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P

Prashant Khirsariya

Masaryk University
H指数:11
被引数:477

个人简介

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教育背景

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工作经历

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荣誉奖项

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Discovery of Two Structurally Distinct Classes of Inhibitors Targeting the Nuclease MUS81 and Enhancing Efficacy of Chemotherapy in Cancer Cells

针对核酸酶MUS81的两类结构不同的抑制剂的发现及其在增强癌细胞化疗疗效中的作用

Journal of Medicinal Chemistry
IF6.8
2026-02-010
OA
Prochazkova, Jana; Carbain, Benoit; Marini, Victoria; Nikulenkov, Fedor; Havel, Stepan; Akavaram, Naresh; Khirsariya, Prashant; Sisakova, Alexandra; Cibulka, Jakub; Boudova, Michala; Zacpalova, Magdalena; Kalovska, Magdalena; Rodrigues, Joana; Daniel, Lukas; Brezovsky, Jan; Bartunek, Petr; Azzalin, Claus; Paruch, Kamil; Krejci, Lumir
CDK7-CDK11 axis in spliceosome regulation and pre-mRNA splicing

CDK7-CDK11轴在剪接体调控和前体mRNA剪接中的作用

NUCLEIC ACIDS RESEARCH
IF13.1
2025-12-110
PRE
Rajecky, Michal; Gajduskova, Pavla; Manik, Peter; Hluchy, Milan; Hegedusova, Eva; Krystofova, Karolina; Potesil, David; Martinkova, Petra; Slaba, Zuzana; Khirsariya, Prashant; Sebesta, Marek; Paruch, Kamil; Friedel, Caroline C.; Zdrahal, Zbynek; Blazek, Dalibor
Discovery of new inhibitors of nuclease MRE11
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
IF5.9
2025-03-010
PRE
Nikulenkov, Fedor; Carbain, Benoit; Biswas, Raktim; Havel, Stepan; Prochazkova, Jana; Sisakova, Alexandra; Zacpalova, Magdalena; Chavdarova, Melita; Marini, Victoria; Vsiansky, Vit; Weisova, Veronika; Slavikova, Kristina; Biradar, Dhanraj; Khirsariya, Prashant; Vitek, Marco; Sedlak, David; Bartunek, Petr; Daniel, Lukas; Brezovsky, Jan; Damborsky, Jiri; Paruch, Kamil; Krejci, Lumir
The CHK1 inhibitor MU380 significantly increases the sensitivity of human docetaxel-resistant prostate cancer cells to gemcitabine through the induction of mitotic catastrophe

CHK1抑制剂MU380通过诱导有丝分裂灾难显着增加人类多西他赛耐药前列腺癌细胞对吉西他滨的敏感性

MOLECULAR ONCOLOGY
IF4.5
2020-07-1614
OAAI
Drapela, Stanislav; Khirsariya, Prashant; van Weerden, Wytske M.; Fedr, Radek; Suchankova, Tereza; Buzova, Diana; Cerveny, Jan; Hampl, Ales; Puhr, Martin; Watson, William R.; Culig, Zoran; Krejci, Lumir; Paruch, Kamil; Soucek, Karel
Synthesis and Profiling of a Novel Potent Selective Inhibitor of CHK1 Kinase Possessing Unusual N-trifluoromethylpyrazole Pharmacophore Resistant to Metabolic N-dealkylation
MOLECULAR CANCER THERAPEUTICS
IF5.5
2017-09-0422
OAAI
Samadder, Pounami; Suchankova, Tereza; Hylse, Ondrej; Khirsariya, Prashant; Nikulenkov, Fedor; Drapela, Stanislav; Strakova, Nicol; Vanhara, Petr; Vasickova, Katerina; Kolarova, Hana; Bino, Lucia; Bittova, Miroslava; Ovesna, Petra; Kollar, Peter; Fedr, Radek; Esner, Milan; Jaros, Josef; Hampl, Ales; Krejci, Lumir; Paruch, Kamil; Soucek, Karel

研究方向

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K
Kamil Paruch
H 指数:25论文数:253被引数:2,548
K
Karel Souček
H 指数:32论文数:287被引数:4,125
L
Lumír Krejčí
H 指数:43论文数:182被引数:7,308
S
Stanislav Drápela
H 指数:13论文数:70被引数:644
L
Lukáš Maier
H 指数:12论文数:78被引数:456
B
Benoît Carbain
H 指数:12论文数:34被引数:460
F
Fedor Nikulenkov
H 指数:12论文数:44被引数:977
H 指数:0论文数:18被引数:28
P
Petr Bartůněk
H 指数:30论文数:164被引数:2,908
A
Aleš Hampl
H 指数:39论文数:481被引数:6,283