Roberto A. Chica - Publications, H-index & Citations

Roberto A. Chica

University of Ottawa

22H指数

82论文数

2.2K被引数

收录论文 23

发表时间

Protein engineering: status report 蛋白质工程：现状报告

Protein Engineering, Design and Selection

IF0

2026-07-17

OAAI

Hui-wang Ai; Frances H Arnold; Doug Barrick; Hagan Bayley; Alfie-Louise R Brownless; Robert E Campbell; Roger Castells-Graells; Pimchai Chaiyen; Roberto A Chica; Lauren O Chisholm; Daniel Christ; Guo-Chao Chu; Michael Chungyoun; Vincent G H Eijsink; Michael B Elowitz; Douglas J Fansher; Rudi Fasan; Gabriel Foley; Michelle S Frei; Andreas Gagsteiger; Ruiyan Gao; Elizabeth M J Gillam; Jeffrey J Gray; Luis F Guerra; Birte Höcker; Zhiyang Jin; Shina Caroline Lynn Kamerlin; Nobuyasu Koga; Roland E Kontermann; Brian Kuhlman; Olivia A Langlois; Dongyang Li; Roberto D Lins; Chang C Liu; Lei Liu; Diego López Barreiro; Peilong Lu; Sohum Mehta; Ikumi Miyazaki; Manuel M Müller; Serge Muyldermans; Naoto Nemoto; Jeff Nivala; James K Nuñez; Izaiah J Ornelas; Joelle N Pelletier; Andreas Plückthun; Owen T Porth; Kridsadakorn Prakinee; Yujia Qing; Julia C Reisenbauer; Sandy Schmidt; Oliver Seifert; Mikhail G Shapiro; Rachna Sharma; Nilmani Singh; Benjamin J Smith; Jamie B Spangler; Rie Tatsumi-Koga; Takuya Terai; Henrik Terholsen; Mattias Tolhurst; Katherine W Tripp; Vanessa Tanja Trossmann; Chandra L Tucker; Onur Turak; James A Van Deventer; Anikó Várnai; Isabelle F T Viana; Amy M Weeks; K Dane Wittrup; Kingsley L-J Wong; Chenggang Xi; Todd O Yeates; Andy Hsien-Wei Yeh; Jin Zhang; Tiger S Zhang; Huimin Zhao; Fang Zheng; Jingyi Zhu; Sacha Zinn

Customizing the structure of minimal TIM barrels to craft efficient de novo enzymes 定制最小TIM桶结构以构建高效的从头设计酶

Nature Chemical Biology

IF13.7

2026-06-15

OAAI

Julian Beck; Benjamin J. Smith; Mark Kriegel; Niayesh Zarifi; Emily Freund; Ahana G. Harsha; Jan Hartmann; Roberto A. Chica; Birte Höcker

Design of Efficient Artificial Enzymes Using Crystallographically Enhanced Conformational Sampling

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

IF15.6

2024-03-27

OAAI

Rakotoharisoa, Rojo V.; Seifinoferest, Behnoush; Zarifi, Niayesh; Miller, Jack D. M.; Rodriguez, Joshua M.; Thompson, Michael C.; Chica, Roberto A.

What does it take for an 'AlphaFold Moment' in functional protein engineering and design?

NATURE BIOTECHNOLOGY

IF41.7

2024-02-15

PREAI

Chica, Roberto A.; Ferruz, Noelia

Generation of bright monomeric red fluorescent proteins via computational design of enhanced chromophore packing

CHEMICAL SCIENCE

IF7.4

2022-01-01

OAAI

Legault, Sandrine; Fraser-Halberg, Derek P.; McAnelly, Ralph L.; Eason, Matthew G.; Thompson, Michael C.; Chica, Roberto A.

Genetically Encoded Fluorescent Biosensor for Rapid Detection of Protein Expression 用于快速检测蛋白质表达的基因编码荧光生物传感器

ACS SYNTHETIC BIOLOGY

IF3.9

2020-10-12

OAAI

Eason, Matthew G.; Pandelieva, Antonia T.; Mayer, Marc M.; Khan, Safwat T.; Garcia, Hernan G.; Chica, Roberto A.

Ensemble-based enzyme design can recapitulate the effects of laboratory directed evolution in silico

NATURE COMMUNICATIONS

IF15.7

2020-09-23

OAAI

Broom, Aron; Rakotoharisoa, Rojo V.; Thompson, Michael C.; Zarifi, Niayesh; Nguyen, Erin; Mukhametzhanov, Nurzhan; Liu, Lin; Fraser, James S.; Chica, Roberto A.

Origin of conformational dynamics in a globular protein

COMMUNICATIONS BIOLOGY

IF5.1

2019-11-26

OAAI

Damry, Adam M.; Mayer, Marc M.; Broom, Aron; Goto, Natalie K.; Chica, Roberto A.

Designer sense-response systems

SCIENCE

IF45.8

2019-11-22

PREAI

Chica, Roberto A.

Computational Design of Multisubstrate Enzyme Specificity 多底物酶特异性的计算设计

ACS CATALYSIS

IF13.1

2019-05-09

PREAI

St-Jacques, Antony D.; Eyahpaise, Marie-Eve C.; Chica, Roberto A.

One-Pot Biocatalytic Synthesis of Substituted D-Tryptophans from Indoles Enabled by an Engineered Aminotransferase

ACS CATALYSIS

IF13.1

2019-03-15

OAAI

Parmeggiani, Fabio; Casamajo, Arnau Rue; Walton, Curtis J. W.; Galman, James L.; Turner, Nicholas J.; Chica, Roberto A.

Biocatalytic retrosynthesis approaches to d-(2,4,5-trifluorophenyl)alanine, key precursor of the antidiabetic sitagliptin

GREEN CHEMISTRY

IF9.2

2019-01-01

OAAI

Parmeggiani, Fabio; Casamajo, Arnau Rue; Colombo, Danilo; Ghezzi, Maria Chiara; Galman, James L.; Chica, Roberto A.; Brenna, Elisabetta; Turner, Nicholas J.

BIOCHEMISTRY Designer proteins activate fluorescence 生物化学设计蛋白激活荧光

NATURE

IF48.5

2018-09-12

OAAI

Chica, Roberto A.

Engineered Aminotransferase for the Production of d-Phenylalanine Derivatives Using Biocatalytic Cascades

CHEMCATCHEM

IF3.9

2017-12-05

OAAI

Walton, Curtis J. W.; Parmeggiani, Fabio; Barber, Janet E. B.; McCann, Jenna L.; Turner, Nicholas J.; Chica, Roberto A.

Rational design of proteins that exchange on functional timescales

NATURE CHEMICAL BIOLOGY

IF13.7

2017-10-23

OAAI

Davey, James A.; Damry, Adam M.; Goto, Natalie K.; Chica, Roberto A.

Structure-guided rational design of red fluorescent proteins: towards designer genetically-encoded fluorophores

CURRENT OPINION IN STRUCTURAL BIOLOGY

IF7

2017-08-01

PREAI

Eason, Matthew G.; Damry, Adam M.; Chica, Roberto A.

Brighter Red Fluorescent Proteins by Rational Design of Triple-Decker Motif

ACS CHEMICAL BIOLOGY

IF3.8

2016-01-05

PREAI

Pandelieva, Antonia T.; Baran, Miranda J.; Calderini, Guido F.; McCann, Jenna L.; Tremblay, Veronique; Sarvan, Sabina; Davey, James A.; Couture, Jean-Francois; Chica, Roberto A.

Improving the accuracy of protein stability predictions with multistate design using a variety of backbone ensembles

PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

IF2.8

2013-11-22

PREAI

Davey, James A.; Chica, Roberto A.

Bioanalysis for Biocatalysis: Multiplexed Capillary Electrophoresis-Mass Spectrometry Assay for Aminotransferase Substrate Discovery and Specificity Profiling

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

IF15.6

2013-09-05

PREAI

Mironov, Gleb G.; St-Jacques, Antony D.; Mungham, Alexander; Eason, Matthew G.; Chica, Roberto A.; Berezovski, Maxim V.

Iterative approach to computational enzyme design 计算酶设计的迭代方法

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

IF9.1

2012-02-22

321

OAAI

Privett, Heidi K.; Kiss, Gert; Lee, Toni M.; Blomberg, Rebecca; Chica, Roberto A.; Thomas, Leonard M.; Hilvert, Donald; Houk, Kendall N.; Mayo, Stephen L.

研究方向