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F

Frederik Rombouts

Johnson & Johnson
H指数:24
被引数:1,808

个人简介

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教育背景

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工作经历

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荣誉奖项

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Discovery of an Oral, Beyond-Rule-of-Five Mcl-1 Protein-Protein Interaction Modulator with the Potential of Treating Hematological Malignancies
JOURNAL OF MEDICINAL CHEMISTRY
IF6.8
2023-04-2810
PRE
Romanov-Michailidis, Fedor; Hsiao, Chien-Chi; Urner, Lorenz M.; Jerhaoui, Soufyan; Surkyn, Michel; Miller, Bradley; Vos, Ann; Blanco, Maria Dominguez; Bueters, Ruud; Vinken, Petra; Bekkers, Mariette; Walker, David; Pietrak, Beth; Eyckmans, Werner; Dores-Sousa, Jose Luis; Koo, Seong Joo; Lento, William; Bauser, Marcus; Philippar, Ulrike; Rombouts, Frederik J. R.
JNJ-67569762, A 2-Aminotetrahydropyridine-Based Selective BACE1 Inhibitor Targeting the S3 Pocket: From Discovery to Clinical Candidate
JOURNAL OF MEDICINAL CHEMISTRY
IF6.8
2021-09-2311
PREAI
Rombouts, Frederik J. R.; Kusakabe, Ken-ichi; Alexander, Richard; Austin, Nigel; Borghys, Herman; De Cleyn, Michel; Dhuyvetter, Deborah; Gijsen, Harrie J. M.; Hrupka, Brian; Jacobs, Tom; Jerhaoui, Soufyan; Lammens, Lieve; Leclercq, Laurent; Tsubone, Koichi; Ueno, Tatsuhiko; Morimoto, Kenji; Einaru, Shunsuke; Sumiyoshi, Hirokazu; Van den Bergh, An; Vos, Ann; Surkyn, Michel; Teisman, Ard; Moechars, Diederik
Structure-Based Approaches to Improving Selectivity through Utilizing Explicit Water Molecules: Discovery of Selective β-Secretase (BACE1) Inhibitors over BACE2
JOURNAL OF MEDICINAL CHEMISTRY
IF6.8
2021-03-1512
PRE
Fujimoto, Kazuki; Yoshida, Shuhei; Tadano, Genta; Asada, Naoya; Fuchino, Kouki; Suzuki, Shinji; Matsuoka, Eriko; Yamamoto, Takahiko; Yamamoto, Shiho; Ando, Shigeru; Kanegawa, Naoki; Tonomura, Yutaka; Ito, Hisanori; Moechars, Diederik; Rombouts, Frederik J. R.; Gijsen, Harrie J. M.; Kusakabe, Ken-ichi
Discovery of N-(4-[18F]Fluoro-5-methylpyridin-2-yl)isoquinolin-6-amine (JNJ-64326067), a New Promising Tau Positron Emission Tomography Imaging Tracer (vol 62, pg 2974, 2019)
JOURNAL OF MEDICINAL CHEMISTRY
IF6.8
2020-02-181
OAAI
Rombouts, Frederik J. R.; Declercq, Lieven; Andres, Jose-Ignacio; Bottelbergs, Astrid; Chen, Lu; Iturrino, Laura; Leenaerts, Joseph E.; Marien, Jonas; Song, Fengbin; Wintmolders, Cindy; Wuyts, Stijn; Xia, Chunfang A.; te Riele, Paula; Bormans, Guy; Vandenberghe, Rik; Kolb, Hartmuth; Moechars, Diederik
Evaluation of a Series of β-Secretase 1 Inhibitors Containing Novel Heteroaryl-Fused-Piperazine Amidine Warheads
ACS MEDICINAL CHEMISTRY LETTERS
IF4
2019-07-0227
OAAI
Oehlrich, Daniel; Peschiulli, Aldo; Tresadern, Gary; Van Gool, Michiel; Antonio Vega, Juan; Isabel De Lucas, Ana; Alonso de Diego, Sergio A.; Prokopcova, Hana; Austin, Nigel; Van Brandt, Sven; Surkyn, Michel; De Cleyn, Michel; Vos, Ann; Rombouts, Frederik J. R.; Macdonald, Gregor; Moechars, Dieder; Gijsen, Harrie J. M.; Trabanco, Andres A.
Discovery of N-(4-[18F]Fluoro-5-methylpyridin-2-yl)isoquinolin-6-amine (JNJ-64326067), a New Promising Tau Positron Emission Tomography Imaging Tracer
JOURNAL OF MEDICINAL CHEMISTRY
IF6.8
2019-02-2726
PREAI
Rombouts, Frederik J. R.; Declercq, Lieven; Andres, Jose-Ignacio; Bottelbergs, Astrid; Chen, Lu; Iturrino, Laura; Leenaerts, Joseph E.; Marien, Jonas; Song, Fengbin; Wintmolders, Cindy; Wuyts, Stijn; Xia, Chunfang A.; te Riele, Paula; Bormans, Guy; Vandenberghe, Rik; Kolb, Hartmuth; Moechars, Diederik
Optimization of 1,4-Oxazine β-Secretase 1 (BACE1) Inhibitors Toward a Clinical Candidate (vol 61, pg 5292, 2018)
JOURNAL OF MEDICINAL CHEMISTRY
IF6.8
2018-12-071
PREAI
Gijsen, Harrie J. M.; de Diego, Sergio A. Alonso; De Cleyn, Michel; Garcia-Molina, Aranzazu; Macdonald, Gregor J.; Martinez-Lamenca, Carolina; Oehlrich, Daniel; Prokopcova, Hana; Rombouts, Frederik J. R.; Surkyn, Michel; Trabanco, Andres A.; Van Brandt, Sven; Van den Bossche, Dries; Van Gool, Michiel; Austin, Nigel; Borghys, Herman; Dhuyvetter, Deborah; Urmaliya, Vijay; Teisman, Ard; Moechars, Diederik
Optimization of 1,4-Oxazine β-Secretase 1 (BACE1) Inhibitors Toward a Clinical Candidate
JOURNAL OF MEDICINAL CHEMISTRY
IF6.8
2018-05-2913
PREAI
Gijsen, Harrie J. M.; Alonso de Diego, Sergio A.; De Cleyn, Michel; Garcia-Molina, Aranzazu; Macdonald, Gregor J.; Martinez-Lamenca, Carolina; Oehlrich, Daniel; Prokopcova, Hana; Rombouts, Frederik J. R.; Surkyn, Michel; Trabanco, Andres A.; Van Brandt, Sven; van den Bossche, Dries; Van Gool, Michiel; Austin, Nigel; Borghys, Herman; Dhuyvetter, Deborah; Moechars, Diederik
Discovery of N-(Pyridin-4-yl)-1,5-naphthyridin-2-amines as Potential Tau Pathology PET Tracers for Alzheimer's Disease
JOURNAL OF MEDICINAL CHEMISTRY
IF6.8
2017-02-1033
PREAI
Rombouts, Frederik J. R.; Andres, Jose-Ignacio; Ariza, Manuela; Manuel Alonso, Jose; Austin, Nigel; Bottelbergs, Astrid; Chen, Lu; Chupakhin, Vladimir; Cleiren, Erna; Fierens, Katleen; Fontana, Alberto; Langlois, Xavier; Leenaerts, Joseph E.; Marien, Jonas; Lamenca, Carolina Martinez; Salter, Rhys; Schmidt, Mark E.; Te Riele, Paula; Wintmolders, Cindy; Trabanco, Andres A.; Zhang, Wei; Macdonald, Gregor; Moechars, Dieder

研究方向

暂未获取到该数据
A
Andrés A. Trabanco
H 指数:37论文数:134被引数:4,052
D
Daniel Oehlrich
H 指数:25论文数:65被引数:1,868
D
Diederik Moechars
H 指数:29论文数:127被引数:5,694
H
HillsleyKirk
H 指数:29论文数:99被引数:3,401
A
Ann Vos
H 指数:21论文数:51被引数:1,718
G
Gary Tresadern
H 指数:40论文数:166被引数:4,531
G
Gregor J. Macdonald
H 指数:32论文数:133被引数:2,541
N
Nigel Austin
H 指数:20论文数:60被引数:1,872
M
Michel Surkyn
H 指数:11论文数:28被引数:374
M
Michel De Cleyn
H 指数:7论文数:22被引数:252