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F

F. von Delft

University of Oxford

55H指数
2.0K论文数
1.2W被引数
收录论文 115
发表时间
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Structure-Activity-Relationships can be directly extracted from high-throughput crystallographic evaluation of fragment elaborations in crude reaction mixtures构效关系可以直接从粗反应混合物中片段修饰的高通量晶体学评估中提取。
errChem. Sci.
IF0
err2025-12-23
err0
errOAAI
errHarold Grosjean; Kate K Fieseler; Ruben Sanchez-Garcia; Warren Athol Thompson; Charlotte Mary Deane; Frank von Delft; Philip Biggin
err分享
err收藏
Water Networks as Hydrophobic Recognition Motifs in Proteins水网络作为蛋白质中的疏水识别基序
errANGEWANDTE CHEMIE-INTERNATIONAL EDITION
IF16.9
err2025-11-01
err0
errOAAI
errPiticchio, Serena G.; Martinez-Cartro, Miriam; Scaffidi, Salvatore; Rodriguez-Arevalo, Sergio; Bagan, Andrea; Sanchez-Arfelis, Ainoa; Picaud, Sarah; Krojer, Tobias; Filippakopoulos, Panagis; von Delft, Frank; Escolano, Carmen; Galdeano, Carles; Barril, Xavier
err分享
err收藏
Crystal structure of fatty acid thioesterase A bound by 129 fragments provides diverse development opportunities脂肪酸硫酯酶A与129个片段结合的晶体结构提供了多样的开发机会
errPest Management Science
IF3.8
err2025-09-12
err0
errOAAI
errEkaterina Kot; Matteo Paolo Ferla; Patricia Helen Hollinshead; Charles William Ernest Tomlinson; Daren Fearon; Jasmin Cara Aschenbrenner; Lizbé Koekemoer; Max Winokan; Michael Fairhead; Xiaomin Ni; Rod Chalk; Katherine Sara England; Laura Ortega Varga; Mark Greer Montgomery; Nicholas Phillip Mulholland; Frank von Delft
err分享
err收藏
Covalently constrained ‘Di-Gembodies’ enable parallel structure solutions by cryo-EM共价约束的“Di-Gembodies”通过冷冻电镜实现平行结构解析
errNature Chemical Biology
IF13.7
err2025-08-15
err0
errOAAI
errGangshun Yi; Dimitrios Mamalis; Mingda Ye; Loic Carrique; Michael Fairhead; Huanyu Li; Katharina L. Duerr; Peijun Zhang; David B. Sauer; Frank von Delft; Benjamin G. Davis; Robert J. C. Gilbert
err分享
err收藏
Crystallographic fragment screening reveals ligand hotspots in TRIM21 PRY-SPRY domain晶体学片段筛选揭示了TRIM21 PRY-SPRY结构域中的配体热点
errCommunications Chemistry
IF6.2
err2025-06-13
err0
errOAAI
errYeojin Kim; Aleksandar Lučić; Christopher Lenz; Frederic Farges; Martin P. Schwalm; Krishna Saxena; Thomas Hanke; Peter G. Marples; Jasmin C. Aschenbrenner; Daren Fearon; Frank von Delft; Andreas Krämer; Stefan Knapp
err分享
err收藏
Fragmenstein: predicting protein-ligand structures of compounds derived from known crystallographic fragment hits using a strict conserved-binding-based methodology
errJOURNAL OF CHEMINFORMATICS
IF5.7
err2025-01-13
err1
errOAAI
errFerla, Matteo P.; Sanchez-Garcia, Ruben; Skyner, Rachael E.; Gahbauer, Stefan; Taylor, Jenny C.; von Delft, Frank; Marsden, Brian D.; Deane, Charlotte M.
err分享
err收藏
Toward target 2035: EUbOPEN - a public-private partnership to enable & unlock biology in the open迈向目标2035: EUbOPEN-一个公私合作伙伴关系，以开放和解锁生物学
errRSC MEDICINAL CHEMISTRY
IF3.6
err2025-01-01
err1
errOAAI
errTredup, Claudia; Ackloo, Suzanne; Beck, Hartmut; Brown, Peter J.; Bullock, Alex N.; Ciulli, Alessio; Dikic, Ivan; Edfeldt, Kristina; Edwards, Aled M.; Elkins, Jonathan M.; Farin, Henner F.; Fon, Edward A.; Gstaiger, Matthias; Guenther, Judith; Gustavsson, Anna-Lena; Haeberle, Sandra; Isigkeit, Laura; Huber, Kilian V. M.; Kotschy, Andras; Kraemer, Oliver; Leach, Andrew R.; Marsden, Brian D.; Matsui, Hisanori; Merk, Daniel; Montel, Florian; Mulder, Monique P. C.; Mueller, Susanne; Owen, Dafydd R.; Proschak, Ewgenij; Roehm, Sandra; Stolz, Alexandra; Sundstroem, Michael; von Delft, Frank; Willson, Timothy M.; Arrowsmith, Cheryl H.; Knapp, Stefan
err分享
err收藏
Rational fragment-based design of compounds targeting the PWWP domain of the HRP family
errEUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
IF5.9
err2024-12-01
err2
PREAI
errVantieghem, Thibault; Aslam, Nayyar A.; Osipov, Evgenii M.; Akele, Muluembet; Van Belle, Siska; Beelen, Steven; Drexler, Matus; Paulovcakova, Terezia; Lux, Vanda; Fearon, Daren; Douangamath, Alice; von Delft, Frank; Christ, Frauke; Veverka, Vaclav; Verwilst, Peter; Van Aerschot, Arthur; Debyser, Zeger; Strelkov, Sergei V.
err分享
err收藏
Critical assessment of LC3/GABARAP ligands used for degrader development and ligandability of LC3/GABARAP binding pockets
errNATURE COMMUNICATIONS
IF15.7
err2024-11-25
err0
errOAAI
errSchwalm, Martin P.; Dopfer, Johannes; Kumar, Adarsh; Greco, Francesco A.; Bauer, Nicolas; Loehr, Frank; Heering, Jan; Cano-Franco, Sara; Lechner, Severin; Hanke, Thomas; Jaser, Ivana; Morasch, Viktoria; Lenz, Christopher; Fearon, Daren; Marples, Peter G.; Tomlinson, Charles W. E.; Brunello, Lorene; Saxena, Krishna; Adams, Nathan B. P.; von Delft, Frank; Mueller, Susanne; Stolz, Alexandra; Proschak, Ewgenij; Kuster, Bernhard; Knapp, Stefan; Rogov, Vladimir V.
err分享
err收藏
Learnt representations of proteins can be used for accurate prediction of small molecule binding sites on experimentally determined and predicted protein structures
errJOURNAL OF CHEMINFORMATICS
IF5.7
err2024-03-14
err5
errOAAI
errCarbery, Anna; Buttenschoen, Martin; Skyner, Rachael; von Delft, Frank; Deane, Charlotte M.
err分享
err收藏
Fragment library screening by X-ray crystallography and binding site analysis on thioredoxin glutathione reductase of Schistosoma mansoni
errSCIENTIFIC REPORTS
IF3.9
err2024-01-18
err5
errOAAI
errNeto, Lauro Ribeiro de Souza; Montoya, Bogar Omar; Brandao-Neto, Jose; Verma, Anil; Bowyer, Sebastian; Moreira-Filho, Jose Teofilo; Dantas, Rafael Ferreira; Neves, Bruno Junior; Andrade, Carolina Horta; von Delft, Frank; Owens, Raymond J.; Furnham, Nicholas; Silva-Jr, Floriano Paes
err分享
err收藏
Fragment Merging Using a Graph Database Samples Different Catalogue Space than Similarity Search
errJOURNAL OF CHEMICAL INFORMATION AND MODELING
IF5.3
err2023-05-25
err7
errOAAI
errWills, Stephanie; Sanchez-Garcia, Ruben; Dudgeon, Tim; Roughley, Stephen D.; Merritt, Andy; Hubbard, Roderick E.; Davidson, James; von Delft, Frank; Deane, Charlotte M.
err分享
err收藏
A Small Step Toward Generalizability: Training a Machine Learning Scoring Function for Structure-Based Virtual Screening
errJOURNAL OF CHEMICAL INFORMATION AND MODELING
IF5.3
err2023-05-11
err22
errOAAI
errScantlebury, Jack; Vost, Lucy; Carbery, Anna; Hadfield, Thomas E.; Turnbull, Oliver M.; Brown, Nathan; Chenthamarakshan, Vijil; Das, Payel; Grosjean, Harold; von Delft, Frank; Deane, Charlotte M.
err分享
err收藏
Allosteric regulation and crystallographic fragment screening of SARS-CoV-2 NSP15 endoribonuclease
errNUCLEIC ACIDS RESEARCH
IF13.1
err2023-04-28
err7
errOAAI
errGodoy, Andre Schutzer; Nakamura, Aline Minalli; Douangamath, Alice; Song, Yun; Noske, Gabriela Dias; Gawriljuk, Victor Oliveira; Fernandes, Rafaela Sachetto; Pereira, Humberto D. Muniz; Oliveira, Ketllyn Irene Zagato; Fearon, Daren; Dias, Alexandre; Krojer, Tobias; Fairhead, Michael; Powell, Alisa; Dunnet, Louise; Brandao-Neto, Jose; Skyner, Rachael; Chalk, Rod; Bajusz, David; Bege, Miklos; Borbas, Aniko; Keseru, Gyoergy Miklos; von Delft, Frank; Oliva, Glaucius
err分享
err收藏
Room-temperature crystallography reveals altered binding of small-molecule fragments to PTP1B室温晶体学揭示小分子片段与PTP1B的结合改变
errELIFE
IF0
err2023-03-07
err30
errOAAI
errSkaist Mehlman, Tamar; Biel, Justin T.; Azeem, Syeda Maryam; Nelson, Elliot R.; Hossain, Sakib; Dunnett, Louise; Paterson, Neil G.; Douangamath, Alice; Talon, Romain; Axford, Danny; Orins, Helen; von Delft, Frank; Keedy, Daniel A.; Cui, Qiang
err分享
err收藏
Turning high-throughput structural biology into predictive inhibitor design
errPROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
IF9.1
err2023-03-06
err8
errOAAI
errSaar, Kadi L.; McCorkindale, William; Fearon, Daren; Boby, Melissa; Barr, Haim; Ben-Shmuel, Amir; London, Nir; von Delft, Frank; Chodera, John D.; Lee, Alpha A.; COVID Moonshot, Alpha A.
err分享
err收藏
Discovery and Development Strategies for SARS-CoV-2 NSP3 Macrodomain Inhibitors
errPATHOGENS
IF3.3
err2023-02-15
err9
errOAAI
errSchuller, Marion; Zarganes-Tzitzikas, Tryfon; Bennett, James; De Cesco, Stephane; Fearon, Daren; von Delft, Frank; Fedorov, Oleg; Brennan, Paul E. E.; Ahel, Ivan
err分享
err收藏
Iterative computational design and crystallographic screening identifies potent inhibitors targeting the Nsp3 macrodomain of SARS-CoV-2
errPROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
IF9.1
err2023-01-04
err50
errOAAI
errGahbauera, Stefan; Correy, Galen J.; Schuller, Marion; Ferlad, Matteo P.; Doruk, Yagmur Umay; Rachman, Moira; Wu, Taiasean; Diolaiti, Morgan; Wang, Siyi; Neitz, R. Jeffrey; Fearon, Daren; Radchenko, Dmytro S.; Moroz, Yurii S.; Irwin, John J.; Renslo, Adam R.; Taylor, Jenny C.; Gestwicki, Jason E.; von Delft, Frank; Ashworth, Alan; Ahel, Ivan; Shoichet, Brian K.; Fraser, James S.
err分享
err收藏
CoPriNet: graph neural networks provide accurate and rapid compound price prediction for molecule prioritisation
errDIGITAL DISCOVERY
IF5.6
err2023-01-01
err8
errOAAI
errSanchez-Garcia, Ruben; Havasi, David; Takacs, Gergely; Robinson, Matthew C.; Lee, Alpha; von Delft, Frank; Deane, Charlotte M.
err分享
err收藏
Fragment Libraries Designed to Be Functionally Diverse Recover Protein Binding Information More Efficiently Than Standard Structurally Diverse Libraries
errJOURNAL OF MEDICINAL CHEMISTRY
IF6.8
err2022-08-12
err20
errOAAI
errCarbery, Anna; Skyner, Rachael; von Delft, Frank; Deane, Charlotte M.
err分享
err收藏

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