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Inhibition of ATP synthase reverse activity restores energy homeostasis in mitochondrial pathologies Acin-Perez, Rebeca; Beninca, Cristiane; del Rio, Lucia Fernandez; Shu, Cynthia; Baghdasarian, Siyouneh; Zanette, Vanessa; Gerle, Christoph; Jiko, Chimari; Khairallah, Ramzi; Khan, Shaharyar; Pacheco, David Rincon Fernandez; Shabane, Byourak; Erion, Karel; Masand, Ruchi; Dugar, Sundeep; Ghenoiu, Cristina; Schreiner, George; Stiles, Linsey; Liesa, Marc; Shirihai, Orian S. 分享 收藏
SPR965, a Dual PI3K/mTOR Inhibitor, as a Targeted Therapy in Ovarian Cancer Tran, Arthur-Quan; Sullivan, Stephanie A.; Chan, Leo Li-Ying; Yin, Yajie; Sun, Wenchuan; Fang, Ziwei; Dugar, Sundeep; Zhou, Chunxiao; Bae-Jump, Victoria 分享 收藏
Stimulatory effects of (-)-epicatechin and its enantiomer (+)-epicatechin on mouse frontal cortex neurogenesis markers and short-term memory: proof of concept Navarrete-Yanez, Viridiana; Garate-Carrillo, Alejandra; Ayala, Marcos; Rodriguez-Castaneda, Antonio; Mendoza-Lorenzo, Patricia; Ceballos, Guillermo; Ordonez-Razo, Rosa; Dugar, Sundeep; Schreiner, George; Villarreal, Francisco; Ramirez-Sanchez, Israel 分享 收藏
Discovery and Development of SPR519 as a Potent, Selective, and Orally Bioavailable Inhibitor of PI3Kα and mTOR Kinases for the Treatment of Solid Tumors Mahajan, Dinesh; Sen, Somdutta; Kuila, Bilash; Sharma, Amit; Arora, Reena; Sagar, Milind; Mahapatra, Amal Ray; Gawade, Lalita Babasaheb; Dugar, Sundeep 分享 收藏
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A pilot study on clinical pharmacokinetics and preclinical pharmacodynamics of (+)-epicatechin on cardiometabolic endpoints Moreno-Ulloa, Aldo; Najera-Garcia, Nayelli; Hernandez, Marcela; Ramirez-Sanchez, Israel; Taub, Pam R.; Su, Yongxuan; Beltran-Partida, Ernesto; Ceballos, Guillermo; Dugar, Sundeep; Schreiner, George; Best, Brookie M.; Ciaraldi, Theodore P.; Henry, Robert R.; Villarreal, Francisco 分享 收藏
A randomized, placebo-controlled, double-blind study on the effects of (-)- epicatechin on the triglyceride/HDLc ratio and cardiometabolic profile of subjects with hypertriglyceridemia: Unique in vitro effects Gutierrez-Salmean, Gabriela; Meaney, Eduardo; Lanaspa, Miguel A.; Cicerchi, Christina; Johnson, Richard J.; Dugar, Sundeep; Taub, Pam; Ramirez-Sanchez, Israel; Villarreal, Francisco; Schreiner, George; Ceballos, Guillermo 分享 收藏
Discovery of Novel and Orally Bioavailable Inhibitors of PI3 Kinase Based on Indazole Substituted Morpholino-Triazines Dugar, Sundeep; Hollinger, Frank P.; Mahajan, Dinesh; Sen, Somdutta; Kuila, Bilash; Arora, Reena; Pawar, Yogesh; Shinde, Vaibhav; Rahinj, Mahesh; Kapoor, Kamal K.; Bhumkar, Rahul; Rai, Santosh; Kulkarni, Rakesh 分享 收藏
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Pharmacokinetic, partial pharmacodynamic and initial safety analysis of (-)-epicatechin in healthy volunteers Barnett, Christopher F.; Moreno-Ulloa, Aldo; Shiva, Sruti; Ramirez-Sanchez, Israel; Taub, Pam R.; Su, Yongxuan; Ceballos, Guillermo; Dugar, Sundeep; Schreinerf, George; Villarreal, Francisco 分享 收藏
SPR965: an oral PI3K/ mTOR C1/C2 inhibitor for the treatment of solid tumors Arora, Reena; Dutta, Bakul K.; Goel, Ravinder; Hollinger, Frank P.; Kulia, Bilash; Mahajan, Dinesh; Mahapatra, Amal R.; Sagar, Milind; Sen, Somdutta; Sharma, Amit; Dugar, Sundeep 分享 收藏
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p38α-selective mitogen-activated protein kinase inhibitor SD-282 reduces inflammation in a subchronic model of tobacco smoke-induced airway inflammation Medicherla, Satyanarayana; Fitzgerald, Mary F.; Spicer, Dianne; Woodman, Paul; Ma, Jing Y.; Kapoun, Ann M.; Chakravarty, Sarvajit; Dugar, Sundeep; Protter, Andrew A.; Higgins, Linda S. 分享 收藏
Inhibiting TGF-β signaling restores immune surveillance in the SMA-560 glioma model Tran, Thomas-Toan; Uhl, Martin; Ma, Jing Ying; Janssen, Lisa; Sriram, Venkataraman; Aulwurm, Steffen; Kerr, Irene; Lam, Andrew; Webb, Heather K.; Kapoun, Ann M.; Kizer, Darin E.; McEnroe, Glenn; Hart, Barry; Axon, Jonathan; Murphy, Alison; Chakravarty, Sarvajit; Dugar, Sundeep; Protter, Andrew A.; Higgins, Linda S.; Wick, Wolfgang; Weller, Michael; Wong, Darren H. 分享 收藏
A p38α selective mitogen-activated protein kinase inhibitor prevents periodontal bone loss Kirkwood, Keith L.; Li, Fei; Rogers, Jill E.; Otremba, Jodie; Coatney, Derek D.; Kreider, Jaclynn M.; D'Silva, Nisha J.; Chakravarty, Sarvajit; Dugar, Sundeep; Higgins, Linda S.; Protter, Andrew A.; Medicherla, Satyanarayana 分享 收藏
Transforming growth factor-β receptor type 1 (TGFβRI) kinase activity but not p38 activation is required for TGF βRI-induced myofibroblast differentiation and profibrotic gene expression Kapoun, Ann M.; Gaspar, Nicholas J.; Wang, Ying; Damm, Debby; Liu, Yu-Wang; O'Young, Gilbert; Quon, Diana; Lam, Andrew; Munson, Kimberly; Tran, Thomas-Toan; Ma, Jing Ying; Murphy, Alison; Dugar, Sundeep; Chakravarty, Sarvajit; Protter, Andrew A.; Wen, Fu-Qiang; Liu, Xiangde; Rennard, Stephen I.; Higgins, Linda Slanec 分享 收藏
Inhibition of growth and metastasis of mouse mammary carcinoma by selective inhibitor of transforming growth factor-β type I receptor kinase in vivo Ge, Rongrong; Rajeev, Vaishali; Ray, Partha; Lattime, Edmund; Rittling, Susan; Medicherla, Satya; Protter, Andy; Murphy, Alison; Chakravarty, Jit; Dugar, Sundeep; Schreiner, George; Barnard, Nicola; Reiss, Michael 分享 收藏
A selective p38α mitogen-activated protein kinase inhibitor reverses cartilage and bone destruction in mice with collagen-induced arthritis Medicherla, Satyanarayana; Ma, Jing Ying; Mangadu, Ruban; Jiang, Yebin; Zhao, Jenny J.; Almirez, Ramona; Kerr, Irene; Stebbins, Elizabeth G.; O'Young, Gilbert; Kapoun, Ann M.; Luedtke, Gregory; Chakravarty, Sarvajit; Dugar, Sundeep; Genant, Harry K.; Protter, Andrew A. 分享 收藏
Preventive and therapeutic potential of p38α-selective mitogen-activated protein kinase inhibitor in nonobese diabetic mice with type 1 diabetes Medicherla, Satyanarayana; Protter, Andrew A.; Ma, Jing Ying; Mangadu, Ruban; Almirez, Ramona; Koppelman, Bruce; Kerr, Irene; Navas, Tony A.; Movius, Fabiola; Reddy, Mamatha; Liu, Yu-Wang; Luedtke, Gregory; Perumattam, John; Mavunkel, Babu; Dugar, Sundeep; Schreiner, George F. 分享 收藏
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