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Alexander Schleiffer

vienna biocenter

52H指数
178论文数
9.3K被引数
收录论文 61
发表时间
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Structural Basis for Substrate Recruitment and Catalytic Ubiquitin Transfer by the E2/E3 Hybrid Enzyme UBE2O.UBE2O E2/E3杂合酶的底物募集和催化泛素转移的结构基础。
errJournal of Biological Chemistry
IF3.9
err2025-12-17
err0
errOAAI
errDarja Kordic; Thomas L. Williams; Luiza Deszcz; Julian F. Ehrmann; Renato Arnese; Alexander Schleiffer; Tim Clausen; Anton Meinhart
err分享
err收藏
Architecture of the UBR4 complex; a giant E4 ligase central to eukaryotic protein quality controlUBR4复合物的结构；一个在真核蛋白质质量控制中起核心作用的巨大E4连接酶。
errScience
IF45.8
err2025-08-28
err0
errOAAI
errDaniel B. Grabarczyk; Julian F. Ehrmann; Paul Murphy; Woo Seok Yang; Robert Kurzbauer; Lillie E. Bell; Luiza Deszcz; Jana Neuhold; Alexander Schleiffer; Alexandra Shulkina; Juyeon Lee; Jin Seok Shin; Anton Meinhart; Gijs A. Versteeg; Eszter Zavodszky; Hyun Kyu Song; Ramanujan S. Hegde; Tim Clausen
err分享
err收藏
A split-site E3 ligase mechanism enables ZNFX1 to ubiquitinate and cluster single-stranded RNA into ubiquitin-coated nucleoprotein particles一种裂分位点E3连接酶机制使ZNFX1能够泛素化并聚集单链RNA，形成泛素包被的核蛋白颗粒。
errCell
IF42.5
err2025-08-27
err0
errOAAI
errDaniel B. Grabarczyk; Eric J. Aird; Vanessa Reznikow; Paul C. Kirchgatterer; Julian F. Ehrmann; Robert Kurzbauer; Lillie E. Bell; Max J. Kellner; Ritika Aggarwal; Alexander Schleiffer; Victoria Faas; Luiza Deszcz; Anton Meinhart; Gijs A. Versteeg; Josef M. Penninger; Lukas S. Stelzl; Moritz M. Gaidt; Ingrid Tessmer; Jacob E. Corn; Tim Clausen
err分享
err收藏
CLEC18A interacts with sulfated glycosaminoglycans and controls clear cell renal cell carcinoma progressionCLEC18A与硫酸糖胺聚糖相互作用，并调控透明细胞肾细胞癌的进展
errfebs journal
IF0
err2025-08-23
err0
errOAAI
errGustav Jonsson; Maura Hofmann; Stefan Mereiter; Lauren Hartley-Tassell; Masahiro Onji; Irma Sakic; Tiago Oliveira; David Hoffmann; Maria Novatchkova; Alexander Schleiffer; Josef M. Penninger
err分享
err收藏
Conservation and divergence of the molecular regulators of the vertebrate fertilization synapse脊椎动物受精突触中分子调控因子的保守性与分歧性
errCurrent Opinion in Genetics & Development
IF3.6
err2025-05-06
err0
errOAAI
errAndreas Blaha; Alexander Schleiffer; Andrea Pauli
err分享
err收藏
A genome-wide screen identifies silencers with distinct chromatin properties and mechanisms of repression全基因组筛选鉴定具有不同染色质特性和抑制机制的沉默子
errMOLECULAR CELL
IF16.6
err2024-12-01
err0
errOAAI
errHofbauer, Lorena; Pleyer, Lisa-Marie; Reiter, Franziska; Schleiffer, Alexander; Vlasova, Anna; Serebreni, Leonid; Huang, Annie; Stark, Alexander
err分享
err收藏
Sororin is an evolutionary conserved antagonist of WAPLSororin是WAPL的进化保守拮抗剂
errNATURE COMMUNICATIONS
IF15.7
err2024-06-03
err0
errOAAI
errPrusen Mota, Ignacio; Galova, Marta; Schleiffer, Alexander; Nguyen, Tan-Trung; Kovacikova, Ines; Farias Saad, Carolina; Litos, Gabriele; Nishiyama, Tomoko; Gregan, Juraj; Peters, Jan-Michael; Schloegelhofer, Peter
err分享
err收藏
Cohesin mediates DNA loop extrusion and sister chromatid cohesion by distinct mechanismsCohesin通过不同的机制介导DNA环挤出和姐妹染色单体凝聚
errMOLECULAR CELL
IF16.6
err2023-09-01
err10
errOAAI
errNagasaka, Kota; Davidson, Iain F.; Stocsits, Roman R.; Tang, Wen; Wutz, Gordana; Batty, Paul; Panarotto, Melanie; Litos, Gabriele; Schleiffer, Alexander; Gerlich, Daniel W.; Peters, Jan-Michael
err分享
err收藏
Cryo-EM structure of the chain-elongating E3 ubiquitin ligase UBR5
errEMBO JOURNAL
IF8.3
err2023-07-06
err12
errOAAI
errHodakova, Zuzana; Grishkovskaya, Irina; Brunner, Hanna L.; Bolhuis, Derek L.; Belacic, Katarina; Schleiffer, Alexander; Kotisch, Harald; Brown, Nicholas G.; Haselbach, David
err分享
err收藏
A phylogenetic profiling approach identifies novel ciliogenesis genes in Drosophila and C. elegans系统发育分析方法鉴定了果蝇和秀丽隐杆线虫中的新型纤毛发生基因
errEMBO JOURNAL
IF8.3
err2023-06-15
err7
errOAAI
errDobbelaere, Jeroen; Su, Tiffany Y.; Erdi, Balazs; Schleiffer, Alexander; Dammermann, Alexander
err分享
err收藏
Divergent molecular signatures in fish Bouncer proteins define cross-fertilization boundaries
errNATURE COMMUNICATIONS
IF15.7
err2023-06-14
err4
errOAAI
errGert, Krista R. B.; Panser, Karin; Surm, Joachim; Steinmetz, Benjamin S.; Schleiffer, Alexander; Jovine, Luca; Moran, Yehu; Kondrashov, Fyodor; Pauli, Andrea
err分享
err收藏
Systematic identification and characterization of repressive domains in Drosophila transcription factors果蝇转录因子中抑制结构域的系统鉴定和表征
errEMBO JOURNAL
IF8.3
err2022-12-22
err7
errOAAI
errKlaus, Loni; de Almeida, Bernardo P.; Vlasova, Anna; Nemcko, Filip; Schleiffer, Alexander; Bergauer, Katharina; Hofbauer, Lorena; Rath, Martina; Stark, Alexander
err分享
err收藏
Homologous chromosomes are stably conjoined for Drosophila male meiosis I by SUM, a multimerized protein assembly with modules for DNA-binding and for separase-mediated dissociation co-opted from cohesin
errPLOS GENETICS
IF3.7
err2022-12-08
err7
errOAAI
errKabakci, Zeynep; Reichle, Heidi E.; Lemke, Bianca; Rousova, Dorota; Gupta, Samir; Weber, Joe; Schleiffer, Alexander; Weir, John R.; Lehner, Christian F.
err分享
err收藏
Human Papillomavirus 42 Drives Digital Papillary Adenocarcinoma and Elicits a Germ Cell-like Program Conserved in HPV-Positive Cancers人乳头瘤病毒42驱动数字乳头状腺癌并引发在HPV阳性癌症中保守的生殖细胞样程序
errCANCER DISCOVERY
IF33.3
err2022-10-10
err24
errOAAI
errLeiendecker, Lukas; Neumann, Tobias; Jung, Pauline S.; Cronin, Shona M.; Steinacker, Thomas L.; Schleiffer, Alexander; Schutzbier, Michael; Mechtler, Karl; Kervarrec, Thibault; Laurent, Estelle; Bachiri, Kamel; Coyaud, Etienne; Murali, Rajmohan; Busam, Klaus J.; Itzinger-Monshi, Babak; Kirnbauer, Reinhard; Cerroni, Lorenzo; Calonje, Eduardo; Rutten, Arno; Stubenrauch, Frank; Griewank, Klaus G.; Wiesner, Thomas; Obenauf, Anna C.
err分享
err收藏
Cryo-EM structure of the plant 26S proteasome
errPLANT COMMUNICATIONS
IF11.6
err2022-05-01
err5
errOAAI
errKandolf, Susanne; Grishkovskaya, Irina; Belacic, Katarina; Bolhuis, Derek L.; Amann, Sascha; Foster, Brent; Imre, Richard; Mechtler, Karl; Schleiffer, Alexander; Tagare, Hemant D.; Zhong, Ellen D.; Meinhart, Anton; Brown, Nicholas G.; Haselbach, David
err分享
err收藏
Cornelia de Lange syndrome mutations in NIPBL can impair cohesin-mediated DNA loop extrusion
errPROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
IF9.1
err2022-04-27
err13
errOAAI
errPanarotto, Melanie; Davidson, Iain F.; Litos, Gabriele; Schleiffer, Alexander; Peters, Jan-Michael
err分享
err收藏
HUWE1 employs a giant substrate-binding ring to feed and regulate its HECT E3 domain
errNATURE CHEMICAL BIOLOGY
IF13.7
err2021-07-22
err22
errOAAI
errGrabarczyk, Daniel B.; Petrova, Olga A.; Deszcz, Luiza; Kurzbauer, Robert; Murphy, Paul; Ahel, Juraj; Vogel, Antonia; Gogova, Rebeca; Faas, Victoria; Kordic, Darja; Schleiffer, Alexander; Meinhart, Anton; Imre, Richard; Lehner, Anita; Neuhold, Jana; Bader, Gerd; Stolt-Bergner, Peggy; Boettcher, Jark; Wolkerstorfer, Bernhard; Fischer, Gerhard; Grishkovskaya, Irina; Haselbach, David; Kessler, Dirk; Clausen, Tim
err分享
err收藏
Caenorhabditis elegans RMI2 functional homolog-2 (RMIF-2) and RMI1 (RMH-1) have both overlapping and distinct meiotic functions within the BTR complex
errPLOS GENETICS
IF3.7
err2021-07-12
err5
errOAAI
errVelkova, Maria; Silva, Nicola; Dello Stritto, Maria Rosaria; Schleiffer, Alexander; Barraud, Pierre; Hartl, Markus; Jantsch, Verena
err分享
err收藏
The oxidoreductase PYROXD1 uses NAD(P)+ as an antioxidant to sustain tRNA ligase activity in pre-tRNA splicing and unfolded protein response
errMOLECULAR CELL
IF16.6
err2021-06-01
err19
errOAAI
errAsanovi, Igor; Strandback, Emilia; Kroupova, Alena; Pasajlic, Djurdja; Meinhart, Anton; Tsung-Pin, Pai; Djokovic, Nemanja; Anrather, Dorothea; Schuetz, Thomas; Suskiewicz, Marcin Jozef; Sillamaa, Sirelin; Kocher, Thomas; Beveridge, Rebecca; Nikolic, Katarina; Schleiffer, Alexander; Jinek, Martin; Hartl, Markus; Clausen, Tim; Penninger, Josef; Macheroux, Peter; Weitzer, Stefan; Martinez, Javier
err分享
err收藏
Zebrafish Ski7 tunes RNA levels during the oocyte-to-embryo transition斑马鱼Ski7在卵母细胞到胚胎的过渡过程中调节RNA水平
errPLOS GENETICS
IF3.7
err2021-02-18
err10
errOAAI
errCabrera-Quio, Luis Enrique; Schleiffer, Alexander; Mechtler, Karl; Pauli, Andrea
err分享
err收藏

研究方向

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