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Alternative splicing in the DBD linker region of p63 modulates binding to DNA and iASPP in vitro Lotz, Rebecca; Osterburg, Christian; Chaikuad, Apirat; Weber, Sabrina; Akutsu, Masato; Machel, Anne Christin; Beyer, Ulrike; Gebel, Jakob; Loehr, Frank; Knapp, Stefan; Dobbelstein, Matthias; Lu, Xin; Doetsch, Volker 分享 收藏
DARPins as a novel tool to detect and degrade p73 Muenick, Philipp; Zielinski, Jasmin; Strubel, Alexander; Gutfreund, Niklas; Dreier, Birgit; Schaefer, Jonas V.; Schaefer, Birgit; Gebel, Jakob; Osterburg, Christian; Chaikuad, Apirat; Knapp, Stefan; Plueckthun, Andreas; Doetsch, Volker 分享 收藏
Thieno[3,2-b]pyridine: Attractive scaffold for highly selective inhibitors of underexplored protein kinases with variable binding mode Moyano, Paula Martin; Kubina, Tadeas; Paruch, Stepan Owen; Jaroskova, Aneta; Novotny, Jan; Skockova, Veronika; Ovesna, Petra; Suchankova, Tereza; Prokofeva, Polina; Kuster, Bernhard; Smida, Michal; Chaikuad, Apirat; Kraemer, Andreas; Knapp, Stefan; Soucek, Karel; Paruch, Kamil 分享 收藏
Structure-Guided Design of a Highly Potent Partial RXR Agonist with Superior Physicochemical Properties Lewandowski, Max; Carmina, Melania; Knuemann, Loris; Sai, Minh; Willems, Sabine; Kasch, Till; Pollinger, Julius; Knapp, Stefan; Marschner, Julian A.; Chaikuad, Apirat; Merk, Daniel 分享 收藏
DARPins detect the formation of hetero-tetramers of p63 and p73 in epithelial tissues and in squamous cell carcinoma Strubel, Alexander; Muenick, Philipp; Hartmann, Oliver; Chaikuad, Apirat; Dreier, Birgit; Schaefer, Jonas V.; Gebel, Jakob; Osterburg, Christian; Tuppi, Marcel; Schaefer, Birgit; Buck, Viktoria; Rosenfeldt, Mathias; Knapp, Stefan; Pluckthun, Andreas; Diefenbacher, Markus E.; Doetsch, Volker 分享 收藏
Targeting the Alternative Vitamin E Metabolite Binding Site Enables Noncanonical PPARγ Modulation Arifi, Silvia; Marschner, Julian A.; Pollinger, Julius; Isigkeit, Laura; Heitel, Pascal; Kaiser, Astrid; Obeser, Lennart; Hoefner, Georg; Proschak, Ewgenij; Knapp, Stefan; Chaikuad, Apirat; Heering, Jan; Merk, Daniel 分享 收藏
Structure-Based Development of Isoform-Selective Inhibitors of Casein Kinase 1ε vs Casein Kinase 1δ Choi, Jun Yong; Noguchi, Yoshihiko; Alburger, James M.; Bayle, Simon; Chung, Eugene; Grant, Wayne; Chaikuad, Apirat; Knapp, Stefan; Duckett, Derek R.; Roush, William R. 分享 收藏
Modulation of tau tubulin kinases (TTBK1 and TTBK2) impacts ciliogenesis Bashore, Frances M. M.; Marquez, Ariana B. B.; Chaikuad, Apirat; Howell, Stefanie; Dunn, Andrea S. S.; Beltran, Alvaro A. A.; Smith, Jeffery L. L.; Drewry, David H. H.; Beltran, Adriana S. S.; Axtman, Alison D. D. 分享 收藏
Design, synthesis and characterisation of a novel type II B-RAF paradox breaker inhibitor Arora, Rohit; Linders, Joannes T. M.; Aci-Seche, Samia; Verheyen, Thomas; Van Heerde, Erika; Brehmer, Dirk; Chaikuad, Apirat; Knapp, Stefan; Bonnet, Pascal 分享 收藏
Discovery of Potent and Exquisitely Selective Inhibitors of Kinase CK1 with Tunable Isoform Selectivity Nemec, Vaclav; Khirsariya, Prashant; Janovska, Pavlina; Moyano, Paula Martin; Maier, Lukas; Prochazkova, Petra; Kebkova, Pavlina; Gybel', Tomas; Berger, Benedict-Tilman; Chaikuad, Apirat; Reinecke, Maria; Kuster, Bernhard; Knapp, Stefan; Bryja, Vitezslav; Paruch, Kamil 分享 收藏
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Mechanistic Impact of Different Ligand Scaffolds on FXR Modulation Suggests Avenues to Selective Modulators Heering, Jan; Jores, Nathalie; Kilu, Whitney; Schallmayer, Espen; Peelen, Evelyn; Muehler, Andreas; Kohlhof, Hella; Vitt, Daniel; Linhard, Verena; Gande, Santosh L.; Chaikuad, Apirat; Sreeramulu, Sridhar; Schwalbe, Harald; Merk, Daniel 分享 收藏
Designed Ankyrin Repeat Proteins as a tool box for analyzing p63 Strubel, Alexander; Munick, Philipp; Chaikuad, Apirat; Dreier, Birgit; Schaefer, Jonas; Gebel, Jakob; Osterburg, Christian; Tuppi, Marcel; Schaefer, Birgit; Knapp, Stefan; Plueckthun, Andreas; Doetsch, Volker 分享 收藏
Synthesis and biological evaluation of Haspin inhibitors: Kinase inhibitory potency and cellular activity Zeinyeh, Wael; Esvan, Yannick J.; Josselin, Beatrice; Defois, Mathilde; Baratte, Blandine; Knapp, Stefan; Chaikuad, Apirat; Anizon, Fabrice; Giraud, Francis; Ruchaud, Sandrine; Moreau, Pascale 分享 收藏
Kinase domain autophosphorylation rewires the activity and substrate specificity of CK1 enzymes Cullati, Sierra N.; Chaikuad, Apirat; Chen, Jun-Song; Gebel, Jakob; Tesmer, Laura; Zhubi, Rezart; Navarrete-Perea, Jose; Guillen, Rodrigo X.; Gygi, Steven P.; Hummer, Gerhard; Dotsch, Volker; Knapp, Stefan; Gould, Kathleen L. 分享 收藏
Kinase Domain Autophosphorylation Rewires the Activity and Substrate Specificity of CK1 Enzymes Cullati, Sierra; Chaikuad, Apirat; Chen, Jun-Song; Gebel, Jakob; Tesmer, Laura; Zhubi, Rezart; Navarrete-Perea, Jose; Guillen, Rodrigo X.; Gygi, Steven P.; Hummer, Gerhard 分享 收藏
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