Katherine A. Donovan - Publications, H-index & Citations

Katherine A. Donovan

dana-farber cancer institute

42H指数

191论文数

7.3K被引数

收录论文 86

发表时间

Degron-independent recruitment of KAT2A expands the target space of CRBN molecular glues 泛素化位点不依赖的KAT2A招募扩展了CRBN分子胶的目标空间

Science

IF45.8

2026-07-09

PREAI

Samuel Ojeda; Meng Wang; Kheewoong Baek; Wallace Bourgeois; Alba Sommerschield; Hong Yue; Rebecca J. Metivier; Panos Karagiannis; Talya S. Levitz; Yuan Xiong; Katherine A. Donovan; Scott A. Armstrong; Eric S. Fischer

A Type II CDK6 Degrader Enables Cellular Targeting beyond the Limits of Type II Inhibition II型CDK6降解剂超越了II型抑制的极限，实现了细胞靶向

Journal of the American Chemical Society

IF15.6

2026-06-26

OAAI

Ji Hyeon Kim; Caitlin E. Mills; Zuzanna Kozicka; Daniel C. Scott; Cyrus Jin; Zixuan Jiang; Brendan G. Dwyer; Qixiang Geng; Sean T. Toenjes; Woong Sub Byun; Dina ElHarouni; Hongyu Li; Keith L. Ligon; Abby M. Thornhill; Hannah M. Jones; Bryan A. Romero; Stephen M. Hinshaw; Benjamin L. Ebert; Brenda A. Schulman; Katherine A. Donovan; Eric S. Fischer; Nathanael S. Gray

Charged molecular glue discovery enabled by targeted degron display 靶向降解基序展示驱动的带电分子胶发现

Nature Chemical Biology

IF13.7

2026-04-06

OAAI

Zhe Zhuang; Woong Sub Byun; Jakub Chrustowicz; Zuzanna Kozicka; Veronica L. Li; Dinah M. Abeja; Katherine A. Donovan; Sara Sepic; Inchul You; Mikołaj Słabicki; Eric S. Fischer; Stephen M. Hinshaw; Benjamin L. Ebert; Brenda A. Schulman; Nathanael S. Gray

High-throughput ligand diversification to discover chemical inducers of proximity 高通量配体多样化以发现邻近性的化学诱导剂

Nature Chemical Biology

IF13.7

2026-02-16

OAAI

James B. Shaum; Miquel Muñoz i Ordoño; Erica A. Steen; Daniela V. Wenge; Hakyung Cheong; Jordan Janowski; Moritz Hunkeler; Eric M. Bilotta; Zoe J. Rutter; Paige A. Barta; Abby M. Thornhill; Natalia Milosevich; Lauren M. Hargis; Timothy R. Bishop; Trever R. Carter; Bryce da Camara; Matthias Hinterndorfer; Lucas Dada; Wen-Ji He; Fabian Offensperger; Hirotake Furihata; Sydney R. Schweber; Charlie Hatton; Yanhe Wen; Benjamin F. Cravatt; Keary M. Engle; Katherine A. Donovan; Bruno Melillo; Seiya Kitamura; Alessio Ciulli; Scott A. Armstrong; Eric S. Fischer; Georg E. Winter; Michael A. Erb

Degraders of the dengue virus capsid protein exhibit differentiated pharmacology relative to capsid inhibitors 登革病毒衣壳蛋白的降解剂相对于衣壳抑制剂表现出差异化的药理学特性。

Nature Communications

IF15.7

2026-02-10

OAAI

Antara Chakravarty; Lu-Ning Wang; Ryan P. Golden; Zhengnian Li; Katherine A. Donovan; Oshri Afanzar; Yupeng Zhang; Eric S. Fischer; Nathanael S. Gray; Priscilla L. Yang

Development of FBXO22 Degraders and the Recruitment Ligand 2-Pyridinecarboxyaldehyde (2-PCA)FBXO22降解剂的开发及招募配体2-吡啶甲酰肼(2-PCA)

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

IF15.6

2025-11-01

PREAI

Qiu, Tian; Zhuang, Zhe; Byun, Woong Sub; Kozicka, Zuzanna; Baek, Kheewoong; Zhong, Jianing; Thornhill, Abby M.; Ryan, Julia K.; Donovan, Katherine A.; Fischer, Eric S.; Ebert, Benjamin L.; Gray, Nathanael S.

Covariation MS uncovers a protein that controls cysteine catabolism 协变量MS揭示了控制半胱氨酸分解代谢的蛋白质

Nature

IF48.5

2025-09-17

OAAI

Haopeng Xiao; Martha Ordonez; Emma C. Fink; Taylor A. Covington; Hilina B. Woldemichael; Junyi Chen; Mika Sarkin Jain; Milan H. Rohatgi; Shelley M. Wei; Nils Burger; Muneeb A. Sharif; Julius Jan; Yaoyu Wang; Jonathan J. Petrocelli; Katherine Blackmore; Amanda L. Smythers; Bingsen Zhang; Matthew Gilbert; Hakyung Cheong; Sumeet A. Khetarpal; Arianne Smith; Dina Bogoslavski; Yu Lei; Laura Pontano Vaites; Fiona E. McAllister; Nick Van Bruggen; Katherine A. Donovan; Edward L. Huttlin; Evanna L. Mills; Eric S. Fischer; Edward T. Chouchani

Expanding the druggable zinc-finger proteome defines properties of drug-induced degradation 扩展可成药的锌指蛋白质组界定了药物诱导降解的特性

Molecular Cell

IF16.6

2025-08-21

OAAI

Mikołaj Słabicki; Jiho Park; Radosław P. Nowak; Shourya S. Roy Burman; Jesse Pellman; Charles Zou; Hlib Razumkov; Jeannie Carreiro; Simran Rastogi; Anna Goldstein; Marek M. Nagiec; Katherine A. Donovan; Jianwei Che; Moritz Hunkeler; Qixiang Geng; Chi-Lin Hsu; Megha Lakshminarayan; Chelsea Shu; Rebecca L. Zon; Zuzanna Kozicka; Paul M.C. Park; Jonathan M. Tsai; Hojong Yoon; Lyn H. Jones; Adam S. Sperling; Nathanael S. Gray; Eric S. Fischer; Benjamin L. Ebert

Unveiling the hidden interactome of CRBN molecular glues 揭示CRBN分子胶的隐藏互作组

Nature Communications

IF15.7

2025-07-24

OAAI

Kheewoong Baek; Rebecca J. Metivier; Shourya S. Roy Burman; Jonathan W. Bushman; Hojong Yoon; Ryan J. Lumpkin; Julia K. Ryan; Dinah M. Abeja; Megha Lakshminarayan; Hong Yue; Samuel Ojeda; Yuan Xiong; Jianwei Che; Alyssa L. Verano; Anna M. Schmoker; Nathanael S. Gray; Katherine A. Donovan; Eric S. Fischer

Rational Design of CDK12/13 and BRD4 Molecular Glue Degraders CDK12/13和BRD4分子胶降解剂的合理设计

Angewandte Chemie International Edition

IF0

2025-07-08

PREAI

Dr. Zhe Zhuang; Dr. Woong Sub Byun; Dr. Zuzanna Kozicka; Dr. Katherine A. Donovan; Dr. Brendan G. Dwyer; Abby M. Thornhill; Hannah M. Jones; Zixuan Jiang; Xijun Zhu; Prof. Dr. Eric S. Fischer; Prof. Dr. Nicolas H. Thomä; Prof. Dr. Nathanael S. Gray

Structural ubiquitin contributes to K48 linkage specificity of the HECT ligase Tom1 结构泛素有助于HECT连接酶Tom1的K48连接特异性

CELL REPORTS

IF6.9

2025-05-01

OAAI

Warner, Katrina; Hunkeler, Moritz; Baek, Kheewoong; Schmoker, Anna; Burman, Shourya S. Roy; Overwijn, Daan; Jin, Cyrus; Donovan, Katherine A.; Fischer, Eric S.

Structure-guided design of a truncated heterobivalent chemical probe degrader of IRE1α

RSC MEDICINAL CHEMISTRY

IF3.6

2025-03-01

PREAI

Zerfas, Breanna L.; Liu, Yingpeng; Che, Jianwei; Donovan, Katherine A.; Hatcher, John M.; Huerta, Fidel; Metivier, Rebecca J.; Nowak, Radoslaw P.; Ragosta, Leah; Tsang, Tiffany; Fischer, Eric S.; Jones, Lyn H.

SMAC mimetics induce human macrophages to phagocytose live cancer cells SMAC模拟物诱导人巨噬细胞吞噬活癌细胞

IMMUNOTHERAPY ADVANCES

IF4.9

2025-01-01

OAAI

Liu, Samantha Y.; Hulsman, Max P. M.; Leyendecker, Philipp; Chang, Eugena; Donovan, Katherine A.; Strobel, Fabian; Dougan, James; Fischer, Eric S.; Dougan, Michael; Dougan, Stephanie K.; Qiang, Li

Niclosamide: CRL4AMBRA1 mediated degradation of cyclin D1 following mitochondrial membrane depolarization 尼洛酰胺：线粒体膜去极化后，CRL4AMBRA1介导的cyclin D1降解

RSC MEDICINAL CHEMISTRY

IF3.6

2025-01-01

OAAI

Coomar, Seemon; Gasser, Jessica A.; Slabicki, Mikolaj; Donovan, Katherine A.; Fischer, Eric S.; Ebert, Benjamin L.; Gillingham, Dennis; Thomae, Nicolas H.

A Kinetic Scout Approach Accelerates Targeted Protein Degrader Development

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

IF16.9

2024-12-16

OAAI

Fan, Angela T.; Gadbois, Gillian E.; Huang, Hai-Tsang; Chaudhry, Charu; Jiang, Jiewei; Sigua, Logan H.; Smith, Emily R.; Wu, Sitong; Poirier, Grace J.; Dunne-Dombrink, Kara; Goyal, Pavitra; Tao, Andrew J.; Sellers, William R.; Fischer, Eric S.; Donovan, Katherine A.; Ferguson, Fleur M.

Discovery of CRBN-Dependent WEE1 Molecular Glue Degraders from a Multicomponent Combinatorial Library 从多组分组合库中发现依赖CRBN的WEE1分子胶降解剂

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

IF15.6

2024-11-05

OAAI

Razumkov, Hlib; Jiang, Zixuan; Baek, Kheewoong; You, Inchul; Geng, Qixiang; Donovan, Katherine A.; Tang, Michelle T.; Metivier, Rebecca J.; Mageed, Nada; Seo, Pooreum; Li, Zhengnian; Byun, Woong Sub; Hinshaw, Stephen M.; Sarott, Roman C.; Fischer, Eric S.; Gray, Nathanael S.

Discovery of Potent Degraders of the Dengue Virus Envelope Protein 发现登革热病毒包膜蛋白的有效降解物

ADVANCED SCIENCE

IF14.1

2024-08-15

OAAI

Li, Zhengnian; Liu, Han-Yuan; He, Zhixiang; Chakravarty, Antara; Golden, Ryan P.; Jiang, Zixuan; You, Inchul; Yue, Hong; Donovan, Katherine A.; Du, Guangyan; Che, Jianwei; Tse, Jason; Che, Isaac; Lu, Wenchao; Fischer, Eric S.; Zhang, Tinghu; Gray, Nathanael S.; Yang, Priscilla L.

Template-assisted covalent modification underlies activity of covalent molecular glues 模板辅助的共价修饰是共价分子胶活性的基础

NATURE CHEMICAL BIOLOGY

IF13.7

2024-07-29

OAAI

Li, Yen-Der; Ma, Michelle W.; Hassan, Muhammad Murtaza; Hunkeler, Moritz; Teng, Mingxing; Puvar, Kedar; Rutter, Justine C.; Lumpkin, Ryan J.; Sandoval, Brittany; Jin, Cyrus Y.; Schmoker, Anna M.; Ficarro, Scott B.; Cheong, Hakyung; Metivier, Rebecca J.; Wang, Michelle Y.; Xu, Shawn; Byun, Woong Sub; Groendyke, Brian J.; You, Inchul; Sigua, Logan H.; Tavares, Isidoro; Zou, Charles; Tsai, Jonathan M.; Park, Paul M. C.; Yoon, Hojong; Majewski, Felix C.; Sperling, Haniya T.; Marto, Jarrod A.; Qi, Jun; Nowak, Radoslaw P.; Donovan, Katherine A.; Slabicki, Mikolaj; Gray, Nathanael S.; Fischer, Eric S.; Ebert, Benjamin L.

Polymerization of ZBTB transcription factors regulates chromatin occupancy ZBTB转录因子的聚合调节染色质占有率

MOLECULAR CELL

IF16.6

2024-07-01

PREAI

Park, Paul M. C.; Park, Jiho; Brown, Jared; Hunkeler, Moritz; Burman, Shourya S. Roy; Donovan, Katherine A.; Yoon, Hojong; Nowak, Radosaw P.; Sabicki, Mikoaj; Ebert, Benjamin L.; Fischer, Eric S.

Broad-spectrum activity against mosquito-borne flaviviruses achieved by a targeted protein degradation mechanism 通过靶向蛋白质降解机制实现的针对蚊媒黄病毒的广谱活性

NATURE COMMUNICATIONS

IF15.7

2024-06-19

OAAI

Liu, Han-Yuan; Li, Zhengnian; Reindl, Theresia; He, Zhixiang; Qiu, Xueer; Golden, Ryan P.; Donovan, Katherine A.; Bailey, Adam; Fischer, Eric S.; Zhang, Tinghu; Gray, Nathanael S.; Yang, Priscilla L.

研究方向