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S

Stephen C. Mack

st jude childrens research hospital
H指数:61
被引数:1.8万

个人简介

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Nuclear export as a therapeutic vulnerability in ZFTA-RELA ependymoma

ZFTA-RELA室管膜瘤中核输出作为治疗易损性

Neuro-Oncology
IF13.4
2026-05-030
OA
Siri M Ippagunta; Amir Arabzade; Srinidhi Varadharajan; Erik Emanus; Amanda Bland; Alisha Kardian; Nicholas Laboe; Hua Sun; Tuyu Zheng; Amelia Hancock; Mark Zhai; Emma Caesar; Maxwell Park; Wilda Orisme; Melissa Johnson; Brittany Rodgers; Gregory H Turner; Jeffrey Steinberg; Burgess Freeman; Martine F Roussel; Anang Shelat; Richard Kriwacki; Thomas E Merchant; Benjamin Deneen; Michael D Taylor; Sameer Agnihotri; Shondra Pruett-Miller; Jacob A Steele; Anoop Murthy Kavirayani; David W Ellison; Arzu Onar-Thomas; Giles Robinson; Stephen C Mack; Kelsey C Bertrand; null
Dominant clones leverage developmental epigenomic states to drive ependymoma

优势克隆利用发育期表观基因组状态驱动室管膜瘤

Nature
IF48.5
2026-03-250
OAAI
Alisha S. Kardian; Hua Sun; Siri Ippagunta; Nicholas Laboe; Srinidhi Varadharajan; Kwanha Yu; Hsiao-Chi Chen; Erik Emanus; Tuyu Zheng; Riley M. Deneen; Jon P. Connelly; Yong-Dong Wang; Jiangshan Zhan; Hengxi Liu; Kimberley Lowe; Taylor Bugbee; Rakesh Pathak; Amanda Bland; Sanya Mehta; Sophie Cochiolo; Amir Arabzade; Blake Holcomb; Kaitlin M. Budd; Gabriele Kembuan; Tristen Wright; Emma Caesar; Maxwell Park; Amelia Hancock; David Gee; Joel Murdoch; Yi Xiao; Samuel K. McBrayer; Thomas E. Merchant; Jun Qi; Adam D. Durbin; Lindsay A. Schwarz; Li Wang; Andrew M. Donson; Nicholas K. Foreman; Sameer Agnihotri; Alfonso Lavado; Suzanne J. Baker; David W. Ellison; Hyun Kyoung Lee; Shondra M. Pruett-Miller; Kelsey C. Bertrand; Benjamin Deneen; Stephen C. Mack
Discovery of Genetic Susceptibility Variants in Pediatric and Adult Ependymoma
Neuro-Oncology Advances
IF4.1
2026-01-160
OAAI
Joshua D Strauss; Priya B Shetty; Spiridon Tsavachidis; Jinyoung Byun; Stephen C Mack; Xiao Xiangjun; Terri S Armstrong; Mark R Gilbert; Lisa Mirabello; Smita Bhatia; Wendy M Leisenring; Lindsay M Morton; Gregory T Armstrong; Jon Foss-Skiftesvik; Christian Munch Hagen; Jonas Bybjerg-Grauholm; iPSYCH Consortium; Manel Ghozal; Audrey Bonaventure; Jacqueline Clavel; Melissa L Bondy; Christopher I Amos; Thanh T Hoang; Michael E Scheurer
Synthetic ZFTA-fusions pinpoint IDR acquisition as a mechanism of brain tumor development

合成ZFTA融合蛋白将IDR的获得确定为脑肿瘤发展的机制

NEURO-ONCOLOGY
IF13.4
2025-11-010
OAAI
Arabzade, Amir; Shirnekhi, Hazheen; Varadharajan, Srinidhi; Ippagunta, Siri; Philips, Aaron; Laboe, Nicholas; Baggett, David; Wahiduzzaman, Fnu; Jo, Minjeong; Zheng, Tuyu; Tripathi, Swarnendu; Pathak, Rakesh; Emanus, Erik; Bland, Amanda; Kardian, Alisha; Holcomb, Blake; Wright, Tristen; Bugbee, Taylor; Hancock, Amelia; Chandra, Bappaditya; Ellison, David; Deneen, Benjamin; Bertrand, Kelsey; Kriwacki, Richard; Mack, Stephen
DOMINANT MALIGNANT LINEAGE LEVERAGE RESTRICTED EPIGENOMIC PROGRAMS TO DRIVE EPENDYMOMA DEVELOPMENT

优势恶性谱系利用受限的表观基因组程序来驱动室管膜瘤发展

NEURO-ONCOLOGY
IF13.4
2025-11-010
OAAI
Sun, Hua; Kardian, Alisha; Ippagunta, Siri; Laboe, Nicholas; Chen, Hsiao-Chi; Zhan, Jiangshan; Emanus, Erik; Varadharajan, Srinidhi; Zheng, Tuyu; Holcomb, Blake; Connelly, Jon P.; Wang, Yong-Dong; Lowe, Kimberley; Lee, Hyun Kyoung; Pruett-Miller, Shondra M.; Bertrand, Kelsey C.; Deneen, Benjamin; Mack, Stephen C.
Locoregional B7-H3 CAR-T cells for relapsed/refractory CNS tumors: preliminary clinical experience of the Loc3CAR trial

局部区域B7-H3 CAR-T细胞治疗复发/难治性中枢神经系统肿瘤：Loc3CAR试验的初步临床经验

NEURO-ONCOLOGY
IF13.4
2025-11-010
OAAI
Bertrand, Kelsey; Hanzlik, Emily; Chiang, Jason; Pinto, Soniya; Selukar, Subodh; Kosteka, Anna; Smith, Kyle; Han, Katie; Ibanez, Jorge; Tlais, Dana; Orr, Brent; Langfitt, Deanna; Metais, Jean-Yves; Lockey, Timothy; Willis, Catherine; Fazio, Frank; Shanmugmam, Raghu; Tian, Liqing; Walhart, Tara; Wang, Yu; Allmon, Patricia; Perry, Scott; Schell, Sarah; Adams, Polly; Ward, Meghan; Meehl, Michaela; Akel, Salem; Poston, Leigh; Bag, Asim; Mack, Stephen; Klimo, Paul; Gajjar, Amar; Thomas, Paul; Crawford, Jeremy; Robinson, Giles; Park, Julie; Northcott, Paul; Gottschalk, Stephen; Krenciute, Giedre; Derenzo, Christopher
Nuclear Transport as a Therapeutic Vulnerability in ZFTA-RELA Ependymoma

ZFTA-RELA室管膜瘤中核转运作为治疗性易损靶点

NEURO-ONCOLOGY
IF13.4
2025-11-010
OAAI
Ippagunta, Siri; Arabzade, Amir; Varadharajan, Srinidhi; Emanus, Erik; Bland, Amanda; Kardian, Alisha; Laboe, Nicolas; Sun, Hua; Zheng, Tuyu; Orisme, Wilda; Johnson, Melissa; Rodgers, Britanny; Turner, Gregory; Steinberg, Jeffrey; Freeman, Burgess; Roussel, Martine; Shelat, Anang; Kriwacki, Richard; Merchant, Thomas; Deneen, Benjamin; Miller, Shondra; Kavirayani, Anoop Murthy; Ellison, David; Onar-thomas, Arzu; Robinson, Giles; Mack, Stephen; Bertrand, Kelsey
Mutant IDH silences GSX2 to reprogram neural progenitor cell fate and promote gliomagenesis

突变IDH沉默GSX2以重编程神经祖细胞命运并促进胶质瘤发生

NEURO-ONCOLOGY
IF13.4
2025-11-010
OAAI
Xiao, Yi; Shi, Diana; Guo, Lei; Neumann, Ethan; Levitt, Michael; Kaphle, Pranita; Shipman, Tracey; Li, Haocheng; Cai, Feng; Ramirez, Denise; Zacharias, Lauren; Chen, Zhenkang; Lin, Mathew; Thidil, Vinesh; Mathews, Thomas; Mishra, Prashant; Kim, Yoon Jung; Xu, Jian; Mack, Stephen; Deberardinis, Ralph; Tirosh, Itay; Suva, Mario; Xu, Lin; Abdullah, Kalil; Mcbrayer, Samuel
Synthetic ZFTA fusions pinpoint disordered protein domain acquisition as a mechanism of brain tumorigenesis

合成ZFTA融合蛋白将无序蛋白质结构域的获取确定为脑肿瘤发生的一种机制

Nature Cell Biology
IF19.1
2025-08-270
OAAI
A. Arabzade; H. K. Shirnekhi; S. Varadharajan; S. M. Ippagunta; A. H. Phillips; N. Laboe; D. W. Baggett; Wahiduzzaman; M. Jo; T. Zheng; R. Pathak; D. Gee; D. Bhimsaria; H. Wu; X. Gao; J. Liu; E. Emanus; A. Bland; A. Kardian; A. Hancock; B. Holcomb; T. Wright; T. Bugbee; H. Sun; M. Zhai; E. Caesar; M. Park; S. Tripathi; A. Shirinifard; K. Lowe; A. Khalighifar; R. A. Petersen; S. King; D. Stabley; A. Pitre; G. E. Campbell; C-G Park; W. T. Freyaldenhoven; B. Chandra; Y. Xia; E. Bonten; A. Achari; S. Kandikonda; A. Carisey; S. B. Pounds; J. Xu; D. W. Ellison; B. Deneen; K. C. Bertrand; R. W. Kriwacki; S. C. Mack
LOCOREGIONAL ADMINISTRATION OF B7-H3-CAR T CELLS EXPRESSING 41BB LIGAND FOR PEDIATRIC PATIENTS WITH PRIMARY CNS TUMORS: PRELIMINARY RESULTS FROM A PHASE I STUDY
NEURO-ONCOLOGY
IF13.4
2024-11-110
PRE
Bertrand, Kelsey C.; Kostecka, Anna; Smith, Kyle; Han, Katie; Chiang, Jason; Pinto, Soniya; Tlais, Dana; Selukar, Subodh; Orr, Brent; Hanzlik, Emily; Langfitt, Deanna; Metais, Jean-Yves; Lockey, Timothy; Willis, Catherine; Fazio, Frank; Shanmugam, Raghu; Tian, Liqing; Walhart, Tara; Wang, Yu; Allmon, Patricia; Perry, Scott; Schell, Sarah; Adams, Polly; Ward, Meghan B.; Meehl, Michaela; Akel, Salem; Poston, Leigh; Bag, Asim; Mack, Stephen C.; Leggas, Markos; Klimo, Paul; Gajjar, Amar; Thomas, Paul; Robinson, Giles W.; Park, Julie R.; Crawford, Jeremy Chase; Gottschalk, Stephen; Northcott, Paul A.; Krenciute, Giedre; Derenzo, Christopher
A peptide encoded by upstream open reading frame of MYC binds to tropomyosin receptor kinase B and promotes glioblastoma growth in mice

由MYC上游开放阅读框编码的肽与原肌球蛋白受体激酶B结合并促进小鼠胶质母细胞瘤的生长

SCIENCE TRANSLATIONAL MEDICINE
IF14.6
2024-10-021
PRE
Li, Fanying; Yang, Kailin; Gao, Xinya; Zhang, Maolei; Gu, Danling; Wu, Xujia; Lu, Chenfei; Wu, Qiulian; Dixit, Deobrat; Gimple, Ryan C.; You, Yongping; Mack, Stephen C.; Shi, Yu; Kang, Tiebang; Agnihotri, Sameer A.; Taylor, Michael D.; Rich, Jeremy N.; Zhang, Nu; Wang, Xiuxing
Histone serotonylation regulates ependymoma tumorigenesis

组蛋白血清素化调控室管膜瘤肿瘤发生

Nature
IF48.5
2024-07-310
PRE
Hsiao-Chi Chen; Peihao He; Malcolm McDonald; Michael R. Williamson; Srinidhi Varadharajan; Brittney Lozzi; Junsung Woo; Dong-Joo Choi; Debosmita Sardar; Emmet Huang-Hobbs; Hua Sun; Siri M. Ippagunta; Antrix Jain; Ganesh Rao; Thomas E. Merchant; David W. Ellison; Jeffrey L. Noebels; Kelsey C. Bertrand; Stephen C. Mack; Benjamin Deneen

研究方向

暂未获取到该数据
M
Michael D. Taylor
H 指数:132论文数:1,683被引数:7.6万
S
Srinidhi Varadharajan
H 指数:15论文数:140被引数:1,095
K
Kelsey C. Bertrand
H 指数:18论文数:151被引数:2,051
J
Jeremy N. Rich
H 指数:127论文数:1,484被引数:6.0万
S
Sameer Agnihotri
H 指数:48论文数:480被引数:1.0万
S
Stefan M. Pfister
H 指数:159论文数:2,105被引数:12.7万
汪秀星 封面图
汪秀星
H 指数:41论文数:245被引数:6,650
A
Andrey Korshunov
H 指数:127论文数:831被引数:7.2万
V
Vijay Ramaswamy
H 指数:74论文数:660被引数:2.6万
B
Benjamin Deneen
H 指数:49论文数:317被引数:1.1万