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Impact of BCR::ABL1 single nucleotide variants on asciminib efficacy Innes, Andrew J.; Hayden, Chloe; Orovboni, Victoria; Claudiani, Simone; Fernando, Fiona; Khan, Afzal; Rees, David; Byrne, Jennifer; Gallipoli, Paolo; Francis, Sebastian; Copland, Mhairi; Horne, Gillian; Raghavan, Manoj; Arnold, Claire; Collins, Angela; Cranfield, Tanya; Cunningham, Nicholas; Danga, Akila; Forsyth, Peter; Frewin, Rebecca; Garland, Paula; Hannah, Guy; Avenoso, Daniele; Hassan, Sandra; Huntly, Brian J. P.; Husain, Jissan; Makkuni, Sudhakaran; Rothwell, Kate; Khorashad, Jamshid; Apperley, Jane F.; Milojkovic, Dragana 分享 收藏
Nutrient-sensitizing drug repurposing screen identifies lomerizine as a mitochondrial metabolism inhibitor of chronic myeloid leukemia Khalaf, Ahmed; de Beauchamp, Lucie; Kalkman, Eric; Rattigan, Kevin; Himonas, Ekaterini; Jones, Joe; James, Daniel; Abd Shokry, Engy Shokry; Scott, Mary T.; Dunn, Karen; Tardito, Saverio; Copland, Mhairi; Sumpton, David; Shanks, Emma; Helgason, G. Vignir 分享 收藏
Inhibition of mitochondrial folate metabolism drives differentiation through mTORC1 mediated purine sensing Zarou, Martha M.; Rattigan, Kevin M.; Sarnello, Daniele; Shokry, Engy; Dawson, Amy; Ianniciello, Angela; Dunn, Karen; Copland, Mhairi; Sumpton, David; Vazquez, Alexei; Helgason, G. Vignir 分享 收藏
Leukaemia exposure alters the transcriptional profile and function of BCR::ABL1 negative macrophages in the bone marrow niche Dawson, Amy; Zarou, Martha M.; Prasad, Bodhayan; Bittencourt-Silvestre, Joana; Zerbst, Desiree; Himonas, Ekaterini; Hsieh, Ya-Ching; van Loon, Isabel; Blanco, Giovanny Rodriguez; Ianniciello, Angela; Kerekes, Zsombor; Krishnan, Vaidehi; Agarwal, Puneet; Almasoudi, Hassan; McCluskey, Laura; Hopcroft, Lisa E. M.; Scott, Mary T.; Baquero, Pablo; Dunn, Karen; Vetrie, David; Copland, Mhairi; Bhatia, Ravi; Coffelt, Seth B.; Tiong, Ong Sin; Wheadon, Helen; Zanivan, Sara; Kirschner, Kristina; Helgason, G. Vignir 分享 收藏
Activating p53 abolishes self-renewal of quiescent leukaemic stem cells in residual CML disease Scott, Mary T.; Liu, Wei; Mitchell, Rebecca; Clarke, Cassie J.; Kinstrie, Ross; Warren, Felix; Almasoudi, Hassan; Stevens, Thomas; Dunn, Karen; Pritchard, John; Drotar, Mark E.; Michie, Alison M.; Jorgensen, Heather G.; Higgins, Brian; Copland, Mhairi; Vetrie, David 分享 收藏
Pyruvate anaplerosis is a targetable vulnerability in persistent leukaemic stem cells Rattigan, Kevin M.; Brabcova, Zuzana; Sarnello, Daniele; Zarou, Martha M.; Roy, Kiron; Kwan, Ryan; de Beauchamp, Lucie; Dawson, Amy; Ianniciello, Angela; Khalaf, Ahmed; Kalkman, Eric R.; Scott, Mary T.; Dunn, Karen; Sumpton, David; Michie, Alison M.; Copland, Mhairi; Tardito, Saverio; Gottlieb, Eyal; Helgason, G. Vignir 分享 收藏
Arginine dependency is a therapeutically exploitable vulnerability in chronic myeloid leukaemic stem cells Rattigan, Kevin M.; Zarou, Martha M.; Brabcova, Zuzana; Prasad, Bodhayan; Zerbst, Desiree; Sarnello, Daniele; Kalkman, Eric R.; Ianniciello, Angela; Scott, Mary T.; Dunn, Karen; Shokry, Engy; Sumpton, David; Copland, Mhairi; Tardito, Saverio; Vande Voorde, Johan; Mussai, Francis; Cheng, Paul; Helgason, G. Vignir 分享 收藏
A Lack of Diversity, Equity, and Inclusion in Clinical Research Has Direct Impact on Patient Care El-Galaly, Tarec Christoffer; Gaidzik, Verena I.; Gaman, Mihnea-Alexandru; Antic, Darko; Okosun, Jessica; Copland, Mhairi; Sexl, Veronika; Fielding, Adele K.; Doeswijk, Robin; Parker, Helen; Dreyling, Martin; Doehner, Konstanze; Almeida, Antonio Medina; Macintyre, Elizabeth; Gribben, John G.; Gronbaek, Kirsten 分享 收藏
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Longitudinal dynamics of clonal hematopoiesis identifies gene-specific fitness effects 克隆造血的纵向动力学确定基因特异性适应性效应 Robertson, Neil A.; Latorre-Crespo, Eric; Terradas-Terradas, Maria; Lemos-Portela, Jorge; Purcell, Alison C.; Livesey, Benjamin J.; Hillary, Robert F.; Murphy, Lee; Fawkes, Angie; MacGillivray, Louise; Copland, Mhairi; Marioni, Riccardo E.; Marsh, Joseph A.; Harris, Sarah E.; Cox, Simon R.; Deary, Ian J.; Schumacher, Linus J.; Kirschner, Kristina; Chandra, Tamir 分享 收藏
Ponatinib with fludarabine, cytarabine, idarubicin, and granulocyte colony-stimulating factor chemotherapy for patients with blast-phase chronic myeloid leukaemia (MATCHPOINT): a single-arm, multicentre, phase 1/2 trial Copland, Mhairi; Slade, Daniel; McIlroy, Graham; Horne, Gillian; Byrne, Jenny L.; Rothwell, Kate; Brock, Kristian; De Lavallade, Hugues; Craddock, Charles; Clark, Richard E.; Smith, Matthew L.; Fletcher, Rachel; Bishop, Rebecca; Milojkovic, Dragana; Yap, Christina 分享 收藏
Randomized evaluation of quizartinib and low-dose ara-C vs low-dose ara-C in older acute myeloid leukemia patients Dennis, Mike; Thomas, Ian F.; Ariti, Cono; Upton, Laura; Burnett, Alan K.; Gilkes, Amanda; Radia, Rohini; Hemmaway, Claire; Mehta, Priyanka; Knapper, Steven; Clark, Richard E.; Copland, Mhairi; Russell, Nigel; Hills, Robert K. 分享 收藏
ULK1 inhibition promotes oxidative stress-induced differentiation and sensitizes leukemic stem cells to targeted therapy Ianniciello, Angela; Zarou, Martha M.; Rattigan, Kevin M.; Scott, Mary; Dawson, Amy; Dunn, Karen; Brabcova, Zuzana; Kalkman, Eric R.; Nixon, Colin; Michie, Alison M.; Copland, Mhairi; Vetrie, David; Ambler, Martin; Saxty, Barbara; Helgason, G. Vignir 分享 收藏
Spred1 deficit promotes treatment resistance and transformation of chronic phase CML Qiao, Junjing; Liang, Chen; Zhao, Dandan; Le Xuan Truong Nguyen; Chen, Fang; Suo, Shanshan; Dinh Hoa Hoang; Pellicano, Francesca; Rodriguez, Ivan Rodriguez; Elhajmoussa, Yasmin; Ghoda, Lucy; Yoshimura, Akihiko; Stein, Anthony S.; Ali, Haris; Koller, Paul; Perrotti, Danilo; Copland, Mhairi; Han, Anjia; Zhang, Bin Amber; Marcucci, Guido 分享 收藏
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