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Xavier Brazzolotto

universidade de santiago de compostela
H指数:27
被引数:3,212

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Design, synthesis and biological evaluation of pleiotropic prodrugs activated by cholinesterases and releasing a 5-HT4R agonist, with in vivo antiamnesic activity.

设计、合成及生物学评价：经胆碱酯酶激活并释放5-HT<sub>4</sub>R激动剂、具有体内抗遗忘活性的多效前药

European Journal of Medicinal Chemistry
IF5.9
2026-10-100
OAAI
Alice Wang; Caroline Lahogue; Thomas Curel; Caroline Lanthier; Anne-Claire Groo; Audrey Davis; Sophie Corvaisier; Dimitri Fayolle; Fabrice Modeste; Xavier Brazzolotto; Florian Nachon; Cédric Lecoutey; Sylvie Claeysen; Aurélie Malzert-Fréon; Thomas Freret; Michel Boulouard; Marc Since; Christophe Rochais; Patrick Dallemagne
Leveraging multitargeting BChE-MAO B inhibitors against microglia-related neuroinflammation: in vitro biological evaluation, structure-activity relationships, drug-like properties, and X-ray crystal complexes

利用多靶点BChE-MAO B抑制剂对抗小胶质细胞相关神经炎症：体外生物评价、构效关系、类药性以及X射线晶体复合物

European Journal of Medicinal Chemistry
IF5.9
2026-09-291
PRE
Rullo, Mariagrazia; La Spada, Gabriella; Brazzolotto, Xavier; Marchese, Sara; El Idrissi, Imane Ghafir; Miciaccia, Morena; Colella, Marco; Brea, Jose M.; Macchia, Eleonora; Loza, Maria I.; Gottinger, Andrea; Scilimati, Antonio; Perrone, Maria Grazia; Stefanachi, Angela; Binda, Claudia; Leonetti, Francesco; Pisani, Leonardo
Access to novel potent pleiotropic prodrugs, targeting both butyrylcholinesterase and serotonin reuptake, with anti-amnesic activities in Alzheimer’s disease model.

获得新型强效多效性前药，其靶向丁酰胆碱酯酶和血清素再摄取，并在阿尔茨海默病模型中具有抗遗忘活性。

European Journal of Medicinal Chemistry
IF5.9
2026-02-120
PRE
Valentin Travers--Lesage; Lucie Crouzier; Mirjana Antonijevic; Alice Wang; François-Xavier Toublet; Audrey Davis; Fabrice Modeste; Xavier Brazzolotto; Florian Nachon; Marc Since; Tangui Maurice; Christophe Rochais; Patrick Dallemagne
Dual Cholinergic Modulation in Dementia: Quinuclidine Carbamates Targeting Butyrylcholinesterase and α7 Nicotinic Receptor

痴呆症的双胆碱能调节：靶向丁酰胆碱酯酶和α7烟碱型受体喹啉环碳酸酯类化合物

Chemico-Biological Interactions
IF5.4
2025-11-150
PRE
Peter Mastnak-Sokolov; Damijan Knez; Anže Meden; Nika Strašek Benedik; Svit Ferjančič Benetik; Martina Hrast Rambaher; Maša Zorman; Florian Nachon; Xavier Brazzolotto; Kent Jardemark; Oscar Jungholm; Joseph Bruton; Emilia Strandback; Tomas Nyman; Mohammed Shahid; Stanislav Gobec
Multifunctional, Fluorene-Based Modulator of Cholinergic and GABAergic Neurotransmission as a Novel Drug Candidate for Palliative Treatment of Alzheimer's Disease
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
IF16.9
2024-11-220
OA
Panek, Dawid; Pasieka, Anna; Jonczyk, Jakub; Gawlinska, Milena; Zareba, Paula; Siwek, Agata; Wolak, Malgorzata; Mordyl, Barbara; Gluch-Lutwin, Monika; Latacz, Gniewomir; Brazzolotto, Xavier; Chantegreil, Fabien; Nachon, Florian; Zdarova Karasova, Jana; Pejchal, Jaroslav; Mzik, Martin; Sestak, Vit; Prchal, Lukas; Odvarkova, Jitka; Soukup, Ondrej; Korabecny, Jan; Sorf, Ales; Hamsikova, Marie; Zemanova, Lucie; Muckova, Lubica; Vanova, Nela; Dryja, Pola; Salat, Kinga; Hoefner, Georg; Wanner, Klaus; Wieckowska, Anna; Malawska, Barbara
8-Hydroxyquinolylnitrones as multifunctional ligands for the therapy of neurodegenerative diseases
ACTA PHARMACEUTICA SINICA B
IF14.6
2023-05-0118
OAAI
Knez, Damijan; Diez-Iriepa, Daniel; Chioua, Mourad; Gottinger, Andrea; Denic, Milica; Chantegreil, Fabien; Nachon, Florian; Brazzolotto, Xavier; Skrzypczak-Wiercioch, Anna; Meden, Anze; Pislar, Anja; Kos, Janko; Zakelj, Simon; Stojan, Jure; Salat, Kinga; Serrano, Julia; Fernandez, Ana Patricia; Sanchez-Garcia, Aitana; Martinez-Murillo, Ricardo; Binda, Claudia; Lopez-Munoz, Francisco; Gobec, Stanislav; Marco-Contelles, Jose
Highly selective butyrylcholinesterase inhibitors related to Amaryllidaceae alkaloids- Design, synthesis, and biological evaluation
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
IF5.9
2023-04-016
PRE
Pidany, Filip; Kroustkova, Jana; Al Mamun, Abdullah; Suchankova, Daniela; Brazzolotto, Xavier; Nachon, Florian; Chantegreil, Fabien; Dolezal, Rafael; Pulkrabkova, Lenka; Muckova, Lubica; Hrabinova, Martina; Finger, Vladimir; Kufa, Martin; Soukup, Ondrej; Jun, Daniel; Jenco, Jaroslav; Kunes, Jiri; Novakova, Lucie; Korabecny, Jan; Cahlikova, Lucie
Discovery of new, highly potent and selective inhibitors of BuChE- design synthesis, in vitro and in vivo evaluation and crystallography studies

发现新的，高效和选择性的BuChE抑制剂-设计合成，体外和体内评估和晶体学研究

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
IF5.9
2023-03-018
PRE
Panek, Dawid; Pasieka, Anna; Latacz, Gniewomir; Zareba, Paula; Szczech, Michal; Godyn, Justyna; Chantegreil, Fabien; Nachon, Florian; Brazzolotto, Xavier; Skrzypczak-Wiercioch, Anna; Walczak, Maria; Smolik, Magdalena; Salat, Kinga; Hoefner, Georg; Wanner, Klaus; Wieckowska, Anna; Malawska, Barbara
Pseudo-irreversible butyrylcholinesterase inhibitors: Structure-activity relationships, computational and crystallographic study of the N-dialkyl O-arylcarbamate warhead

假不可逆丁酰胆碱酯酶抑制剂: N-二烷基O-芳基氨基甲酸酯弹头的构效关系，计算和晶体学研究

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
IF5.9
2023-02-016
PRE
Meden, Anze; Knez, Damijan; Brazzolotto, Xavier; Modeste, Fabrice; Perdih, Andrej; Pislar, Anja; Zorman, Masa; Zorovic, Maja; Denic, Milica; Pajk, Stane; Zivin, Marko; Nachon, Florian; Gobec, Stanislav

研究方向

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F
Florian Nachon
H 指数:48论文数:259被引数:7,962
S
Stanislav Gobec
H 指数:51论文数:507被引数:9,458
D
Damijan Knez
H 指数:28论文数:114被引数:2,309
A
Anja Pišlar
H 指数:25论文数:73被引数:2,207
J
José Dias
H 指数:15论文数:47被引数:581
K
Kinga Sałat
H 指数:30论文数:152被引数:3,264
J
Jure Stojan
H 指数:30论文数:129被引数:3,232
U
Urban Košak
H 指数:10论文数:44被引数:912
J
Janko Kos
H 指数:65论文数:505被引数:1.4万
J
Jacques‐Philippe Colletier
H 指数:46论文数:188被引数:7,040