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收藏Improved In Vivo Metabolic Stability and Silencing Efficacy of siRNAs with Phosphorothioate Linkage-Free, GalNAc-Conjugated Sense Strands Containing Morpholino-LNA Modifications
Datta, Dhrubajyoti; Kumar, Pawan; Kundu, Jayanta; Qin, June; Gilbert, Jason A.; Schofield, Sally; Donnelly, Daniel P.; Liu, Ju; Degaonkar, Rohan; Egli, Martin; Manoharan, Muthiah
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收藏An LNA-amide modification that enhances the cell uptake and activity of phosphorothioate exon-skipping oligonucleotides
Baker, Ysobel R.; Thorpe, Cameron; Chen, Jinfeng; Poller, Laura M.; Cox, Lina; Kumar, Pawan; Lim, Wooi F.; Lie, Lillian; McClorey, Graham; Epple, Sven; Singleton, Daniel; McDonough, Michael A.; Hardwick, Jack S.; Christensen, Kirsten E.; Wood, Matthew J. A.; Hall, James P.; El-Sagheer, Afaf H.; Brown, Tom
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收藏Small circular interfering RNAs (sciRNAs) as a potent therapeutic platform for gene-silencing
Jahns, Hartmut; Degaonkar, Rohan; Podbevsek, Peter; Gupta, Swati; Bisbe, Anna; Aluri, Krishna; Szeto, John; Kumar, Pawan; LeBlanc, Sarah; Racie, Tim; Brown, Christopher R.; Castoreno, Adam; Guenther, Dale C.; Jadhav, Vasant; Maier, Martin A.; Plavec, Janez; Egli, Martin; Manoharan, Muthiah; Zlatev, Ivan
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收藏siRNAs containing 2′-fluorinated Northern-methanocarbacyclic (2′-F-NMC) nucleotides: in vitro and in vivo RNAi activity and inability of mitochondrial polymerases to incorporate 2′-F-NMC NTPs
Akabane-Nakata, Masaaki; Erande, Namrata D.; Kumar, Pawan; Degaonkar, Rohan; Gilbert, Jason A.; Qin, June; Mendez, Martha; Woods, Lauren Blair; Jiang, Yongfeng; Janas, Maja M.; O'Flaherty, Derek K.; Zlatev, Ivan; Schlegel, Mark K.; Matsuda, Shigeo; Egli, Martin; Manoharan, Muthiah
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收藏Chimeric siRNAs with chemically modified pentofuranose and hexopyranose nucleotides: altritol-nucleotide (ANA) containing GalNAc-siRNA conjugates: in vitro and in vivo RNAi activity and resistance to 5′-exonuclease
Kumar, Pawan; Degaonkar, Rohan; Guenther, Dale C.; Abramov, Mikhail; Schepers, Guy; Capobianco, Marie; Jiang, Yongfeng; Harp, Joel; Kaittanis, Charalambos; Janas, Maja M.; Castoreno, Adam; Zlatev, Ivan; Schlegel, Mark K.; Herdewijn, Piet; Egli, Martin; Manoharan, Muthiah
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收藏5′-Morpholino modification of the sense strand of an siRNA makes it a more effective passenger
Kumar, Pawan; Parmar, Rubina G.; Brown, Christopher R.; Willoughby, Jennifer L. S.; Foster, Donald J.; Babu, I. Ramesh; Schofield, Sally; Jadhav, Vasant; Charisse, Klaus; Nair, Jayaprakash K.; Rajeev, Kallanthottathil G.; Maier, Martin A.; Egli, Martin; Manoharan, Muthiah
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