Henry I. Mosberg - Publications, H-index & Citations

Henry I. Mosberg

university of michigan

54H指数

223论文数

1.3W被引数

收录论文 66

发表时间

High potency μ-opioid receptor agonists engage sodium-bound receptor states 高活性μ-阿片受体激动剂激活钠离子结合的受体状态

Molecular Pharmacology

IF3

2026-08-24

OAAI

Alexander J. Powell; Nicholas W. Griggs; Jorge A. Iñiguez-Lluhí; Henry I. Mosberg; John R. Traynor

IF0

2026-04-27

PREAI

Jessica P. Anand; Kelsey E. Kochan; Deanna Montgomery; Anthony F. Nastase; Henry I. Mosberg; Emily M. Jutkiewicz

SAR Matrices Enable Discovery of Mixed Efficacy μ-Opioid Receptor Agonist Peptidomimetics with Simplified Structures through an Aromatic-Amine Pharmacophore SAR矩阵可以通过芳香胺药效团发现具有简化结构的混合功效 μ 阿片受体激动剂肽模拟物

ACS CHEMICAL NEUROSCIENCE

IF3.9

2020-12-21

OAAI

Henry, Sean; Anand, Jessica P.; Brinkel, Ashley C.; McMillan, Douglas M.; Twarozynski, Jack J.; Loo, Christian E.; Traynor, John R.; Mosberg, Henry, I

Aromatic-Amine Pendants Produce Highly Potent and Efficacious Mixed Efficacy μ-Opioid Receptor (MOR)/δ-Opioid Receptor (DOR) Peptidomimetics with Enhanced Metabolic Stability

JOURNAL OF MEDICINAL CHEMISTRY

IF6.8

2020-01-27

OAAI

Henry, Sean; Anand, Jessica P.; Twarozynski, Jack J.; Brinkel, Ashley C.; Pogozheva, Irina D.; Sears, Bryan F.; Jutkiewicz, Emily M.; Traynor, John R.; Mosberg, Henry, I

Incorporation of Agouti-Related Protein (AgRP) Human Single Nucleotide Polymorphisms (SNPs) in the AgRP-Derived Macrocyclic Scaffold c[Pro-Arg-Phe-Phe-Asn-Ala-Phe-DPro] Decreases Melanocortin-4 Receptor Antagonist Potency and Results in the Discovery of Melanocortin-5 Receptor Antagonists

JOURNAL OF MEDICINAL CHEMISTRY

IF6.8

2019-12-17

OAAI

Koerperich, Zoe M.; Ericson, Mark D.; Freeman, Katie T.; Speth, Robert C.; Pogozheva, Irina D.; Mosberg, Henry, I; Haskell-Luevano, Carrie

Structure-Activity Relationships of 7-Substituted Dimethyltyrosine-Tetrahydroisoquinoline Opioid Peptidomimetics

MOLECULES

IF4.6

2019-11-26

OAAI

Montgomery, Deanna; Anand, Jessica P.; Baber, Mason A.; Twarozynski, Jack J.; Hartman, Joshua G.; Delong, Lennon J.; Traynor, John R.; Mosberg, Henry I.

Novel Dimethyltyrosine-Tetrahydroisoquinoline Peptidomimetics with Aromatic Tetrahydroisoquinoline Substitutions Show in Vitro Kappa and Mu Opioid Receptor Agonism

ACS CHEMICAL NEUROSCIENCE

IF3.9

2019-06-14

OAAI

Montgomery, Deanna; Anand, Jessica P.; Griggs, Nicholas W.; Fernandez, Thomas J.; Hartman, Joshua G.; Sanchez-Santiago, Ashley A.; Pogozheva, Irina D.; Traynor, John R.; Mosberg, Henry, I

Structural Simplification of a Tetrahydroquinoline-Core Peptidomimetic μ-Opioid Receptor (MOR) Agonist/δ-Opioid Receptor (DOR) Antagonist Produces Improved Metabolic Stability

JOURNAL OF MEDICINAL CHEMISTRY

IF6.8

2019-03-29

OAAI

Henry, Sean P.; Fernandez, Thomas J.; Anand, Jessica P.; Griggs, Nicholas W.; Traynor, John R.; Mosberg, Henry I.

Dual Pharmacophores Explored via Structure-Activity Relationship (SAR) Matrix: Insights into Potent, Bifunctional Opioid Ligand Design

JOURNAL OF MEDICINAL CHEMISTRY

IF6.8

2019-03-27

OAAI

Nastase, Anthony F.; Anand, Jessica P.; Bender, Aaron M.; Montgomery, Deanna; Griggs, Nicholas W.; Fernandez, Thomas J.; Jutkiewicz, Emily M.; Traynor, John R.; Mosberg, Henry I.

In vivo effects of -opioid receptor agonist/δ-opioid receptor antagonist peptidomimetics following acute and repeated administration

BRITISH JOURNAL OF PHARMACOLOGY

IF7.7

2018-04-24

OAAI

Anand, Jessica P.; Kochan, Kelsey E.; Nastase, Anthony F.; Montgomery, Deanna; Griggs, Nicholas W.; Traynor, John R.; Mosberg, Henry I.; Jutkiewicz, Emily M.

Synthesis and Pharmacological Evaluation of Novel C-8 Substituted Tetrahydroquinolines as Balanced-Affinity Mu/Delta Opioid Ligands for the Treatment of Pain

ACS CHEMICAL NEUROSCIENCE

IF3.9

2018-04-20

OAAI

Nastase, Anthony F.; Griggs, Nicholas W.; Anand, Jessica P.; Fernandez, Thomas J.; Harland, Aubrie A.; Trask, Tyler J.; Jutkiewicz, Emily M.; Traynor, John R.; Mosberg, Henry, I

PerMM: Web Server and Database for Prediction of Membrane Permeability and Translocation Pathways of Molecules

BIOPHYSICAL JOURNAL

IF3.1

2018-02-01

OAAI

Pogozheva, Irina D.; Mosberg, Henry I.; Lomize, Andrei

Placement of Hydroxy Moiety on Pendant of Peptidomimetic Scaffold Modulates Mu and Kappa Opioid Receptor Efficacy

ACS CHEMICAL NEUROSCIENCE

IF3.9

2017-08-10

OAAI

Harland, Aubrie A.; Pogozheva, Irina D.; Griggs, Nicholas W.; Trask, Tyler J.; Traynor, John R.; Mosberg, Henry I.

Effects of N-Substitutions on the Tetrahydroquinoline (THQ) Core of Mixed-Efficacy μ-Opioid Receptor (MOR)/δ-Opioid Receptor (DOR) Ligands

JOURNAL OF MEDICINAL CHEMISTRY

IF6.8

2016-05-16

OAAI

Harland, Aubrie A.; Bender, Aaron M.; Griggs, Nicholas W.; Gao, Chao; Anand, Jessica P.; Pogozheya, Irma D.; Traynor, John R.; Jutkiewicz, Emily M.; Mosberg, Henry I.

The behavioral effects of a mixed efficacy antinociceptive peptide, VRP26, following chronic administration in mice

PSYCHOPHARMACOLOGY

IF3.3

2016-04-27

OAAI

Anand, Jessica P.; Boyer, Brett T.; Mosberg, Henry I.; Jutkiewicz, Emily M.

Further Optimization and Evaluation of Bioavailable, Mixed-Efficacy μ-Opioid Receptor (MOR) Agonists/δ-Opioid Receptor (DOR) Antagonists: Balancing MOR and DOR Affinities

JOURNAL OF MEDICINAL CHEMISTRY

IF6.8

2015-11-13

OAAI

Harland, Aubrie A.; Yeomans, Larisa; Griggs, Nicholas W.; Anand, Jessica P.; Pogozheva, Irina D.; Jutkiewicz, Emily M.; Traynor, John R.; Mosberg, Henry I.

Rapid Synthesis of Boc-2′,6′-dimethyl-L-tyrosine and Derivatives and Incorporation into Opioid Peptidomimetics

ACS MEDICINAL CHEMISTRY LETTERS

IF4

2015-10-21

OAAI

Bender, Aaron M.; Griggs, Nicholas W.; Gao, Chao; Trask, Tyler J.; Traynor, John R.; Mosberg, Henry I.

Use of Functional Polymorphisms To Elucidate the Peptide Binding Site of TAP Complexes

JOURNAL OF IMMUNOLOGY

IF3.4

2015-10-01

OAAI

Geng, Jie; Pogozheva, Irina D.; Mosberg, Henry I.; Raghavan, Malini

Asymmetric Synthesis and in Vitro and in Vivo Activity of Tetrahydroquinolines Featuring a Diverse Set of Polar Substitutions at the 6 Position as Mixed-Efficacy μ Opioid Receptor/δ Opioid Receptor Ligands 四氢喹啉的不对称合成以及在6位具有多种极性取代的混合功效 μ 阿片受体/δ 阿片受体配体的体内和体外活性

ACS CHEMICAL NEUROSCIENCE

IF3.9

2015-05-13

OAAI

Bender, Aaron M.; Griggs, Nicholas W.; Anand, Jessica P.; Traynor, John R.; Jutkiewicz, Emily M.; Mosberg, Henry I.

Selectively Promiscuous Opioid Ligands: Discovery of High Affinity/Low Efficacy Opioid Ligands with Substantial Nociceptin Opioid Peptide Receptor Affinity

JOURNAL OF MEDICINAL CHEMISTRY

IF6.8

2014-05-09

OAAI

Kumar, Vinod; Ridzwan, Irna E.; Grivas, Konstantinos; Lewis, John W.; Clark, Mary J.; Meurice, Claire; Jimenez-Gomez, Corina; Pogozheva, Irina; Mosberg, Henry; Traynor, John R.; Husbands, Stephen M.

研究方向