Kostiantyn P. Melnykov

enamine ltd

15H指数

97论文数

836被引数

收录论文 26

发表时间

Rapid Fragment Screening by 19F Steady-State Free Precession NMR 通过19F稳态自由进动NMR进行快速片段筛选

Angewandte Chemie International Edition

IF16.9

2026-05-26

OAAI

Laura Ruduša; Sintija Ozola; Kostiantyn P. Melnykov; Yaroslav I. Filatov; Serhiy V. Ryabukhin; Raitis Bobrovs; Dmytro M. Volochnyuk; Kristaps Jaudzems; Rihards Aleksis

Physicochemical Properties of α-Fluoroalkyl-Substituted Cycloalkylamines and Amino Acids α-氟烷基取代环烷胺和氨基酸的物理化学性质

ChemMedChem

IF3.4

2026-05-24

PREAI

Kostiantyn P. Melnykov; Oleksandr S. Liashuk; Andrii Koblianskyi; Oleh Smyrnov; Sofiia Slobodianyk; Bohdan Bobovskyi; Dmytro Lesyk; Svetlana V. Shishkina; Andrii Frolov; Petro Borysko; Oleksandr O. Grygorenko

Synthesis and Physicochemical Properties of trans-2-Fluoroalkyl-Substituted Cyclopentane Building Blocks trans-2-氟烷基取代环戊烷砌块的合成与物理化学性质

European Journal of Organic Chemistry

IF2.7

2026-04-29

PREAI

Bohdan V. Bobovskyi; Oleksandr V. Kudryk; Oleksandr Demchuk; Oleksandr V. Hryshchuk; Bohdan S. Sosunovych; Bohdan V. Vashchenko; Dmytro Lesyk; Anton V. Chernykh; Kostiantyn P. Melnykov; Petro Borysko; Igor Gerus; Oleksandr O. Grygorenko

Synthesis of Multifunctional 2,3-Dihydroquinolin-4(1H)-one Building Blocks via Permanganate-Promoted Oxidation of 1,2,3,4-Tetrahydroquinolines 通过高锰酸盐促进的1,2,3,4-四氢喹啉氧化合成多功能2,3-二氢喹啉-4(1H)-酮砌块

ChemistrySelect

IF2

2026-02-09

PREAI

Yakubovskyi, Viktor; Semoshkina, Olena; Melnykov, Kostiantyn; Grygorenko, Oleksandr O.; Liashuk, Oleksandr S.

Gram-scale synthesis and physicochemical properties of exo- and endo-5,5-difluorooctahydropentalen-2-amines

JOURNAL OF FLUORINE CHEMISTRY

IF1.9

2025-10-01

PREAI

Voloshyna, Olena; Moroz, Bohdan; Melnykov, Kostiantyn P.; Holovach, Serhii; Lesyk, Dmytro; Holota, Yuliia; Borysko, Petro; Filatov, Andrey A.; Grygorenko, Oleksandr O.

Basicity and Lipophilicity of gem-Difluorinated Saturated Bicyclic Amines: Advanced Building Blocks for Drug Discovery 碱性和脂溶性：gem-二氟代饱和双环胺：药物发现中的先进构建模块

European Journal of Organic Chemistry

IF2.7

2025-09-09

PREAI

Oleksandr S. Liashuk; Bohdan Moroz; Kostiantyn P. Melnykov; Serhii Holovach; Dmytro Lesyk; Yaroslav Lesyk; Daniil Skrypnik; Yuliia Holota; Petro Borysko; Andrey A. Filatov; Oleksandr O. Grygorenko

Machine Learning-Based Retention Time Prediction Tool for Routine LC-MS Data Analysis 基于机器学习的保留时间预测工具，用于常规LC-MS数据分析

Journal of Chemical Information and Modeling

IF5.3

2025-07-16

PREAI

Sofiia A. Dymura; Oleksandr O. Viniichuk; Kostiantyn P. Melnykov; Dmytro S. Radchenko; Oleksandr O. Grygorenko

DOS-Like Strategy for the Spirocyclic MedChem Relevant Building Blocks via Petasis / Grubbs Reactions Sequence 通过Petasis/Grubbs反应序列合成螺环类药物化学相关砌块的DOS-Like策略

CHEMISTRY-A EUROPEAN JOURNAL

IF3.7

2025-05-02

PREAI

Herasymchuk, Maksym V.; Melnykov, Kostiantyn P.; Druzhenko, Tetiana V.; Filatov, Yaroslav I.; Dudenko, Dmytro V.; Ostapchuk, Eugeniy M.; Volochnyuk, Dmytro M.; Ryabukhin, Serhiy V.

Filling the Gap in LogP and pKa Evaluation for Saturated Fluorine-Containing Derivatives With Machine Learning

JOURNAL OF COMPUTATIONAL CHEMISTRY

IF4.8

2025-01-13

PREAI

Gurbych, Oleksandr; Pavliuk, Petro; Krasnienkov, Dmytro; Liashuk, Oleksandr; Melnykov, Kostiantyn; Grygorenko, Oleksandr O.

Physicochemical and Biological Evaluation of gem-Difluorinated Saturated Oxygen Heterocycles as Bioisosteres for Drug Discovery

CHEMISTRY-A EUROPEAN JOURNAL

IF3.7

2024-12-18

PREAI

Melnykov, Kostiantyn P.; Liashuk, Oleksandr S.; Holovach, Serhii; Shatnia, Valeriia; Horbenko, Artur; Lesyk, Dmytro; Melnyk, Varvara; Skrypnik, Daniil; Beshtynarska, Anna; Borysko, Petro; Viniichuk, Oleksandr; Grygorenko, Oleksandr O.

3,3-Difluorooxetane-A Versatile Functional Group for Bioisosteric Replacements in Drug Discovery

CHEMISTRY-A EUROPEAN JOURNAL

IF3.7

2024-10-31

PREAI

Liashuk, Oleksandr S.; Fedinchyk, Anastasiya; Melnykov, Kostiantyn P.; Herasymchuk, Maksym; Alieksieieva, Diana; Lesyk, Dmytro; Bas, Yuliia P.; Keda, Tetiana Ye.; Yatsymyrskiy, Andriy V.; Holota, Yuliia; Borysko, Petro; Yarmolchuk, Volodymyr S.; Grygorenko, Oleksandr O.

Fluorinated building blocks in drug design: new pathways and targets

FUTURE MEDICINAL CHEMISTRY

IF3.4

2024-07-29

OAAI

Grygorenko, Oleksandr O.; Melnykov, Kostiantyn P.

Stellane at the Forefront: Derivatization and Reactivity Studies of a Promising Saturated Bioisostere of ortho-Substituted Benzenes

ORGANIC LETTERS

IF5

2024-05-28

PREAI

Smyrnov, Oleh K.; Melnykov, Kostiantyn P.; Pashenko, Olexandr Ye.; Volochnyuk, Dmytro M.; Ryabukhin, Serhiy V.

Parallel Minisci Reaction of gem-Difluorocycloalkyl Building Blocks

acs nanoscience au

IF4.4

2024-05-15

OAAI

Holovach, Serhii; Poroshyn, Illia; Melnykov, Kostiantyn P.; Liashuk, Oleksandr S.; Pariiska, Olena O.; Kolotilov, Sergey V.; Rozhenko, Alexander B.; Volochnyuk, Dmytro M.; Grygorenko, Oleksandr O.

Bicyclo[m.n.k]alkane Building Blocks as Promising Benzene and Cycloalkane Isosteres: Multigram Synthesis, Physicochemical and Structural Characterization

CHEMISTRY-A EUROPEAN JOURNAL

IF3.7

2024-01-11

PREAI

Semeno, Volodymyr V.; Vasylchenko, Vadym O.; Fesun, Ihor M.; Ruzhylo, Liudmyla Yu.; Kipriianov, Mykhailo O.; Melnykov, Kostiantyn P.; Skreminskyi, Artem; Iminov, Rustam; Mykhailiuk, Pavel; Vashchenko, Bohdan V.; Grygorenko, Oleksandr O.

Multigram Synthesis of Dimethyl Stellane-1,5-Dicarboxylate as a Key Precursor for ortho-Benzene Mimics

CHEMISTRY-A EUROPEAN JOURNAL

IF3.7

2023-11-02

PREAI

Smyrnov, Oleh K.; Melnykov, Kostiantyn P.; Rusanov, Eduard B.; Suikov, Sergey Yu.; Pashenko, Olexandr E.; Fokin, Andrey A.; Volochnyuk, Dmytro M.; Ryabukhin, Serhiy V.

Mono- and Difluorinated Saturated Heterocyclic Amines for Drug Discovery: Systematic Study of Their Physicochemical Properties

CHEMISTRY-A EUROPEAN JOURNAL

IF3.7

2023-07-26

PREAI

Melnykov, Kostiantyn P.; Nazar, Kostiantyn; Smyrnov, Oleh; Skreminskyi, Artem; Pavlenko, Serhii; Klymenko-Ulianov, Oleksii; Shishkina, Svitlana; Volochnyuk, Dmitriy M.; Grygorenko, Oleksandr O.

C-C Coupling through Nitrogen Deletion: Application to Library Synthesis

CHEMISTRY-A EUROPEAN JOURNAL

IF3.7

2023-01-04

OAAI

Holovach, Serhii; Melnykov, Kostiantyn P.; Poroshyn, Illia; Iminov, Rustam T.; Dudenko, Dmytro; Kondratov, Ivan; Levin, Mark; Grygorenko, Oleksandr O.

C-C Coupling through Nitrogen Deletion: Application to Library Synthesis

CHEMISTRY-A EUROPEAN JOURNAL

IF3.7

2022-12-21

PREAI

Holovach, Serhii; Melnykov, Kostiantyn P.; Poroshyn, Illia; Iminov, Rustam T.; Dudenko, Dmytro; Kondratov, Ivan; Levin, Mark; Grygorenko, Oleksandr O.

Fluorinated Cycloalkyl Building Blocks for Drug Discovery 用于药物发现的氟化环烷基构件

CHEMMEDCHEM

IF3.4

2022-10-05

PREAI

Grygorenko, Oleksandr O.; Melnykov, Kostiantyn P.; Holovach, Serhii; Demchuk, Oleksandr

研究方向