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T

Tuyu Zheng

st jude childrens research hospital
H指数:4
被引数:380

个人简介

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教育背景

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工作经历

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荣誉奖项

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Nuclear export as a therapeutic vulnerability in ZFTA-RELA ependymoma

ZFTA-RELA室管膜瘤中核输出作为治疗易损性

Neuro-Oncology
IF13.4
2026-05-030
OA
Siri M Ippagunta; Amir Arabzade; Srinidhi Varadharajan; Erik Emanus; Amanda Bland; Alisha Kardian; Nicholas Laboe; Hua Sun; Tuyu Zheng; Amelia Hancock; Mark Zhai; Emma Caesar; Maxwell Park; Wilda Orisme; Melissa Johnson; Brittany Rodgers; Gregory H Turner; Jeffrey Steinberg; Burgess Freeman; Martine F Roussel; Anang Shelat; Richard Kriwacki; Thomas E Merchant; Benjamin Deneen; Michael D Taylor; Sameer Agnihotri; Shondra Pruett-Miller; Jacob A Steele; Anoop Murthy Kavirayani; David W Ellison; Arzu Onar-Thomas; Giles Robinson; Stephen C Mack; Kelsey C Bertrand; null
Ependymoma group-specific blood-brain barrier differences uncovered by a multi-omics approach

室管膜瘤组特异性血脑屏障差异的多组学方法揭示

Scientific Reports
IF3.9
2026-04-100
OAAI
Julia K. Sundheimer; Julia Benzel; Aniello Federico; Stefanie Volz; Maximilian Knoll; Britta Statz; Tuyu Zheng; Szymon W. Kmiecik; Jürgen Burhenne; Gzona Bajraktari-Sylejmani; Sophia Scheuermann; Anke King; Torsten Müller; Jens-Martin Hübner; Mathias Kalxdorf; Heike Peterziel; Ina Oehme; Jeroen Krijgsveld; Christian M. Seitz; Marcel Kool; Stefan M. Pfister; Kristian W. Pajtler; Kendra K. Maaß
Dominant clones leverage developmental epigenomic states to drive ependymoma

优势克隆利用发育期表观基因组状态驱动室管膜瘤

Nature
IF48.5
2026-03-250
OAAI
Alisha S. Kardian; Hua Sun; Siri Ippagunta; Nicholas Laboe; Srinidhi Varadharajan; Kwanha Yu; Hsiao-Chi Chen; Erik Emanus; Tuyu Zheng; Riley M. Deneen; Jon P. Connelly; Yong-Dong Wang; Jiangshan Zhan; Hengxi Liu; Kimberley Lowe; Taylor Bugbee; Rakesh Pathak; Amanda Bland; Sanya Mehta; Sophie Cochiolo; Amir Arabzade; Blake Holcomb; Kaitlin M. Budd; Gabriele Kembuan; Tristen Wright; Emma Caesar; Maxwell Park; Amelia Hancock; David Gee; Joel Murdoch; Yi Xiao; Samuel K. McBrayer; Thomas E. Merchant; Jun Qi; Adam D. Durbin; Lindsay A. Schwarz; Li Wang; Andrew M. Donson; Nicholas K. Foreman; Sameer Agnihotri; Alfonso Lavado; Suzanne J. Baker; David W. Ellison; Hyun Kyoung Lee; Shondra M. Pruett-Miller; Kelsey C. Bertrand; Benjamin Deneen; Stephen C. Mack
Investigation of a global mouse methylome atlas reveals subtype-specific copy number alterations in pediatric cancer models

全球小鼠甲基化图谱的研究揭示了小儿癌症模型中的亚型特异性拷贝数改变

Nature Genetics
IF29
2025-12-110
OAAI
Melanie Schoof; Tuyu Zheng; Martin Sill; Roland Imle; Alessia Cais; Lea Altendorf; Alicia Fürst; Nina Hofmann; Kati Ernst; Dominik Vonficht; Kenneth Chun-Ho Chan; Tim Holland-Letz; Andreas Postlmayr; Ryo Shiraishi; Wanchen Wang; Alaide Morcavallo; Michael Spohn; Carolin Göbel; Judith Niesen; Levke-Sophie Peter; Franck Bourdeaut; Zhi-Yan Han; Yanxin Pei; Najiba Murad; Fredrik J. Swartling; Jessica Taylor; Monika Yadav; Garrett R. Gibson; Richard J. Gilbertson; Matthias Dottermusch; Rajanya Roy; Kornelius Kerl; Rainer Glass; Jiying Cheng; Martin A. Horstmann; Gerrit Wolters-Eisfeld; Haotian Zhao; Dominik Sturm; Viveka Nand Yadav; Louis Chesler; Simon Haas; William A. Weiss; Paul A. Northcott; Lena M. Kutscher; Ana Guerreiro Stucklin; Olivier Ayrault; Julia E. Neumann; Daisuke Kawauchi; David T. W. Jones; Kristian Pajtler; Ana Banito; Stefan M. Pfister; Ulrich Schüller; Marc Zuckermann
Synthetic ZFTA-fusions pinpoint IDR acquisition as a mechanism of brain tumor development

合成ZFTA融合蛋白将IDR的获得确定为脑肿瘤发展的机制

NEURO-ONCOLOGY
IF13.4
2025-11-010
OAAI
Arabzade, Amir; Shirnekhi, Hazheen; Varadharajan, Srinidhi; Ippagunta, Siri; Philips, Aaron; Laboe, Nicholas; Baggett, David; Wahiduzzaman, Fnu; Jo, Minjeong; Zheng, Tuyu; Tripathi, Swarnendu; Pathak, Rakesh; Emanus, Erik; Bland, Amanda; Kardian, Alisha; Holcomb, Blake; Wright, Tristen; Bugbee, Taylor; Hancock, Amelia; Chandra, Bappaditya; Ellison, David; Deneen, Benjamin; Bertrand, Kelsey; Kriwacki, Richard; Mack, Stephen
DOMINANT MALIGNANT LINEAGE LEVERAGE RESTRICTED EPIGENOMIC PROGRAMS TO DRIVE EPENDYMOMA DEVELOPMENT

优势恶性谱系利用受限的表观基因组程序来驱动室管膜瘤发展

NEURO-ONCOLOGY
IF13.4
2025-11-010
OAAI
Sun, Hua; Kardian, Alisha; Ippagunta, Siri; Laboe, Nicholas; Chen, Hsiao-Chi; Zhan, Jiangshan; Emanus, Erik; Varadharajan, Srinidhi; Zheng, Tuyu; Holcomb, Blake; Connelly, Jon P.; Wang, Yong-Dong; Lowe, Kimberley; Lee, Hyun Kyoung; Pruett-Miller, Shondra M.; Bertrand, Kelsey C.; Deneen, Benjamin; Mack, Stephen C.
Nuclear Transport as a Therapeutic Vulnerability in ZFTA-RELA Ependymoma

ZFTA-RELA室管膜瘤中核转运作为治疗性易损靶点

NEURO-ONCOLOGY
IF13.4
2025-11-010
OAAI
Ippagunta, Siri; Arabzade, Amir; Varadharajan, Srinidhi; Emanus, Erik; Bland, Amanda; Kardian, Alisha; Laboe, Nicolas; Sun, Hua; Zheng, Tuyu; Orisme, Wilda; Johnson, Melissa; Rodgers, Britanny; Turner, Gregory; Steinberg, Jeffrey; Freeman, Burgess; Roussel, Martine; Shelat, Anang; Kriwacki, Richard; Merchant, Thomas; Deneen, Benjamin; Miller, Shondra; Kavirayani, Anoop Murthy; Ellison, David; Onar-thomas, Arzu; Robinson, Giles; Mack, Stephen; Bertrand, Kelsey
Synthetic ZFTA fusions pinpoint disordered protein domain acquisition as a mechanism of brain tumorigenesis

合成ZFTA融合蛋白将无序蛋白质结构域的获取确定为脑肿瘤发生的一种机制

Nature Cell Biology
IF19.1
2025-08-270
OAAI
A. Arabzade; H. K. Shirnekhi; S. Varadharajan; S. M. Ippagunta; A. H. Phillips; N. Laboe; D. W. Baggett; Wahiduzzaman; M. Jo; T. Zheng; R. Pathak; D. Gee; D. Bhimsaria; H. Wu; X. Gao; J. Liu; E. Emanus; A. Bland; A. Kardian; A. Hancock; B. Holcomb; T. Wright; T. Bugbee; H. Sun; M. Zhai; E. Caesar; M. Park; S. Tripathi; A. Shirinifard; K. Lowe; A. Khalighifar; R. A. Petersen; S. King; D. Stabley; A. Pitre; G. E. Campbell; C-G Park; W. T. Freyaldenhoven; B. Chandra; Y. Xia; E. Bonten; A. Achari; S. Kandikonda; A. Carisey; S. B. Pounds; J. Xu; D. W. Ellison; B. Deneen; K. C. Bertrand; R. W. Kriwacki; S. C. Mack
Biglycan-driven risk stratification in ZFTA-RELA fusion supratentorial ependymomas through transcriptome profiling

通过转录组分析，在zfta-rela融合幕上室上膜瘤中由双糖链蛋白聚糖驱动的风险分层

ACTA NEUROPATHOLOGICA COMMUNICATIONS
IF5.7
2025-01-070
OAAI
Okonechnikov, Konstantin; Ghasemi, David R.; Schrimpf, Daniel; Tonn, Svenja; Mynarek, Martin; Koster, Jan; Milde, Till; Zheng, Tuyu; Sievers, Philipp; Sahm, Felix; Jones, David T. W.; von Deimling, Andreas; Pfister, Stefan M.; Kool, Marcel; Pajtler, Kristian W.; Korshunov, Andrey
SOLID PEDIATRIC TUMORS IN MICE REVEAL MODEL-SPECIFIC GLOBAL DNA METHYLATION AND CNV PROFILES CORRESPONDING TO HUMAN COUNTERPARTS
NEURO-ONCOLOGY
IF13.4
2024-06-180
OAAI
Schoof, Melanie; Zheng, Tuyu; Sill, Martin; Imle, Roland; Hofmann, Nina; Ernst, Kati; Vonficht, Dominik; Chan, Chun Ho; Cais, Alessia; Holland-Letz, Tim; Postlmayr, Andreas; Shiraishi, Ryo; Wang, Wanchen; Morcavallo, Alaide; Spohn, Michael; Goebel, Carolin; Niesen, Judith; Peter, Levke-Sophie; Eckhardt, Alicia; Bourdeaut, Franck; Han, Zhi-Yan; Pei, Yanxin; Murad, Najiba; Swartling, Fredrik J.; Taylor, Jessica; Gilbertson, Richard J.; Dottermusch, Matthias; Kerl, Kornelius; Glass, Rainer; Cheng, Jiying; Horstmann, Martin A.; Nollau, Peter; Wolters-Eisfeld, Gerrit; Zhao, Haotian; Sturm, Dominik; Chesler, Louis; Haas, Simon; Weiss, William A.; Northcott, Paul A.; Kutscher, Lena M.; Stuecklin, Ana Guerreiro; Ayrault, Olivier; Neumann, Julia E.; Kawauchi, Daisuke; Jones, David; Pfister, Stefan M.; Pajtler, Kristian; Banito, Ana; Schueller, Ulrich; Zuckermann, Marc
Recurrent fusions in PLAGL1 define a distinct subset of pediatric-type supratentorial neuroepithelial tumors

PLAGL1的复发性融合定义了儿科型幕上神经上皮肿瘤的独特子集

ACTA NEUROPATHOLOGICA
IF9.3
2021-08-0537
OAAI
Sievers, Philipp; Henneken, Sophie C.; Blume, Christina; Sill, Martin; Schrimpf, Daniel; Stichel, Damian; Okonechnikov, Konstantin; Reuss, David E.; Benzel, Julia; Maass, Kendra K.; Kool, Marcel; Sturm, Dominik; Zheng, Tuyu; Ghasemi, David R.; Kohlhof-Meinecke, Patricia; Cruz, Ofelia; Sunol, Mariona; Lavarino, Cinzia; Ruf, Viktoria; Boldt, Henning B.; Pages, Melanie; Pouget, Celso; Schweizer, Leonille; Kranendonk, Mariette E. G.; Akhtar, Noreen; Bunkowski, Stephanie; Stadelmann, Christine; Schueller, Ulrich; Mueller, Wolf C.; Dohmen, Hildegard; Acker, Till; Harter, Patrick N.; Mawrin, Christian; Beschorner, Rudi; Brandner, Sebastian; Snuderl, Matija; Abdullaev, Zied; Aldape, Kenneth; Gilbert, Mark R.; Armstrong, Terri S.; Ellison, David W.; Capper, David; Ichimura, Koichi; Reifenberger, Guido; Grundy, Richard G.; Jabado, Nada; Krskova, Lenka; Zapotocky, Michal; Vicha, Ales; Varlet, Pascale; Wesseling, Pieter; Rutkowski, Stefan; Korshunov, Andrey; Wick, Wolfgang; Pfister, Stefan M.; Jones, David T. W.; von Deimling, Andreas; Pajtler, Kristian W.; Sahm, Felix
Cross-Species Genomics Reveals Oncogenic Dependencies in ZFTA/C11orf95 Fusion-Positive Supratentorial Ependymomas

跨物种基因组学揭示了ZFTA/C11orf95融合阳性的幕上室管膜瘤的致癌依赖性

CANCER DISCOVERY
IF33.3
2021-04-2036
OA
Zheng, Tuyu; Ghasemi, David R.; Okonechnikov, Konstantin; Korshunov, Andrey; Sill, Martin; Maass, Kendra K.; da Silva, Patricia Benites Goncalves; Ryzhova, Marina; Gojo, Johannes; Stichel, Damian; Arabzade, Amir; Kupp, Robert; Benzel, Julia; Taya, Shinichiro; Adachi, Toma; Shiraishi, Ryo; Gerber, Nicolas U.; Sturm, Dominik; Ecker, Jonas; Sievers, Philipp; Selt, Florian; Chapman, Rebecca; Haberler, Christine; Figarella-Branger, Dominique; Reifenberger, Guido; Fleischhack, Gudrun; Rutkowski, Stefan; Donson, Andrew M.; Ramaswamy, Vijay; Capper, David; Ellison, David W.; Herold-Mende, Christel C.; Schueller, Ulrich; Brandner, Sebastian; Driever, Pablo Hernaiz; Kros, Johan M.; Snuderl, Matija; Milde, Till; Grundy, Richard G.; Hoshino, Mikio; Mack, Stephen C.; Gilbertson, Richard J.; Jones, David T. W.; Kool, Marcel; von Deimling, Andreas; Pfister, Stefan M.; Sahm, Felix; Kawauchi, Daisuke; Pajtler, Kristian W.
ZFTA Translocations Constitute Ependymoma Chromatin Remodeling and Transcription Factors
CANCER DISCOVERY
IF33.3
2021-03-1934
OA
Kupp, Robert; Ruff, Lisa; Terranova, Sabrina; Nathan, Erica; Ballereau, Stephane; Stark, Rory; Chilamakuri, Chandra Sekhar Reddy; Hoffmann, Nadin; Wickham-Rahrmann, Katherine; Widdess, Marcus; Arabzade, Amir; Zhao, Yanhua; Varadharajan, Srinidhi; Zheng, Tuyu; Murugesan, Mohankumar; Pfister, Stefan M.; Kawauch, Daisuke; Pajtler, Kristian W.; Deneen, Benjamin; Mack, Stephen C.; Masih, Katherine E.; Gryder, Berkley E.; Khan, Javed; Gilbertson, Richard J.

研究方向

暂未获取到该数据
S
Stephen C. Mack
H 指数:61论文数:529被引数:1.8万
K
Kristian W. Pajtler
H 指数:51论文数:445被引数:1.5万
S
Stefan M. Pfister
H 指数:159论文数:2,105被引数:12.7万
S
Srinidhi Varadharajan
H 指数:15论文数:140被引数:1,099
D
David Jones
H 指数:144论文数:1,486被引数:10.4万
B
Benjamin Deneen
H 指数:49论文数:317被引数:1.1万
D
David W. Ellison
H 指数:113论文数:757被引数:7.8万
R
Richard J. Gilbertson
H 指数:89论文数:482被引数:3.8万
M
Martin Sill
H 指数:58论文数:336被引数:1.8万
D
Daisuke Kawauchi
H 指数:28论文数:196被引数:5,505