Karen Keeshan

university of glasgow

H指数:29

被引数:3,025

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教育背景

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Fetal defense against leukemia: a developmental shield

胎儿对白血病的防御：一种发育性屏障

Blood

IF23.1

2026-01-010

PRE

Caspase-resistant ROCK1 expression prolongs survival of Ep-Myc B cell lymphoma mice

DISEASE MODELS & MECHANISMS

IF3.3

2024-05-210

OAAI

Insights into the molecular profiles of adult and paediatric acute myeloid leukaemia

MOLECULAR ONCOLOGY

IF4.5

2021-02-1122

BRD4-mediated repression of p53 is a target for combination therapy in AML

NATURE COMMUNICATIONS

IF15.7

2021-01-1154

OAAI

Latif, Anne-Louise; Newcombe, Ashley; Li, Sha; Gilroy, Kathryn; Robertson, Neil A.; Lei, Xue; Stewart, Helen J. S.; Cole, John; Terradas, Maria Terradas; Rishi, Loveena; McGarry, Lynn; McKeeve, Claire; Reid, Claire; Clark, William; Campos, Joana; Kirschner, Kristina; Davis, Andrew; Lopez, Jonathan; Sakamaki, Jun-ichi; Morton, Jennifer P.; Ryan, Kevin M.; Tait, Stephen W. G.; Abraham, Sheela A.; Holyoake, Tessa; Higgins, Brian; Huang, Xu; Blyth, Karen; Copland, Mhairi; Chevassut, Timothy J. T.; Keeshan, Karen; Adams, Peter D.

Pharmacological impact of FLT3 mutations on receptor activity and responsiveness to tyrosine kinase inhibitors

FLT3突变对受体活性和酪氨酸激酶抑制剂反应性的药理学影响

BIOCHEMICAL PHARMACOLOGY

IF5.6

2021-01-0113

OAAI

A synthetic lethality approach to eradicate AML via synergistic activation of pro-apoptotic p53 by MDM2 and BET inhibitors

CANCER RESEARCH

IF16.6

2020-08-150

PRE

The deubiquitinase USP7 uses a distinct ubiquitin-like domain to deubiquitinate NF-κB subunits

去泛素酶USP7使用独特的泛素样结构域去泛素化nf-κb亚基

JOURNAL OF BIOLOGICAL CHEMISTRY

IF3.9

2020-08-0129

OAAI

The I.B-protein BCL-3 controls Toll-like receptor-induced MAPK activity by promoting TPL-2 degradation in the nucleus

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

IF9.1

2019-11-2610

OAAI

Pseudokinases: a tribble-edged sword

FEBS JOURNAL

IF4.2

2019-10-3145

OAAI

The regulation of sequence specific NF-κB DNA binding and transcription by IKKβ phosphorylation of NF-κB p50 at serine 80

NUCLEIC ACIDS RESEARCH

IF13.1

2019-10-1018

OAAI

Highlights of the 2nd International Symposium on Tribbles and Diseases: tribbles tremble in therapeutics for immunity, metabolism, fundamental cell biology and cancer

第二届国际疾病与疾病研讨会: 免疫，代谢，基础细胞生物学和癌症治疗学中的Tribbles颤抖

ACTA PHARMACEUTICA SINICA B

IF14.6

2019-03-014

OAAI

Cui, Bing; Eyers, Patrick A.; Dobens, Leonard L.; Tan, Nguan Soon; Mace, Peter D.; Link, Wolfgang A.; Kiss-Toth, Endre; Keeshan, Karen; Nakamura, Takuro; Pear, Warren S.; Feseha, Yodit; Johnston, Jessica; Carracedo, Arkatiz; Scheideler, Marcel; llyas, Zabran; Bauer, Robert C.; Erusalimsky, Jorge D.; Grzesik, Dominika; Salamanca-Viloria, Juan; Lv, Xiaoxi; Jin, Yishi; Li, Ke; Velasco, Guillermo; Shang, Shuang; Lizcano, Jose M.; Zhang, Xiaowei; Zhou, Jichao; Yu, Jiaojiao; Hua, Fang; Wang, Feng; Liu, Shanshan; Yu, Jinmei; Hu, Zhuowei

Targeting the arginine metabolic brake enhances immunotherapy for leukaemia

INTERNATIONAL JOURNAL OF CANCER

IF4.7

2019-01-1165

OAAI

Age-specific biological and molecular profiling distinguishes paediatric from adult acute myeloid leukaemias

NATURE COMMUNICATIONS

IF15.7

2018-12-1155

OAAI

Covalent inhibitors of EGFR family protein kinases induce degradation of human Tribbles 2 (TRIB2) pseudokinase in cancer cells

SCIENCE SIGNALING