Jianwei Che

Harvard Medical School

40H指数

249论文数

8.1K被引数

收录论文 65

发表时间

DCAF11-dependent molecular glue degrader activated by glutathionylation DCAF11依赖性分子胶降解剂由谷胱甘肽化作用激活

Nature

IF48.5

2026-08-05

OAAI

Hojong Yoon; Franziska Wachter; Katharine A. Barrett; Cyrus Jin; Anna Rodríguez-Pöhnlein; Justine C. Rutter; Ryan J. Lumpkin; Rebecca J. Metivier; Katherine A. Donovan; Kheewoong Baek; Yongying Jiang; Minwoo Lee; Robert W. Kalis; Jianwei Che; Yuan Xiong; Eric S. Fischer; Benjamin L. Ebert

An AKR1C3-activated kinase inhibitor prodrug AKR1C3激活的激酶抑制剂前药

RSC Chem. Biol.

IF0

2025-12-20

OAAI

Zhengnian Li; Michael Martinez; Woong Sub Byun; Anuradha Thathireddy; Tian Qiu; Yaning Wang; Leon Katzengruber; Ani Chouldjian; Wenchao Lu; Wenzhi Ji; Jianwei Che; Tinghu Zhang; Stephen M. Hinshaw; Nathanael S. Gray

Expanding the druggable zinc-finger proteome defines properties of drug-induced degradation 扩展可成药的锌指蛋白质组界定了药物诱导降解的特性

Molecular Cell

IF16.6

2025-08-21

OAAI

Mikołaj Słabicki; Jiho Park; Radosław P. Nowak; Shourya S. Roy Burman; Jesse Pellman; Charles Zou; Hlib Razumkov; Jeannie Carreiro; Simran Rastogi; Anna Goldstein; Marek M. Nagiec; Katherine A. Donovan; Jianwei Che; Moritz Hunkeler; Qixiang Geng; Chi-Lin Hsu; Megha Lakshminarayan; Chelsea Shu; Rebecca L. Zon; Zuzanna Kozicka; Paul M.C. Park; Jonathan M. Tsai; Hojong Yoon; Lyn H. Jones; Adam S. Sperling; Nathanael S. Gray; Eric S. Fischer; Benjamin L. Ebert

Unveiling the hidden interactome of CRBN molecular glues 揭示CRBN分子胶的隐藏互作组

Nature Communications

IF15.7

2025-07-24

OAAI

Kheewoong Baek; Rebecca J. Metivier; Shourya S. Roy Burman; Jonathan W. Bushman; Hojong Yoon; Ryan J. Lumpkin; Julia K. Ryan; Dinah M. Abeja; Megha Lakshminarayan; Hong Yue; Samuel Ojeda; Yuan Xiong; Jianwei Che; Alyssa L. Verano; Anna M. Schmoker; Nathanael S. Gray; Katherine A. Donovan; Eric S. Fischer

Plasmodium falciparum protein kinase 6 and hemozoin formation are inhibited by a type II human kinase inhibitor exhibiting antimalarial activity Plasmodium falciparum蛋白激酶6和血红素晶体的形成被一种具有抗疟疾活性的II型人源激酶抑制剂所抑制

Cell Chemical Biology

IF7.2

2025-07-07

PREAI

Flore Nardella; Tiantian Jiang; Lushun Wang; Monica J. Bohmer; Subhoja Chakraborty; John Okombo; Jaeson Calla; Tatiane Macedo Silva; Samuel Pazicky; Jianwei Che; Jin Jeon; Evie Vincent; Nonlawat Boonyalai; Rachael Coyle; Mairi J. Buchanan; Samuel Schaefer; Daisy Chen; Amaan Khan; Emily Mayville; Mariana Laureano De Souza; Mayland Treat; Jordan Charlton; Patrick K. Tumwebaze; Seth Tjia; Lukas Montejo; Karen Cover; Philip J. Rosenthal; Roland A. Cooper; Zbynek Bozdech; Marcus C.S. Lee; Ratna Chakrabarti; Sanjay A. Desai; David A. Fidock; Jinhua Wang; Nathanael S. Gray; Elizabeth A. Winzeler; Debopam Chakrabarti

Structure-guided design of a truncated heterobivalent chemical probe degrader of IRE1α

RSC MEDICINAL CHEMISTRY

IF3.6

2025-03-01

PREAI

Zerfas, Breanna L.; Liu, Yingpeng; Che, Jianwei; Donovan, Katherine A.; Hatcher, John M.; Huerta, Fidel; Metivier, Rebecca J.; Nowak, Radoslaw P.; Ragosta, Leah; Tsang, Tiffany; Fischer, Eric S.; Jones, Lyn H.

Molecular dynamics study of the groove-forming mechanism of mechanically scratched grating multilayer aluminum films

MECHANICS OF ADVANCED MATERIALS AND STRUCTURES

IF0

2024-08-29

PREAI

Liu, Jiye; Shi, Guangfeng; Che, Jianwei; Jiang, Ziwei; Yao, Dong; Xu, Ying; Li, He

Discovery of Potent Degraders of the Dengue Virus Envelope Protein 发现登革热病毒包膜蛋白的有效降解物

ADVANCED SCIENCE

IF14.1

2024-08-15

OAAI

Li, Zhengnian; Liu, Han-Yuan; He, Zhixiang; Chakravarty, Antara; Golden, Ryan P.; Jiang, Zixuan; You, Inchul; Yue, Hong; Donovan, Katherine A.; Du, Guangyan; Che, Jianwei; Tse, Jason; Che, Isaac; Lu, Wenchao; Fischer, Eric S.; Zhang, Tinghu; Gray, Nathanael S.; Yang, Priscilla L.

Activating Point Mutations in the MET Kinase Domain Represent a Unique Molecular Subset of Lung Cancer and Other Malignancies Targetable with MET Inhibitors

CANCER DISCOVERY

IF33.3

2024-04-02

OAAI

Pecci, Federica; Nakazawa, Seshiru; Ricciuti, Biagio; Harada, Guilherme; Lee, Jessica K.; Alessi, Joao V.; Barrichello, Adriana; Vaz, Victor R.; Lamberti, Giuseppe; Di Federico, Alessandro; Gandhi, Malini M.; Gazgalis, Dimitris; Feng, William W.; Jiang, Jie; Baldacci, Simon; Locquet, Marie-Anais; Gottlieb, Felix H.; Chen, Monica F.; Lee, Elinton; Haradon, Danielle; Smokovich, Anna; Voligny, Emma; Nguyen, Tom; Goel, Vikas K.; Zimmerman, Zachary; Atwal, Sumandeep; Wang, Xinan; Bahcall, Magda; Heist, Rebecca S.; Iqbal, Sumaiya; Gandhi, Nishant; Elliott, Andrew; Vanderwalde, Ari M.; Ma, Patrick C.; Halmos, Balazs; Liu, Stephen V.; Che, Jianwei; Schrock, Alexa B.; Drilon, Alexander; Janne, Pasi A.; Awad, Mark M.

Molecular Bidents with Two Electrophilic Warheads as a New Pharmacological Modality 具有两个亲电子弹头的分子Bidents作为一种新的药理形式

ACS CENTRAL SCIENCE

IF10.4

2024-02-26

OAAI

Li, Zhengnian; Jiang, Jie; Ficarro, Scott B.; Beyett, Tyler S.; To, Ciric; Tavares, Isidoro; Zhu, Yingde; Li, Jiaqi; Eck, Michael J.; Janne, Pasi A.; Marto, Jarrod A.; Zhang, Tinghu; Che, Jianwei; Gray, Nathanael S.

ZNL0325, a Pyrazolopyrimidine-Based Covalent Probe, Demonstrates an Alternative Binding Mode for Kinases ZNL0325是一种基于吡唑并嘧啶的共价探针，展示了激酶的另一种结合模式

JOURNAL OF MEDICINAL CHEMISTRY

IF6.8

2024-02-01

PREAI

Li, Zhengnian; Lu, Wenchao; Beyett, Tyler S.; Ficarro, Scott B.; Jiang, Jie; Tse, Jason; Kim, Audrey Yong-Ju; Marto, Jarrod A.; Che, Jianwei; Janne, Pasi A.; Eck, Michael J.; Zhang, Tinghu; Gray, Nathanael S.

Development of sulfonyl fluoride chemical probes to advance the discovery of cereblon modulators

RSC MEDICINAL CHEMISTRY

IF3.6

2024-01-01

PREAI

Liu, Yingpeng; Nowak, Radoslaw P.; Che, Jianwei; Donovan, Katherine A.; Huerta, Fidel; Liu, Hu; Metivier, Rebecca J.; Fischer, Eric S.; Jones, Lyn H.

Catalytic Degraders Effectively Address Kinase Site Mutations in EML4-ALK Oncogenic Fusions

JOURNAL OF MEDICINAL CHEMISTRY

IF6.8

2023-04-10

PREAI

Gao, Yang; Jiang, Baishan; Kim, Hellen; Berberich, Matthew J.; Che, Jianwei; Donovan, Katherine A.; Hatcher, John M.; Huerta, Fidel; Kwiatkowski, Nicholas P.; Liu, Yingpeng; Liuni, Peter P.; Metivier, Rebecca J.; Murali, Vineeth K.; Nowak, Radoslaw P.; Zhang, Tinghu; Fischer, Eric S.; Gray, Nathanael S.; Jones, Lyn H.

HiBiT-SpyTag: A Minimal Tag for Covalent Protein Capture and Degrader Development

ACS CHEMICAL BIOLOGY

IF3.8

2023-04-05

PREAI

Tsang, Tiffany; Huerta, Fidel; Liu, Yingpeng; Che, Jianwei; Metivier, Rebecca J.; Ferrao, Silas; Donovan, Katherine A.; Jones, Lyn H.; Zerfas, Breanna L.; Nowak, Radoslaw P.

Catalytic degraders effectively address kinase site mutations in EML-ALK oncogenic fusions

CANCER RESEARCH

IF16.6

2023-04-04

PREAI

Gao, Yang; Jiang, Baishan; Kim, Hellen; Che, Jianwei; Donovan, Katherine; Hatcher, John; Huerta, Fidel; Kwiatkowski, Nicholas; Liu, Yingpeng; Liuni, Peter; Metivier, Rebecca J.; Murali, Vineeth; Nowak, Radoslaw; Zhang, Tinghu; Fischer, Eric; Gray, Nathanael; Jones, Lyn

Structure-Based Design of Y-Shaped Covalent TEAD Inhibitors

JOURNAL OF MEDICINAL CHEMISTRY

IF6.8

2023-03-22

OAAI

Lu, Wenchao; Fan, Mengyang; Ji, Wenzhi; Tse, Jason; You, Inchul; Ficarro, Scott B.; Tavares, Isidoro; Che, Jianwei; Kim, Audrey Y.; Zhu, Xijun; Boghossian, Andrew; Rees, Matthew G.; Ronan, Melissa M.; Roth, Jennifer A.; Hinshaw, Stephen M.; Nabet, Behnam; Corsello, Steven M.; Kwiatkowski, Nicholas; Marto, Jarrod A.; Zhang, Tinghu; Gray, Nathanael S.

Development of a Covalent Inhibitor of c-Jun N-Terminal Protein Kinase (JNK) 2/3 with Selectivity over JNK1

JOURNAL OF MEDICINAL CHEMISTRY

IF6.8

2023-02-24

PREAI

Lu, Wenchao; Liu, Yao; Gao, Yang; Geng, Qixiang; Gurbani, Deepak; Li, Lianbo; Ficarro, Scott B.; Meyer, Cynthia J.; Sinha, Dhiraj; You, Inchul; Tse, Jason; He, Zhixiang; Ji, Wenzhi; Che, Jianwei; Kim, Audrey Y.; Yu, Tengteng; Wen, Kenneth; Anderson, Kenneth C.; Marto, Jarrod A.; Westover, Kenneth D.; Zhang, Tinghu; Gray, Nathanael S.

Depletion of creatine phosphagen energetics with a covalent creatine kinase inhibitor 用共价肌酸激酶抑制剂消耗肌酸磷酸原能量

NATURE CHEMICAL BIOLOGY

IF13.7

2023-02-23

OAAI

Darabedian, Narek; Ji, Wenzhi; Fan, Mengyang; Lin, Shan; Seo, Hyuk-Soo; Vinogradova, Ekaterina V. V.; Yaron, Tomer M. M.; Mills, Evanna L. L.; Xiao, Haopeng; Senkane, Kristine; Huntsman, Emily M. M.; Johnson, Jared L. L.; Che, Jianwei; Cantley, Lewis C. C.; Cravatt, Benjamin F. F.; Dhe-Paganon, Sirano; Stegmaier, Kimberly; Zhang, Tinghu; Gray, Nathanael S. S.; Chouchani, Edward T. T.

Structural rationalization of GSPT1 and IKZF1 degradation by thalidomide molecular glue derivatives

RSC MEDICINAL CHEMISTRY

IF3.6

2023-01-01

PREAI

Nowak, Radoslaw P.; Che, Jianwei; Ferrao, Silas; Kong, Nikki R.; Liu, Hu; Zerfas, Breanna L.; Jones, Lyn H.

Pharmacological blockade of TEAD-YAP reveals its therapeutic limitation in cancer cells

NATURE COMMUNICATIONS

IF15.7

2022-11-08

OAAI

Sun, Yang; Hu, Lu; Tao, Zhipeng; Jarugumilli, Gopala K.; Erb, Hannah; Singh, Alka; Li, Qi; Cotton, Jennifer L.; Greninger, Patricia; Egan, Regina K.; Ip, Y. Tony; Benes, Cyril H.; Che, Jianwei; Mao, Junhao; Wu, Xu

研究方向