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M

Matthias Müller

tu dortmund university

46H指数
148论文数
6.3K被引数
收录论文 58
发表时间
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Isoform-Selective Targeting of Akt Through Covalent Allosteric Inhibition通过共价别构抑制对Akt的选择性亚型靶向
errAngewandte Chemie-International Edition
IF16.9
err2026-09-08
err0
PREAI
errGiovanni Danilo D'Angelo; Kosmas Alexandros Pervanidis; Ioannis Athanasiadis; Vladimir Lukianchikov; Andrea Scrima; Laura Depta; Sara Stier; Matthias P. Müller; Henner F. Farin; Lena Quambusch; Daniel Rauh
err分享
err收藏
Structure-based scaffold hopping reveals strategies to overcome oncogenic KIT and PDGFRA mutation-driven drug-resistance in GIST基于结构的骨架跳跃揭示克服胃肠道间质瘤中致癌KIT和PDGFRA突变驱动的药物耐药性的策略
errNature Communications
IF15.7
err2026-08-06
err0
errOAAI
errT. Schulz; M. Beerbaum; A. Scrima; H. Jantzen; A. Teuber; T. Mühlenberg; L. Ebel; F. Garcia-Fossa; A. George; N. Berner; J. Weisner; M. P. Müller; S. Wilhelm; S. Sievers; S. Bauer; D. Rauh
err分享
err收藏
Fred Wittinghofer and the GTP/GDP-binding proteinsFred Wittinghofer与GTP/GDP结合蛋白
errBiological Chemistry
IF2.4
err2026-05-26
err0
errOAAI
errGoody, Roger S.; Muller, Matthias P.
err分享
err收藏
Lessons from Structural Biology for Understanding Drug Resistance in Gastrointestinal Stromal Tumors (GIST)结构生物学对理解胃肠道间质瘤(GIST)药物耐药性的启示
errJournal of Medicinal Chemistry
IF6.8
err2026-03-02
err0
PREAI
errGiorgia Mancino; Tom Schulz; Andrea Scrima; Matthias P. Müller; Sebastian Bauer; Daniel Rauh
err分享
err收藏
Advancing TET Inhibitor Development: From Structural Insights to Biological Evaluation
errACS MEDICINAL CHEMISTRY LETTERS
IF4
err2025-04-01
err0
PREAI
errWillems, Suzanne; Maksumic, Lejla; Niggenaber, Janina; Lin, Tzu-Chen; Schulz, Tom; Weisner, Joern; Sievers, Sonja; Mueller, Matthias P.; Summerer, Daniel; Rauh, Daniel
err分享
err收藏
Targeting KRAS Diversity: Covalent Modulation of G12X and Beyond in Cancer Therapy
errJOURNAL OF MEDICINAL CHEMISTRY
IF6.8
err2024-04-15
err6
PREAI
errKirschner, Tonia; Mueller, Matthias P.; Rauh, Daniel
err分享
err收藏
A high-throughput effector screen identifies a novel small molecule scaffold for inhibition of ten-eleven translocation dioxygenase 2 (vol 13, pg 1540, 2022)
errRSC MEDICINAL CHEMISTRY
IF3.6
err2024-01-01
err1
errOAAI
errPalei, Shubhendu; Weisner, Joern; Vogt, Melina; Gontla, Rajesh; Buchmuller, Benjamin; Ehrt, Christiane; Grabe, Tobias; Kleinboelting, Silke; Mueller, Matthias; Clever, Guido H.; Rauh, Daniel; Summerer, Daniel
err分享
err收藏
FRAGTORY: Pharmacophore-Focused Design, Synthesis, and Evaluation of an sp3-Enriched Fragment Library
errJOURNAL OF MEDICINAL CHEMISTRY
IF6.8
err2023-05-02
err3
PREAI
errBuehrmann, Mike; Kallepu, Shivakrishna; Warmuth, Jonas D.; Wiese, Jan N.; Ehrt, Christiane; Vatheuer, Helge; Hiller, Wolf; Seitz, Carina; Levy, Laura; Czodrowski, Paul; Sievers, Sonja; Mueller, Matthias P.; Rauh, Daniel
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err收藏
Addressing the Osimertinib Resistance Mutation EGFR-L858R/C797S with Reversible Aminopyrimidines
errACS MEDICINAL CHEMISTRY LETTERS
IF4
err2023-04-18
err9
errOAAI
errGrabe, Tobias; Jeyakumar, Kirujan; Niggenaber, Janina; Schulz, Tom; Koska, Sandra; Kleinboelting, Silke; Beck, Michael Edmund; Mueller, Matthias P.; Rauh, Daniel
err分享
err收藏
Targeting oncogenic KRasG13C with nucleotide-based covalent inhibitors用基于核苷酸的共价抑制剂靶向致癌KRasG13C
errELIFE
IF0
err2023-03-27
err1
errOAAI
errGoebel, Lisa; Kirschner, Tonia; Koska, Sandra; Rai, Amrita; Janning, Petra; Maffini, Stefano; Vatheuer, Helge; Czodrowski, Paul; Goody, Roger S.; Mueller, Matthias P.; Rauh, Daniel
err分享
err收藏
Optimization of Covalent MKK7 Inhibitors via Crude Nanomole- Scale Libraries
errJOURNAL OF MEDICINAL CHEMISTRY
IF6.8
err2022-07-30
err8
errOAAI
errGehrtz, Paul; Marom, Shir; Buehrmann, Mike; Hardick, Julia; Kleinboelting, Silke; Shraga, Amit; Dubiella, Christian; Gabizon, Ronen; Wiese, Jan N.; Mueller, Matthias P.; Cohen, Galit; Babaev, Ilana; Shurrush, Khriesto; Avram, Liat; Resnick, Efrat; Barr, Haim; Rauh, Daniel; London, Nir
err分享
err收藏
Insight into Targeting Exon20 Insertion Mutations of the Epidermal Growth Factor Receptor with Wild Type-Sparing Inhibitors
errJOURNAL OF MEDICINAL CHEMISTRY
IF6.8
err2022-04-29
err18
PREAI
errLategahn, Jonas; Tumbrink, Hannah L.; Schultz-Fademrecht, Carsten; Heimsoeth, Alena; Werr, Lisa; Niggenaber, Janina; Keul, Marina; Parmaksiz, Fatma; Baumann, Matthias; Menninger, Sascha; Zent, Eldar; Landel, Ina; Weisner, Joern; Jeyakumar, Kirujan; Heyden, Leonie; Russ, Nicole; Mueller, Fabienne; Lorenz, Carina; Braegelmann, Johannes; Spille, Inga; Grabe, Tobias; Mueller, Matthias P.; Heuckmann, Johannes M.; Klebl, Bert M.; Nussbaumer, Peter; Sos, Martin L.; Rauh, Daniel
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err收藏
Covalent Allosteric Inhibitors of Akt Generated Using a Click Fragment Approach使用点击片段方法产生的Akt的共价变构抑制剂
errCHEMMEDCHEM
IF3.4
err2022-03-09
err4
errOAAI
errWesthuizen, Leandi; Weisner, Joern; Taher, Abu; Landel, Ina; Quambusch, Lena; Lindemann, Marius; Uhlenbrock, Niklas; Mueller, Matthias P.; Green, Ivan R.; Pelly, Stephen C.; Rauh, Daniel; van Otterlo, Willem A. L.
err分享
err收藏
A high-throughput effector screen identifies a novel small molecule scaffold for inhibition of ten-eleven translocation dioxygenase 2
errRSC MEDICINAL CHEMISTRY
IF3.6
err2022-01-01
err3
errOAAI
errPalei, Shubhendu; Weisner, Jorn; Vogt, Melina; Gontla, Rajesh; Buchmuller, Benjamin; Ehrt, Christiane; Grabe, Tobias; Kleinbolting, Silke; Muller, Matthias; Clever, Guido H.; Rauh, Daniel; Summerer, Daniel
err分享
err收藏
Cellular model system to dissect the isoform-selectivity of Akt inhibitors
errNATURE COMMUNICATIONS
IF15.7
err2021-09-06
err25
errOAAI
errQuambusch, Lena; Depta, Laura; Landel, Ina; Lubeck, Melissa; Kirschner, Tonia; Nabert, Jonas; Uhlenbrock, Niklas; Weisner, Joern; Kostka, Michael; Levy, Laura M.; Schultz-Fademrecht, Carsten; Glanemann, Franziska; Althoff, Kristina; Mueller, Matthias P.; Siveke, Jens T.; Rauh, Daniel
err分享
err收藏
Complex Crystal Structures of EGFR with Third-Generation Kinase Inhibitors and Simultaneously Bound Allosteric LigandsEGFR与第三代激酶抑制剂和同时结合的变构配体的复杂晶体结构
errACS MEDICINAL CHEMISTRY LETTERS
IF4
err2020-11-05
err32
errOAAI
errNiggenaber, Janina; Heyden, Leonie; Grabe, Tobias; Mueller, Matthias P.; Lategahn, Jonas; Rauh, Daniel
err分享
err收藏
Targeting Her2-insYVMA with Covalent Inhibitors-A Focused Compound Screening and Structure-Based Design Approach
errJOURNAL OF MEDICINAL CHEMISTRY
IF6.8
err2020-09-15
err13
PREAI
errLategahn, Jonas; Hardick, Julia; Grabe, Tobias; Niggenaber, Janina; Jeyakumar, Kirujan; Keul, Marina; Tumbrink, Hannah L.; Becker, Christian; Hodson, Luke; Kirschner, Tonia; Kloevekorn, Philip; Ketzer, Julia; Baumann, Matthias; Terheyden, Susanne; Unger, Anke; Weisner, Joern; Mueller, Matthias P.; van Otterlo, Willem A. L.; Bauer, Sebastian; Rauh, Daniel
err分享
err收藏
KRasG12C inhibitors in clinical trials: a short historical perspective
errRSC MEDICINAL CHEMISTRY
IF3.6
err2020-01-01
err72
errOAAI
errGoebel, Lisa; Mueller, Matthias P.; Goody, Roger S.; Rauh, Daniel
err分享
err收藏
Augmented Reality in Scientific Publications Taking the Visualization of 3D Structures to the Next Level (vol 13, pg 496, 2018)
errACS CHEMICAL BIOLOGY
IF3.8
err2019-12-12
err0
PREAI
errWolle, Patrik; Mueller, Matthias P.; Rauh, Daniel
err分享
err收藏
Mutant-Specific Targeting of Ras G12C Activity by Covalently Reacting Small Molecules
errCELL CHEMICAL BIOLOGY
IF7.2
err2019-10-01
err12
errOAAI
errGoody, Roger S.; Mueller, Matthias P.; Rauh, Daniel
err分享
err收藏

研究方向

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