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D

Dmytro Lesyk

v. p. kukhar institute of bioorganic chemistry & petrochemistry of the national academy of sciences of ukraine

8H指数
48论文数
274被引数
收录论文 17
发表时间
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Structure-Activity Relationships in a Series of Dihydrouracil-JQ1 Conjugates: Discovery of Highly Potent BRD4 Degraders二氢尿嘧啶-JQ1缀合物的构效关系研究：高活性BRD4降解剂的发现
errrsc med. chem.
IF0
err2026-05-07
err0
PREAI
errOleh Shyshlyk; Vladyslav Stadnichenko; Oleksandr Diachenko; Iryna Chernysh; Anna Beshtynarska; Diana Alieksieieva; Diana Khotinets; Oleksii Oleksiak; Dmytro Lesyk; Yelyzaveta Yeremenko; Angelina V. Biitseva; Petro Borysko; Volodymyr Yarmolchuk; Ganna M. Tolstanova; Oleksandr O. Grygorenko
err分享
err收藏
Expanding the biocatalytic toolbox: PLE-catalyzed kinetic resolution and lipophilicity modulation of 2-fluoroalkyl chroman-4-ols拓展生物催化工具箱：PLE催化下2-氟烷基色满-4-醇的动力学拆分和脂溶性调控
errJournal of Fluorine Chemistry
IF1.9
err2026-04-01
err0
PREAI
errTimokhin, Oleksii S.; Rashevskyi, Andrii S.; Kucher, Olexandr, V; Lesyk, Dmytro; Holota, Yuliia; Borysko, Petro; Pilyo, Stepan G.; Grygorenko, Oleksandr O.; Moskvina, Viktoriia S.
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α-Fluoroalkyl-substituted cyclopentane building blocks for drug discoveryα-氟代烷基取代的环戊烷构建模块用于药物发现
errJournal of Fluorine Chemistry
IF1.9
err2026-04-01
err1
PREAI
errBobovskyi, Bohdan, V; Demchuk, Oleksandr; Sosunovych, Bohdan S.; Vashchenko, Bohdan V.; Razhik, Bohdan, V; Lesyk, Dmytro; Melnykov, Kostiantyn P.; Borysko, Petro; Gerus, Igor; Grygorenko, Oleksandr O.
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Synthesis, Physicochemical Properties, and Computational Analysis of Tris(fluoromethyl)Alkyl Building Blocks
errChemistry – A European Journal
IF3.7
err2026-01-28
err0
PREAI
errDenys Klyukovskyi; Oleksandr S. Liashuk; Mykhailo Redka; Alina T. Bezuhla; Oleksandr P. Blahun; Dmytro Lesyk; Petro Borysko; Anton V. Chernykh; Yurii M. Pustovit; Oleksandr O. Grygorenko
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Bicyclic 1,4-Dioxepanes for Drug Discovery: Multigram Synthesis, Physicochemical, and Structural Characterization
errCHEMISTRY-A EUROPEAN JOURNAL
IF3.7
err2025-12-01
err0
PREAI
errBondarenko, Andrii V.; Kozyriev, Yevhenii; Doroshenko, Illia O.; Lesyk, Dmytro; Borysko, Petro; Shishkina, Svetlana V.; Vashchenko, Bohdan V.; Grygorenko, Oleksandr O.
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Synthesis and Physicochemical Characterization of 5-Trifluoromethyl-Substituted Tetrahydrofurans and Tetrahydrothiophenes5-三氟甲基取代四氢呋喃和四氢噻吩的合成与物理化学表征
errEUROPEAN JOURNAL OF ORGANIC CHEMISTRY
IF2.7
err2025-12-01
err0
errOAAI
errRedka, Mykhailo O.; Dovhaniuk, Nazar; Blahun, Oleksandr; Liashuk, Oleksandr S.; Hurieva, Anastasiia M.; Lesyk, Dmytro; Skrypnik, Daniil; Holota, Yuliia; Durylin, Dmytro; Borysko, Petro; Kondratov, Ivan S.; Grygorenko, Oleksandr O.
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Gram-scale synthesis and physicochemical properties of exo- and endo-5,5-difluorooctahydropentalen-2-amines
errJOURNAL OF FLUORINE CHEMISTRY
IF1.9
err2025-10-01
err0
PREAI
errVoloshyna, Olena; Moroz, Bohdan; Melnykov, Kostiantyn P.; Holovach, Serhii; Lesyk, Dmytro; Holota, Yuliia; Borysko, Petro; Filatov, Andrey A.; Grygorenko, Oleksandr O.
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Basicity and Lipophilicity of gem-Difluorinated Saturated Bicyclic Amines: Advanced Building Blocks for Drug Discovery碱性和脂溶性：gem-二氟代饱和双环胺：药物发现中的先进构建模块
errEuropean Journal of Organic Chemistry
IF2.7
err2025-09-09
err0
PREAI
errOleksandr S. Liashuk; Bohdan Moroz; Kostiantyn P. Melnykov; Serhii Holovach; Dmytro Lesyk; Yaroslav Lesyk; Daniil Skrypnik; Yuliia Holota; Petro Borysko; Andrey A. Filatov; Oleksandr O. Grygorenko
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Synthesis and Physicochemical Properties of Functionalized cis–2-((Fluoro)Alkyl)Cyclobutanes功能化顺式-2-((氟)烷基)环丁烷的合成与物理化学性质
errChemPlusChem
IF2.8
err2025-07-09
err0
PREAI
errAnton V. Chernykh; Oleksandr S. Liashuk; Kyrylo O. Kononenko; Artem Y. Michuda; Oleksandr S. Olifir; Dmytro Lesyk; Karina Turenko; Andrii V. Kozytskyi; Svitlana V. Shishkina; Petro Borysko; Serhiy V. Ryabukhin; Dmytro M. Volochnyuk; Oleksandr O. Grygorenko
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Physicochemical and Biological Evaluation of gem-Difluorinated Saturated Oxygen Heterocycles as Bioisosteres for Drug Discovery
errCHEMISTRY-A EUROPEAN JOURNAL
IF3.7
err2024-12-18
err1
PREAI
errMelnykov, Kostiantyn P.; Liashuk, Oleksandr S.; Holovach, Serhii; Shatnia, Valeriia; Horbenko, Artur; Lesyk, Dmytro; Melnyk, Varvara; Skrypnik, Daniil; Beshtynarska, Anna; Borysko, Petro; Viniichuk, Oleksandr; Grygorenko, Oleksandr O.
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err收藏
Angular Spirocyclic Azetidines: Synthesis, Characterization, and Evaluation in Drug Discovery
errANGEWANDTE CHEMIE-INTERNATIONAL EDITION
IF16.9
err2024-12-12
err0
errOAAI
errKirichok, Alexander A.; Tkachuk, Hennadii; Levchenko, Kostiantyn; Granat, Dmitry; Yegorova, Tetyana; Lesyk, Dmytro; Anisiforova, Anna; Holota, Yuliia; Zomchak, Viktoriia; Bodenchuk, Iryna; Kosach, Viktoriia; Borysko, Petro; Korzh, Rodion A.; Al-Maali, Galeb; Kubyshkin, Vladimir; Rzepa, Henry S.; Mykhailiuk, Pavel K.
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4-Azaspiro[2.3]hexane, an Overlooked Piperidine Isostere: Multigram Synthesis and Physicochemical and Structural Evaluation
errJOURNAL OF ORGANIC CHEMISTRY
IF3.6
err2024-11-26
err1
PREAI
errGalavskyy, Sergiy; Chernykh, Anton; Liashuk, Oleksandr; Lesyk, Dmytro; Shishkina, Svitlana V.; Kliukovskyi, Denys; Volochnyuk, Dmytro M.; Ryabukhin, Serhiy V.; Grygorenko, Oleksandr O.
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CF3-Cyclobutanes: Synthesis, Properties, and Evaluation as a Unique tert-Butyl Group AnalogueCF3-Cyclobutanes: 独特的叔丁基类似物的合成，性质和评价
errJACS AU
IF8.7
err2024-11-11
err0
errOAAI
errAhunovych, Volodymyr; Klipkov, Anton A.; Bugera, Maksym; Tarasenko, Karen; Trofymchuk, Serhii; Razhyk, Bohdan; Boretskyi, Andrii; Stanko, Oleh; Panasiuk, Yaroslav; Shablykin, Oleh; Al-Maali, Galeb; Lesyk, Dmytro; Klymenko-Ulianov, Oleksii; Horbatok, Kateryna; Bodenchuk, Iryna; Kosach, Viktoriia; Borysko, Petro; Kubyshkin, Vladimir; Mykhailiuk, Pavel K.
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err收藏
3,3-Difluorooxetane-A Versatile Functional Group for Bioisosteric Replacements in Drug Discovery
errCHEMISTRY-A EUROPEAN JOURNAL
IF3.7
err2024-10-31
err1
PREAI
errLiashuk, Oleksandr S.; Fedinchyk, Anastasiya; Melnykov, Kostiantyn P.; Herasymchuk, Maksym; Alieksieieva, Diana; Lesyk, Dmytro; Bas, Yuliia P.; Keda, Tetiana Ye.; Yatsymyrskiy, Andriy V.; Holota, Yuliia; Borysko, Petro; Yarmolchuk, Volodymyr S.; Grygorenko, Oleksandr O.
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2-Oxabicyclo[2.1.1]hexanes: Synthesis, Properties, and Validation as Bioisosteres of ortho- and meta-Benzenes2-氧杂双环 [2.1.1] 己烷: 邻苯和间苯的生物电子等排体的合成，性质和验证
errANGEWANDTE CHEMIE-INTERNATIONAL EDITION
IF16.9
err2024-04-03
err13
errOAAI
errLevterov, Vadym V.; Panasiuk, Yaroslav; Shablykin, Oleh; Stashkevych, Oleksandr; Sahun, Kateryna; Rassokhin, Artur; Sadkova, Iryna; Lesyk, Dmytro; Anisiforova, Anna; Holota, Yuliia; Borysko, Petro; Bodenchuk, Iryna; Voloshchuk, Nataliya M.; Mykhailiuk, Pavel K.
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1-Azaspiro[3.3]heptane as a Bioisostere of Piperidine1-氮杂螺 [3.3] 庚烷作为哌啶的生物电子等排物
errANGEWANDTE CHEMIE-INTERNATIONAL EDITION
IF16.9
err2023-11-14
err9
errOAAI
errKirichok, Alexander A.; Tkachuk, Hennadii; Kozyriev, Yevhenii; Shablykin, Oleh; Datsenko, Oleksandr; Granat, Dmitry; Yegorova, Tetyana; Bas, Yuliya P.; Semirenko, Vitalii; Pishel, Iryna; Kubyshkin, Vladimir; Lesyk, Dmytro; Klymenko-Ulianov, Oleksii; Mykhailiuk, Pavel K.
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1,2-Disubstituted bicyclo[2.1.1]hexanes as saturated bioisosteres of ortho-substituted benzene
errChemical Science
IF7.4
err2023-01-01
err32
errOAAI
errDenisenko, Aleksandr; Garbuz, Pavel; Makovetska, Yelyzaveta; Shablykin, Oleh; Lesyk, Dmytro; Al-Maali, Galeb; Korzh, Rodion; Sadkova, Iryna V.; Mykhailiuk, Pavel K.
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研究方向

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合作学者
合作期刊
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