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R

Rita Maria Concetta Di Martino

Istituto Italiano di Tecnologia
H指数:20
被引数:1,407

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A Polypharmacology-Driven Approach to Alzheimer’s Disease and Tauopathies: Rational Design; Synthesis and Characterization of Amino-Pyrazole-Based Multikinase (GSK-3β/FYN-α/DYRK1A) Inhibitors

基于多靶点药物策略的阿尔茨海默病和tau蛋白病研究：氨基酸-吡唑类多靶点激酶（GSK-3β/FYN-α/DYRK1A）抑制剂的理性设计、合成与表征

Journal of Medicinal Chemistry
IF6.8
2026-04-290
OA
Stefania Demuro; Debora Russo; Ilaria Penna; Siranuysh Grabska; Hovakim Grabski; Andrea Dalle Vedove; Aurora Valeri; Conall Sauvey; Giuliana Ottonello; Maria Summa; Sine Mandrup Bertozzi; Jose Ortega; Rosalia Bertorelli; Paola Storici; Stefania Girotto; Gabriele Cruciani; Rita M. C. Di Martino; Ruben Abagyan; Andrea Cavalli
Rational optimization of D3R/GSK-3β dual target-directed ligands as potential treatment for bipolar disorder: Design, synthesis, X-ray crystallography, molecular dynamics simulations, in vitro ADME, and in vivo pharmacokinetic studies

基于理性的D3R/GSK-3β双靶点导向配体的优化及其作为双相情感障碍潜在治疗药物的研究：设计、合成、X射线晶体学、分子动力学模拟、体外ADME及体内药代动力学研究

European Journal of Medicinal Chemistry
IF5.9
2025-06-250
PRE
R.M.C. Di Martino; D. Russo; I. Penna; S. Demuro; A. Dalle Vedove; R. Spagnuolo; G. Ottonello; S.M. Bertozzi; M. Summa; J. Desantis; A. Valeri; L. Pruccoli; S.K. Tripathi; A. Tarozzi; P. Storici; S. Girotto; R. Bertorelli; A. Armirotti; G. Cruciani; T. Bandiera; A. Cavalli; G. Bottegoni
Targeting the multifaceted neurotoxicity of Alzheimer?s disease by tailored functionalisation of the curcumin scaffold
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
IF5.9
2023-04-012
OAAI
De Lorenzi, Ersilia; Seghetti, Francesca; Tarozzi, Andrea; Pruccoli, Letizia; Contardi, Cecilia; Serra, Massimo; Bisi, Alessandra; Gobbi, Silvia; Vistoli, Giulio; Gervasoni, Silvia; Argentini, Carla; Ghirardo, Giulia; Guarato, Giulia; Orso, Genny; Belluti, Federica; Martino, Rita Maria Concetta Di; Zusso, Morena

研究方向

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Alessandra Bisi
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Angela Rampa
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Tracey Pirali
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Giovanni Bottegoni
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F
Francesca Seghetti
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