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陆

陆小云 (Xiaoyun Lu)

jinan university

39H指数
198论文数
5.2K被引数
收录论文 128
发表时间
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Covalent Recruitment of E3 Ligases: A New Path for Rational Design of Protein Degraders共价招募E3连接酶：蛋白质降解剂理性设计的新途径
errMedicinal Research Reviews
IF11.6
err2026-10-08
err0
PREAI
errZiyan Yu; Jianqiang Zhang; Man Tong; Lanlan Zang; Jie Sun; Xiaoyun Lu
err分享
err收藏
Dual-Site Covalent Targeting Enables BD2-Selective BET Inhibition With Potent Antitumor Activity in Mice双位点共价靶向实现BD2选择性BET抑制，并展现强大的抗肿瘤活性（小鼠）
errAngewandte Chemie-International Edition
IF16.9
err2026-09-05
err0
PREAI
errJibo Kang; Xuan Wang; Hong Zhang; Jieying Lin; Peng Chen; Zuqin Wang; Zengjun Hao; Fengfei Miao; Fengcai Zhang; Tao Li; Yusheng Xie; Junjian Wang; Zhi-Min Zhang; Shao Q. Yao; Xiaoyun Lu
err分享
err收藏
p38β-mediated BiP phosphorylation drives stemness and chemoresistance by suppressing UPR activation in hepatocellular carcinomap38β介导的BiP磷酸化通过抑制UPR激活驱动肝细胞癌的干细胞特性和化疗耐药性
errNature Communications
IF15.7
err2026-08-05
err0
errOAAI
errLiang Xu; Ianto Bosheng Huang; Minghe Zhang; Yunong Xie; Bing Li; Linglin Liu; Long Hin Ng; Yimiao He; Yan Liu; Tin-Lok Wong; Xiaoyun Lu; Terence Kin-Wah Lee; Jing-Ping Yun; Lei Jin; Stephanie Ma; Man Tong
err分享
err收藏
Development of a Scalable Synthesis for the Spirocyclic Benzoxepane–Pyridine Core of FXR Agonist HEC96719开发一种可扩展合成方法用于FXR激动剂HEC96719螺环苯并氧杂环庚烷-吡啶核心
errORGANIC PROCESS RESEARCH & DEVELOPMENT
IF3.5
err2026-07-01
err0
PREAI
errJiayang Zhang; Junwen Wu; Shengqiang Pan; Hong Chen; Zhongqing Wang; Xiaoyun Lu; Xinye Yang; Yingjun Zhang
err分享
err收藏
Large-Scale Profiling of Kinase Degradation by Using Norbornene-Based Hydrophobic Tag (HyT) Strategy基于降冰片烯基疏水标签（HyT）策略的大规模激酶降解分析
errAngewandte Chemie-International Edition
IF16.9
err2026-04-01
err0
PREAI
errGu, Mingxi; Miao, Fengfei; Peng, Lvyang; Sun, Jie; Chen, Peng; Yang, Fang; Yan, Jiachang; Gao, Liqian; Lu, Xiaoyun; Yao, Shao Q.; Yuan, Peiyan
err分享
err收藏
Discovery of a Potent RXRγ Degrader WCF-598 for the Treatment of Castration-Resistant Prostate Cancer发现一种用于治疗去势抵抗性前列腺癌的高效RXRγ降解剂WCF-598
errJournal of Medicinal Chemistry
IF6.8
err2026-03-20
err0
PREAI
errChaofan Wang; Jieying Lin; Junping Pei; Zhanfang Kang; Zhuoheng Liu; Junwei Li; Guodi Cai; Yang Zhou; Junjian Wang; Hong Wang; Xiaoyun Lu
err分享
err收藏
Structure-Based Design of 4-(1-Methyl-1H-indol-3-yl)pyrimidin-2-amine Derivatives as the First Covalent FGFR3 Selective Inhibitors4-(1-甲基-1h-吲哚-3-基) pyrimidin-2-amine衍生物作为第一个共价FGFR3选择性抑制剂的结构设计
errJournal of Medicinal Chemistry
IF6.8
err2026-02-06
err0
PREAI
errWenjian Zhu; Xiaojuan Chen; Xiaofei Li; Jieying Lin; Xiaojing Lin; Xueru Liu; Wuqing Deng; Xiaojuan Song; Zhengchao Tu; Adam V. Patterson; Jeff B. Smaill; Yongheng Chen; Xiaoyun Lu
err分享
err收藏
Macrocycle-DB: a comprehensive database for macrocycle-based drug discoveryMacrocycle-DB：一个用于基于大环化合物的药物发现的综合数据库
errNUCLEIC ACIDS RESEARCH
IF13.1
err2025-11-01
err1
PREAI
errJiang, Minchuan; Liu, Tianyue; Hussain, Muzammal; Luo, Yixin; Zheng, Rui; Hou, Tingjun; Lu, Xiaoyun; Zhou, Yang
err分享
err收藏
WEE-family kinases in cancer: synthetic lethal interactions and drug discoveryWEE家族激酶在癌症中的作用：合成致死相互作用与药物发现
errTrends in Pharmacological Sciences
IF19.9
err2025-10-21
err0
PREAI
errChaofan Wang; Xiaoyun Lu
err分享
err收藏
Highly Ordered DNA Framework Interface Enables Efficient Enzymatic Oligonucleotide Synthesis高度有序的DNA框架界面能够实现高效的酶促寡核苷酸合成
errAdvanced Science
IF14.1
err2025-09-03
err0
errOAAI
errKunjie Li; Dongbao Tang; Xiaoyun Lu; Xinyao Yang; Luxuan Liu; Zhaoyuan Jia; Zhi Zhu; Yuyu Tan; Huimin Zhang; Chaoyong Yang
err分享
err收藏
Cell-Active, Irreversible Covalent Inhibitors Targeting a Surface-Exposed Non-Catalytic Lysine on Aurora a Kinase by Using Squarate Chemistry细胞活性、不可逆共价抑制剂通过使用四嗪化学靶向Aurora a激酶表面暴露的非催化赖氨酸
errAngewandte Chemie International Edition
IF0
err2025-08-28
err0
PREAI
errZuqin Wang; Xuan Wang; Yong Li; Peishan Li; Shengjie Huang; Peng Chen; Guanghui Tang; Xiaotong Ding; Prof. Dr. Zhang Zhang; Prof. Dr. Zhi-Min Zhang; Prof. Dr. Yang Zhou; Prof. Dr. Shao Q. Yao; Prof. Dr. Xiaoyun Lu
err分享
err收藏
Dynamic Modulation of Multicellular Interactions via ATP-Dissipative DNA Assembly通过ATP耗散DNA组装对多细胞间相互作用进行动态调控
errJournal of the American Chemical Society
IF15.6
err2025-07-23
err0
PREAI
errYi Xu; Yao Luo; Xiaoyun Lu; Jingyi Ye; Zeyu Chen; Yao Hu; Chen Shen; Bin Zhao; Erfeng Kou; Jie Deng; Chunhai Fan; Huan Zhang; Honglu Zhang
err分享
err收藏
Comprehensive Drug-Likeness Prediction Using a Pretrained Transformer Model and Multitask Learning基于预训练Transformer模型和多任务学习的全面药物相似性预测
errJOURNAL OF CHEMICAL INFORMATION AND MODELING
IF5.3
err2025-05-20
err0
PREAI
errCai, Yi; Zhang, Qian; Tan, Wenchong; Li, Jing; Chen, Dong; Lu, Xiaoyun
err分享
err收藏
Design, synthesis and evaluation of diarylidenyl piperidone-ligated platinum (IV) complexes as chemoimmunotherapeutic agents
errEUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
IF5.9
err2025-04-01
err0
PREAI
errMao, Zhi-Chen; Chen, Lei; Chen, Xiao-Man; Lu, Xiao-Yun; Mo, Zu-Yu; Gou, Yi; Wei, Jian-Hua; Huang, Ri-Zhen; Zhang, Ye
err分享
err收藏
Designing Macrocyclic Kinase Inhibitors Using Macrocycle Scaffold Hopping with Reinforced Learning (Macro-Hop)使用宏观骨架跳跃（Macro-Hop）与强化学习设计大环激酶抑制剂
errJOURNAL OF MEDICINAL CHEMISTRY
IF6.8
err2025-03-18
err0
PREAI
errLiang, Hong; Huang, Shengjie; Xu, Xinxin; Yin, Zhao; Hussain, Muzammal; Song, Xiaojuan; Yi, Jianqiao; He, Yingqi; Guo, Jing; Tu, Zhengchao; Zhang, Zhang; Zhou, Yang; Lu, Xiaoyun
err分享
err收藏
A patent review of small molecular inhibitors targeting EGFR exon 20 insertion (Ex20ins) (2019-present)
errEXPERT OPINION ON THERAPEUTIC PATENTS
IF4.6
err2024-12-27
err0
PREAI
errZhu, Wenjian; Pei, Junping; Lu, Xiaoyun
err分享
err收藏
Pharmacological targeting of casein kinase 1δ suppresses oncogenic NRAS-driven melanoma
errNATURE COMMUNICATIONS
IF15.7
err2024-11-21
err0
errOAAI
errWen, Yalei; Wang, Hui; Yang, Xiao; Zhu, Yingjie; Li, Mei; Ma, Xiuqing; Huang, Lei; Wan, Rui; Zhang, Caishi; Li, Shengrong; Jia, Hongling; Guo, Qin; Lu, Xiaoyun; Li, Zhengqiu; Shen, Xiangchun; Zhang, Qiushi; Si, Lu; Yin, Chengqian; Liu, Tongzheng
err分享
err收藏
Design, Synthesis, and Biological Evaluation of Novel Diaminopyrimidine Macrocycles as Fourth Generation Reversible EGFR Inhibitors That Overcome Clinical Resistance to Osimertinib Mediated by C797S Mutation
errJOURNAL OF MEDICINAL CHEMISTRY
IF6.8
err2024-11-13
err0
PREAI
errHu, Shiliang; Tong, Linjiang; Qin, Qiao; Wen, Jiaxin; Li, Yan; Feng, Fang; Wu, Kunzhong; Zhou, Yang; Shang, Jinsai; Wang, Junjian; Liu, Jinbao; Xie, Hua; Lu, Xiaoyun
err分享
err收藏
Multidisciplinary Training for Fostering Next-Generation Medicinal Chemists
errJOURNAL OF MEDICINAL CHEMISTRY
IF6.8
err2024-10-07
err1
errOAAI
errYu, Bin; Lu, Xiaoyun; Chang, Junbiao
err分享
err收藏
paper Design, synthesis and biological evaluation of 5-amino-1 H-pyrazole-4-carboxamide derivatives as pan-FGFR covalent inhibitors
errEUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
IF5.9
err2024-09-01
err1
PREAI
errDeng, Wuqing; Chen, Xiaojuan; Liang, Hong; Song, Xiaojuan; Xiang, Shuang; Guo, Jing; Tu, Zhengchao; Zhou, Yang; Chen, Yongheng; Lu, Xiaoyun
err分享
err收藏

研究方向

新型激酶抑制剂的发现研究诱导耐药突变激酶抑制剂的发现研究激酶抑制剂的计算设计方法研究
合作学者
合作期刊
樊春海 封面图
樊春海 (Chunhai Fan)
H 指数: 148 · 论文数: 1.2K
X
Xun Xu
H 指数: 148 · 论文数: 1.1K
Shaomeng Wang 封面图
Shaomeng Wang (Shaomeng Wang)
H 指数: 101 · 论文数: 1.0K
J
Jinsong Liu
H 指数: 98 · 论文数: 1.1K
C
Chaoyong Yang
H 指数: 97 · 论文数: 741
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