Karsten Niefind - Publications, H-index & Citations

Karsten Niefind

University of Cologne

31H指数

178论文数

4.1K被引数

收录论文 36

发表时间

Targeting Human Protein Kinase CK2 by a Library of Indeno[1,2-b]Indoles: Contribution of Thermal Shift Assay to Pre-Screening and Co-Crystallization to Post-Screening 靶向人蛋白激酶CK2的 inden o[1,2-b]吲哚文库：热迁移分析对预筛选的贡献和共晶化对后筛选的贡献

Archiv der Pharmazie

IF3.6

2026-09-07

OAAI

Matheus M. Guimarães; Christian Werner; Belen Leroy; Johana Charles; Jean Guillon; Noël Pinaud; Angélique Mularoni; Marc Jean-Baptiste; Perrine Ximenes; Alexander Gast; Helge Prinz; Dagmar Aichele; Alan G. Gonçalves; Christelle Marminon; Zouhair Bouaziz; Joachim Jose; Jean-Guy Delcros; Karsten Niefind; Marc Le Borgne

Discovery and characterization of a novel class of cyclic peptidic compounds inhibiting the subunit interaction of the protein kinase CK2α2β2 holoenzyme 发现并表征一类新型环状肽类化合物，抑制蛋白激酶CK2α2β2全酶的亚基相互作用

RSC Chemical Biology

IF3.1

2026-09-02

PREAI

Christian Werner; Sophia Eimermacher; Miriam Lauwers; Dirk Lindenblatt; Esra Seymen; Ekaterina Kulko; Leonard Klein; Michaela Steinkrüger; Robin Baumann; Sarah Salamon; Cora Fried; Dietmar Fischer; Andreas Oder; Martin Neuenschwander; Claudia Götz; Karsten Niefind Corresponding Author; Markus Pietsch Corresponding Author

Functional characterization of 42 CK2α de novo variants associated with Okur-Chung neurodevelopmental syndrome 42个与Okur-Chung神经发育综合征相关的CK2α新发变异的功能表征

the febs journal

IF0

2026-04-13

OAAI

Alexander Gast; Christian Werner; Karsten Niefind; Joachim Jose

Novel fluoro-brominated benzotriazoles as potential CK2 inhibitors. How does fluorination affect the properties of benzotriazoles?新型氟溴化苯并三氮唑作为潜在的CK2抑制剂。氟化如何影响苯并三氮唑的性质？

Bioorganic Chemistry

IF4.7

2025-12-26

PREAI

Sławomir Kasperowicz; Christian Werner; Małgorzata Podsiadła-Białoskórska; Ewa Szołajska; Agnieszka M. Maciejewska; Dirk Lindenblatt; Karsten Niefind; Jarosław Poznański; Maria Winiewska-Szajewska

A CK2α′ mutant indicating why CK2α and CK2α′, the isoforms of the catalytic subunit of human protein kinase CK2, deviate in affinity to CK2β 一个CK2α′突变体表明，人类蛋白激酶CK2催化亚基的两种异构体CK2α和CK2α′，在亲和CK2β方面存在差异。

biological chemistry

IF2.4

2025-04-14

PREAI

Werner, Christian; Eimermacher, Sophia; Harasimowicz, Hugo; Fischer, Dietmar; Pietsch, Markus; Niefind, Karsten

De novo variants of CSNK2B cause a new intellectual disability-craniodigital syndrome by disrupting the canonical Wnt signaling pathway

HUMAN GENETICS AND GENOMICS ADVANCES

IF3.6

2022-07-01

OAAI

Asif, Maria; Kaygusuz, Emrah; Shinawi, Marwan; Nickelsen, Anna; Hsieh, Tzung-Chien; Wagle, Prerana; Budde, Birgit S.; Hochscherf, Jennifer; Abdullah, Uzma; Honing, Stefan; Nienberg, Christian; Lindenblatt, Dirk; Noegel, Angelika A.; Altmuller, Janine; Thiele, Holger; Motameny, Susanne; Fleischer, Nicole; Segal, Idan; Pais, Lynn; Tinschert, Sigrid; Samra, Nadra Nasser; Savatt, Juliann M.; Rudy, Natasha L.; De Luca, Chiara; Fortugno, Paola; White, Susan M.; Krawitz, Peter; Hurst, Anna C. E.; Niefind, Karsten; Jose, Joachim; Brancati, Francesco; Nurnberg, Peter; Hussain, Muhammad Sajid

Structural and Enzymological Evidence for an Altered Substrate Specificity in Okur-Chung Neurodevelopmental Syndrome Mutant CK2αLys198Arg Okur-chung神经发育综合征突变体CK2αLys198Arg底物特异性改变的结构和酶学证据

FRONTIERS IN MOLECULAR BIOSCIENCES

IF4

2022-04-04

OAAI

Werner, Christian; Gast, Alexander; Lindenblatt, Dirk; Nickelsen, Anna; Niefind, Karsten; Jose, Joachim; Hochscherf, Jennifer

Molecular Plasticity of Crystalline CK2α′ Leads to KN2, a Bivalent Inhibitor of Protein Kinase CK2 with Extraordinary Selectivity

JOURNAL OF MEDICINAL CHEMISTRY

IF6.8

2021-07-29

PREAI

Lindenblatt, Dirk; Applegate, Violetta; Nickelsen, Anna; Klussmann, Merlin; Neundorf, Ines; Goetz, Claudia; Jose, Joachim; Niefind, Karsten

Structural basis for the design of bisubstrate inhibitors of protein kinase CK2 provided by complex structures with the substrate-competitive inhibitor heparin

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

IF5.9

2021-03-01

PREAI

Schnitzler, Alexander; Niefind, Karsten

Expanding the Application Range of Microbial Oxidoreductases by an Alcohol Dehydrogenase from Comamonas testosteroni with a Broad Substrate Spectrum and pH Profile

CATALYSTS

IF4

2020-11-04

OAAI

Bakonyi, Daniel; Toelzer, Christine; Stricker, Michael; Hummel, Werner; Niefind, Karsten; Groeger, Harald

Structural and Mechanistic Basis of the Inhibitory Potency of Selected 2-Aminothiazole Compounds on Protein Kinase CK2

JOURNAL OF MEDICINAL CHEMISTRY

IF6.8

2020-06-26

PREAI

Lindenblatt, Dirk; Nickelsen, Anna; Applegate, Violetta M.; Jose, Joachim; Niefind, Karsten

Arabidopsis immunity regulator EDS1 in a PAD4/SAG101-unbound form is a monomer with an inherently inactive conformation

JOURNAL OF STRUCTURAL BIOLOGY

IF5.1

2019-12-01

PREAI

Voss, Martin; Toelzer, Christine; Bhandari, Deepak D.; Parker, Jane E.; Niefind, Karsten

Diacritic Binding of an Indenoindole Inhibitor by CK2α Paralogs Explored by a Reliable Path to Atomic Resolution CK2α′ Structures

ACS OMEGA

IF4.3

2019-03-19

OAAI

Lindenblatt, Dirk; Nickelsen, Anna; Applegate, Violetta M.; Hochscherf, Jennifer; Witulski, Benedict; Bouaziz, Zouhair; Marminon, Christelle; Bretner, Maria; Le Borgne, Marc; Jose, Joachim; Niefind, Karsten

Design of CK2β-Mimicking Peptides as Tools To Study the CK2α/CK2β Interaction in Cancer Cells

CHEMMEDCHEM

IF3.4

2019-03-12

PREAI

Lindenblatt, Dirk; Horn, Mareike; Goetz, Claudia; Niefind, Karsten; Neundorf, Ines; Pietsch, Markus

An EDS1 heterodimer signalling surface enforces timely reprogramming of immunity genes in Arabidopsis

NATURE COMMUNICATIONS

IF15.7

2019-02-15

OAAI

Bhandari, Deepak D.; Lapin, Dmitry; Kracher, Barbara; von Born, Patrick; Bautor, Jaqueline; Niefind, Karsten; Parker, Jane E.

A π-Halogen Bond of Dibenzofuranones with the Gatekeeper Phe113 in Human Protein Kinase CK2 Leads to Potent Tight Binding Inhibitors

PHARMACEUTICALS

IF4.8

2018-02-17

OAAI

Schnitzler, Alexander; Gratz, Andreas; Bollacke, Andre; Weyrich, Michael; Kucklaender, Uwe; Wuensch, Bernhard; Goetz, Claudia; Niefind, Karsten; Jose, Joachim

Unexpected Binding Mode of a Potent Indeno[1,2-b]indole-Type Inhibitor of Protein Kinase CK2 Revealed by Complex Structures with the Catalytic Subunit CK2α and Its Paralog CK2α′

PHARMACEUTICALS

IF4.8

2017-12-13

OAAI

Hochscherf, Jennifer; Lindenblatt, Dirk; Witulski, Benedict; Birus, Robin; Aichele, Dagmar; Marminon, Christelle; Bouaziz, Zouhair; Le Borgne, Marc; Jose, Joachim; Niefind, Karsten

Structural Hypervariability of the Two Human Protein Kinase CK2 Catalytic Subunit Paralogs Revealed by Complex Structures with a Flavonol- and a Thieno[2,3-d]pyrimidine-Based Inhibitor

PHARMACEUTICALS

IF4.8

2017-01-11

OAAI

Niefind, Karsten; Bischoff, Nils; Golub, Andriy G.; Bdzhola, Volodymyr G.; Balanda, Anatoliy O.; Prykhod'ko, Andriy O.; Yarmoluk, Sergiy M.

A novel esterase subfamily with α/β-hydrolase fold suggested by structures of two bacterial enzymes homologous to L-homoserine O-acetyl transferases

FEBS LETTERS

IF3

2015-12-28

OAAI

Toelzer, Christine; Pal, Sonia; Watzlawick, Hildegard; Altenbuchner, Josef; Niefind, Karsten