未登录A pan-cancer screen identifies drug combination benefit in cancer cell lines at the individual and population level
Vis, Daniel J.; Jaaks, Patricia; Aben, Nanne; Coker, Elizabeth A.; Barthorpe, Syd; Beck, Alexandra; Hall, Caitlin; Hall, James; Lightfoot, Howard; Lleshi, Ermira; Mironenko, Tatiana; Richardson, Laura; Tolley, Charlotte; Garnett, Mathew J.; Wessels, Lodewyk F. A. .png)
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收藏Novel WRN Helicase Inhibitors Selectively Target Microsatellite-Unstable Cancer CellsPicco, Gabriele; Rao, Yanhua; Al Saedi, Angham; Lee, Yang; Vieira, Sara F.; Bhosle, Shriram; May, Kieron; Herranz-Ors, Carmen; Walker, Samantha J.; Shenje, Raynold; Dincer, Cansu; Gibson, Freddy; Banerjee, Ruby; Hewitson, Zoe; Werner, Thilo; Cottom, Joshua E.; Peng, Yang; Deng, Nanhua; Zhang, Youyou; Nartey, Eldridge N.; Nickels, Leng; Landis, Philip; Conticelli, Daniela; McCarten, Katrina; Bush, Jacob; Sharma, Mamta; Lightfoot, Howard; House, David; Milford, Emma; Grant, Emma K.; Glogowski, Michal P.; Wagner, Craig D.; Bantscheff, Marcus; Rutkowska-Klute, Anna; Zappacosta, Francesca; Pettinger, Jonathan; Barthorpe, Syd; Eberl, H. Christian; Jones, Brian T.; Schneck, Jessica L.; Murphy, Dennis J.; Voest, Emile E.; Taygerly, Joshua P.; DeMartino, Michael P.; Coelho, Matthew A.; Houseley, Jonathan; Sharma, Geeta; Schwartz, Benjamin; Garnett, Mathew J. 分享 收藏 Novel WRN helicase inhibitors selectively target microsatellite unstable cancer cellsPicco, Gabriele; Rao, Yanhua; Al Saedi, Angham; Vieira, Sara F.; Lee, Yang; Shenje, Ray; Bhosle, Shriram; Walker, Samantha; May, Kieron; Herranz-Ors, Carmen; Dicer, Cansu; Gibson, Freddy; Banerjee, Ruby; Werner, Thilo; Cottom, Josh; Peng, Yang; Deng, Nanhua; Landis, Phil; Angel, Thomas; Bush, Jacob; Rees, Matthew G.; Ronan, Melissa M.; Roth, Jennifer A.; Lightfoot, Howard; Zappacosta, Francesca; Pettinger, Jonathan; Barthorpe, Syd; Eberl, Chris; Jones, Brian; Schneck, Jess; Murphy, Dennis; Taygerly, Josh; DeMartino, Mike; Coelho, Matthew; Houseley, Jon; Schwartz, Benjamin; Garnett, Mathew J. 分享 收藏 分享 收藏 Large scale pan cancer drug combination screening to identify effective and actionable combinations and biomarker hypothesisBashi, Azadeh; Coker, Elizabeth A.; Bulusu, Krishna; Milo, Marta; Crafter, Claire; Lynch, James; Jenkins, David; Lightfoot, Howard; Willis, Brandon; Andersen, Courtney; Tavana, Omid; Mongeon, Kevin; Gordon, Jacob; Smith, Paul; Barry, Simon; McDermott, Ultan; Drew, Lisa; Critchlow, Susan; Garnett, Mathew J.; Mettetal, Jerome 分享 收藏 A suspension technique for efficient large-scale cancer organoid culturing and perturbation screens用于高效大规模癌症类器官培养和扰动筛选的悬浮技术Price, Stacey; Bhosle, Shriram; Goncalves, Emanuel; Li, Xiaodun; McClurg, Dylan P.; Barthorpe, Syd; Beck, Alex; Hall, Caitlin; Lightfoot, Howard; Farrow, Luke; Ansari, Rizwan; Jackson, David A.; Allen, Laura; Roberts, Kirsty; Beaver, Charlotte; Francies, Hayley E.; Garnett, Mathew J. 分享 收藏 Integrated cross-study datasets of genetic dependencies in cancerPacini, Clare; Dempster, Joshua M.; Boyle, Isabella; Goncalves, Emanuel; Najgebauer, Hanna; Karakoc, Emre; van der Meer, Dieudonne; Barthorpe, Andrew; Lightfoot, Howard; Jaaks, Patricia; McFarland, James M.; Garnett, Mathew J.; Tsherniak, Aviad; Iorio, Francesco 分享 收藏 Project Score database: a resource for investigating cancer cell dependencies and prioritizing therapeutic targetsDwane, Lisa; Behan, Fiona M.; Goncalves, Emanuel; Lightfoot, Howard; Yang, Wanjuan; van der Meer, Dieudonne; Shepherd, Rebecca; Pignatelli, Miguel; Iorio, Francesco; Garnett, Mathew J. 分享 收藏 Drug mechanism-of-action discovery through the integration of pharmacological andCRISPRscreensGoncalves, Emanuel; Segura-Cabrera, Aldo; Pacini, Clare; Picco, Gabriele; Behan, Fiona M.; Jaaks, Patricia; Coker, Elizabeth A.; van der Meer, Donny; Barthorpe, Andrew; Lightfoot, Howard; Mironenko, Tatiana; Beck, Alexandra; Richardson, Laura; Yang, Wanjuan; Lleshi, Ermira; Hall, James; Tolley, Charlotte; Hall, Caitlin; Mali, Iman; Thomas, Frances; Morris, James; Leach, Andrew R.; Lynch, James T.; Sidders, Ben; Crafter, Claire; Iorio, Francesco; Fawell, Stephen; Garnett, Mathew J. 分享 收藏 A high-throughput screen to identify effective and translationally-relevant drug combinations for breast, colorectal, and pancreatic cancersCoker, Elizabeth A.; Jaaks, Patricia; Vis, Daniel J.; Aben, Nanne; Barthorpe, Syd; van der Meer, Dieudonne; Lightfoot, Howard; Wessels, Lodewyk; Garnett, Mathew 分享 收藏 LOSS OF BAP1 FUNCTION LEADS TO TRAIL SENSITIVITY IN MESOTHELIOMAKumar, N.; Kolluri, K. K.; Alifrangis, C.; Ishii, Y.; Price, S.; Michaut, M.; Williams, S.; Barthorpe, S.; Lightfoot, H.; Busacca, S.; Sharkey, A.; Yuan, Z.; Sage, E. K.; Vallath, S.; Le Quesne, J.; Tice, D. A.; Alrifai, D.; von Karstedt, S.; Montinaro, A.; Guppy, N.; Waller, D. A.; Nakas, A.; Good, R.; Holmes, A.; Walczak, H.; Fennell, D. A.; Garnett, M.; Iorio, F.; Wessels, L.; McDermott, U.; Janes, S. M. 分享 收藏 分享 收藏 Organoid cultures recapitulate esophageal adenocarcinoma heterogeneity providing a model for clonality studies and precision therapeuticsLi, Xiaodun; Francies, Hayley E.; Secrier, Maria; Perner, Juliane; Miremadi, Ahmad; Galeano-Dalmau, Nuria; Barendt, William J.; Letchford, Laura; Leyden, Genevieve M.; Goffin, Emma K.; Barthorpe, Andrew; Lightfoot, Howard; Chen, Elisabeth; Gilbert, James; Noorani, Ayesha; Devonshire, Ginny; Bower, Lawrence; Grantham, Amber; MacRae, Shona; Grehan, Nicola; Wedge, David C.; Fitzgerald, Rebecca C.; Garnett, Mathew J. 分享 收藏 Loss of functional BAP1 augments sensitivity to TRAIL in cancer cellsKolluri, Krishna Kalyan; Alifrangis, Constantine; Kumar, Neelam; Ishii, Yuki; Price, Stacey; Michaut, Magali; Williams, Steven; Barthorpe, Syd; Lightfoot, Howard; Busacca, Sara; Sharkey, Annabel; Yuan, Zhenqiang; Sage, Elizabeth K.; Vallath, Sabarinath; Le Quesne, John; Tice, David A.; Alrifai, Doraid; von Karstedt, Sylvia; Montinaro, Antonella; Guppy, Naomi; Waller, David A.; Nakas, Apostolos; Good, Robert; Holmes, Alan; Walczak, Henning; Fennel, Dean A.; Garnett, Mathew; Iorio, Francesco; Wessels, Lodewyk; McDermott, Ultan; Janes, Samuel M. 分享 收藏 Genomics of Drug Sensitivity in Cancer (GDSC): A resource for biomarker discovery in cancer cellsYang, W.; Lightfoot, H.; Bignell, G.; Behan, F.; Cokelear, T.; Haber, D.; Engelman, J.; Stratton, M.; Benes, C.; McDermott, U.; Garnett, M. 分享 收藏 分享 收藏 分享 收藏 Genomics of Drug Sensitivity in Cancer (GDSC): a resource for therapeutic biomarker discovery in cancer cellsYang, Wanjuan; Soares, Jorge; Greninger, Patricia; Edelman, Elena J.; Lightfoot, Howard; Forbes, Simon; Bindal, Nidhi; Beare, Dave; Smith, James A.; Thompson, I. Richard; Ramaswamy, Sridhar; Futreal, P. Andrew; Haber, Daniel A.; Stratton, Michael R.; Benes, Cyril; McDermott, Ultan; Garnett, Mathew J. 分享 收藏 分享 收藏 分享 收藏 
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