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Esther C. Y. Woon

National University of Singapore

H指数:26

被引数:3,027

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Inhibition of AlkB Nucleic Acid Demethylases: Promising New Epigenetic Targets

JOURNAL OF MEDICINAL CHEMISTRY

IF6.8

2021-11-1819

OA

Micro cell vesicle technology (mCVT): a novel hybrid system of gene delivery for hard-to-transfect (HTT) cells

IF5.1

2020-01-015

OAAI

A general strategy exploiting m5C duplex-remodelling effect for selective detection of RNA and DNA m5C methyltransferase activity in cells

NUCLEIC ACIDS RESEARCH

IF13.1

2019-11-0620

OAAI

Multiprotein Dynamic Combinatorial Chemistry: A Strategy for the Simultaneous Discovery of Subfamily-Selective Inhibitors for Nucleic Acid Demethylases FTO and ALKBH3

CHEMISTRY-AN ASIAN JOURNAL

IF3.3

2018-09-1429

OA

A fluorescent methylation-switchable probe for highly sensitive analysis of FTO N6-methyladenosine demethylase activity in cells

CHEMICAL SCIENCE

IF7.4

2018-01-0133

OAAI

Doxorubicin-loaded cell-derived nanovesicles: an alternative targeted approach for anti-tumor therapy

负载阿霉素的细胞衍生纳米囊泡: 抗肿瘤治疗的另一种靶向方法

INTERNATIONAL JOURNAL OF NANOMEDICINE

IF6.5

2017-04-0195

OAAI

N6-Methyladenosine: a conformational marker that regulates the substrate specificity of human demethylases FTO and ALKBH5

SCIENTIFIC REPORTS

IF3.9

2016-05-09144

OAAI

A methylation-switchable conformational probe for the sensitive and selective detection of RNA demethylase activity

CHEMICAL COMMUNICATIONS

IF4.2

2016-01-0126

OAAI

Exploration of the nicotinamide-binding site of the tankyrases, identifying 3-arylisoquinolin-1-ones as potent and selective inhibitors in vitro

BIOORGANIC & MEDICINAL CHEMISTRY

IF3

2015-09-0133

OAAI

Evaluation of anti-tumor enone-based bioactive compounds as specific thioredoxin reductase inhibitors

CANCER RESEARCH

IF16.6

2015-08-011

PRE

A strategy based on nucleotide specificity leads to a subfamily-selective and cell-active inhibitor of N6-methyladenosine demethylase FTO

CHEMICAL SCIENCE

IF7.4

2015-01-01113

OAAI

One-pot tandem Hurtley-retro-Claisen-cyclisation reactions in the synthesis of 3-substituted analogues of 5-aminoisoquinolin-1-one (5-AIQ), a water-soluble inhibitor of PARPs

BIOORGANIC & MEDICINAL CHEMISTRY

IF3

2013-09-0122

OAAI

A safe lithium mimetic for bipolar disorder

双相情感障碍的安全锂模拟物

NATURE COMMUNICATIONS

IF15.7

2013-01-08235

OAAI

Plant Growth Regulator Daminozide Is a Selective Inhibitor of Human KDM2/7 Histone Demethylases

JOURNAL OF MEDICINAL CHEMISTRY

IF6.8

2012-07-11130

OA

Rose, Nathan R.; Woon, Esther C. Y.; Tumber, Anthony; Walport, Louise J.; Chowdhury, Rasheduzzaman; Li, Xuan Shirley; King, Oliver N. F.; Lejeune, Clarisse; Ng, Stanley S.; Krojer, Tobias; Chan, Mun Chiang; Rydzik, Anna M.; Hopkinson, Richard J.; Che, Ka Hing; Daniel, Michelle; Strain-Damerell, Claire; Gileadi, Carina; Kochan, Grazyna; Leung, Ivanhoe K. H.; Dunford, James; Yeoh, Kar Kheng; Ratcliffe, Peter J.; Burgess-Brown, Nicola; von Delft, Frank; Muller, Susanne; Marsden, Brian; Brennan, Paul E.; McDonough, Michael A.; Oppermann, Udo; Klose, Robert J.; Schofield, Christopher J.; Kawamura, Akane

Dynamic Combinatorial Chemistry Employing Boronic Acids/Boronate Esters Leads to Potent Oxygenase Inhibitors

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

IF16.9

2012-05-2582

PREAI

Dynamic Combinatorial Mass Spectrometry Leads to Inhibitors of a 2-Oxoglutarate-Dependent Nucleic Acid Demethylase

JOURNAL OF MEDICINAL CHEMISTRY

IF6.8

2012-02-2249

PREAI

Linking of 2-Oxoglutarate and Substrate Binding Sites Enables Potent and Highly Selective Inhibition of JmjC Histone Demethylases

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

IF16.9

2012-01-1283

PREAI

Structure-Guided Design of Cell Wall Biosynthesis Inhibitors That Overcome β-Lactam Resistance in Staphylococcus aureus (MRSA)

ACS CHEMICAL BIOLOGY

IF3.8

2011-08-0354

PREAI

The oncometabolite 2-hydroxyglutarate inhibits histone lysine demethylases

IF6.2

2011-04-01924

OAAI

5-Benzamidoisoquinolin-1-ones and 5-(ω-Carboxyalkyl)isoquinolin-1-ones as Isoform-Selective Inhibitors of Poly(ADP-ribose) Polymerase 2 (PARP-2)

JOURNAL OF MEDICINAL CHEMISTRY

IF6.8

2011-03-1856

OAAI