方

方显杨 (Xianyang Fang)

chinese academy of sciences

H指数:23

被引数:1,754

个人简介

"1998 - 2002 武汉大学，获理学学士学位 (化学) 2002 - 2008 中国科学院生物物理研究所，获理学博士学位 (生物化学与分子生物学) 2009 - 2015 美国国立卫生研究院，博士后 2015 - 2022 清华大学生命科学学院，助理教授/副教授，博士生导师 2022 - 至今中国科学院生物物理研究所，研究员，博士生导师"

教育背景

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工作经历

暂无内容

荣誉奖项

暂无内容

Structural basis for genome-wide site-specific DNA recognition by Nuclear Factor IA

核因子IA全基因组位点特异性DNA识别的结构基础

Nature Communications

IF15.7

2025-12-150

tRNA-dependent conformational dynamics and folding coordinate translational regulation by a full-length T-box riboswitch

tRNA依赖的构象动力学和折叠坐标通过全长T-box核酶开关调控翻译

Nature Communications

IF15.7

2025-11-250

OAAI

CRISPR live-cell imaging reveals chromatin dynamics and enhancer interactions at multiple non-repetitive loci

CRISPR活细胞成像揭示了多个非重复基因座的染色质动力学和增强子相互作用

Nature Biotechnology

IF41.7

2025-11-060

Crystal structures of PAK2 reveal new insights into its autoinhibitory mechanism

PAK2的晶体结构揭示了其自抑制机制的新见解

Structure

IF4.3

2025-08-010

PRE

Empowering the molecular ruler techniques with unnatural base pair system to explore conformational dynamics of flaviviral RNAs

CURRENT OPINION IN STRUCTURAL BIOLOGY

IF7

2024-12-010

PRE

Structural mechanisms for binding and activation of a contact-quenched fluorophore by RhoBAST

NATURE COMMUNICATIONS

IF15.7

2024-05-172

OAAI

Molecular mechanism of specific HLA-A mRNA recognition by the RNA-binding-protein hMEX3B to promote tumor immune escape

COMMUNICATIONS BIOLOGY

IF5.1

2024-02-070

OAAI

Structural and dynamic mechanisms for coupled folding and tRNA recognition of a translational T-box riboswitch

翻译t-box核糖开关的折叠和tRNA识别偶联的结构和动力学机制

NATURE COMMUNICATIONS

IF15.7

2023-11-154

OAAI

A single amino acid substitution in the capsid protein of Zika virus contributes to a neurovirulent phenotype

NATURE COMMUNICATIONS

IF15.7

2023-10-264

OAAI

RNA structure determination: From 2D to 3D

FUNDAMENTAL RESEARCH

IF6.3

2023-09-0113

OAAI

A review on recent advances in methods for site-directed spin labeling of long RNAs

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

IF8.5

2023-06-013

PRE

Structural insights into translation regulation by the THF-II riboswitch

NUCLEIC ACIDS RESEARCH

IF13.1

2023-01-097

OAAI

Phosphorothioate-Based Site-Specific Labeling of Large RNAs for Structural and Dynamic Studies

ACS CHEMICAL BIOLOGY

IF3.8

2022-09-0712

Long-range distance determination in fully deuterated RNA with pulsed EPR spectroscopy

BIOPHYSICAL JOURNAL

IF3.1

2022-01-0118

OAAI

Pseudoknot length modulates the folding, conformational dynamics, and robustness of Xrn1 resistance of flaviviral xrRNAs

假结长度调节黄病毒xrrna的Xrn1抗性的折叠，构象动力学和稳健性

NATURE COMMUNICATIONS

IF15.7

2021-11-0519

OAAI

Structural mechanism for modulation of functional amyloid and biofilm formation by Staphylococcal Bap protein switch

EMBO JOURNAL

IF8.3

2021-05-2818

A novel partially open state of SHP2 points to a multiple gear regulation mechanism

JOURNAL OF BIOLOGICAL CHEMISTRY

IF3.9

2021-01-0124

OAAI

Revisiting Bap Multidomain Protein: More Than Sticking Bacteria Together

FRONTIERS IN MICROBIOLOGY

IF4.5

2020-12-2321

OAAI

Molecular mechanisms underlying the extreme mechanical anisotropy of the flaviviral exoribonuclease-resistant RNAs (xrRNAs)

黄病毒外切核糖核酸酶抗性rna (xrrna) 的极端机械各向异性的分子机制

NATURE COMMUNICATIONS

IF15.7

2020-10-3014

OAAI

Site-specific covalent labeling of large RNAs with nanoparticles empowered by expanded genetic alphabet transcription

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

IF9.1

2020-08-3116

OAAI

研究方向

RNA整合结构生物学RNA高级结构研究RNA疗法构象动态RNA高级结构研究新方法与新方案的开发体外与活细胞内RNA的位点特异性与区段选择性标记技术环状RNA的制备技术活细胞内RNA高级结构研究的方法长链RNA高级结构与功能研究电子顺磁共振/核磁共振技术X射线晶体学单分子荧光共振能量转移X射线散射干涉以及计算模拟等)，开展致病病毒 (包括黄病毒冠状病毒RNA致病细菌(如结核杆菌)RNA神经退行性疾病相关RNA结构RNA构象动态与功能研究单分子纳米孔技术等)与系综技术(包括小角射线电子顺磁共振RNA的构象动态与功能关系研究靶向RNA与基于RNA的新疗法开发RNA的稳定化技术mRNA分子的理性设计和优化策略RNA靶向降解技术RNA结合蛋白靶向降解