未登录 Macrocyclic Carbon-Linked Pyrazoles As Novel Inhibitors of MCL-1 Demin, Samuel; Peschiulli, Aldo; Velter, Adriana I.; Vos, Ann; De Boeck, Benoit; Miller, Bradley; Rombouts, Frederik J. R.; Reuillon, Tristan; Lento, William; Blanco, Maria Dominguez; Jouffroy, Matthieu; Steyvers, Helena; Bekkers, Mariette; Altrocchi, Cristina; Pietrak, Beth; Koo, Seong Joo; Szewczuk, Lawrence; Attar, Ricardo; Philippar, Ulrike 分享 收藏
Discovery of an Oral, Beyond-Rule-of-Five Mcl-1 Protein-Protein Interaction Modulator with the Potential of Treating Hematological Malignancies Romanov-Michailidis, Fedor; Hsiao, Chien-Chi; Urner, Lorenz M.; Jerhaoui, Soufyan; Surkyn, Michel; Miller, Bradley; Vos, Ann; Blanco, Maria Dominguez; Bueters, Ruud; Vinken, Petra; Bekkers, Mariette; Walker, David; Pietrak, Beth; Eyckmans, Werner; Dores-Sousa, Jose Luis; Koo, Seong Joo; Lento, William; Bauser, Marcus; Philippar, Ulrike; Rombouts, Frederik J. R. 分享 收藏
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Modulating physicochemical properties of tetrahydropyridine-2-amine BACE1 inhibitors with electron-withdrawing groups: A systematic study Rombouts, Frederik J. R.; Hsiao, Chien-Chi; Bache, Solene; Cleyn, Michel De; Heckmann, Pauline; Leenaerts, Jos; Martinez-Lamenca, Carolina; Brandt, Sven Van; Peschiulli, Aldo; Vos, Ann; Gijsen, Harrie J. M. 分享 收藏
A Brain-Penetrant and Bioavailable Pyrazolopiperazine BACE1 Inhibitor Elicits Sustained Reduction of Amyloid β In Vivo Peschiulli, Aldo; Oehlrich, Daniel; Van Gool, Michiel; Austin, Nigel; Van Brandt, Sven; Surkyn, Michel; De Cleyn, Michel; Vos, Ann; Tresadern, Gary; Rombouts, Frederik J. R.; Macdonald, Gregor J.; Moechars, Diederik; Trabanco, Andres A.; Gijsen, Harrie J. M. 分享 收藏
JNJ-67569762, A 2-Aminotetrahydropyridine-Based Selective BACE1 Inhibitor Targeting the S3 Pocket: From Discovery to Clinical Candidate Rombouts, Frederik J. R.; Kusakabe, Ken-ichi; Alexander, Richard; Austin, Nigel; Borghys, Herman; De Cleyn, Michel; Dhuyvetter, Deborah; Gijsen, Harrie J. M.; Hrupka, Brian; Jacobs, Tom; Jerhaoui, Soufyan; Lammens, Lieve; Leclercq, Laurent; Tsubone, Koichi; Ueno, Tatsuhiko; Morimoto, Kenji; Einaru, Shunsuke; Sumiyoshi, Hirokazu; Van den Bergh, An; Vos, Ann; Surkyn, Michel; Teisman, Ard; Moechars, Diederik 分享 收藏
Development and implementation of an enterprise-wide predictive model for early absorption, distribution, metabolism and excretion properties Kumar, Kiran; Chupakhin, Vladimir; Vos, Ann; Morrison, Denise; Rassokhin, Dmitrii; Dellwo, Martin J.; McCormick, Keith; Paternoster, Eric; Ceulemans, Hugo; DesJarlais, Renee L. 分享 收藏
Discovery of 3-({5-Chloro-1-[3-(methylsulfonyl)propyl]-1H-indol-2-yl}methyl)-1-(2,2,2-trifluoroethyl)-1,3-dihydro-2H-imidazo[4,5-c]pyridin-2-one (JNJ-53718678), a Potent and Orally Bioavailable Fusion Inhibitor of Respiratory Syncytial Virus Vendeville, Sandrine; Tahri, Abdellah; Hu, Lili; Demin, Samuel; Cooymans, Ludwig; Vos, Ann; Kwanten, Leen; Van den Berg, Joke; Battles, Michael B.; McLellan, Jason S.; Koul, Anil; Raboisson, Pierre; Roymans, Dirk; Jonckers, Tim H. M. 分享 收藏
Preparation of 4′-Spirocyclobutyl Nucleoside Analogues as Novel and Versatile Adenosine Scaffolds Verhoeven, Jonas; De Vleeschouwer, Freija; Kong, Hanchu; Van Hecke, Kristof; Pande, Vineet; Sun, Weimei; Vos, Ann; Wu, Tongfei; Meerpoel, Lieven; Thuring, Jan Willem; Verniest, Guido 分享 收藏
Evaluation of a Series of β-Secretase 1 Inhibitors Containing Novel Heteroaryl-Fused-Piperazine Amidine Warheads Oehlrich, Daniel; Peschiulli, Aldo; Tresadern, Gary; Van Gool, Michiel; Antonio Vega, Juan; Isabel De Lucas, Ana; Alonso de Diego, Sergio A.; Prokopcova, Hana; Austin, Nigel; Van Brandt, Sven; Surkyn, Michel; De Cleyn, Michel; Vos, Ann; Rombouts, Frederik J. R.; Macdonald, Gregor; Moechars, Dieder; Gijsen, Harrie J. M.; Trabanco, Andres A. 分享 收藏
Minisci-Photoredox-Mediated α-Heteroarylation of N-Protected Secondary Amines: Remarkable Selectivity of Azetidines Bosset, Cyril; Beucher, Helene; Bretel, Guillaume; Pasquier, Elisabeth; Queguiner, Laurence; Henry, Cyril; Vos, Ann; Edwards, James P.; Meerpoel, Lieven; Berthelot, Didier 分享 收藏
Synthesis and Evaluation of N-Phenyl-3-sulfamoyl-benzamide Derivatives as Capsid Assembly Modulators Inhibiting Hepatitis B Virus (HBV) Vandyck, Koen; Rombouts, Geert; Stoops, Bart; Tahri, Abdellah; Vos, Ann; Verschueren, Wim; Wu, Yiming; Yang, Jingmei; Hou, Fuliang; Huang, Bing; Vergauwen, Karen; Dehertogh, Pascale; Berke, Jan Martin; Raboisson, Pierre 分享 收藏
Fragment Binding to β-Secretase 1 without Catalytic Aspartate Interactions Identified via Orthogonal Screening Approaches Rombouts, Frederik J. R.; Alexander, Richard; Cleiren, Erna; De Groot, Alex; Carpentier, Michel; Dijkmans, Joyce; Fierens, Katleen; Masure, Stefan; Moechars, Diederik; Palomino-Schatzlein, Martina; Pineda-Lucena, Antonio; Trabanco, Andres A.; Van Glabbeek, Daan; Vos, Ann; Tresadern, Gary 分享 收藏
1,4-Oxazine β-Secretase 1 (BACE1) Inhibitors: From Hit Generation to Orally Bioavailable Brain Penetrant Leads Rombouts, Frederik J. R.; Tresadern, Gary; Delgado, Oscar; Martinez-Lamenca, Carolina; Van Gool, Michiel; Garcia-Molina, Aranzazu; de Diego, Sergio A. Alonso; Oehlrich, Daniel; Prokopcova, Hana; Alonso, Jose Manuel; Austin, Nigel; Borghys, Herman; Van Brandt, Sven; Surkyn, Michel; De Cleyn, Michel; Vos, Ann; Alexander, Richard; Macdonald, Gregor; Moechars, Dieder; Gijsen, Harrie; Trabanco, Andres A. 分享 收藏
Molecular blueprint of allosteric binding sites in a homologue of the agonist-binding domain of the α7 nicotinic acetylcholine receptor Α7烟碱型乙酰胆碱受体激动剂结合域同系物中变构结合位点的分子蓝图 Spurny, Radovan; Debaveye, Sarah; Farinha, Ana; Veys, Ken; Vos, Ann M.; Gossas, Thomas; Atack, John; Bertrand, Sonia; Bertrand, Daniel; Danielson, U. Helena; Tresadern, Gary; Ulens, Chris 分享 收藏
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1a/1b Subtype Profiling of Nonnucleoside Polymerase Inhibitors of Hepatitis C Virus Nyanguile, Origene; Devogelaere, Benoit; Vijgen, Leen; Van den Broeck, Walter; Pauwels, Frederik; Cummings, Maxwell D.; De Bondt, Hendrik L.; Vos, Ann M.; Berke, Jan M.; Lenz, Oliver; Vandercruyssen, Genevieve; Vermeiren, Katrien; Mostmans, Wendy; Dehertogh, Pascale; Delouvroy, Frederic; Vendeville, Sandrine; VanDyck, Koen; Dockx, Koen; Cleiren, Erna; Raboisson, Pierre; Simmen, Kenneth A.; Fanning, Gregory C. 分享 收藏
Resistance Mutations in Human Immunodeficiency Virus Type 1 Integrase Selected with Elvitegravir Confer Reduced Susceptibility to a Wide Range of Integrase Inhibitors Goethals, Olivia; Clayton, Reginald; Van Ginderen, Marcia; Vereycken, Inge; Wagemans, Elisabeth; Geluykens, Peggy; Dockx, Koen; Strijbos, Rudy; Smits, Veerle; Vos, Ann; Meersseman, Geert; Jochmans, Dirk; Vermeire, Kurt; Schols, Dominique; Hallenberger, Sabine; Hertogs, Kurt 分享 收藏
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