Krejci, Lumir; Janscak, Pavel 分享 收藏
Recognition and coacervation of G-quadruplexes by a multifunctional disordered region in RECQ4 helicase Papageorgiou, Anna C.; Pospisilova, Michaela; Cibulka, Jakub; Ashraf, Raghib; Waudby, Christopher A.; Kaderavek, Pavel; Maroz, Volha; Kubicek, Karel; Prokop, Zbynek; Krejci, Lumir; Tripsianes, Konstantinos 分享 收藏
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Single-molecule visualization of human RECQ5 interactions with single-stranded DNA recombination intermediates Xue, Chaoyou; Molnarova, Lucia; Steinfeld, Justin B.; Zhao, Weixing; Ma, Chujian; Spirek, Mario; Kaniecki, Kyle; Kwon, Youngho; Belan, Ondrej; Krejci, Katerina; Boulton, Simon J.; Sung, Patrick; Greene, Eric C.; Krejci, Lumir 分享 收藏
TREX2 Exonuclease Causes Spontaneous Mutations and Stress-Induced Replication Fork Defects in Cells Expressing RAD51K133A Ko, Jun Ho; Son, Mi Young; Zhou, Qing; Molnarova, Lucia; Song, Lambert; Mlcouskova, Jarmila; Jekabsons, Atis; Montagna, Cristina; Krejci, Lumir; Hasty, Paul 分享 收藏
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The CHK1 inhibitor MU380 significantly increases the sensitivity of human docetaxel-resistant prostate cancer cells to gemcitabine through the induction of mitotic catastrophe CHK1抑制剂MU380通过诱导有丝分裂灾难显着增加人类多西他赛耐药前列腺癌细胞对吉西他滨的敏感性 Drapela, Stanislav; Khirsariya, Prashant; van Weerden, Wytske M.; Fedr, Radek; Suchankova, Tereza; Buzova, Diana; Cerveny, Jan; Hampl, Ales; Puhr, Martin; Watson, William R.; Culig, Zoran; Krejci, Lumir; Paruch, Kamil; Soucek, Karel 分享 收藏
DSS1 interacts with and stimulates RAD52 to promote the repair of DSBs Stefanovie, Barbora; Hengel, Sarah R.; Mlcouskova, Jarmila; Prochazkova, Jana; Spirek, Mario; Nikulenkov, Fedor; Nemecek, Daniel; Koch, Brandon G.; Bain, Fletcher E.; Yu, Liping; Spies, Maria; Krejci, Lumir 分享 收藏
Deficiency and haploinsufficiency of histone macroH2A1.1 in mice recapitulate hematopoietic defects of human myelodysplastic syndrome 组蛋白macroH2A1.1在小鼠中的缺乏和单倍体不足概括了人类骨髓增生异常综合征的造血缺陷 Bereshchenko, Oxana; Lo Re, Oriana; Nikulenkov, Fedor; Flamini, Sara; Kotaskova, Jana; Mazza, Tommaso; Le Pannerer, Marguerite-Marie; Buschbeck, Marcus; Giallongo, Cesarina; Palumbo, Giuseppe; Li Volti, Giovanni; Pazienza, Valerio; Cervinek, Libor; Riccardi, Carlo; Krejci, Lumir; Pospisilova, Sarka; Stewart, A. Francis; Vinciguerra, Manlio 分享 收藏
CDK12 controls G1/S progression by regulating RNAPII processivity at core DNA replication genes CDK12通过调节核心DNA复制基因的RNAPII持续合成来控制G1/S进程 Manavalan, Anil Paul Chirackal; Pilarova, Kveta; Kluge, Michael; Bartholomeeusen, Koen; Rajecky, Michal; Oppelt, Jan; Khirsariya, Prashant; Paruch, Kamil; Krejci, Lumir; Friedel, Caroline C.; Blazek, Dalibor 分享 收藏
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