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Olga I. Lavrik

Siberian Branch of the Russian Academy of Sciences

46H指数
536论文数
9.3K被引数
收录论文 119
发表时间
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Synthesis and Biological Evaluation of TDP1 Inhibitors Based on Coumarin and Monoterpenoid Fragments Conjoined by Heterocyclic Moieties基于香豆素和单萜片段通过杂环基团连接的TDP1抑制剂的合成与生物评价
errInternational Journal of Molecular Sciences
IF4.9
err2026-08-12
err0
errOAAI
errDmitriy Tsypyshev; Tatyana Khomenko; Tatyana Kornienko; Alexandra Zakharenko; Nina Komarova; Vyacheslav Krasnov; Natalya Soldatova; Pavel Postnikov; Suat Sari; Konstantin Volcho; Olga Lavrik; Nariman Salakhutdinov
err分享
err收藏
Synthesis of New Usnic Acid Derivatives with a Thiadiazine Substituent as Inhibitors of Tyrosyl-DNA-Phosphodiesterase 1
errJOURNAL OF STRUCTURAL CHEMISTRY
IF1.4
err2025-11-01
err0
PREAI
errZernov, S. P.; Filimonov, A. S.; Luzina, O. A.; Zakharenko, A. L.; Volcho, K. P.; Salakhutdinov, N. F.; Lavrik, O. I.
err分享
err收藏
DNA Repair in Ensuring Genome Stability and Human Health
errRussian Journal of Genetics
IF0.5
err2025-11-01
err0
PREAI
errRechkunova, N. I.; Lavrik, O. I.
err分享
err收藏
Amidothiazole Derivatives of (+)-Usnic Acid Effectively Inhibit TDP1 and Sensitize Tumor Cells to the Effects of Topotecan(+)-Usnic Acid的酰胺硫唑衍生物有效抑制TDP1并使肿瘤细胞对Topotecan的作用更敏感
errMOLECULAR BIOLOGY
IF1.2
err2025-10-01
err0
errOAAI
errChepanova, A. A.; Zakharenko, A. L.; Dyrkheeva, N. S.; Chernyshova, I. A.; Filimonov, A. S.; Luzina, O. A.; Kupryushkin, M. S.; Zhukov, S. A.; Tsukanov, A. V.; Salakhutdinov, N. F.; Lavrik, O. I.
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err收藏
Deciphering the dark side of histone ADP-ribosylation: what structural features of damaged nucleosome regulate the activities of PARP1 and PARP2解析组蛋白ADP-核糖基化的阴暗面：受损核小体的哪些结构特征调控PARP1和PARP2的活性
errNUCLEIC ACIDS RESEARCH
IF13.1
err2025-09-23
err0
errOAAI
errKurgina, Tatyana A.; Moor, Nina A.; Kutuzov, Mikhail M.; Endutkin, Anton, V; Lavrik, Olga, I
err分享
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Tissue distribution of OL9-116, a Tdp1 inhibitor based on usnic acid, is significantly altered in Lewis lung carcinoma-bearing mice compared to healthy animalsOL9-116（一种基于地衣酸的Tdp1抑制剂）的组织分布，在Lewis肺癌模型小鼠中较健康动物发生显著改变。
errJournal of Pharmaceutical and Biomedical Analysis
IF3.1
err2025-07-09
err0
PREAI
errAlina A. Okhina; Tatyana E. Kornienko; Artem D. Rogachev; Olga A. Luzina; Nelly A. Popova; Valery P. Nikolin; Alexandra L. Zakharenko; Nadezhda S. Dyrkheeva; Andrey G. Pokrovsky; Nariman F. Salakhutdinov; Olga I. Lavrik
err分享
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HPF1 Regulates Pol β Efficiency in Nucleosomes via the Modulation of Total Poly(ADP-Ribose) SynthesisHPF1通过调控总多聚(ADP-核糖)合成来调节核小体中Pol β的效率
errINTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
IF4.9
err2025-02-20
err0
errOAAI
errKutuzov, Mikhail; Sayfullina, Dinara; Belousova, Ekaterina; Lavrik, Olga
err分享
err收藏
Design, synthesis, and evaluation of dehydroabietyl imidazolidine-2,4-diones, 2,4,5-triones, and 2-thioxoimidazolidine-4,5-diones as TDP1 inhibitors and dual TDP1/TDP2 inhibitors脱氢abietyl咪唑烷二酮-2,4-二酮、2,4,5-三酮和2-噻唑基咪唑烷-4,5-二酮的设计、合成及作为TDP1抑制剂和双重TDP1/TDP2抑制剂的评估
errARCHIV DER PHARMAZIE
IF3.6
err2025-01-13
err0
PREAI
errKovaleva, Kseniya S.; Yarovaya, Olga I.; Gatilov, Yuriy V.; Lastovka, Anastasiya V.; Chernyshova, Irina A.; Dyrkheeva, Nadezhda S.; Chepanova, Arina A.; Lavrik, Olga I.; Salakhutdinov, Nariman F.
err分享
err收藏
Proteins Associated with Neurodegenerative Diseases: Link to DNA Repair
errBIOMEDICINES
IF3.9
err2024-12-11
err0
errOAAI
errKhodyreva, Svetlana N.; Dyrkheeva, Nadezhda S.; Lavrik, Olga I.
err分享
err收藏
Synthesis of furanotriterpenoids from betulin and evaluation of Tyrosyl-DNA phosphodiesterase 1 (Tdp1) inhibitory properties of new semi-synthetic triterpenoids
errEUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
IF5.9
err2024-10-01
err0
PREAI
errTolmacheva, Irina; Eroshenko, Daria; Chernyshova, Irina; Nazarov, Mikhail; Lavrik, Olga; Grishko, Victoria
err分享
err收藏
Divalent and multivalent cations control liquid-like assembly of poly(ADP-ribosyl)ated PARP1 into multimolecular associates in vitro
errCOMMUNICATIONS BIOLOGY
IF5.1
err2024-09-15
err3
errOAAI
errSukhanova, Maria V.; Anarbaev, Rashid O.; Maltseva, Ekaterina A.; Kutuzov, Mikhail M.; Lavrik, Olga I.
err分享
err收藏
Apurinic/apyrimidinic endonuclease 1 has major impact in prevention of suicidal covalent DNA-protein crosslink with apurinic/apyrimidinic site in cellular extracts
errIUBMB LIFE
IF3.2
err2024-07-04
err1
PREAI
errLebedeva, Natalia A.; Dyrkheeva, Nadezhda S.; Rechkunova, Nadejda I.; Lavrik, Olga I.
err分享
err收藏
Human DNA ligases I and IIIa as determinants of accuracy and efficiency of base excision DNA repair人类DNA连接酶I和IIIa是碱基切除DNA修复的准确性和效率的决定因素
errBIOCHIMIE
IF3
err2024-04-01
err1
PREAI
errMoor, Nina A.; Vasil'eva, Inna A.; Lavrik, Olga I.
err分享
err收藏
A Knockout of Poly(ADP-Ribose) Polymerase 1 in a Human Cell Line: An Influence on Base Excision Repair Reactions in Cellular Extracts
errCELLS
IF5.2
err2024-02-06
err1
errOAAI
errKhodyreva, Svetlana N.; Ilina, Ekaterina S.; Dyrkheeva, Nadezhda S.; Kochetkova, Alina S.; Yamskikh, Alexandra A.; Maltseva, Ekaterina A.; Malakhova, Anastasia A.; Medvedev, Sergey P.; Zakian, Suren M.; Lavrik, Olga I.
err分享
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New Dual Inhibitors of Tyrosyl-DNA Phosphodiesterase 1 and 2 Based on Deoxycholic Acid: Design, Synthesis, Cytotoxicity, and Molecular Modeling
errMOLECULES
IF4.6
err2024-01-24
err2
errOAAI
errSalomatina, Oksana V.; Kornienko, Tatyana E.; Zakharenko, Alexandra L.; Komarova, Nina I.; Achara, Chigozie; Reynisson, Johannes; Salakhutdinov, Nariman F.; Lavrik, Olga I.; Volcho, Konstantin P.
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Pharmacokinetic study of Tdp1 inhibitor resulted in a significant increase in antitumor effect in the treatment of Lewis lung carcinoma in mice by its combination with topotecan
errJOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
IF3.1
err2023-11-01
err0
PREAI
errOkhina, Alina A.; Kornienko, Tatyana E.; Rogachev, Artem D.; Luzina, Olga A.; Popova, Nelly A.; Nikolin, Valery P.; Zakharenko, Alexandra L.; Dyrkheeva, Nadezhda S.; Pokrovsky, Andrey G.; Salakhutdinov, Nariman F.; Lavrik, Olga I.
err分享
err收藏
FUS RRM regulates poly(ADP-ribose) levels after transcriptional arrest and PARP-1 activation on DNA damage
errCELL REPORTS
IF6.9
err2023-10-01
err6
errOAAI
errMamontova, Evgeniya M.; Clement, Marie-Jeanne; Sukhanova, Maria V.; Joshi, Vandana; Bouhss, Ahmed; Rengifo-Gonzalez, Juan Carlos; Desforges, Benedicte; Hamon, Loic; Lavrik, Olga I.; Pastre, David
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err收藏
FUS fibrillation occurs through a nucleation-based process below the critical concentration required for liquid-liquid phase separationFUS原纤化通过基于成核的过程发生，低于液-液相分离所需的临界浓度
errSCIENTIFIC REPORTS
IF3.9
err2023-05-13
err9
errOAAI
errBertrand, Emilie; Demongin, Clement; Dobra, Ioana; Rengifo-Gonzalez, Juan Carlos; Singatulina, Anastasia S.; Sukhanova, Maria V.; Lavrik, Olga I.; Pastre, David; Hamon, Loic
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err收藏
The Lipophilic Purine Nucleoside-Tdp1 Inhibitor-Enhances DNA Damage Induced by Topotecan In Vitro and Potentiates the Antitumor Effect of Topotecan In Vivo
errMOLECULES
IF4.6
err2022-12-31
err6
errOAAI
errChernyshova, Irina A.; Zakharenko, Aleksandra L.; Kurochkin, Nikolay N.; Dyrkheeva, Nadezhda S.; Kornienko, Tatyana E.; Popova, Nelly A.; Nikolin, Valeriy P.; Ilina, Ekaterina S.; Zharkov, Timofey D.; Kupryushkin, Maxim S.; Oslovsky, Vladimir E.; Drenichev, Mikhail S.; Lavrik, Olga I.
err分享
err收藏
PARP1 Activation Controls Stress Granule Assembly after Oxidative Stress and DNA Damage
errCELLS
IF5.2
err2022-12-05
err2
errOAAI
errSingatulina, Anastasia S.; Sukhanova, Maria V.; Desforges, Benedicte; Joshi, Vandana; Pastre, David; Lavrik, Olga I.
err分享
err收藏

研究方向

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合作学者
合作期刊
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Elisabeth Kremmer
H 指数: 109 · 论文数: 508
S
Samuel H. Wilson
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J
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H 指数: 82 · 论文数: 517
B
Bennett Van Houten
H 指数: 81 · 论文数: 373
V
Vera Gorbunova
H 指数: 80 · 论文数: 458
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