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S

Simone Bonazzi

novartis biomedical research
H指数:15
被引数:1,147

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荣誉奖项

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Discovery and Optimization of First-in-Class Molecular Glue Degraders of the WIZ Transcription Factor for Fetal Hemoglobin Induction to Treat Sickle Cell Disease
JOURNAL OF MEDICINAL CHEMISTRY
IF6.8
2024-11-140
PRE
Kerrigan, John Ryan; Thomsen, Noel M.; Cernijenko, Artiom; Kochanek, Sarah E.; Dewhurst, Janetta; O'Brien, Gary; Ware, Nathaniel F.; Sanchez, Carina C.; Manning, James R.; Ma, Xiaolei; Ornelas, Elizabeth; Savage, Nikolas A.; Partridge, James R.; Patterson, Andrew W.; Lam, Philip; Dales, Natalie A.; Bonazzi, Simone; Borikar, Sneha; Hinman, Amelia E.; Ting, Pamela Y.
Diversity-oriented synthesis encoded by deoxyoligonucleotides (vol 14, 4930, 2023)
NATURE COMMUNICATIONS
IF15.7
2023-11-210
OAAI
Hudson, Liam; Mason, Jeremy W.; Westphal, Matthias V.; Richter, Matthieu J. R.; Thielman, Jonathan R.; Hua, Bruce K.; Gerry, Christopher J.; Xia, Guoqin; Osswald, Heather L.; Knapp, John M.; Tan, Zher Yin; Kokkonda, Praveen; Tresco, Ben I. C.; Liu, Shuang; Reidenbach, Andrew G.; Lim, Katherine S.; Poirier, Jennifer; Capece, John; Bonazzi, Simone; Gampe, Christian M.; Smith, Nichola J.; Bradner, James E.; Coley, Connor W.; Clemons, Paul A.; Melillo, Bruno; Hon, C. Suk-Yee; Ottl, Johannes; Dumelin, Christoph E.; Schaefer, Jonas V.; Faust, Ann Marie E.; Berst, Frederic; Schreiber, Stuart L.; Zecri, Frederic J.; Briner, Karin
Diversity-oriented synthesis encoded by deoxyoligonucleotides
NATURE COMMUNICATIONS
IF15.7
2023-08-157
OAAI
Hudson, Liam; Mason, Jeremy W.; Westphal, Matthias V.; Richter, Matthieu J. R.; Thielman, Jonathan R.; Hua, Bruce K.; Gerry, Christopher J.; Xia, Guoqin; Osswald, Heather L.; Knapp, John M.; Tan, Zher Yin; Kokkonda, Praveen; Tresco, Ben I. C.; Liu, Shuang; Reidenbach, Andrew G.; Lim, Katherine S.; Poirier, Jennifer; Capece, John; Bonazzi, Simone; Gampe, Christian M.; Smith, Nichola J.; Bradner, James E.; Coley, Connor W.; Clemons, Paul A.; Melillo, Bruno; Hon, C. Suk-Yee; Ottl, Johannes; Dumelin, Christoph E.; Schaefer, Jonas V.; Faust, Ann Marie E.; Berst, Frederic; Schreiber, Stuart L.; Zecri, Frederic J.; Briner, Karin
Seizure reduction in TSC2-mutant mouse model by an mTOR catalytic inhibitor
ANNALS OF CLINICAL AND TRANSLATIONAL NEUROLOGY
IF3.9
2023-08-063
OAAI
Dhamne, Sameer C.; Modi, Meera E.; Gray, Audrey; Bonazzi, Simone; Craig, Lucas; Bainbridge, Elizabeth; Lalani, Lahin; Super, Chloe E.; Schaeffer, Samantha; Capre, Ketthsy; Lubicka, Danuta; Liang, Guiqing; Burdette, Doug; McTighe, Stephanie M.; Gurnani, Sarika; Vermudez, Sheryl Anne D.; Curtis, Daniel; Wilson, Christopher J.; Hameed, Mustafa Q.; D'Amore, Angelica; Rotenberg, Alexander; Sahin, Mustafa
Identification of Brain-Penetrant ATP-Competitive mTOR Inhibitors for CNS Syndromes
JOURNAL OF MEDICINAL CHEMISTRY
IF6.8
2023-07-030
PRE
Bonazzi, Simone; Gray, Audrey; Thomsen, Noel M.; Biag, Jonathan; Labbe-Giguere, Nancy; Keaney, Erin P.; Malik, Hasnain A.; Sun, Yingchuan; Nunez, Jill; Karki, Rajeshri G.; Knapp, Mark; Elling, Robert; Fuller, John; Pardee, Gwynn; Craig, Lucas; Capre, Ketthsy; Salas, Sarah; Gorde, Aakruti; Liang, Guiqing; Lubicka, Danuta; McTighe, Stephanie M.; Goold, Carleton; Liu, Shanming; Deng, Lin; Hong, Jin; Fekete, Alexander; Stadelmann, Pascal; Frieauff, Wilfried; Elhajouji, Azeddine; Bauer, Daniel; Lerchner, Andreas; Radetich, Branko; Furet, Pascal; Piizzi, Grazia; Burdette, Doug; Wilson, Christopher J.; Peukert, Stefan; Hamann, Lawrence G.; Murphy, Leon O.; Curtis, Daniel
Discovery and characterization of a selective IKZF2 glue degrader for cancer immunotherapy

用于癌症免疫治疗的选择性IKZF2胶降解剂的发现和表征

CELL CHEMICAL BIOLOGY
IF7.2
2023-03-0159
OAAI
Bonazzi, Simone; d'Hennezel, Eva; Beckwith, Rohan E. J.; Xu, Lei; Fazal, Aleem; Magracheva, Anna; Ramesh, Radha; Cernijenko, Artiom; Antonakos, Brandon; Bhang, Hyo-eun C.; Caro, Roxana Garcia; Cobb, Jennifer S.; Ornelas, Elizabeth; Ma, Xiaolei; Wartchow, Charles A.; Clifton, Matthew C.; Forseth, Ry R.; Fortnam, Bethany Hughes; Lu, Hongbo; Csibi, Alfredo; Tullai, Jennifer; Carbonneau, Seth; Thomsen, Noel M.; Larrow, Jay; Chie-Leon, Barbara; Hainzl, Dominik; Gu, Yi; Lu, Darlene; Meyer, Matthew J.; Alexander, Dylan; Kinyamu-Akunda, Jacqueline; Sabatos-Peyton, Catherine A.; Dales, Natalie A.; Zecri, Frederic J.; Jain, Rishi K.; Shulok, Janine; Wang, Y. Karen; Briner, Karin; Porter, Jeffery A.; Tallarico, John A.; Engelman, Jeffrey A.; Dranoff, Glenn; Bradner, James E.; Visser, Michael; Solomon, Jonathan M.
Discovery of a Brain-Penetrant ATP-Competitive Inhibitor of the Mechanistic Target of Rapamycin (mTOR) for CNS Disorders
JOURNAL OF MEDICINAL CHEMISTRY
IF6.8
2020-01-2023
PREAI
Bonazzi, Simone; Goold, Carleton P.; Gray, Audrey; Thomsen, Noel M.; Nunez, Jill; Karki, Rajeshri G.; Gorde, Aakruti; Biag, Jonathan D.; Malik, Hasnain A.; Sun, Yingchuan; Liang, Guiqing; Lubicka, Danuta; Salas, Sarah; Labbe-Giguere, Nancy; Keaney, Erin P.; McTighe, Stephanie; Liu, Shanming; Deng, Lin; Piizzi, Grazia; Lombardo, Franco; Burdette, Doug; Dodart, Jean-Cosme; Wilson, Christopher J.; Peukert, Stefan; Curtis, Daniel; Hamann, Lawrence G.; Murphy, Leon O.

研究方向

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F
Frédéric J. Zécri
H 指数:23论文数:78被引数:2,436
K
Karl Gademann
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S
Stuart L. Schreiber
H 指数:166论文数:1,312被引数:13.3万
F
Frédéric Berst
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S
Shuang Liu
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K
Karin Briner
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Z
Zher Yin Tan
H 指数:9论文数:16被引数:926
J
Jeremy W. Mason
H 指数:10论文数:20被引数:407
N
Noel M. Thomsen
H 指数:7论文数:14被引数:439
P
Paul A. Clemons
H 指数:58论文数:224被引数:3.3万