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Identification of small molecule inhibitors of PPM1D using an integrated drug discovery platform 使用集成药物发现平台鉴定PPM1D小分子抑制剂 Shaw, Subrata; Jiang, Wei; Rush, Jason; Dumont, Nancy; Kim, John; Singh, Ritu; Skepner, Adam; Khodier, Carol; Raffier, Cerise; Murphy, Zachary; Yan, Ni; Schluter, Cameron; Yu, Xiao; Szuchnicki, Mateusz; Sathappa, Murugappan; Kahn, Josephine; Sperling, Adam S.; Wagner, Florence; Mckinney, David C.; Gould, Alexandra E.; Garvie, Colin W.; Miller, Peter G. 分享 收藏
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A Fast-Binding, Functionally Reversible, COX-2 Radiotracer for CNS PET Imaging Placzek, Michael S.; Wilton, Daniel K.; Weiwer, Michel; Manter, Mariah A.; Reid, Sarah E.; Meyer, Christopher J.; Campbell, Arthur J.; Bajrami, Besnik; Bigot, Antoine; Bricault, Sarah; Fayet, Agathe; Frouin, Arnaud; Gergits, Frederick; Gupta, Mehak; Jiang, Wei; Melanson, Michelle; Romano, Chiara D.; Riley, Misha M.; Wang, Jessica M.; Wey, Hsiao-Ying; Wagner, Florence F.; Stevens, Beth; Hooker, Jacob M. 分享 收藏
Virtual screening for small-molecule pathway regulators by image-profile matching Rohban, Mohammad H.; Fuller, Ashley M.; Tan, Ceryl; Goldstein, Jonathan T.; Syangtan, Deepsing; Gutnick, Amos; DeVine, Ann; Nijsure, Madhura P.; Rigby, Megan; Sacher, Joshua R.; Corsello, Steven M.; Peppler, Grace B.; Bogaczynska, Marta; Boghossian, Andrew; Ciotti, Gabrielle E.; Hands, Allison T.; Mekareeya, Aroonroj; Doan, Minh; Gale, Jennifer P.; Derynck, Rik; Turbyville, Thomas; Boerckel, Joel D.; Singh, Shantanu; Kiessling, Laura L.; Schwarz, Thomas L.; Varelas, Xaralabos; Wagner, Florence F.; Kafri, Ran; Eisinger-Mathason, T. S. Karin; Carpenter, Anne E. 分享 收藏
Discovery of a First-in-Class Inhibitor of the PRMT5-Substrate Adaptor Interaction McKinney, David C.; McMillan, Brian J.; Ranaghan, Matthew; Moroco, Jamie A.; Brousseau, Merissa; Mullin-Bernstein, Zachary; O'Keefe, Meghan; McCarren, Patrick; Mesleh, Michael F.; Mulvaney, Kathleen M.; Robinson, Foxy; Singh, Ritu; Bajrami, Besnik; Wagner, Florence F.; Hilgraf, Robert; Drysdale, Martin J.; Campbell, Arthur J.; Skepner, Adam; Timm, David E.; Porter, Dale; Kaushik, Virendar K.; Sellers, William R.; Ianari, Alessandra 分享 收藏
HDAC2 targeting stabilizes the CoREST complex in renal tubular cells and protects against renal ischemia/reperfusion injury HDAC2靶向稳定肾小管细胞中的CoREST复合物并保护肾脏缺血/再灌注损伤 Aufhauser, David D., Jr.; Hernandez, Paul; Concors, Seth J.; O'Brien, Ciaran; Wang, Zhonglin; Murken, Douglas R.; Samanta, Arabinda; Beier, Ulf H.; Krumeich, Lauren; Bhatti, Tricia R.; Wang, Yanfeng; Ge, Guanghui; Wang, Liqing; Cheraghlou, Shayan; Wagner, Florence F.; Holson, Edward B.; Kalin, Jay H.; Cole, Philip A.; Hancock, Wayne W.; Levine, Matthew H. 分享 收藏
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Exploiting the Therapeutic Interaction of WNT Pathway Activation and Asparaginase for Colorectal Cancer Therapy Hinze, Laura; Labrosse, Roxane; Degar, James; Han, Teng; Schatoff, Emma M.; Schreek, Sabine; Karim, Salmaan; McGuckin, Connor; Sacher, Joshua R.; Wagner, Florence; Stanulla, Martin; Yuan, Chen; Sicinska, Ewa; Giannakis, Marios; Ng, Kimmie; Dow, Lukas E.; Gutierrez, Alejandro 分享 收藏
A High-Content Screen for Mucin-1-Reducing Compounds Identifies Fostamatinib as a Candidate for Rapid Repurposing for Acute Lung Injury Kost-Alimova, Maria; Sidhom, Eriene-Heidi; Satyam, Abhigyan; Chamberlain, Brian T.; Dvela-Levitt, Moran; Melanson, Michelle; Alper, Seth L.; Santos, Jean; Gutierrez, Juan; Subramanian, Ayshwarya; Byrne, Patrick J.; Grinkevich, Elizabeth; Reyes-Bricio, Estefania; Kim, Choah; Clark, Abbe R.; Watts, Andrew J. B.; Thompson, Rebecca; Marshall, Jamie; Pablo, Juan Lorenzo; Coraor, Juliana; Roignot, Julie; Vernon, Katherine A.; Keller, Keith; Campbell, Alissa; Emani, Maheswarareddy; Racette, Matthew; Bazua-Valenti, Silvana; Padovano, Valeria; Weins, Astrid; McAdoo, Stephen P.; Tam, Frederick W. K.; Ronco, Luciene; Wagner, Florence; Tsokos, George C.; Shaw, Jillian L.; Greka, Anna 分享 收藏
Comprehensive characterization of amino acid positions in protein structures reveals molecular effect of missense variants Iqbal, Sumaiya; Perez-Palma, Eduardo; Jespersen, Jakob B.; May, Patrick; Hoksza, David; Heyne, Henrike O.; Ahmed, Shehab S.; Rifat, Zaara T.; Rahman, M. Sohel; Lage, Kasper; Palotie, Aarno; Cottrell, Jeffrey R.; Wagner, Florence F.; Daly, Mark J.; Campbell, Arthur J.; Lal, Dennis 分享 收藏
Multimodal small-molecule screening for human prion protein binders Reidenbach, Andrew G.; Mesleh, Michael F.; Casalena, Dominick; Vallabh, Sonia M.; Dahlin, Jayme L.; Leed, Alison J.; Chan, Alix I.; Usanov, Dmitry L.; Yehl, Jenna B.; Lemke, Christopher T.; Campbell, Arthur J.; Shah, Rishi N.; Shrestha, Om K.; Sacher, Joshua R.; Rangel, Victor L.; Moroco, Jamie A.; Sathappa, Murugappan; Nonato, Maria Cristina; Nguyen, Kong T.; Wright, S. Kirk; Liu, David R.; Wagner, Florence F.; Kaushik, Virendar K.; Auld, Douglas S.; Schreiber, Stuart L.; Minikel, Eric Vallabh 分享 收藏
Autism-Associated Shank3 Is Essential for Homeostatic Compensation in Rodent V1 Tatavarty, Vedakumar; Pacheco, Alejandro Torrado; Kuhnle, Chelsea Groves; Lin, Heather; Koundinya, Priya; Miska, Nathaniel J.; Hengen, Keith B.; Wagner, Florence F.; Van Hooser, Stephen D.; Turrigiano, Gina G. 分享 收藏
Selective inhibition of glycogen synthase kinase 3α corrects pathophysiology in a mouse model of fragile X syndrome McCamphill, Patrick K.; Stoppel, Laura J.; Senter, Rebecca K.; Lewis, Michael C.; Heynen, Arnold J.; Stoppel, David C.; Sridhar, Vinay; Collins, Katie A.; Shi, Xi; Pan, Jen Q.; Madison, Jon; Cottrell, Jeffrey R.; Huber, Kimberly M.; Scolnick, Edward M.; Holson, Edward B.; Wagner, Florence F.; Bear, Mark F. 分享 收藏
MISCAST: MIssense variant to protein StruCture Analysis web SuiTe Iqbal, Sumaiya; Hoksza, David; Perez-Palma, Eduardo; May, Patrick; Jespersen, Jakob B.; Ahmed, Shehab S.; Rifat, Zaara T.; Heyne, Henrike O.; Rahman, M. Sohel; Cottrell, Jeffrey R.; Wagner, Florence F.; Daly, Mark J.; Campbell, Arthur J.; Lal, Dennis 分享 收藏
Translation of HDAC6 PET Imaging Using [18F]EKZ-001-cGMP Production and Measurement of HDAC6 Target Occupancy in Nonhuman Primates Celen, Sofie; Rokka, Johanna; Gilbert, Tonya M.; Koole, Michel; Vermeulen, Isabeau; Serdons, Kim; Schroeder, Frederick A.; Wagner, Florence F.; Bleeser, Tom; Hightower, Baileigh G.; Hu, Jiyun; Rahal, Dania; Beyzavi, M. Hassan; Vanduffel, Wim; Van Laere, Koen; Kranz, Janice E.; Hooker, Jacob M.; Bormans, Guy; Cawthorne, Christopher J. 分享 收藏
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Dynamic architecture of the Escherichia coli structural maintenance of chromosomes (SMC) complex, MukBEF Rajasekar, Karthik, V; Baker, Rachel; Fisher, Gemma L. M.; Bolla, Jani R.; Makela, Jarno; Tang, Minzhe; Zawadzka, Katarzyna; Koczy, Oliwia; Wagner, Florence; Robinson, Carol, V; Arciszewskal, Lidia K.; Sherratt, David J. 分享 收藏
Histone deacetylases 1 and 2 inhibition suppresses cytokine production and osteoclast bone resorption in vitro Algate, Kent; Haynes, David; Fitzsimmons, Tracy; Romeo, Ornella; Wagner, Florence; Holson, Edward; Reid, Robert; Fairlie, David; Bartold, Peter; Cantley, Melissa 分享 收藏
Functional Interpretation of Single Amino Acid Substitutions in 1,330 Disease-Associated Genes Iqbal, Sumaiya; Jespersen, Jakob Berg; Perez-Palma, Eduardo; May, Patrick; Palotie, Aarno; Cottrell, Jeffrey R.; Wagner, Florence F.; Daly, Mark J.; Campbell, Arthur J.; Lal, Dennis 分享 收藏
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