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S

Srinidhi Varadharajan

st jude childrens research hospital
H指数:15
被引数:1,095

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Nuclear export as a therapeutic vulnerability in ZFTA-RELA ependymoma

ZFTA-RELA室管膜瘤中核输出作为治疗易损性

Neuro-Oncology
IF13.4
2026-05-030
OA
Siri M Ippagunta; Amir Arabzade; Srinidhi Varadharajan; Erik Emanus; Amanda Bland; Alisha Kardian; Nicholas Laboe; Hua Sun; Tuyu Zheng; Amelia Hancock; Mark Zhai; Emma Caesar; Maxwell Park; Wilda Orisme; Melissa Johnson; Brittany Rodgers; Gregory H Turner; Jeffrey Steinberg; Burgess Freeman; Martine F Roussel; Anang Shelat; Richard Kriwacki; Thomas E Merchant; Benjamin Deneen; Michael D Taylor; Sameer Agnihotri; Shondra Pruett-Miller; Jacob A Steele; Anoop Murthy Kavirayani; David W Ellison; Arzu Onar-Thomas; Giles Robinson; Stephen C Mack; Kelsey C Bertrand; null
Dominant clones leverage developmental epigenomic states to drive ependymoma

优势克隆利用发育期表观基因组状态驱动室管膜瘤

Nature
IF48.5
2026-03-250
OAAI
Alisha S. Kardian; Hua Sun; Siri Ippagunta; Nicholas Laboe; Srinidhi Varadharajan; Kwanha Yu; Hsiao-Chi Chen; Erik Emanus; Tuyu Zheng; Riley M. Deneen; Jon P. Connelly; Yong-Dong Wang; Jiangshan Zhan; Hengxi Liu; Kimberley Lowe; Taylor Bugbee; Rakesh Pathak; Amanda Bland; Sanya Mehta; Sophie Cochiolo; Amir Arabzade; Blake Holcomb; Kaitlin M. Budd; Gabriele Kembuan; Tristen Wright; Emma Caesar; Maxwell Park; Amelia Hancock; David Gee; Joel Murdoch; Yi Xiao; Samuel K. McBrayer; Thomas E. Merchant; Jun Qi; Adam D. Durbin; Lindsay A. Schwarz; Li Wang; Andrew M. Donson; Nicholas K. Foreman; Sameer Agnihotri; Alfonso Lavado; Suzanne J. Baker; David W. Ellison; Hyun Kyoung Lee; Shondra M. Pruett-Miller; Kelsey C. Bertrand; Benjamin Deneen; Stephen C. Mack
Synthetic ZFTA-fusions pinpoint IDR acquisition as a mechanism of brain tumor development

合成ZFTA融合蛋白将IDR的获得确定为脑肿瘤发展的机制

NEURO-ONCOLOGY
IF13.4
2025-11-010
OAAI
Arabzade, Amir; Shirnekhi, Hazheen; Varadharajan, Srinidhi; Ippagunta, Siri; Philips, Aaron; Laboe, Nicholas; Baggett, David; Wahiduzzaman, Fnu; Jo, Minjeong; Zheng, Tuyu; Tripathi, Swarnendu; Pathak, Rakesh; Emanus, Erik; Bland, Amanda; Kardian, Alisha; Holcomb, Blake; Wright, Tristen; Bugbee, Taylor; Hancock, Amelia; Chandra, Bappaditya; Ellison, David; Deneen, Benjamin; Bertrand, Kelsey; Kriwacki, Richard; Mack, Stephen
DOMINANT MALIGNANT LINEAGE LEVERAGE RESTRICTED EPIGENOMIC PROGRAMS TO DRIVE EPENDYMOMA DEVELOPMENT

优势恶性谱系利用受限的表观基因组程序来驱动室管膜瘤发展

NEURO-ONCOLOGY
IF13.4
2025-11-010
OAAI
Sun, Hua; Kardian, Alisha; Ippagunta, Siri; Laboe, Nicholas; Chen, Hsiao-Chi; Zhan, Jiangshan; Emanus, Erik; Varadharajan, Srinidhi; Zheng, Tuyu; Holcomb, Blake; Connelly, Jon P.; Wang, Yong-Dong; Lowe, Kimberley; Lee, Hyun Kyoung; Pruett-Miller, Shondra M.; Bertrand, Kelsey C.; Deneen, Benjamin; Mack, Stephen C.
Nuclear Transport as a Therapeutic Vulnerability in ZFTA-RELA Ependymoma

ZFTA-RELA室管膜瘤中核转运作为治疗性易损靶点

NEURO-ONCOLOGY
IF13.4
2025-11-010
OAAI
Ippagunta, Siri; Arabzade, Amir; Varadharajan, Srinidhi; Emanus, Erik; Bland, Amanda; Kardian, Alisha; Laboe, Nicolas; Sun, Hua; Zheng, Tuyu; Orisme, Wilda; Johnson, Melissa; Rodgers, Britanny; Turner, Gregory; Steinberg, Jeffrey; Freeman, Burgess; Roussel, Martine; Shelat, Anang; Kriwacki, Richard; Merchant, Thomas; Deneen, Benjamin; Miller, Shondra; Kavirayani, Anoop Murthy; Ellison, David; Onar-thomas, Arzu; Robinson, Giles; Mack, Stephen; Bertrand, Kelsey
Synthetic ZFTA fusions pinpoint disordered protein domain acquisition as a mechanism of brain tumorigenesis

合成ZFTA融合蛋白将无序蛋白质结构域的获取确定为脑肿瘤发生的一种机制

Nature Cell Biology
IF19.1
2025-08-270
OAAI
A. Arabzade; H. K. Shirnekhi; S. Varadharajan; S. M. Ippagunta; A. H. Phillips; N. Laboe; D. W. Baggett; Wahiduzzaman; M. Jo; T. Zheng; R. Pathak; D. Gee; D. Bhimsaria; H. Wu; X. Gao; J. Liu; E. Emanus; A. Bland; A. Kardian; A. Hancock; B. Holcomb; T. Wright; T. Bugbee; H. Sun; M. Zhai; E. Caesar; M. Park; S. Tripathi; A. Shirinifard; K. Lowe; A. Khalighifar; R. A. Petersen; S. King; D. Stabley; A. Pitre; G. E. Campbell; C-G Park; W. T. Freyaldenhoven; B. Chandra; Y. Xia; E. Bonten; A. Achari; S. Kandikonda; A. Carisey; S. B. Pounds; J. Xu; D. W. Ellison; B. Deneen; K. C. Bertrand; R. W. Kriwacki; S. C. Mack
Histone serotonylation regulates ependymoma tumorigenesis

组蛋白血清素化调控室管膜瘤肿瘤发生

Nature
IF48.5
2024-07-310
PRE
Hsiao-Chi Chen; Peihao He; Malcolm McDonald; Michael R. Williamson; Srinidhi Varadharajan; Brittney Lozzi; Junsung Woo; Dong-Joo Choi; Debosmita Sardar; Emmet Huang-Hobbs; Hua Sun; Siri M. Ippagunta; Antrix Jain; Ganesh Rao; Thomas E. Merchant; David W. Ellison; Jeffrey L. Noebels; Kelsey C. Bertrand; Stephen C. Mack; Benjamin Deneen
ZFTA FUSION ONCOPROTEINS DRIVE ONCOGENESIS THROUGH ASSEMBLY OF BIOMOLECULAR CONDENSATES
NEURO-ONCOLOGY
IF13.4
2024-06-180
OAAI
Varadharajan, Srinidhi; Arabzade, Amir; Shirnekhi, Hazheen K.; Ippagunta, Siri; Laboe, Nic; Gee, David; Emanus, Erik; Kardian, Alisha; Phillips, Aaron H.; Tripathi, Swarnendu; Shirinifard, Abbas; Petersen, Becky; King, Sharon; Stabley, Daniel; Pitre, Aaron; Campbell, George; Park, Cheon-Gil; Durbin, Adam D.; Qi, Jun; Bertrand, Kelsey; Taylor, Michael D.; Northcott, Paul A.; Deneen, Benjamin; Ansari, Aseem Z.; Kriwacki, Richard W.; Mack, Stephen C.
An ERK5-PFKFB3 axis regulates glycolysis and represents a therapeutic vulnerability in pediatric diffuse midline glioma
CELL REPORTS
IF6.9
2024-01-012
OA
Casillo, Stephanie M.; Gatesman, Taylor A.; Chilukuri, Akanksha; Varadharajan, Srinidhi; Johnson, Brenden J.; Premkumar, Daniel R. David; Jane, Esther P.; Plute, Tritan J.; Koncar, Robert F.; Stanton, Ann-Catherine J.; Biagi, Carlos A. O.; Barber, Callie S.; Halbert, Matthew E.; Golbourn, Brian J.; Halligan, Katharine; Cruz, Andrea F.; Mansi, Neveen M.; Cheney, Allison; Mullett, Steven J.; Van't Land, Clinton; Perez, Jennifer L.; Myers, Max I.; Agrawal, Nishant; Michel, Joshua J.; Chang, Yue-Fang; Vaske, Olena M.; Michaelraj, Antony; Lieberman, Frank S.; Felker, James; Shiva, Sruti; Bertrand, Kelsey C.; Amankulor, Nduka; Hadjipanayis, Costas G.; Abdullah, Kalil G.; Zinn, Pascal O.; Friedlander, Robert M.; Abel, Taylor J.; Nazarian, Javad; Venneti, Sriram; Filbin, Mariella G.; Gelhaus, Stacy L.; Mack, Stephen C.; Pollack, Ian F.; Agnihotri, Sameer
H3K27M HISTONE MUTANT GLIOMAS ARE SENSITIVE TO METHIONINE LOSS AND MAT2A INHIBITION THROUGH A NOVEL FEEDBACK MECHANISM BETWEEN AMD1 AND METTL16
NEURO-ONCOLOGY
IF13.4
2023-06-120
OAAI
Chilukuri, Akanksha; Halbert, Matthew; Golbourn, Brian; Varadharajan, Srinidhi; Krug, Brian; Mbah, Nneka; Casillo, Stephanie; Gatesman, Taylor; Cruz, Andrea; Zapotocky, Michael; Hu, Baoli; Kohanbash, Gary; Bertrand, Kelsey; Kleinman, Claudia; Lyssiotis, Costas; Jabado, Nada; Pollack, Ian; Mack, Stephen; Agnihotri, Sameer
K27M in canonical and noncanonical H3 variants occurs in distinct oligodendroglial cell lineages in brain midline gliomas
NATURE GENETICS
IF31.8
2022-12-0549
OA
Jessa, Selin; Mohammadnia, Abdulshakour; Harutyunyan, Ashot S.; Hulswit, Maud; Varadharajan, Srinidhi; Lakkis, Hussein; Kabir, Nisha; Bashardanesh, Zahedeh; Hebert, Steven; Faury, Damien; Vladoiu, Maria C.; Worme, Samantha; Coutelier, Marie; Krug, Brian; Faria Andrade, Augusto; Pathania, Manav; Bajic, Andrea; Weil, Alexander G.; Ellezam, Benjamin; Atkinson, Jeffrey; Dudley, Roy W. R.; Farmer, Jean-Pierre; Perreault, Sebastien; Garcia, Benjamin A.; Larouche, Valerie; Blanchette, Mathieu; Garzia, Livia; Bhaduri, Aparna; Ligon, Keith L.; Bandopadhayay, Pratiti; Taylor, Michael D.; Mack, Stephen C.; Jabado, Nada; Kleinman, Claudia L.

研究方向

暂未获取到该数据
S
Stephen C. Mack
H 指数:61论文数:529被引数:1.8万
B
Benjamin Deneen
H 指数:49论文数:317被引数:1.1万
K
Kelsey C. Bertrand
H 指数:18论文数:151被引数:2,051
A
Alisha Kardian
H 指数:7论文数:83被引数:373
S
Siri Ippagunta
H 指数:5论文数:56被引数:191
A
Amir Arabzade
H 指数:4论文数:101被引数:286
T
Tuyu Zheng
H 指数:4论文数:64被引数:380
H
Hsiao‐Chi Chen
H 指数:8论文数:65被引数:553
S
Sameer Agnihotri
H 指数:48论文数:480被引数:1.0万
E
Erik Emanus
H 指数:1论文数:49被引数:5