Malcolm D. Walkinshaw - Publications, H-index & Citations

Malcolm D. Walkinshaw

University of Edinburgh

63H指数

478论文数

1.3W被引数

收录论文 55

发表时间

Democratized Discovery of Microsclerodermin F as an Immunophilin Ligand 平民化发现 Microsclerodermin F 作为免疫亲和素配体

Marine Drugs 2025, Vol. 23, Page 336

IF5.4

2025-09-20

OAAI

Manfred Auer; Malcolm D. Walkinshaw; Jacqueline Dornan; Nhan T. Pham; Xinru Xue; Miaomiao Liu; Ronald J. Quinn; Eric M. Ross; Abimael D. Rodríguez; James J. La Clair

The unusual kinetics of lactate dehydrogenase of Schistosoma mansoni and their role in the rapid metabolic switch after penetration of the mammalian host

INTERNATIONAL JOURNAL FOR PARASITOLOGY

IF3.2

2024-06-01

OAAI

Bexkens, Michiel L.; Martin, Olivier M. F.; Heuvel, Jos M. van den; Schmitz, Marion G. J.; Teusink, Bas; Bakker, Barbara M.; Hellemond, Jaap J. van; Haanstra, Jurgen R.; Walkinshaw, Malcolm D.; Tielens, Aloysius G. M.

Peripheral blood immune cell profiling of acute corneal transplant rejection

AMERICAN JOURNAL OF TRANSPLANTATION

IF8.2

2022-10-01

OAAI

Hjortdal, Jesper; Griffin, Matthew D.; Cadoux, Marion; Armitage, W. John; Bylesjo, Max; Gabhann, Peadar Mac; Murphy, Conor C.; Pleyer, Uwe; Tole, Derek; Vabres, Bertrand; Walkinshaw, Malcolm D.; Gourraud, Pierre-Antoine; Karakachoff, Matilde; Brouard, Sophie; Degauque, Nicolas

Fast acting allosteric phosphofructokinase inhibitors block trypanosome glycolysis and cure acute African trypanosomiasis in mice 速效变构磷酸果糖激酶抑制剂阻断锥虫糖酵解并治愈小鼠急性非洲锥虫病

NATURE COMMUNICATIONS

IF15.7

2021-02-16

OAAI

McNae, Iain W.; Kinkead, James; Malik, Divya; Yen, Li-Hsuan; Walker, Martin K.; Swain, Chris; Webster, Scott P.; Gray, Nick; Fernandes, Peter M.; Myburgh, Elmarie; Blackburn, Elizabeth A.; Ritchie, Ryan; Austin, Carol; Wear, Martin A.; Highton, Adrian J.; Keats, Andrew J.; Vong, Antonio; Dornan, Jacqueline; Mottram, Jeremy C.; Michels, Paul A. M.; Pettit, Simon; Walkinshaw, Malcolm D.

Biochemical and transcript level differences between the three human phosphofructokinases show optimisation of each isoform for specific metabolic niches 三种人类磷酸果糖激酶之间的生化和转录水平差异显示了特定代谢生态位的每种同工型的优化

BIOCHEMICAL JOURNAL

IF4.3

2020-11-27

OAAI

Fernandes, Peter M.; Kinkead, James; McNae, Iain; Michels, Paul A. M.; Walkinshaw, Malcolm D.

Kinetic and structural studies of Trypanosoma and Leishmania phosphofructokinases show evolutionary divergence and identify AMP as a switch regulating glycolysis versus gluconeogenesis 锥虫和利什曼原虫磷酸果糖激酶的动力学和结构研究显示出进化差异，并将AMP确定为调节糖酵解与糖异生的开关

FEBS JOURNAL

IF4.2

2020-01-08

OAAI

Fernandes, Peter M.; Kinkead, James; McNae, Iain W.; Vasquez-Valdivieso, Monserrat; Wear, Martin A.; Michels, Paul A. M.; Walkinshaw, Malcolm D.

Dynamic design: manipulation of millisecond timescale motions on the energy landscape of cyclophilin A

CHEMICAL SCIENCE

IF7.4

2020-01-01

OAAI

Juarez-Jimenez, Jordi; Gupta, Arun A.; Karunanithy, Gogulan; Mey, Antonia S. J. S.; Georgiou, Charis; Ioannidis, Harris; De Simone, Alessio; Barlow, Paul N.; Hulme, Alison N.; Walkinshaw, Malcolm D.; Baldwin, Andrew J.; Michel, Julien

Allosteric effects in cyclophilin mutants may be explained by changes in nano-microsecond time scale motions

COMMUNICATIONS CHEMISTRY

IF6.2

2019-03-29

OAAI

Wapeesittipan, Pattama; Mey, Antonia S. J. S.; Walkinshaw, Malcolm D.; Michel, Julien

The kinetic characteristics of human and trypanosomatid phosphofructokinases for the reverse reaction 逆转反应的人和锥虫磷酸果糖激酶的动力学特征

BIOCHEMICAL JOURNAL

IF4.3

2019-01-18

OAAI

Fernandes, Peter M.; Kinkead, James; McNae, Iain W.; Bringaud, Frederic; Michels, Paul A. M.; Walkinshaw, Malcolm D.

A computationally designed binding mode flip leads to a novel class of potent tri-vector cyclophilin inhibitors

CHEMICAL SCIENCE

IF7.4

2019-01-01

OAAI

De Simone, Alessio; Georgiou, Charis; Ioannidis, Harris; Gupta, Arun A.; Juarez-Jimenez, Jordi; Doughty-Shenton, Dahlia; Blackburn, Elizabeth A.; Wear, Martin A.; Richards, Jonathan P.; Barlow, Paul N.; Carragher, Neil; Walkinshaw, Malcolm D.; Hulme, Alison N.; Michel, Julien

Redox regulation of pyruvate kinase M2 by cysteine oxidation and S-nitrosation 半胱氨酸氧化和S-亚硝化对丙酮酸激酶M2的氧化还原调节

BIOCHEMICAL JOURNAL

IF4.3

2018-10-31

OAAI

Mitchell, Alice Rose; Yuan, Meng; Morgan, Hugh P.; McNae, Iain W.; Blackburn, Elizabeth A.; Le Bihan, Thierry; Homem, Rafael A.; Yu, Manda; Loake, Gary J.; Michels, Paul A.; Wear, Martin A.; Walkinshaw, Malcolm D.

An allostatic mechanism for M2 pyruvate kinase as an amino-acid sensor M2丙酮酸激酶作为氨基酸传感器的同种异体机制

BIOCHEMICAL JOURNAL

IF4.3

2018-05-31

OAAI

Yuan, Meng; McNae, Iain W.; Chen, Yiyuan; Blackburn, Elizabeth A.; Wear, Martin A.; Michels, Paul A. M.; Fothergill-Gilmore, Linda A.; Hupp, Ted; Walkinshaw, Malcolm D.

Molecular dynamics simulations of site point mutations in the TPR domain of cyclophilin 40 identify conformational states with distinct dynamic and enzymatic properties

JOURNAL OF CHEMICAL PHYSICS

IF3.1

2018-04-09

OAAI

Gur, Mert; Blackburn, Elizabeth A.; Ning, Jia; Narayan, Vikram; Ball, Kathryn L.; Walkinshaw, Malcolm D.; Erman, Burak

Allosteric pyruvate kinase-based logic gate synergistically senses energy and sugar levels in Mycobacterium tuberculosis

NATURE COMMUNICATIONS

IF15.7

2017-12-07

OAAI

Zhong, Wenhe; Cui, Liang; Goh, Boon Chong; Cai, Qixu; Ho, Peiying; Chionh, Yok Hian; Yuan, Meng; El Sahili, Abbas; Fothergill-Gilmore, Linda A.; Walkinshaw, Malcolm D.; Lescar, Julien; Dedon, Peter C.

MeCP2 recognizes cytosine methylated tri-nucleotide and di-nucleotide sequences to tune transcription in the mammalian brain

PLOS GENETICS

IF3.7

2017-05-12

112

OAAI

Lagger, Sabine; Connelly, John C.; Schweikert, Gabriele; Webb, Shaun; Selfridge, Jim; Ramsahoye, Bernard H.; Yu, Miao; He, Chuan; Sanguinetti, Guido; Sowers, Lawrence C.; Walkinshaw, Malcolm D.; Bird, Adrian

Design of nucleotide-mimetic and non-nucleotide inhibitors of the translation initiation factor eIF4E: Synthesis, structural and functional characterisation 翻译起始因子eIF4E的核苷酸模拟和非核苷酸抑制剂的设计: 合成，结构和功能表征

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

IF5.9

2016-11-01

OAAI

Soukarieh, Fadi; Nowicld, Matthew W.; Bastide, Amandine; Poyry, Tuija; Jones, Carolyn; Dudek, Kate; Patwardhan, Geetanjali; Meullenet, Francois; Oldham, Neil J.; Walkinshaw, Malcolm D.; Willis, Anne E.; Fischer, Peter M.

Protein-Protein Interactions Modulate the Docking-Dependent E3-Ubiquitin Ligase Activity of Carboxy-Terminus of Hsc70-Interacting Protein (CHIP)

MOLECULAR & CELLULAR PROTEOMICS

IF5.5

2015-11-01

OAAI

Narayan, Vikram; Landre, Vivien; Ning, Jia; Hernychova, Lenka; Muller, Petr; Verma, Chandra; Walkinshaw, Malcolm D.; Blackburn, Elizabeth A.; Ball, Kathryn L.

Cyclophilin40 isomerase activity is regulated by a temperature-dependent allosteric interaction with Hsp90

BIOSCIENCE REPORTS

IF4.7

2015-10-19

OAAI

Blackburn, Elizabeth A.; Wear, Martin A.; Landre, Vivian; Narayan, Vikram; Ning, Jia; Erman, Burak; Ball, Kathryn L.; Walkinshaw, Malcolm D.

A Molecular Dynamics Study of Allosteric Transitions in Leishmania mexicana Pyruvate Kinase 墨西哥利什曼原虫丙酮酸激酶变构转变的分子动力学研究

BIOPHYSICAL JOURNAL

IF3.1

2015-09-01

OAAI

Naithani, Ankita; Taylor, Paul; Erman, Burak; Walkinshaw, Malcolm D.

Inhibition of the ERCC1-XPF structure-specific endonuclease to overcome cancer chemoresistance

DNA REPAIR

IF2.7

2015-07-01

OAAI

McNeil, Ewan M.; Astell, Katy R.; Ritchie, Ann-Marie; Shave, Steven; Houston, Douglas R.; Bakrania, Preeti; Jones, Hayley M.; Khurana, Puneet; Wallace, Claire; Chapman, Tim; Wear, Martin A.; Walkinshaw, Malcolm D.; Saxty, Barbara; Melton, David W.

研究方向