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E

Emanuel Gonçalves

inesc-id

30H指数
156论文数
7.7K被引数
收录论文 28
发表时间
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Transcriptomic-Based Classification Identifies Prognostic Subtypes and Therapeutic Strategies in Soft Tissue Sarcomas转录组学为基础的分类识别软组织肉瘤中的预后亚型和治疗策略
errCancers
IF4.4
err2026-03-03
err0
errOAAI
errMiguel Esperança-Martins; Hugo Vasques; Manuel Sokolov Ravasqueira; Maria Manuel Lemos; Filipa Fonseca; Diogo Coutinho; Jorge Antonio López; Richard S. P. Huang; Sérgio Dias; Lina Gallego-Paez; Luís Costa; Nuno Abecasis; Emanuel Gonçalves; Isabel Fernandes
err分享
err收藏
A next-generation dual guide CRISPR system for genetic interaction library screening一种用于遗传互作文库筛选的下一代双引导CRISPR系统
errNature Communications
IF15.7
err2025-12-06
err0
errOAAI
errThomas Burgold; Emre Karakoc; Emanuel Gonçalves; Inigo Barrio-Hernandez; Lisa Dwane; Romina Silva; Emily Souster; Mamta Sharma; Alexandra Beck; Gene Ching Chiek Koh; Lykourgos-Panagiotis Zalmas; Mathew J. Garnett; Andrew R. Bassett
err分享
err收藏
A compendium of synthetic lethal gene pairs defined by extensive combinatorial pan-cancer CRISPR screening通过广泛的组合泛癌CRISPR筛选定义的合成致死基因对汇编
errGenome Biology
IF9.4
err2025-10-03
err0
errOAAI
errVictoria Harle; Victoria Offord; Birkan Gökbağ; Lazaros Fotopoulos; Thomas Williams; Diana Alexander; Ishan Mehta; Nicola A. Thompson; Rebeca Olvera-León; Stefan Peidli; Vivek Iyer; Emanuel Gonçalves; Narod Kebabci; Barbara De Kegel; Joris van de Haar; Lang Li; Colm J. Ryan; David J. Adams
err分享
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Succinate Dehydrogenase B (SDHB) Overexpression with Enzymatic Dysfunction Defines a Distinct Subtype of Undifferentiated Pleomorphic Sarcoma琥珀酸脱氢酶B (SDHB) 过表达伴随酶功能失调定义了一种未分化多形性肉瘤的独特亚型
errCANCER RESEARCH COMMUNICATIONS
IF0
err2025-10-01
err0
errOAAI
errEsperanca-Martins, Miguel; Vasques, Hugo; Ravasqueira, Manuel Sokolov; Santos, Filipa; Fonseca, Filipa; Queiroz, Antonio Syder; Boavida, Joao; Jordao, Daniel Martins; Soares Do Brito, Joaquim; Corredeira, Patricia; Martins, Marta; Afonso, Angela; Lopez, Jorge Antonio; Huang, Richard S. P.; Melo-Alvim, Cecilia; Fernandes, Isabel; Lopez-Presa, Dolores; Lemos, Maria Manuel; Van Tine, Brian A.; Bastos, Alliny C. S.; Casimiro, Sandra; Abecasis, Nuno; Costa, Luis; Goncalves, Emanuel; Duarte, Iola F.; Dias, Sergio
err分享
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Synthetic lethality in cancer drug discovery: challenges and opportunities癌症药物发现中的合成致死性：挑战与机遇
errNature Reviews Drug Discovery
IF101.8
err2025-09-11
err0
PREAI
errEmanuel Gonçalves; Colm J. Ryan; David J. Adams
err分享
err收藏
The synthetic lethal interaction between CDS1 and CDS2 is a vulnerability in uveal melanoma and across multiple tumor typesCDS1与CDS2之间的合成致死相互作用是葡萄膜黑色素瘤以及多种肿瘤类型的易损性。
errNature Genetics
IF0
err2025-07-04
err0
errOAAI
errPui Ying Chan; Diana Alexander; Ishan Mehta; Larissa Satiko Alcantara Sekimoto Matsuyama; Victoria Harle; Rebeca Olvera-León; Jun Sung Park; Fernanda G. Arriaga-González; Louise van der Weyden; Saamin Cheema; Vivek Iyer; Victoria Offord; David Barneda; Phillip T. Hawkins; Len Stephens; Zuza Kozik; Michael Woods; Kim Wong; Gabriel Balmus; Alessandro Vinceti; Nicola A. Thompson; Martin Del Castillo Velasco-Herrera; Lodewyk Wessels; Joris van de Haar; Emanuel Gonçalves; Sanju Sinha; Martha Estefania Vázquez-Cruz; Luisa Bisceglia; Francesco Raimondi; Jyoti Choudhary; Sumeet Patiyal; Anjan Venkatesh; Francesco Iorio; Colm J. Ryan; David J. Adams
err分享
err收藏
A technical review of multi-omics data integration methods: from classical statistical to deep generative approachesBaião A, Cai Z, Poulos R, Robinson P, Reddel R, Zhong Q, et al. 多组学数据整合方法的技术综述：从经典统计方法到深度生成方法。Brief Bioinform. (2025) 26:bbaf355. doi: 10.1093/bib/bbaf355
errBRIEFINGS IN BIOINFORMATICS
IF7.7
err2025-07-01
err23
errOAAI
errBaiao, Ana R.; Cai, Zhaoxiang; Poulos, Rebecca C.; Robinson, Phillip J.; Reddel, Roger R.; Zhong, Qing; Vinga, Susana; Goncalves, Emanuel
err分享
err收藏
Synthetic augmentation of cancer cell line multi-omic datasets using unsupervised deep learning
errNATURE COMMUNICATIONS
IF15.7
err2024-11-29
err0
errOAAI
errCai, Zhaoxiang; Apolinario, Sofia; Baiao, Ana R.; Pacini, Clare; Sousa, Miguel D.; Vinga, Susana; Reddel, Roger R.; Robinson, Phillip J.; Garnett, Mathew J.; Zhong, Qing; Goncalves, Emanuel
err分享
err收藏
Post-translational regulation of metabolism in fumarate hydratase deficient cancer cells (Vol 45, pg 149, 2018)
errMETABOLIC ENGINEERING
IF6.8
err2024-03-01
err0
errOAAI
errGonsalves, Emanuel; Sciacovelli, Marco; Costa, Ana S. H.; Tran, Maxine Gia Binh; Johnson, Timothy Isaac; Machado, Daniel; Frezza, Christian; Saez-Rodriguez, Julio
err分享
err收藏
The pharmacoepigenomic landscape of cancer cell lines reveals the epigenetic component of drug sensitivity
errCOMMUNICATIONS BIOLOGY
IF5.1
err2023-08-09
err2
errOAAI
errOhnmacht, Alexander Joschua; Rajamani, Anantharamanan; Avar, Goeksu; Kutkaite, Ginte; Goncalves, Emanuel; Saur, Dieter; Menden, Michael Patrick
err分享
err收藏
DNA methylation fingerprint of hepatocellular carcinoma from tissue and liquid biopsies
errSCIENTIFIC REPORTS
IF3.9
err2022-07-07
err19
errOAAI
errGoncalves, Emanuel; Goncalves-Reis, Maria; Pereira-Leal, Jose B.; Cardoso, Joana
err分享
err收藏
A suspension technique for efficient large-scale cancer organoid culturing and perturbation screens用于高效大规模癌症类器官培养和扰动筛选的悬浮技术
errSCIENTIFIC REPORTS
IF3.9
err2022-04-02
err19
errOAAI
errPrice, Stacey; Bhosle, Shriram; Goncalves, Emanuel; Li, Xiaodun; McClurg, Dylan P.; Barthorpe, Syd; Beck, Alex; Hall, Caitlin; Lightfoot, Howard; Farrow, Luke; Ansari, Rizwan; Jackson, David A.; Allen, Laura; Roberts, Kirsty; Beaver, Charlotte; Francies, Hayley E.; Garnett, Mathew J.
err分享
err收藏
Genome and metabolome: chance and necessity
errGENOME BIOLOGY
IF9.4
err2021-09-23
err4
errOAAI
errGoncalves, Emanuel; Frezza, Christian
err分享
err收藏
Integrated cross-study datasets of genetic dependencies in cancer
errNATURE COMMUNICATIONS
IF15.7
err2021-03-12
err163
errOAAI
errPacini, Clare; Dempster, Joshua M.; Boyle, Isabella; Goncalves, Emanuel; Najgebauer, Hanna; Karakoc, Emre; van der Meer, Dieudonne; Barthorpe, Andrew; Lightfoot, Howard; Jaaks, Patricia; McFarland, James M.; Garnett, Mathew J.; Tsherniak, Aviad; Iorio, Francesco
err分享
err收藏
Combinatorial CRISPR screen identifies fitness effects of gene paralogues
errNATURE COMMUNICATIONS
IF15.7
err2021-02-26
err63
errOAAI
errThompson, Nicola A.; Ranzani, Marco; van der Weyden, Louise; Iyer, Vivek; Offord, Victoria; Droop, Alastair; Behan, Fiona; Goncalves, Emanuel; Speak, Anneliese; Iorio, Francesco; Hewinson, James; Harle, Victoria; Robertson, Holly; Anderson, Elizabeth; Fu, Beiyuan; Yang, Fengtang; Zagnoli-Vieira, Guido; Chapman, Phil; Velasco-Herrera, Martin Del Castillo; Garnett, Mathew J.; Jackson, Stephen P.; Adams, David J.
err分享
err收藏
Minimal genome-wide human CRISPR-Cas9 library
errGENOME BIOLOGY
IF9.4
err2021-01-21
err39
errOAAI
errGoncalves, Emanuel; Thomas, Mark; Behan, Fiona M.; Picco, Gabriele; Pacini, Clare; Allen, Felicity; Vinceti, Alessandro; Sharma, Mamta; Jackson, David A.; Price, Stacey; Beaver, Charlotte M.; Dovey, Oliver; Parry-Smith, David; Iorio, Francesco; Parts, Leopold; Yusa, Kosuke; Garnett, Mathew J.
err分享
err收藏
Project Score database: a resource for investigating cancer cell dependencies and prioritizing therapeutic targets
errNUCLEIC ACIDS RESEARCH
IF13.1
err2020-10-17
err58
errOAAI
errDwane, Lisa; Behan, Fiona M.; Goncalves, Emanuel; Lightfoot, Howard; Yang, Wanjuan; van der Meer, Dieudonne; Shepherd, Rebecca; Pignatelli, Miguel; Iorio, Francesco; Garnett, Mathew J.
err分享
err收藏
Genome-wide CRISPR screens of oral squamous cell carcinoma reveal fitness genes in the Hippo pathway
errELIFE
IF0
err2020-09-29
err36
errOAAI
errChai, Annie Wai Yeeng; Yee, Pei San; Price, Stacey; Yee, Shi Mun; Lee, Hui Mei; Tiong, Vivian K. H.; Goncalves, Emanuel; Behan, Fiona M.; Bateson, Jessica; Gilbert, James; Tan, Aik Choon; McDermott, Ultan; Garnett, Mathew J.; Cheong, Sok Ching
err分享
err收藏
Drug mechanism-of-action discovery through the integration of pharmacological andCRISPRscreens
errMOLECULAR SYSTEMS BIOLOGY
IF7.7
err2020-07-06
err59
errOAAI
errGoncalves, Emanuel; Segura-Cabrera, Aldo; Pacini, Clare; Picco, Gabriele; Behan, Fiona M.; Jaaks, Patricia; Coker, Elizabeth A.; van der Meer, Donny; Barthorpe, Andrew; Lightfoot, Howard; Mironenko, Tatiana; Beck, Alexandra; Richardson, Laura; Yang, Wanjuan; Lleshi, Ermira; Hall, James; Tolley, Charlotte; Hall, Caitlin; Mali, Iman; Thomas, Frances; Morris, James; Leach, Andrew R.; Lynch, James T.; Sidders, Ben; Crafter, Claire; Iorio, Francesco; Fawell, Stephen; Garnett, Mathew J.
err分享
err收藏
Agreement between two large pan-cancer CRISPR-Cas9 gene dependency data sets
errNATURE COMMUNICATIONS
IF15.7
err2019-12-20
err155
errOAAI
errDempster, Joshua M.; Pacini, Clare; Pantel, Sasha; Behan, Fiona M.; Green, Thomas; Krill-Burger, John; Beaver, Charlotte M.; Younger, Scott T.; Zhivich, Victor; Najgebauer, Hanna; Allen, Felicity; Goncalves, Emanuel; Shepherd, Rebecca; Doench, John G.; Yusa, Kosuke; Vazquez, Francisca; Parts, Leopold; Boehm, Jesse S.; Golub, Todd R.; Hahn, William C.; Root, David E.; Garnett, Mathew J.; Tsherniak, Aviad; Iorio, Francesco
err分享
err收藏

研究方向

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合作学者
合作期刊
R
Ruedi Aebersold
H 指数: 198 · 论文数: 1.2K
T
Todd R. Golub
H 指数: 176 · 论文数: 749
W
William C. Hahn
H 指数: 147 · 论文数: 1.1K
S
Stephen P. Jackson
H 指数: 136 · 论文数: 667
D
David J. Adams
H 指数: 113 · 论文数: 969
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